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ClinicalTrials.gov public records Last synced Nov 14, 2026, 8:02 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 860 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Tobacco Abuse Clear all

Conditions: Nicotine Addiction
Interventions: transcranial direct current stimulation (tDCS); Device
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 60 Years
Enrollment: 172 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Nicotine Dependence
Interventions: Placebo, Varenicline; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 62 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Nicotine Dependence, Opiate Dependence
Interventions: Intensive, tailored intervention, NJ Quitline Referral; Behavioral
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 18 Years and older
Enrollment: 87 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Tobacco Use Disorder, Nicotine Dependence
Interventions: Low nicotine, Medium nicotine, High nicotine; Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 278 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2016
U.S. locations: 2
States / cities: Minneapolis, Minnesota • Eugene, Oregon

Conditions: Nicotine Dependence
Interventions: Standard Treatment, Traditional Contingency Management, Early Enhanced Contingency Management; Behavioral
Lead sponsor: Wayne State University; Other
Eligibility: 13 Years and older
Enrollment: 84 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Smoking, Tobacco Use, Tobacco Smoking
Interventions: Product A, Product B, Product C, Product D, Product N, Product E; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 42 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 2
States / cities: Lexington, Kentucky • Knoxville, Tennessee

Conditions: Smoking, Nicotine Dependence
Interventions: Naltrexone, Bupropion; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2005
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Tobacco Dependence
Interventions: C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker, Lung Cancer Screening; Behavioral · Drug · Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 50 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Tobacco Use Disorder
Interventions: Internet-delivered continuing professional development, No intervention arm; Behavioral · Other
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 19 Years and older
Enrollment: 190 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2008
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Tobacco Use Disorder
Interventions: Memantine, bupropion, placebo; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 21 Years to 45 Years
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2009
U.S. locations: 1
States / cities: New York, New York

Conditions: Nicotine Dependence, Nicotine Withdrawal
Interventions: Bupropion, Varenicline; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 121 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Cigarette Smoking, Nicotine Dependence
Interventions: Counseling Intervention, Information Intervention; Behavioral
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 13 Years to 18 Years
Enrollment: 1,058 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2010
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Nicotine Dependence, Smoking
Interventions: N-acetylcysteine (NAC), Placebo; Drug · Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 114 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Vaping, Adolescent, Electronic Cigarette Use, Nicotine, Cannabis
Interventions: Vaping Device Labeling; Other
Lead sponsor: University of Southern California; Other
Eligibility: 11 Years to 19 Years
Enrollment: 3,048 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Tobacco Use Disorder, Smoking Cessation
Interventions: Web-based curriculum on tobacco dependence treatment, Tobacco Counseling Role Play, Preceptor Training and Teaching Medical Students, Booster Session; Behavioral
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 13
States / cities: Birmingham, Alabama • Stanford, California • Washington D.C., District of Columbia + 10 more

Conditions: Nicotine Dependence
Interventions: NIC002 in Aluminum hydroxide (Alum), Placebo Vaccine - Aluminum hydroxide; Biological
Lead sponsor: Alexey Mukhin; Other
Eligibility: 18 Years to 55 Years
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 2
States / cities: Durham, North Carolina • Winston-Salem, North Carolina

Conditions: Smoking Cessation
Interventions: Non-invasive vagus nerve stimulator plus nicotine replacement patches, nicotine replacement patches; Combination Product · Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Tobacco Use Disorder, Schizophrenia
Interventions: sensorimotor replacement, 42 mg transdermal nicotine replacement, Placebo transdermal nicotine, usual brand smoking; Behavioral · Drug · Other
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 99 Years
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2011
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Nicotine Withdrawal, Marijuana Dependence, Cannabis Dependence, Nicotine Dependence, Cannabis Abuse
Interventions: Placebo Aprepitant, Active Aprepitant; Drug
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years to 45 Years
Enrollment: 63 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2012
U.S. locations: 2
States / cities: Charlottesville, Virginia

Conditions: Smoking Cessation, Smoking, Nicotine Dependence
Interventions: Varenicline, Nicotine lozenge, Nicotine Patch; Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 99 Years
Enrollment: 1,086 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 2
States / cities: Madison, Wisconsin • Milwaukee, Wisconsin

Conditions: Tobacco Use Disorder
Interventions: AAT-experiment, AAT-placebo; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 13 Years to 18 Years
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Nicotine Dependence
Interventions: e-cig with nicotine, e-cig without nicotine, nicotine inhaler, sham control; Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 21 Years to 45 Years
Enrollment: 148 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Smoking, Nicotine Dependence, Mental Disorders
Interventions: Cognitive / Motivational Individual Sessions, Attention Control Individual Sessions, Nicotine Patch, Group Curriculum; Behavioral · Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 99 Years
Enrollment: 270 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Nicotine Dependence, ADHD
Interventions: Very low nicotine content cigarettes, Conventional nicotine content cigarettes; Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 40 Years
Enrollment: 71 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 2
States / cities: Durham, North Carolina • Pittsburgh, Pennsylvania

Search by objective public record fields.

tDCS Effects on Resisting Smoking: Dose Ranging Study

Effects of Chantix on Relapse Prevention for Smoking Cessation

Developing a Smoking Cessation Intervention for Methadone Maintained Smokers

Novel Determinants and Measures of Smokeless Tobacco Use: Study 2

Prize Reinforcement for Smoking Cessation

CSD201301: Study to Assess Elements of Abuse Liability for Four P13 Nicotine Pouches

Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight Gain

C-Raven, a Virtual Tobacco Cessation Intervention in the Community

Dental Tobacco Control.Net:Improving Practice

The Effects of Memantine and Bupropion on Acute, Reinforcing, and Conditioned Effects of Cigarettes - 1

Human Laboratory Study of Varenicline and Bupropion for Nicotine Dependence

School Nurse-Delivered Smoking Cessation Intervention

N-acetylcysteine for Tobacco Use Disorder

Nicotine and Cannabis Vape Labeling Experiment - Spring 2025

Tobacco Treatment Medical Education in 10 Medical Schools

Improving the Efficacy of Anti-Nicotine Immunotherapy

A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation

Nicotine and Sensorimotor Replacement for Smoking in Smokers With Schizophrenia

Medications Development for the Treatment of Cannabis Related Disorders

A Comparative Effectiveness & Long Term Health Study in Wisconsin Smokers

Tobacco Approach Avoidance Training for Adolescent Smokers-2

E-cigarettes, Nicotine Inhaler, and Blood Vessel Function

Helping Those With Mental Illness Quit Smoking

Effects of Nicotine Reduction on Smoking Behavior in ADHD Smokers