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ClinicalTrials.gov public records Last synced Oct 15, 2026, 6:52 AM EDT

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Showing 505–528 of 860 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Tobacco Abuse Clear all
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Topiramate Alone and in Combination With the Nicotine Patch for Smoking Cessation: A Pilot Study

NCT00755716
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Placebo (sugar pill), Topiramate, Nicotine patch
Drug
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 65 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2013
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 16, 2017 · Synced Oct 15, 2026, 6:52 AM EDT
Completed Phase 4 Interventional Results available

Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking

NCT00365508
View directory record Official record
Conditions
Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer, Head and Neck Cancer, Kidney Cancer, Leukemia, Liver Cancer, Lung Cancer, Pancreatic Cancer, Tobacco Use Disorder
Interventions
nicotine lozenge, nicotine patch
Drug
Lead sponsor
Fox Chase Cancer Center
Other
Eligibility
18 Years and older
Enrollment
642 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
10
States / cities
Washington D.C., District of Columbia • Miami Beach, Florida • Augusta, Georgia + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 29, 2016 · Synced Oct 15, 2026, 6:52 AM EDT
Completed No phase listed Observational Results available

Evaluation of a Smoking Cessation Program for Long-Term Abstinence

NCT06746025
View directory record Official record
Conditions
Nicotine Addiction, Smoking Cessation
Interventions
Quit Center cessation program
Behavioral
Lead sponsor
Quit Center LLC
Industry
Eligibility
18 Years and older
Enrollment
371 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Naples, Florida
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Oct 15, 2026, 6:52 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Safety of Combining Modafinil and Nicotine Replacement Therapy in Treating Nicotine Dependent Adolescents

NCT00258479
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
ModafinilNicotine Replacement Therapy, Modafinil
Drug
Lead sponsor
Catherine Martin, MD
Other
Eligibility
16 Years to 40 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2011
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated May 11, 2017 · Synced Oct 15, 2026, 6:52 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Behavioral Activation Therapy and Nicotine Replacement Therapy in Increasing Smoking Cessation

NCT02697227
View directory record Official record
Conditions
Cigarette Smoker, Tobacco Use Disorder
Interventions
Behavioral Intervention, Laboratory Biomarker Analysis, Nicotine Patch, Questionnaire Administration, Smoking Cessation Intervention
Behavioral · Other · Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years to 75 Years
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Oct 15, 2026, 6:52 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Aspirin and Zileuton and Biomarker Expression in Nasal Tissue of Current Smokers

NCT02348203
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Aspirin, Laboratory Biomarker Analysis, Placebo Administration, Zileuton
Drug · Other
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
2
States / cities
Tucson, Arizona • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 2, 2022 · Synced Oct 15, 2026, 6:52 AM EDT
Completed Not applicable Interventional

Disseminating and Implementing a Smoking Cessation Program for Pregnant and Postpartum Women

NCT02952703
View directory record Official record
Conditions
Smoking, Tobacco Use Disorder
Interventions
brief pre-delivery smoking cessation counseling, additional pre-delivery smoking cessation counseling, post- delivery smoking cessation counseling, incentives
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 12, 2018 · Synced Oct 15, 2026, 6:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Cigar Flavor in Dual Users

NCT04487470
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Flavored filtered cigars, Unflavored filtered cigars
Other
Lead sponsor
UConn Health
Other
Eligibility
21 Years to 34 Years
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Oct 15, 2026, 6:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparative Acceptability of Tobacco and Menthol Flavored E-cigarettes

NCT04996940
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
E-cigarette product
Device
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 13, 2023 · Synced Oct 15, 2026, 6:52 AM EDT
Completed Not applicable Interventional

Transcranial Magnetic Stimulation and Tobacco Use Disorder

NCT03827265
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
repetitive transcranial magnetic stimulation (rTMS)
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 45 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 8, 2025 · Synced Oct 15, 2026, 6:52 AM EDT
Completed Phase 2 Interventional Results available

Combining Varenicline and Naltrexone for Smoking Cessation

NCT02698215
View directory record Official record
Conditions
Nicotine Dependence, Alcohol Use Disorder
Interventions
Varenicline, Varenicline plus Naltrexone
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 65 Years
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 15, 2021 · Synced Oct 15, 2026, 6:52 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Young Adult Tobacco/Nicotine and Cannabis Co-use

NCT06239350
View directory record Official record
Conditions
Tobacco Use Disorder, Nicotine Dependence
Interventions
Counseling, Contingency management, Text-based support
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 25 Years
Enrollment
350 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 15, 2026, 6:52 AM EDT
Completed Phase 2 Interventional

