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ClinicalTrials.gov public records Last synced Oct 14, 2026, 9:54 AM EDT

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Showing 505–528 of 1,795 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Tobacco Products Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Transcranial Magnetic Brain Stimulation to Reduce Cannabis Use in Heavy Cannabis Users

NCT05401929
View directory record Official record
Conditions
Cannabis
Interventions
iTBS
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2029
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 14, 2026, 9:54 AM EDT
Completed Not applicable Interventional Results available

Trial of Integrated Smoking Cessation, Exercise and Weight Management in Serious Mental Illness: TRIUMPH

NCT02424188
View directory record Official record
Conditions
Mental Illness
Interventions
TRIIUMPH Intervention
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 75 Years
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 25, 2025 · Synced Oct 14, 2026, 9:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparative Effectiveness of Adding Weight Control to Smoking Cessation Quitlines

NCT01867983
View directory record Official record
Conditions
Cigarette Smoking, Overweight, Obesity
Interventions
Weight gain prevention and smoking cessation, Smoking cessation
Behavioral
Lead sponsor
Consumer Wellness Solutions
Industry
Eligibility
18 Years and older
Enrollment
2,540 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 15, 2016 · Synced Oct 14, 2026, 9:54 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Educating Smokers About Lung Cancer Screening Using Tobacco Quitlines

NCT04595422
View directory record Official record
Conditions
Lung Carcinoma
Interventions
Educational Intervention, Questionnaire Administration, Survey Administration
Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 6, 2026 · Synced Oct 14, 2026, 9:54 AM EDT
Completed Not applicable Interventional

Effects of Cigar Flavors on Measures of Abuse Liability Among Young Adults

NCT02937051
View directory record Official record
Conditions
Tobacco Products
Interventions
Tobacco product administration and assessment
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 21 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 23, 2019 · Synced Oct 14, 2026, 9:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Study to Evaluate Changes in Smokers Using on!® Nicotine Pouches

NCT05664672
View directory record Official record
Conditions
Tobacco Use
Interventions
OTDN Product 1, OTDN Product 2, OTDN Product 3, No Tobacco
Other
Lead sponsor
Altria Client Services LLC
Industry
Eligibility
21 Years to 65 Years
Enrollment
149 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
3
States / cities
Lexington, Kentucky • Springfield, Missouri • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 9, 2024 · Synced Oct 14, 2026, 9:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cooling Agent Pilot Among Adult Menthol Smokers

NCT06477601
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Assigning cooling agent type cigarettes, Assigning traditional tobacco type cigarettes, Assigning menthol type cigarettes
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 6, 2025 · Synced Oct 14, 2026, 9:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Little Cigar and Cigarillo Warnings to Reduce Tobacco-Related Cancers and Disease - Eye Tracking

NCT06546618
View directory record Official record
Conditions
Tobacco Use
Interventions
LCC pack stimuli images
Behavioral
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
21 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 2, 2026 · Synced Oct 14, 2026, 9:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparative Abuse Liability Among African American and White Smokers

NCT04646668
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
E-cigarette and Heat not burn
Combination Product
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 28, 2023 · Synced Oct 14, 2026, 9:54 AM EDT
Completed Not applicable Interventional Results available

Efficacy of Varenicline in Methadone-Stabilized Cocaine Users

NCT00567320
View directory record Official record
Conditions
Cocaine Dependence, Nicotine Dependence
Interventions
Varenicline, Sugar pill or Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 55 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 2, 2020 · Synced Oct 14, 2026, 9:54 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

E-Cigarette Aerosol, Conventional Cigarette Smoke, and Myocardial Perfusion

NCT02612701
View directory record Official record
Conditions
Coronary Artery Disease, Myocardial Perfusion
Interventions
Cigarettes, E-cigarettes (nicotine free e-liquid), E-cigarettes (low nicotine e-liquid), E-cigarettes (high nicotine e-liquid)
Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 49 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 4, 2021 · Synced Oct 14, 2026, 9:54 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Exenatide for Smoking Cessation and Prevention of Weight Gain

NCT05610800
View directory record Official record
Conditions
Smoking Cessation, Weight Gain
Interventions
Exenatide 2 milligram (mg) Injection, Placebo, Nicotine patch, Smoking Cessation Counseling
Drug · Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 75 Years
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Oct 14, 2026, 9:54 AM EDT
Not yet recruiting Not applicable Interventional

