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Showing 1–24 of 100 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Tobacco Prevention Clear all
Completed Phase 2 Interventional

Brief Voluntary Alcohol and Drug Intervention for Middle School Youth

NCT01081119
View directory record Official record
Conditions
Alcohol Drinking, Cigarette Smoking, Marijuana Smoking
Interventions
Project CHOICE
Behavioral
Lead sponsor
RAND
Other
Eligibility
11 Years to 15 Years
Enrollment
6,455 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2014 · Synced Jun 25, 2026, 5:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Development of a Videogame Prototype Targeting Cigarette and Marijuana Smoking, and Tobacco Product Prevention Among Young Adolescents

NCT03107936
View directory record Official record
Conditions
Smoking
Interventions
smokeSCREEN game
Behavioral
Lead sponsor
Yale University
Other
Eligibility
10 Years to 16 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
4
States / cities
Hamden, Connecticut • New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 18, 2018 · Synced Jun 25, 2026, 5:27 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Peer-to-peer Tobacco and ENDS Prevention

NCT03491865
View directory record Official record
Conditions
Substance Use
Interventions
REAL media Plus curriculum
Behavioral
Lead sponsor
Real Prevention, LLC
Industry
Eligibility
13 Years to 16 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Clifton, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 10, 2019 · Synced Jun 25, 2026, 5:27 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Incentive-based Intervention for Smoking Cessation and Prevention in High Schools

NCT01173835
View directory record Official record
Conditions
Tobacco Prevention and Cessation
Interventions
Incentives for being tobacco free
Behavioral
Lead sponsor
Yale University
Other
Eligibility
13 Years and older
Enrollment
1,651 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 3, 2012 · Synced Jun 25, 2026, 5:27 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Black Raspberry Nectar for the Prevention of Lung Cancer, BE WELL Study

NCT04267874
View directory record Official record
Conditions
Lung Carcinoma, Tobacco-Related Carcinoma
Interventions
Biospecimen Collection, Nutritional Supplementation, Placebo Administration, Questionnaire Administration
Procedure · Dietary Supplement · Drug + 1 more
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
55 Years to 77 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 30, 2023 · Synced Jun 25, 2026, 5:27 PM EDT
Enrolling by invitation Not applicable Interventional

Salvation Army Tobacco Quit Line Referral Implementation Trial

NCT06689774
View directory record Official record
Conditions
Tobacco Use, Smoking, Smoking Cessation
Interventions
Cognitive-Motivational Feedback, Staff Tobacco Quit Line Referral Implementation Support, Consumer Incentives for Immediate Referral to a Tobacco Quit Line
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
233 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Jun 25, 2026, 5:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Lung and Breast Cancer Prevention by an Integrated Intervention of Maternal Smoking Cessation and Breastfeeding

NCT05123118
View directory record Official record
Conditions
Smoking, Cigarette, Breastfeeding
Interventions
Integrated intervention of smoking cessation and breastfeeding, Attention placebo control
Behavioral
Lead sponsor
Xiaozhong Wen
Other
Eligibility
18 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Apr 16, 2025 · Synced Jun 25, 2026, 5:27 PM EDT
Enrolling by invitation Not applicable Interventional

Precision Prevention Strategy to Increase Uptake and Engagement in Lung Cancer Screening and Smoking Cessation Treatment

NCT05627674
View directory record Official record
Conditions
Smoking, Smoking Cessation, Tobacco Use Cessation
Interventions
Usual Care, RiskProfile-Clin, RiskProfile-Gen
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
915 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Jun 25, 2026, 5:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of the Be Vape Free Curriculum of the Tobacco Prevention Toolkit

NCT05493982
View directory record Official record
Conditions
E-cigarette Use
Interventions
Stanford Vaping Prevention curriculum
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
10 Years to 20 Years
Enrollment
2,779 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Jun 25, 2026, 5:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Middle and High School Students' Reactions to a Health Interactive Website: ASPIRE Reactions

NCT02469779
View directory record Official record
Conditions
Tobacco Use Cessation, Tobacco Prevention
Interventions
Surveys, ASPIRE Website, ASPIRE Text-Based Website, Follow Up Survey
Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
11 Years to 18 Years
Enrollment
700 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2021
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 7, 2021 · Synced Jun 25, 2026, 5:27 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Preventing Relapse Following Involuntary Smoking Abstinence

NCT01374724
View directory record Official record
Conditions
Smoking, Smoking Cessation
Interventions
Tobacco Use Ban, Tailored Pamphlet, Informational Pamphlet, Relapse Prevention Intervention
Behavioral
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years and older
Enrollment
23,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2017
U.S. locations
2
States / cities
Memphis, Tennessee • Lackland Air Force Base, Texas
Source: ClinicalTrials.gov public record
Updated Oct 31, 2016 · Synced Jun 25, 2026, 5:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intranet-based Tobacco Prevention Program for Children

NCT00680875
View directory record Official record
Conditions
Health Promotion, Tobacco Smoking
Interventions
Click City
Behavioral
Lead sponsor
Oregon Research Institute
Other
Eligibility
9 Years to 14 Years
Enrollment
3,225 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 13, 2011 · Synced Jun 25, 2026, 5:27 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

QAIAx (AIhealth4U) - AI Public Health Central: Microcity-A (re Quantum AI Agency Aka AI City Hall Project, UPSTO App Nos. 64/074,526, 64/063,557, 63/903,181, 63/729,428