Tobacco Cessation Field Study for Adults in Recovery - 1

NCT00109460
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Tobacco Use Disorder
Behavioral
Lead sponsor
Inflexxion, Inc.
Industry
Eligibility
18 Years and older
Enrollment
203 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
7
States / cities
La Puente, California • Athol, Massachusetts • Ann Arbor, Michigan + 4 more
Source: ClinicalTrials.gov public record
Updated May 13, 2015 · Synced Oct 15, 2026, 6:52 AM EDT
Recruiting Not applicable Interventional

Identify the Optimal TMS Target to Modulate Reward Activity

NCT05766254
View directory record Official record
Conditions
Nicotine Use Disorder
Interventions
Active 10-Hz TMS to the DLPFC, Sham TMS-DLPFC
Device
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 55 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Oct 15, 2026, 6:52 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Screening Protocol for Research Participants

NCT01010620
View directory record Official record
Conditions
Schizophrenia, Substance Abuse, Cocaine Abuse, Tobacco Use Disorder
Interventions
Various Screening psychiatric and medical assessments
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 64 Years
Enrollment
523 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2019
U.S. locations
1
States / cities
Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 19, 2019 · Synced Oct 15, 2026, 6:52 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Beta-Adrenergic Modulation of Drug Cue Reactivity

NCT05587361
View directory record Official record
Conditions
Tobacco Use Disorder, Nicotine Dependence, Cigarette Smoking
Interventions
Propranolol, Nicotine Patch, Placebo Propranolol, Placebo Patch
Drug
Lead sponsor
University of Oklahoma
Other
Eligibility
21 Years to 60 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Oct 15, 2026, 6:52 AM EDT
Completed Not applicable Interventional Results available

Circuitry-Guided Smoking Cessation in Schizophrenia

NCT03281629
View directory record Official record
Conditions
Smoking Cessation, Nicotine Addiction, Schizophrenia
Interventions
Active TMS stimulation, Sham TMS stimulation
Device
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 60 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 18, 2023 · Synced Oct 15, 2026, 6:52 AM EDT
Completed Phase 4 Interventional Results available

Varenicline Effects In Schizophrenic Smokers

NCT00548470
View directory record Official record
Conditions
Schizophrenia, Tobacco Use Disorder, Nicotine Dependance
Interventions
Varenicline
Drug
Lead sponsor
Nathan Kline Institute for Psychiatric Research
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 20, 2018 · Synced Oct 15, 2026, 6:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Examining the Effectiveness of the Nicotine Patch in Male and Female Smokers - 2

NCT00135746
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
nicotine transdermal system
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 50 Years
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 15, 2026, 6:52 AM EDT
Withdrawn Not applicable Interventional

Korean Youth Smoking Cessation Study

NCT02021175
View directory record Official record
Conditions
Smoking
Interventions
Tailored CBME Therapy via Technology, Standard of Care
Behavioral · Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
14 Years to 19 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 25, 2020 · Synced Oct 15, 2026, 6:52 AM EDT
Completed Not applicable Interventional

Evaluation of Very Low Nicotine Content Cigarettes in Adolescent Smokers

NCT02587312
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Very low nicotine content cigarettes, Standard nicotine content cigarettes
Other
Lead sponsor
Brown University
Other
Eligibility
15 Years to 19 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 27, 2022 · Synced Oct 15, 2026, 6:52 AM EDT
Completed Not applicable Interventional

Smokers' Quitline for Asian Language Speakers

NCT01248832
View directory record Official record
Conditions
Smoking Cessation
Interventions
Telephone Counseling, Self-Help Materials
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 75 Years
Enrollment
2,277 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 13, 2020 · Synced Oct 15, 2026, 6:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Manipulating Tobacco Constituents in Male Menthol Smokers

NCT02592772
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Reduced Nicotine Non-Menthol (RNC), Reduced Nicotine Menthol (RNC-Men), Conventional Nicotine Non-Menthol (CN)
Other
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 45 Years · Male only
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
2
States / cities
Farmington, Connecticut • Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 9, 2020 · Synced Oct 15, 2026, 6:52 AM EDT
Completed Not applicable Interventional

Effects of Brief Training on Craving Regulation

NCT02153749
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Cognitive Regulation of Craving, Mindfulness-Based Regulation of Craving
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 60 Years
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 13, 2020 · Synced Oct 15, 2026, 6:52 AM EDT