Evaluation of Community Health Worker Support to Help People With Serious Mental Illness to Quit Smoking

NCT07789132
View directory record Official record
Conditions
Nicotine Dependance, Serious Mental Illness, Smoking (Tobacco) Addiction, Tobacco Cessation, Community Health Workers, Cardiovascular (CV) Risk, Tobacco Use Disorder
Interventions
Integrated CHW Support intervention, Enhanced usual care (EUC)
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
937 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Oct 14, 2026, 9:54 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches

NCT07165808
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Nicotine pouch: Low dose, Nicotine pouch: High dose, Low pH, High pH
Other
Lead sponsor
Emory University
Other
Eligibility
21 Years to 35 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 14, 2026, 9:54 AM EDT
Withdrawn Not applicable Interventional

Progesterone and Atomoxetine for Cocaine Cessation

NCT01741376
View directory record Official record
Conditions
Cocaine Dependence, Nicotine Dependence
Interventions
Progesterone, Placebo
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 6, 2019 · Synced Oct 14, 2026, 9:54 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Biomarker Feedback to Motivate Tobacco Cessation in Pregnant ALaska Native Women: Phase 2

NCT02018640
View directory record Official record
Conditions
Cancer, Tobacco Use, Pregnancy
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 100 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Anchorage, Alaska
Source: ClinicalTrials.gov public record
Updated Dec 19, 2017 · Synced Oct 14, 2026, 9:54 AM EDT
Completed Phase 1 Interventional

Concurrent vs. Sequential Cessation of Dual Cigarette and E-cigarette Use

NCT06027840
View directory record Official record
Conditions
Cigarette Smoking, E-Cigarette Use, Smoking Cessation
Interventions
Varenicline, Counseling, Guided Self-Change Booklets
Drug · Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 14, 2026, 9:54 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cigarette Smoking and Oral Microbiota

NCT01862809
View directory record Official record
Conditions
Microbiota, Lung Cancer, Oral Cancer
Interventions
Not listed
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
25 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2020
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jun 30, 2020 · Synced Oct 14, 2026, 9:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Impact of a Tobacco Control Intervention in African-American Families

NCT01164306
View directory record Official record
Conditions
Tobacco Prevention, Environmental Tobacco Smoke Exposure, Tobacco Cessation
Interventions
LifeSkills Training, Healthy Lifestyle Behavior Choices, NRT and Motivational Interviewing (MI)
Behavioral
Lead sponsor
Augusta University
Other
Eligibility
8 Years and older
Enrollment
688 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2014
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 2, 2015 · Synced Oct 14, 2026, 9:54 AM EDT
Withdrawn Not applicable Interventional

Cognitive and Emotional Skills to Aid Smoking Cessation

NCT03148652
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Enhanced Intervention Condition
Other
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 10, 2019 · Synced Oct 14, 2026, 9:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Extended Facebook Intervention for Young Sexual and Gender Minority Smokers

NCT03553992
View directory record Official record
Conditions
Tobacco Use, Smoking, Tobacco Dependence, Tobacco Use Disorder, Tobacco Use Cessation, Tobacco Smoking, Smoking Cessation, Smoking, Cigarette, Smoking, Tobacco
Interventions
POP-6:, TSP-6:
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 25 Years
Enrollment
173 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Oct 14, 2026, 9:54 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Comparing Smoking Treatment Programs for Lighter Smokers - 1

NCT00086411
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
nicotine transdermal system, bupropion, Medication Management, Mayo Counseling, placebo patch, placebo bupropion
Drug · Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 75 Years
Enrollment
260 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 6, 2019 · Synced Oct 14, 2026, 9:54 AM EDT
Active, not recruiting Not applicable Interventional

Electronic Cigarettes and Reactivity to Smoking Cues

NCT01782599
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Dual nicotine patch and electronic cigarette
Other
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2027
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Oct 14, 2026, 9:54 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Temporal Interference Methods for Addiction Treatment

NCT07210268
View directory record Official record
Conditions
Nicotine Use Disorder, Substance Use Disorders
Interventions
TI-NDBS, Sham TI-NDBS
Device
Lead sponsor
Indiana University
Other
Eligibility
21 Years to 50 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
2
States / cities
Bloomington, Indiana • Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 14, 2026, 9:54 AM EDT