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Showing 1–24 of 805 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Tobacco Cessation Clear all
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Innovative Interventions for Smoking Cessation

NCT01050569
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Nicotine Patch, VLNC Cigarette, VLNC Cigarette Plus Nicotine Patch
Drug · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
235 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
2
States / cities
Duluth, Minnesota • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 17, 2019 · Synced Sep 19, 2026, 6:30 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Maintaining Nonsmoking

NCT01162239
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Varenicline, Initial Individual counseling, Check-ins with medical staff, Extended Individual Counseling - Health Model, Extended Individual Counseling - Relapse Prevention Model
Drug · Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
216 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 11, 2020 · Synced Sep 19, 2026, 6:30 PM EDT
Completed Not applicable Interventional Results available

Kids Safe and Smokefree (KiSS)

NCT01745393
View directory record Official record
Conditions
Second Hand Tobacco Smoke, Nicotine Dependence
Interventions
Clinic Quality Improvement + Behavioral Counseling, Clinic Quality Improvement + Attention Control
Behavioral
Lead sponsor
Temple University
Other
Eligibility
18 Years and older
Enrollment
327 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
4
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 7, 2018 · Synced Sep 19, 2026, 6:30 PM EDT
Terminated Not applicable Interventional

Project QUIT+: Adapting and Testing a Smoking Cessation Intervention for Transgender and Gender Expansive Individuals

NCT06654414
View directory record Official record
Conditions
Smoking Cessation, Depression, Anxiety, Nicotine Dependence, Gender Minority Stress
Interventions
PRIDE QUIT, Enhanced Treatment As Usual (ETAU)
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
3
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Sep 19, 2026, 6:30 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Impact of Smoking Cessation on Sleep - 5

NCT00132821
View directory record Official record
Conditions
Tobacco Use Cessation, Sleep Disorders
Interventions
Bupropion, Transdermal Nicotine Patch, Placebo Bupropion, Placebo transdermal nicotine patch
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
Menlo Park, California
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 19, 2026, 6:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Yoga as a Complementary Therapy for Smoking Cessation

NCT01809678
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Smoking Cessation, Yoga, Wellness
Behavioral · Other
Lead sponsor
The Miriam Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
255 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 18, 2021 · Synced Sep 19, 2026, 6:30 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Semaglutide for Post-Smoking Cessation Weight Management

NCT06173778
View directory record Official record
Conditions
Obesity, Overweight, Cigarette Smoking
Interventions
semaglutide 2.4mg, Placebo, Nicotine Replacement Therapy (NRT, nicotine patch), Brief Smoking Cessation Counseling
Drug · Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 75 Years
Enrollment
197 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
2
States / cities
Austin, Texas • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Sep 19, 2026, 6:30 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Evaluation of National Cancer Institute Young Adult Stop-Smoking Program

NCT01885052
View directory record Official record
Conditions
Smoking, Smoking Cessation, Cigarette Smoking, Tobacco, Smoking
Interventions
QuitTXT Study, Low Contact
Behavioral
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years to 29 Years
Enrollment
4,432 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 8, 2019 · Synced Sep 19, 2026, 6:30 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Reaching and Treating Lesbian, Gay, Bisexual, and Transgender (LGBT) Cigarette Smokers

NCT00634218
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Mail-based Self-help plus Internet-based Smoking Treatment, Self-Help Manual plus Telephone counseling, Self-Help Manual, Self-Help Manual plus Internet-based Intervention plus Telephone Counseling
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
363 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 26, 2012 · Synced Sep 19, 2026, 6:30 PM EDT
Completed Not applicable Interventional

Quit IT: Preliminary Testing of a Web-based, 3D Coping Skills Game to Increase Quitting Self-Efficacy for Maintaining Smoking Abstinence Following Hospitalization

NCT02099097
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
web-based video game (Quit IT), Questionnaires, Salvia sample
Other · Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 29, 2020 · Synced Sep 19, 2026, 6:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Telephone Counseling for Tobacco Cessation

NCT01489579
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Telephone Counseling for Tobacco Cessation, Usual Care
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
192 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 17, 2019 · Synced Sep 19, 2026, 6:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Implementation and Dissemination of an Evidence-Based Tobacco Product Use Prevention Videogame Intervention With Adolescents

NCT03815591
View directory record Official record
Conditions
Smoking Cessation, Smoking
Interventions
smokeSCREEN web-based game
Device
Lead sponsor
Yale University
Other
Eligibility
10 Years to 16 Years
Enrollment
560 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 21, 2022 · Synced Sep 19, 2026, 6:30 PM EDT
Completed Not applicable Interventional Results available