NCT07661823
View directory record Official record
Conditions
Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism, ADHD - Attention Deficit Disorder With Hyperactivity, ADHD, ASD, Alcohol Abuse/Dependence, Alcohol Addiction, Alcohol and Other Drug Use Disorders, Alcohol and Other Substance Use Prevention, Gambling Addiction, Gambling Disorder, Sex Abuse, Sex Behavior, Sex Crimes, Sex Disorder, Sex Disorders, Gender Dysphoria, Adult, Eating Behavior Disorders, Narcotic-Related Disorders, Narcotic Addiction, Narcissism, Psychiatric Disorder, Psychedelic Effects in Healthy Volunteers, Psychedelic Experiences, Psychedelic Drug Dependence, Marijuana Use Disorder, Marijuana Abuse and Dependence, Smoking (Tobacco) Addiction, Smoking Among Youth, Smoking Abstinence, Abstinence, Sex, Opiate Substitution Treatment, Opioid Abuse (Disorder), Opioid Abuse and Addiction, Cocaine Abuse, MDMA ('Ecstasy'), Addiction Disorders, Homeless and Low Incomes People, Refugees, Homelessness, Reliability and Validity, Anger Problems, Child Abuse, Sexual
Interventions
AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
Behavioral
Lead sponsor
Veterans Recovery Network Inc.
Other
Eligibility
17 Years to 99 Years
Enrollment
1,000,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Jun 25, 2026, 5:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tailored Interventions to Prevent Substance Abuse

NCT01482975
View directory record Official record
Conditions
Prevention Harmful Effects
Interventions
Tailored computer based intervention, Tailored computer intervention
Other
Lead sponsor
University of Rhode Island
Other
Eligibility
10 Years to 14 Years
Enrollment
4,158 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Kingston, Rhode Island
Source: ClinicalTrials.gov public record
Updated May 11, 2016 · Synced Jun 25, 2026, 5:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A High School Program for Preventing Prescription Drug Misuse

NCT03219190
View directory record Official record
Conditions
Prescription Drug Abuse, Substance Abuse, Substance Use (Drugs, Alcohol)
Interventions
LST High School Hybrid
Behavioral
Lead sponsor
National Health Promotion Associates, Inc.
Industry
Eligibility
14 Years to 18 Years
Enrollment
1,804 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Jun 25, 2026, 5:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Smoking Prevention Through Social Connections Among Adolescents - ASPIRE

NCT02703597
View directory record Official record
Conditions
Tobacco Use Behavior
Interventions
Surveys, ASPIRE, GSA-ASPIRE-Network
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
11 Years to 18 Years
Enrollment
393 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 22, 2024 · Synced Jun 25, 2026, 5:27 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Maintenance Treatment for Abstinent Smokers

NCT00063323
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Bupropion
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 75 Years
Enrollment
589 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2006
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Jun 25, 2026, 5:27 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Provider and Peer Delivered Youth Smoking Intervention

NCT00435344
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Pediatric Practice-Based Smoking Intervention
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
13 Years to 17 Years
Enrollment
2,711 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2004
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 13, 2007 · Synced Jun 25, 2026, 5:27 PM EDT
Completed Not applicable Interventional

STORIES-Stories to Communicate Risk About Tobacco

NCT00101491
View directory record Official record
Conditions
Cardiovascular Diseases, Heart Diseases
Interventions
Health Communication DVD video
Behavioral
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
19 Years to 78 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
2
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 11, 2016 · Synced Jun 25, 2026, 5:27 PM EDT
Active, not recruiting Not applicable Interventional

Post Acute Cardiac Event Smoking (PACES) Study

NCT03413423
View directory record Official record
Conditions
Acute Coronary Syndrome, Tobacco Use
Interventions
BAT-CS, Smoking Cessation and Health & Wellness
Behavioral
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years to 75 Years
Enrollment
233 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 14, 2025 · Synced Jun 25, 2026, 5:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pittsburgh and Rural Area High School Tobacco Prevention

NCT05081843
View directory record Official record
Conditions
Adolescent Behavior, Tobacco Use, E-Cig Use
Interventions
AD IT UP media literacy intervention, Usual health education curriculum
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
13 Years to 17 Years
Enrollment
318 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 3, 2025 · Synced Jun 25, 2026, 5:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Impact of E-Cigarette Prevention Messages on Adolescents

NCT05985538
View directory record Official record
Conditions
Vaping Behavior
Interventions
Vaping prevention text messages, Wellness behaviors text messages
Behavioral
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
13 Years to 20 Years
Enrollment
480 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Jun 25, 2026, 5:27 PM EDT
Terminated Phase 4 Interventional

Extended Duration Nicotine Replacement Therapy and Bupropion in Smokers With Schizophrenia

NCT01576640
View directory record Official record
Conditions
Nicotine Dependence, Schizophrenia
Interventions
NRT, Bupropion SR 150mg bid, Relapse Prevention-Oriented Cognitive Behavioral Therapy
Drug · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 20, 2015 · Synced Jun 25, 2026, 5:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preventing Cigarette Use Among Urban Youth Via an M-Health Primary Care Preventive Intervention

NCT03855410
View directory record Official record
Conditions
Tobacco Use, Drug Use, Adolescent Behavior, Alcohol Use, Sexual Risk Behavior
Interventions
S4E, Attention-Matched Control Group
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
13 Years to 21 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
2
States / cities
Ann Arbor, Michigan • Ypsilanti, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 25, 2019 · Synced Jun 25, 2026, 5:27 PM EDT