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ClinicalTrials.gov public records Last synced Oct 13, 2026, 10:11 PM EDT

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Showing 361–384 of 1,795 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Tobacco Products Clear all
Terminated Not applicable Interventional

Deep rTMS Modulating Insula Synaptic Density and Smoking Behavior in Schizophrenia

NCT05724810
View directory record Official record
Conditions
Schizophrenia, Smoking Cessation, Tobacco Use
Interventions
Active deep transcranial magnetic stimulation (dTMS), Sham dTMS
Device
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 60 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Oct 13, 2026, 10:11 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Intranasal Insulin for Weight Management During Smoking Cessation

NCT02028871
View directory record Official record
Conditions
Tobacco Abstinence Syndrome
Interventions
Intranasal Insulin, Placebo
Drug
Lead sponsor
Ajna Hamidovic
Other
Eligibility
18 Years to 65 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
2
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Dec 10, 2018 · Synced Oct 13, 2026, 10:11 PM EDT
Completed Not applicable Interventional

SmartQuit Program for Smoking Cessation

NCT04510077
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma, Tobacco-Related Carcinoma
Interventions
SmartQuit Smoking and Tobacco Cessation Program, Survey Administration
Behavioral · Other
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 12, 2020 · Synced Oct 13, 2026, 10:11 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

An Evaluation of the Tobacco Prevention Toolkit Healthy Futures: Alternative-to-Suspension Vaping Intervention

NCT06483412
View directory record Official record
Conditions
Tobacco Use Cessation, Addiction
Interventions
Healthy Futures: Alternative-to-Suspension Curriculum
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
14 Years to 18 Years
Enrollment
2,540 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Oct 13, 2026, 10:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Environmental Emissions From Electronic Cigarettes and Tobacco-Burning Cigarettes

NCT02185898
View directory record Official record
Conditions
Smoking
Interventions
Leading U.S. non-menthol cigarette, Leading U.S. menthol cigarette, Electronic cigarette #1, Electronic cigarette #2, Electronic cigarette #3, U.S. Market-sample electronic cigarettes
Other
Lead sponsor
R.J. Reynolds Vapor Company
Industry
Eligibility
21 Years to 99 Years
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Stockbridge, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 1, 2018 · Synced Oct 13, 2026, 10:11 PM EDT
Completed Not applicable Interventional

Project 2: Strategies for Reducing Nicotine Content in Cigarettes

NCT02139930
View directory record Official record
Conditions
Nicotine Dependence, Tobacco Smoking
Interventions
Normal Nicotine Control Group, Immediate Nicotine Reduction Group, Gradual Nicotine Reduction Group
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
1,250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
10
States / cities
Phoenix, Arizona • San Francisco, California • Tampa, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Aug 15, 2018 · Synced Oct 13, 2026, 10:11 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

The Effects of Sedatives on Tobacco Use Disorder Version 2

NCT05505630
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Ketamine, Midazolam, Dexmedetomidine, Saline
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Oct 13, 2026, 10:11 PM EDT
Completed Phase 2 Interventional

Prevention of Environmental Tobacco Smoke Exposure in Children 0-12 Months Old

NCT00340106
View directory record Official record
Conditions
Environmental Tobacco Smoke (ETS)
Interventions
Counseling
Behavioral
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years and older · Female only
Enrollment
375 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
2
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 13, 2026, 10:11 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Comparison of Bupropion SR and Placebo for Smoking Cessation

NCT00176449
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Bupropion SR, Placebo Oral Tablet
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 64 Years · Female only
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2005
U.S. locations
1
States / cities
Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 16, 2019 · Synced Oct 13, 2026, 10:11 PM EDT
Recruiting Not applicable Interventional

Neural Correlates and Behavioral Impact of Withdrawal-induced Hyperalgesia Among People Who Smoke With and Without Chronic Pain

NCT06983678
View directory record Official record
Conditions
Tobacco Use, Chronic Pain
Interventions
Smoking as usual fMRI session, Abstinent fMRI session
Behavioral
Lead sponsor
Duke University
Other
Eligibility
21 Years to 65 Years
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Oct 13, 2026, 10:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Health-Kit Enabled Mobile App for Tobacco Cessation

NCT06292130
View directory record Official record
Conditions
Cigarette Smoking
Interventions
refresh
Behavioral
Lead sponsor
Pro-Change Behavior Systems
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
South Kingstown, Rhode Island
Source: ClinicalTrials.gov public record
Updated May 16, 2025 · Synced Oct 13, 2026, 10:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tobacco Cessation Intervention

NCT03657511
View directory record Official record
Conditions
Smoking Tobacco
Interventions
Educational Interventions to Promote Tobacco Cessation
Behavioral
Lead sponsor
Barbara Ann Karmanos Cancer Institute
Other
Eligibility
21 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated May 6, 2022 · Synced Oct 13, 2026, 10:11 PM EDT
Active, not recruiting No phase listed Observational

