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Showing 1–24 of 798 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Tobacco Cessation Clear all
Active, not recruiting Not applicable Interventional

Financial Incentives for Smoking Treatment II

NCT03979885
View directory record Official record
Conditions
Smoking Cessation, Tobacco Use Cessation
Interventions
Smoking cessation counseling (Quitline), Smoking cessation pharmacotherapy (e.g, nicotine replacement therapy), Financial incentives for smoking cessation, Financial incentives for use of evidence-based smoking cessation therapies
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
1,058 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
2
States / cities
Los Angeles, California • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Phase 2 Interventional Results available

Meclizine as a Potential Smoking Cessation Treatment

NCT01443858
View directory record Official record
Conditions
Smoking Cessation
Interventions
Meclizine, Nicotine Patch, Placebo
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
4
States / cities
Charlotte, North Carolina • Durham, North Carolina • Raleigh, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 31, 2014 · Synced Jul 21, 2026, 6:07 PM EDT
Terminated Phase 4 Interventional Results available

Pilot Study of Nicotine Nasal Spray and Varenicline on Smoking in Methadone-Maintained Patients

NCT02147132
View directory record Official record
Conditions
Cigarette Smoking, Methadone Maintenance
Interventions
Nicotine Nasal Spray, Varenicline, Placebo Nasal Spray, Placebo Varenicline
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 4, 2018 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Results available

Pilot Testing a Digital Intervention to Improve Smoking Cessation in Persons With Serious Mental Illness

NCT04367506
View directory record Official record
Conditions
Tobacco Cessation
Interventions
BecomeAnEX, Usual Care
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Mobile App Based Cognitive Dissonance Intervention for Smoking Cessation

NCT05797155
View directory record Official record
Conditions
Tobacco Use
Interventions
Support2Quit App - Cognitive Dissonance Based Smoking Cessation + Smoking Cessation Tips, Tips for Smoking Cessation App
Behavioral
Lead sponsor
Oregon Research Behavioral Intervention Strategies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
437 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Springfield, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Text Messaging for Smoking Cessation in College Health Clinics

NCT02191033
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Smoking counseling, Text messaging, Nicotine patch
Behavioral · Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 24 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 31, 2020 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional

Voucher Based Incentives to Treat Pregnant Smokers

NCT01801384
View directory record Official record
Conditions
Efficacy of Financial Incentives
Interventions
Voucher-based incentives
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
166 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated May 11, 2023 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pro-Change Smoking Cessation Intervention

NCT02299076
View directory record Official record
Conditions
Tobacco Smoking Cessation, Motivation
Interventions
Behavioral economics incentives, Minimal incentives
Behavioral · Other
Lead sponsor
VAL Health, LLC
Industry
Eligibility
18 Years and older
Enrollment
422 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Old Greenwich, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 1, 2017 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional

Project HEALS (Helping and Empowering pAtients for Living a Life Smoke-free

NCT05362318
View directory record Official record
Conditions
Smoking, Tobacco Use, Lung Cancer
Interventions
Nicotine patch and lozenges, Telephone counseling sessions, Access to a web-based video, Florida Tobacco Quitline
Drug · Behavioral
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Combined Pharmaco/Behavior Therapy in Adolescent Smokers

NCT00330187
View directory record Official record
Conditions
Nicotine Dependence, Nicotine Use Disorder
Interventions
Bupropion SR, Contingency Management, Placebo
Drug · Behavioral · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
12 Years to 21 Years
Enrollment
134 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2009
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 1, 2018 · Synced Jul 21, 2026, 6:07 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Young Adult Tobacco/Nicotine and Cannabis Co-use

NCT06239350
View directory record Official record
Conditions
Tobacco Use Disorder, Nicotine Dependence
Interventions
Counseling, Contingency management, Text-based support
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 25 Years
Enrollment
350 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Phase 2 Interventional

Interactive Voice Response Technology to Mobilize Contingency Management for Smoking Cessation

NCT01484717
View directory record Official record
Conditions
Cigarette Smoking
Interventions
contingency management for smoking abstinence, transdermal nicotine, Telephone counseling
Behavioral · Drug
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 19, 2017 · Synced Jul 21, 2026, 6:07 PM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

