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ClinicalTrials.gov public records Last synced Oct 11, 2026, 10:20 PM EDT

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Showing 193–216 of 860 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Tobacco Abuse Clear all
Completed Phase 3 Interventional Accepts healthy volunteers

Fluoxetine as a Quit Smoking Aid for Depression-Prone Smokers

NCT00018174
View directory record Official record
Conditions
Depression, Smoking
Interventions
Fluoxetine, Behavioral group smoking cessation treatment, Placebo
Drug · Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 65 Years
Enrollment
247 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1998 – 2005
U.S. locations
1
States / cities
Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 2, 2009 · Synced Oct 11, 2026, 10:20 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Appeal and Impact of E-Cigarettes Among Chronic Smokers With Smoking-Related Cancers

NCT02648178
View directory record Official record
Conditions
Nicotine Dependence, Other Tobacco Product, Bladder Cancer, Lung Cancer, Cancer of Head and Neck
Interventions
HALO
Device
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Sep 19, 2019 · Synced Oct 11, 2026, 10:20 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Nicotine Pharmacokinetics From Research Electronic Nicotine Delivery System S-TA-U001 in Smokers and E-Cigarette Users

NCT02792426
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Research ENDS S-TA-U001, Nicorette Inhalator
Drug
Lead sponsor
NJOY, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Burbank, California
Source: ClinicalTrials.gov public record
Updated May 17, 2018 · Synced Oct 11, 2026, 10:20 PM EDT
Completed Not applicable Interventional

ROSCAP: Reduction of Smoking in Cardiac Patients Study

NCT00301626
View directory record Official record
Conditions
Nicotine Dependence, Tobacco Dependence, Cardiac Disease
Interventions
smoking reduction intervention (including NRT)
Behavioral
Lead sponsor
National Institutes of Health (NIH)
NIH
Eligibility
18 Years to 80 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2005
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 24, 2008 · Synced Oct 11, 2026, 10:20 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Combined Pharmaco/Behavior Therapy in Adolescent Smokers

NCT00330187
View directory record Official record
Conditions
Nicotine Dependence, Nicotine Use Disorder
Interventions
Bupropion SR, Contingency Management, Placebo
Drug · Behavioral · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
12 Years to 21 Years
Enrollment
134 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2009
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 2, 2018 · Synced Oct 11, 2026, 10:20 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci)

NCT00365209
View directory record Official record
Conditions
Healthy, no Evidence of Disease, Tobacco Use Disorder
Interventions
laboratory biomarker analysis, pharmacological study, curcumin
Other · Drug
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
40 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2011
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Aug 27, 2015 · Synced Oct 11, 2026, 10:20 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

RTMS Targets Neural Circuits for Smoking Cessation

NCT04903028
View directory record Official record
Conditions
Tobacco Use, Cigarette Smoking
Interventions
Sham rTMS, Active rTMS 10 Hz DLPFC
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
22 Years to 70 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Oct 11, 2026, 10:20 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effects of Nicotine Reduction on Smoking Behavior in ADHD Smokers

NCT02599571
View directory record Official record
Conditions
Nicotine Dependence, ADHD
Interventions
Very low nicotine content cigarettes, Conventional nicotine content cigarettes
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 40 Years
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
2
States / cities
Durham, North Carolina • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 27, 2020 · Synced Oct 11, 2026, 10:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

DBT for Smoking Cessation in High Risk Veterans

NCT06687577
View directory record Official record
Conditions
Tobacco Dependence, Suicidal
Interventions
DBT-C, Treatment as usual
Behavioral
Lead sponsor
Veterans Medical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Oct 11, 2026, 10:20 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Measuring Smoking Behaviors While Using Varenicline

NCT00948155
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Varenicline
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 16, 2014 · Synced Oct 11, 2026, 10:20 PM EDT
Completed Not applicable Interventional

Intensive Intervention for Smokers - 6

NCT00217984
View directory record Official record
Conditions
Tobacco Use Disorder, Alcohol Dependence
Interventions
Usual Care, Extended cognitive behavior therapy
Other · Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 75 Years
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 1, 2017 · Synced Oct 11, 2026, 10:20 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