Determinants of Bladder Cancer Recurrence Study (The DETER Study)

NCT02400944
View directory record Official record
Conditions
Bladder Cancer
Interventions
questionnaires, Saliva and/or urine sample
Behavioral · Other
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2027
U.S. locations
4
States / cities
Basking Ridge, New Jersey • Commack, New York • Harrison, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Oct 13, 2026, 10:11 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

NCT06372899
View directory record Official record
Conditions
E-cigarette Use, Cigarette Smoking, Harm Reduction, Tobacco Use
Interventions
E-cigarettes, Oral nicotine pouches
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
21 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Oct 13, 2026, 10:11 PM EDT
Completed Not applicable Interventional Results available

Varenicline or Nicotine Patch and Nicotine Gum in Helping Smokers in a Methadone Treatment Program Stop Smoking

NCT00790569
View directory record Official record
Conditions
Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer, Head and Neck Cancer, Kidney Cancer, Leukemia, Liver Cancer, Lung Cancer, Pancreatic Cancer, Tobacco Use Disorder
Interventions
nicotine, varenicline, placebo
Drug · Other
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 120 Years
Enrollment
315 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 6, 2018 · Synced Oct 13, 2026, 10:11 PM EDT
Completed Not applicable Interventional

Interventions to Help Smoking Parents of Inpatients Reduce Exposure (INSPIRE)

NCT02281864
View directory record Official record
Conditions
Tobacco Use Cessation, Second Hand Tobacco Smoke
Interventions
Smoking Cessation Intervention Bundle, Control Group: Quitline
Behavioral · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
Up to 80 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 31, 2023 · Synced Oct 13, 2026, 10:11 PM EDT
Withdrawn Phase 1 Interventional

Stage Ib Trial of mSMART With Varenicline

NCT03069768
View directory record Official record
Conditions
Nicotine Dependence
Interventions
mSMART, Chantix
Device · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 17, 2018 · Synced Oct 13, 2026, 10:11 PM EDT
Recruiting Not applicable Interventional

PASCAL Feasibility Study

NCT07301151
View directory record Official record
Conditions
Smoking Cessation, Smoking (Tobacco) Addiction
Interventions
chatbot, no chatbot
Other
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Oct 13, 2026, 10:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Personalized Feedback for Distress Intolerant Smokers

NCT03918031
View directory record Official record
Conditions
Anxiety Disorders, Depression, Psychological Distress, Tobacco Dependence, Smoking, Tobacco, Smoking, Cigarette
Interventions
PFI for Smoking & Distress Tolerance, PFI for Smoking Only
Behavioral
Lead sponsor
University of Houston
Other
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 15, 2024 · Synced Oct 13, 2026, 10:11 PM EDT
Not listed No phase listed Observational

A Digital Smoking Cessation Intervention for Adults With Substance Use Disorder

NCT04419922
View directory record Official record
Conditions
Tobacco Use Disorder, Substance Use Disorders
Interventions
Smartphone Contingency Management Intervention
Behavioral
Lead sponsor
BrightView LLC
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 9, 2020 · Synced Oct 13, 2026, 10:11 PM EDT
Withdrawn Phase 1Phase 2 Interventional

Primary Care iSBIRT to Reduce Serious Teen Health Risks

NCT00891631
View directory record Official record
Conditions
Substance-related Disorders, Depression, High-risk Sex
Interventions
iSBIRT, iSBIRT/TE
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
12 Years to 21 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 7, 2016 · Synced Oct 13, 2026, 10:11 PM EDT
Recruiting Phase 1Phase 2 Interventional

Overcoming Nicotine Dependence to Enable Quitting

NCT05513872
View directory record Official record
Conditions
Tobacco Use, Smoking Cessation, Smoking Behaviors, Nicotine Dependence, Nicotine Withdrawal
Interventions
Nicotine Replacement Therapy (NRT) Sampling, Practice Quitting (PQ) Counseling, Motivational Interviewing (MI) Counseling
Drug · Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
780 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 13, 2026, 10:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Investigation of Kava Effects on NNK Metabolism

NCT02500472
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Kava
Dietary Supplement
Lead sponsor
Masonic Cancer Center, University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Oct 13, 2026, 10:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Abuse Liability of a Novel Heated Tobacco Product (IQOS) and Its Feasibility as a Menthol Cigarette Substitute

NCT05499377
View directory record Official record
Conditions
Tobacco Use
Interventions
Tobacco product administration and assessment
Device
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years and older
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 31, 2025 · Synced Oct 13, 2026, 10:11 PM EDT