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Showing 1–24 of 538 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Tobacco Dependence Clear all
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Topiramate Alone and in Combination With the Nicotine Patch for Smoking Cessation: A Pilot Study

NCT00755716
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Placebo (sugar pill), Topiramate, Nicotine patch
Drug
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 65 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2013
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 15, 2017 · Synced Sep 14, 2026, 9:47 AM EDT
Completed Not applicable Interventional Results available

Trial on the Effectiveness of Mindfulness Training for Smokers

NCT01093599
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Quit Line plus MTS, Quit Line Only
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 19, 2015 · Synced Sep 14, 2026, 9:47 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Comparison of Bupropion SR and Placebo for Smoking Cessation

NCT00176449
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Bupropion SR, Placebo Oral Tablet
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 64 Years · Female only
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2005
U.S. locations
1
States / cities
Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 15, 2019 · Synced Sep 14, 2026, 9:47 AM EDT
Completed No phase listed Observational

COVID EHR COHORT at the University of Wisconsin

NCT04506528
View directory record Official record
Conditions
COVID-19, Cancer, Nicotine Dependence, Pulmonary Disease, Cardiovascular Diseases, Immunosuppression Disorders
Interventions
Not listed
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
0 Years and older
Enrollment
1,634,381 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 30, 2022 · Synced Sep 14, 2026, 9:47 AM EDT
Completed Phase 2 Interventional Results available

Improving the Efficacy of Anti-Nicotine Immunotherapy

NCT01280968
View directory record Official record
Conditions
Nicotine Dependence
Interventions
NIC002 in Aluminum hydroxide (Alum), Placebo Vaccine - Aluminum hydroxide
Biological
Lead sponsor
Alexey Mukhin
Other
Eligibility
18 Years to 55 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
2
States / cities
Durham, North Carolina • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 4, 2014 · Synced Sep 14, 2026, 9:47 AM EDT
Completed Phase 2 Interventional Results available

Gender Differences in Response to Nicotine Replacement Therapy and De-Nicotinized Cigarettes

NCT00960778
View directory record Official record
Conditions
Nicotine Dependence
Interventions
nicotine patch (Nicoderm Committed Quitter (CQ), Habitrol), denicotinized cigarettes (Quest 3 cigarettes)
Drug · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years to 60 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 22, 2018 · Synced Sep 14, 2026, 9:47 AM EDT
Completed Not applicable Interventional Results available

Electronic Decision Support Systems for Smokers With Severe Mental Illness

NCT01412866
View directory record Official record
Conditions
Severe Mental Illness, Nicotine Dependence, Schizophrenia, Tobacco Use Disorder
Interventions
EDSS with CO feedback and health checklist, EDSS with health checklist feedback alon
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 11, 2018 · Synced Sep 14, 2026, 9:47 AM EDT
Withdrawn Not applicable Interventional

State and Trait Mediated Response to TMS in Substance Use Disorder

NCT03707600
View directory record Official record
Conditions
Nicotine Dependence
Interventions
TMS
Device
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 15, 2020 · Synced Sep 14, 2026, 9:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Web Assisted Tobacco Intervention With Community Colleges

NCT01692730
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Enhanced Web Assisted Tobacco Intervention, Basic Web Assisted Tobacco Intervention
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
1,452 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Nov 19, 2017 · Synced Sep 14, 2026, 9:47 AM EDT
Completed Phase 3 Interventional Results available

Varenicline for Nicotine Dependence Among Those With HIV/AIDS

NCT01710137
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Varenicline, Placebo, Smoking Cessation Counseling
Drug · Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
179 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 17, 2019 · Synced Sep 14, 2026, 9:47 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Equitable Smoking Relapse Prevention

NCT05625685
View directory record Official record
Conditions
Tobacco Use Disorder, Tobacco Dependence
Interventions
Quitbuddy, Control, SDoH Augmentation, SDoH Control
Other
Lead sponsor
Bryan W. Heckman
Other
Eligibility
21 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 7, 2024 · Synced Sep 14, 2026, 9:47 AM EDT
Terminated Phase 2 Interventional Results available

Reducing Tobacco-associated Lung Cancer Risk: A Randomized Clinical Trial of AB-free Kava