QuitAdvisorMD: A Point-of-care Tool for Brief Smoking Cessation Interventions

NCT01065493
View directory record Official record
Conditions
Smoking, Tobacco Use Disorder
Interventions
QuitAdvisorMD Software Algorithm, Standard Smoking Cessation Counseling
Other · Behavioral
Lead sponsor
Silverchair Science & Communications, LLC
Industry
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 18, 2014 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Integrating Clinical Practice Guidelines for Smoking Cessation Into Mental Health Care for Veterans With Posttraumatic Stress Disorder

NCT00118534
View directory record Official record
Conditions
Mental Health, Stress Disorders, Post-Traumatic, Substance-Related Disorders, Tobacco Use Disorder
Interventions
Integrated Care for Smoking Cessation in PTSD patients, Standard of Care
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 80 Years
Enrollment
943 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2009
U.S. locations
11
States / cities
Tuscaloosa, Alabama • San Diego, California • Washington D.C., District of Columbia + 8 more
Source: ClinicalTrials.gov public record
Updated May 4, 2014 · Synced Jul 21, 2026, 6:07 PM EDT
Recruiting Phase 3 Interventional

V+PSF-M for Tobacco Cessation in HIV Care in India

NCT05786547
View directory record Official record
Conditions
Human Immunodeficiency Virus, Smoking Cessation, Smoking, Tobacco
Interventions
Varenicline, Positively Smoke Free Mobile (PSF-M), Standard Care
Drug · Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 14, 2025 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mindset Intervention for Nicotine Dependence

NCT03174730
View directory record Official record
Conditions
Psychology, Social, Smoking Cessation, Smoking (Tobacco) Addiction
Interventions
Growth Mindset, SmartQuit
Behavioral
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
398 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 5, 2018 · Synced Jul 21, 2026, 6:07 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Digital Intervention (ACT on Vaping App) for Vaping Cessation in Young Adult E-Cigarette Users

NCT06909500
View directory record Official record
Conditions
Nicotine Dependence, Tobacco-Related Carcinoma
Interventions
Smartphone app, Text Message, Survey Administration
Behavioral · Other
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years to 30 Years
Enrollment
1,178 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Jul 21, 2026, 6:07 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Measurement of Cancer-Related Risk Perception in Smokers

NCT00588211
View directory record Official record
Conditions
Cancer Related-Risks, Risk Perception, Survey, Focus Group
Interventions
Interviews, focus group, Survey
Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
1,514 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2022
U.S. locations
4
States / cities
Jamaica, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 15, 2022 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reducing Tobacco Related Health Disparities

NCT00984724
View directory record Official record
Conditions
Smoking Cessation, Smoking
Interventions
Standard Treatment (ST), Telephone Counseling, Quitline, Nicotine Replacement Therapy (NRT)
Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
639 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 6, 2016 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Computer MI for Tobacco Quitline Engagement in Smokers Living With HIV

NCT01886924
View directory record Official record
Conditions
Smoking Cessation
Interventions
Brief Computer MI for Smoking Cessation, Nutrition Control
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 19, 2016 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Results available

Evaluating the Feasibility and Efficacy of a Real-time Smoking Intervention Using Wearable Technology

NCT04172623
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Real-Time Smoking Intervention, Standard Treatment
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 12, 2023 · Synced Jul 21, 2026, 6:07 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

CONNECT Cancer Survivors With Tobacco Treatment

NCT07020273
View directory record Official record
Conditions
Tobacco Use, Tobacco Use Cessation, Smoking Cessation, Nicotine Addiction, Tobacco Smoking
Interventions
ELEVATE, ELEVATE-S
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
3,543 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Connecting Alaska Native People to Quit Smoking

NCT03645941
View directory record Official record
Conditions
Tobacco Use, Tobacco Smoking, Tobacco Use Cessation, Smoking Cessation, Smoking, Cigarette, Smoking, Tobacco, Smoking
Interventions
Facebook Group
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
19 Years and older
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 7, 2022 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Results available

A Test of Short and Long Term Naturalistic Outcomes of Smokers Who Sample Smokeless Tobacco

NCT01509586
View directory record Official record
Conditions
Smoking, Smoking Cessation
Interventions
Potentially Reduced Exposure Product (PREP): a smokeless, spit-free tobacco product
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
19 Years and older
Enrollment
1,236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 11, 2023 · Synced Jul 21, 2026, 6:07 PM EDT