EEG & Behavioral Predictors of Changes in Smoking Trajectories in Young Light Smokers

NCT02129387
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Not listed
Lead sponsor
Southern Illinois University Carbondale
Other
Eligibility
18 Years to 25 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2021
U.S. locations
1
States / cities
Carbondale, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 1, 2022 · Synced Oct 11, 2026, 10:20 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

End Nicotine Dependence Clinic

NCT03290430
View directory record Official record
Conditions
Smoking Cessation
Interventions
Group Counseling, Individual Counseling, Phone Counseling, Video Counseling, Texting support, Nicotine Replacement Therapy
Behavioral · Drug
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 14, 2020 · Synced Oct 11, 2026, 10:20 PM EDT
Completed Phase 3 Interventional Results available

Telephone Counseling and the Distribution of Nicotine Patches to Smokers

NCT00851357
View directory record Official record
Conditions
Smoking Cessation
Interventions
Nicotine Patch, Telephone Counseling, Placebo, Self-Help Materials
Drug · Behavioral · Other
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
4,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 13, 2020 · Synced Oct 11, 2026, 10:20 PM EDT
Completed Not applicable Interventional

Positive Psychology for Smoking Cessation

NCT06632756
View directory record Official record
Conditions
Mental Illness, Tobacco Dependence
Interventions
Individual and Group Treatment for Smoking Cessation
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
21 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Manchester, New Hampshire
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Oct 11, 2026, 10:20 PM EDT
Completed Phase 1Phase 2 Interventional

The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence

NCT02590393
View directory record Official record
Conditions
Nicotine Dependence
Interventions
E-cigarettes
Combination Product
Lead sponsor
Duke University
Other
Eligibility
21 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 21, 2024 · Synced Oct 11, 2026, 10:20 PM EDT
Active, not recruiting Not applicable Interventional

Nicotine Replacement Therapy Prescribing and Lung Cancer Screening in Hospitalized Patients

NCT07164404
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
EHR alert
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 8, 2026 · Synced Oct 11, 2026, 10:20 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

UW Withdraw From Tobacco Study

NCT04969198
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Combination nicotine replacement therapy (Nicotine patch + nicotine mini-lozenge)
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
21 Years and older
Enrollment
232 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 8, 2025 · Synced Oct 11, 2026, 10:20 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Effects of Progesterone on IV Nicotine Induced Changes on BOLD fMRI Signal, Hormones and Subjective Ratings of Stimulant Drugs

NCT01589068
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Intravenous Nicotine, Progesterone
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 40 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2015
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 17, 2024 · Synced Oct 11, 2026, 10:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

THC Crossover Study

NCT04429568
View directory record Official record
Conditions
THC, Cannabis, Cannabis Smoking, Cannabis Use, Unspecified, Cigarette Smoking, Tobacco Use, Nicotine Dependence, Nicotine Withdrawal, Cardiovascular Risk Factor
Interventions
Smoked Cannabis, Vaped Cannabis, Tobacco Cigarette
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 1, 2024 · Synced Oct 11, 2026, 10:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Potential Effects of Electronic Nicotine Delivery System Flavor Regulations on African American Menthol Smokers

NCT05023096
View directory record Official record
Conditions
Electronic Nicotine Delivery System Flavors
Interventions
Tobacco product administration and assessment
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years and older
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Oct 11, 2026, 10:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Pharmacology of Electronic Cigarettes

NCT02470754
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Tobacco Cigarette, Electronic Cigarette
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years and older
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 22, 2023 · Synced Oct 11, 2026, 10:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Neural Basis of Cue-Elicited Cigarette Craving and Its Control

NCT01048957
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Real Time Feedback Training
Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 50 Years
Enrollment
79 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Oct 11, 2026, 10:20 PM EDT
Not listed Not applicable Interventional

Stage Ib Trial of mSMART for Smoking Cessation Medication Adherence

NCT02635919
View directory record Official record
Conditions
Nicotine Dependence
Interventions
mSMART
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 3, 2018 · Synced Oct 11, 2026, 10:20 PM EDT