NCT05081882
View directory record Official record
Conditions
Smoking
Interventions
Kava, Placebo
Drug
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 99 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Sep 14, 2026, 9:47 AM EDT
Completed Phase 4 Interventional Results available

Smokers' Health Project: Self-Determination and Maintaining Tobacco Abstinence

NCT00178685
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Self-determination Intervention for Tobacco Dependence
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
837 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Feb 14, 2013 · Synced Sep 14, 2026, 9:47 AM EDT
Not yet recruiting Phase 4 Interventional

Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette Use

NCT07786896
View directory record Official record
Conditions
E Cigarette Use, Cessation, Tobacco, Cessation, Nicotine
Interventions
Nicotine Replacement Therapies, Brief Behavioral Counseling
Drug · Behavioral
Lead sponsor
West Virginia University
Other
Eligibility
21 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Greenville, North Carolina • Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 14, 2026, 9:47 AM EDT
Completed Not applicable Interventional Results available

Adjunctive Mood Management for Telephone-based Smoking Cessation

NCT02500589
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Behavioral mood management, Health education
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced Sep 14, 2026, 9:47 AM EDT
Completed Phase 2 Interventional Results available

Effectiveness of GW468816, an NMDA Glycine Site Antagonist, for Prevention of Relapse to Smoking

NCT00218465
View directory record Official record
Conditions
Nicotine Dependence
Interventions
GW468816, Placebo Comparator: Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
264 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
2
States / cities
Belmont, Massachusetts • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 23, 2017 · Synced Sep 14, 2026, 9:47 AM EDT
Completed Early Phase 1 Interventional Results available

Effects of Flavors on Nicotine Reinforcement in Smokers

NCT03243630
View directory record Official record
Conditions
Nicotine Dependence
Interventions
IV nicotine, Menthol flavor, green apple, green apple and menthol
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 30 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 2, 2020 · Synced Sep 14, 2026, 9:47 AM EDT
Completed Phase 2 Interventional

Very Low-Nicotine Cigarettes in Smokers With SUD

NCT01989507
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine, behavioral counseling for smoking cessation
Drug · Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 75 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 27, 2021 · Synced Sep 14, 2026, 9:47 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

E-cigarette Cessation in Adults Who Co-use Cannabis

NCT06688539
View directory record Official record
Conditions
Nicotine Dependence, Tobacco Use Disorder
Interventions
Varenicline Pill, Contingency management, Counseling
Drug · Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 40 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
3
States / cities
Charleston, South Carolina • Lancaster, South Carolina • Pickens, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Sep 14, 2026, 9:47 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Efficacy of Varenicline in Ambivalent Smokers

NCT00595868
View directory record Official record
Conditions
Tobacco Use Disorder, Tobacco Use Cessation, Nicotine Dependence
Interventions
Varenicline, Placebo
Drug
Lead sponsor
University of Vermont Medical Center
Other
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
2
States / cities
Omaha, Nebraska • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Dec 1, 2011 · Synced Sep 14, 2026, 9:47 AM EDT
Completed Phase 4 Interventional

Bupropion as an Adjunct to the Nicotine Patch Plus CBT

NCT00142831
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Pharmacotherapies for Smoking Cessation
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
20 Years to 65 Years
Enrollment
293 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2006
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 14, 2026, 9:47 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Effect of Bupropion on Smoking Behavior in Smokers With Schizophrenia

NCT00218231
View directory record Official record
Conditions
Schizophrenia, Tobacco Use Disorder
Interventions
300 mg/day bupropion-sr, 0 mg/day bupropion-sr
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 80 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2006
U.S. locations
2
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 14, 2026, 9:47 AM EDT
Withdrawn Not applicable Interventional

cSBI-M for Young Military Personnel

NCT01847300
View directory record Official record
Conditions
Alcohol Abuse, Tobacco Dependence, Substance Abuse
Interventions
cSBI-M
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
18 Years to 25 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 6, 2016 · Synced Sep 14, 2026, 9:47 AM EDT
Completed Phase 2 Interventional

Role of Metabolites in Nicotine Dependence (1) - 1

NCT00000284
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Cotinine fumarate
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 45 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1995 – 2001
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 14, 2026, 9:47 AM EDT