Smoking Cessation for Smokers With Sleep Problems

NCT01277887
View directory record Official record
Conditions
Nicotine Dependence, Cigarette Smoking, Insomnia
Interventions
Cognitive-Behavioral Counseling, Smoking Cessation Counseling
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 75 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 20, 2017 · Synced Sep 19, 2026, 6:30 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Topiramate Alone and in Combination With the Nicotine Patch for Smoking Cessation: A Pilot Study

NCT00755716
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Placebo (sugar pill), Topiramate, Nicotine patch
Drug
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 65 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2013
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 15, 2017 · Synced Sep 19, 2026, 6:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Countering Young Adult Tobacco Marketing in Bars

NCT01686178
View directory record Official record
Conditions
Smoking Cessation
Interventions
Anti-smoking social marketing campaign
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 26 Years
Enrollment
17,422 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 17, 2017 · Synced Sep 19, 2026, 6:30 PM EDT
Not yet recruiting Not applicable Interventional

Smoking Cessation Intervention for Young Adults Using MTM: A Randomized Controlled Trial

NCT07104006
View directory record Official record
Conditions
Tobacco Use Disorder/Cigarette Smoking
Interventions
Multi-Theory Model (MTM)-Based Smoking Cessation Program
Behavioral
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 29 Years
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Aug 10, 2025 · Synced Sep 19, 2026, 6:30 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Low Dose Computed Tomography for Lung Cancer Screening

NCT03084835
View directory record Official record
Conditions
Smoking
Interventions
Usual Care, WEB+TXT, WEB+TXT+TTS
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 28, 2019 · Synced Sep 19, 2026, 6:30 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Addressing Racial/Ethnic Tobacco Health Disparities Via Group Intervention

NCT02511236
View directory record Official record
Conditions
Smoking Cessation
Interventions
Group Cognitive Behavioral Therapy, General Health Education, Transdermal Nicotine Patch
Behavioral · Drug
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
356 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
2
States / cities
Coral Gables, Florida • Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jun 23, 2021 · Synced Sep 19, 2026, 6:30 PM EDT
Completed Phase 2 Interventional Results available

Treatment of Smoking Among Individuals With PTSD

NCT00937235
View directory record Official record
Conditions
Cigarette Smoking, Nicotine Dependence, Post-traumatic Stress Disorder, Tobacco Use Disorder
Interventions
Varenicline, Medication Management Counseling, Prolonged Exposure
Drug · Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 75 Years
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 13, 2017 · Synced Sep 19, 2026, 6:30 PM EDT
Completed Not applicable Interventional

Comparative Effectiveness of Two Tobacco Cessation Interventions for Employees of Partners HealthCare, Inc.

NCT02601521
View directory record Official record
Conditions
Smoking Cessation, Tobacco Use Disorder
Interventions
Internal tobacco coach, External tobacco coach
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 23, 2021 · Synced Sep 19, 2026, 6:30 PM EDT
Completed Phase 1Phase 2 Interventional Results available

STARS (Smoking Treatment And Remote Sampling) Study

NCT04525755
View directory record Official record
Conditions
Smoking, Smoking Cessation, Tobacco Smoking, Cigarette Smoking
Interventions
Varenicline 0.5 MG, Nicotine Replacement Therapy (NRT)
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
652 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 19, 2026, 6:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Varenicline on Brain Activity During Nicotine Abstinence

NCT00602927
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Varenicline, Placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 9, 2011 · Synced Sep 19, 2026, 6:30 PM EDT
Completed Not applicable Interventional Results available

Promoting Oral Health Among Smokers Randomized Trial

NCT02347124
View directory record Official record
Conditions
Oral Disease, Smoking
Interventions
Usual Care Control, Enhanced Intervention
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
718 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 7, 2019 · Synced Sep 19, 2026, 6:30 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Cessation Screening Project

NCT04188873
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Preparation Varenicline and Standard Duration Varenicline, Preparation Varenicline and Extended Duration Varenicline, Standard Duration Varenicline, Extended Duration Varenicline, Preparation Combination NRT and Standard Duration Combination NRT, Preparation Combination NRT and Extended Duration Combination NRT, Standard Duration Combination NRT, Extended Duration Combination NRT, Intensive Counseling, Minimal Counseling
Drug · Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
538 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
2
States / cities
Madison, Wisconsin • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Sep 19, 2026, 6:30 PM EDT