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ClinicalTrials.gov public records Last synced Oct 15, 2026, 12:45 AM EDT

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Showing 625–648 of 1,795 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Tobacco Products Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Nicotine Delivery From Novel Non-Tobacco Electronic System in Smokers

NCT02575885
View directory record Official record
Conditions
Cigarette Smoker, Current Smoker, Healthy Subject
Interventions
Electronic Cigarette, Laboratory Biomarker Analysis, Pharmacological Study, Questionnaire Administration
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years to 55 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 12, 2018 · Synced Oct 15, 2026, 12:45 AM EDT
Terminated Not applicable Interventional Results available

Analysis of Aldehyde Biomarkers of Exposure and Host Response

NCT00482690
View directory record Official record
Conditions
Smoking Cessation
Interventions
nicotine polacrilex, nicotine transdermal system, nicotine inhaler
Drug
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 7, 2023 · Synced Oct 15, 2026, 12:45 AM EDT
Completed Not applicable Interventional Results available

'Questions About Quitting' Smoking Cessation Trial

NCT00992264
View directory record Official record
Conditions
Smoking
Interventions
Message Tone, Navigation, Proactive Outreach, Testimonials
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
1,865 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 13, 2017 · Synced Oct 15, 2026, 12:45 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Veteran Social Support for Enhancing Use of Smoking Cessation Treatment

NCT05868421
View directory record Official record
Conditions
Smoking Cessation, Veterans Health
Interventions
Support Person Coaching Call, SP written materials, Written Smoking Cessation Materials
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
2,376 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 16, 2026 · Synced Oct 15, 2026, 12:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intervention Study to Increase Smoking Cessation Rates Among Public Housing Residents

NCT01651611
View directory record Official record
Conditions
Tobacco Cessation
Interventions
Motivational interviewing, Smoking cessation counseling, Navigation to smoking cessation resources, Social support
Behavioral
Lead sponsor
Boston University
Other
Eligibility
18 Years to 79 Years
Enrollment
330 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 29, 2016 · Synced Oct 15, 2026, 12:45 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Temporal Interference Neurostimulation and Addiction

NCT04432064
View directory record Official record
Conditions
Nicotine Use Disorder, Substance Use Disorders
Interventions
Active TI-NDBS, Sham TI-NDBS, tDCS
Device · Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 50 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 24, 2025 · Synced Oct 15, 2026, 12:45 AM EDT
Completed No phase listed Observational

Tobacco Craving and Triggers in Persons With Schizophrenia

NCT01846065
View directory record Official record
Conditions
Smoker, Schizophrenia Diagnosis
Interventions
Not listed
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 55 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 25, 2019 · Synced Oct 15, 2026, 12:45 AM EDT
Completed Phase 2 Interventional

Combination Pharmacotherapy for Smoking Cessation Among Methadone Patients

NCT00060814
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Combined intervention
Other
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 70 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 15, 2026, 12:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tobacco Status Project: Social Media Intervention for Young Adult Smokers

NCT02207036
View directory record Official record
Conditions
Smoking
Interventions
Facebook intervention, Smokefree.gov
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 25 Years
Enrollment
501 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 8, 2017 · Synced Oct 15, 2026, 12:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Behavioral Therapy for Reduction in Smoking Craving

NCT00449293
View directory record Official record
Conditions
Smoking Cessation, Tobacco Dependence
Interventions
standard cognitive behavioral therapy, Mindfulness Based Cognitive Therapy
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 31, 2017 · Synced Oct 15, 2026, 12:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Smartphone-based Financial Incentives

NCT03922360
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Smartphone-based Financial Incentives, Best Practices
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older · Female only
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 15, 2026, 12:45 AM EDT
Completed No phase listed Observational

Tobacco Smoke and Lead Exposure During Pregnancy

NCT00514280
View directory record Official record
Conditions
Lead Exposure in Pregnant Women, Tobacco Smoke Exposure Pregnant Women
Interventions
Not listed
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years to 49 Years · Female only
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 15, 2026, 12:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Middle and High School Students' Reactions to a Health Interactive Website: ASPIRE Reactions

NCT02469779
View directory record Official record
Conditions
Tobacco Use Cessation, Tobacco Prevention
Interventions
Surveys, ASPIRE Website, ASPIRE Text-Based Website, Follow Up Survey
Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
11 Years to 18 Years
Enrollment
700 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2021
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 8, 2021 · Synced Oct 15, 2026, 12:45 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Evaluation of Acute and Subacute Effects of Nicotine Free Electronic Cigarette(NCFE) Vapors

NCT02585791
View directory record Official record
Conditions
Healthy Lifetime Non-smokers
Interventions
Propylene Glycol, vegetable glycerin, PG+VG
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jan 14, 2020 · Synced Oct 15, 2026, 12:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

THC Crossover Study

NCT04429568
View directory record Official record
Conditions
THC, Cannabis, Cannabis Smoking, Cannabis Use, Unspecified, Cigarette Smoking, Tobacco Use, Nicotine Dependence, Nicotine Withdrawal, Cardiovascular Risk Factor
Interventions
Smoked Cannabis, Vaped Cannabis, Tobacco Cigarette
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 1, 2024 · Synced Oct 15, 2026, 12:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Graphic Cigarette Warnings

NCT02247908
View directory record Official record
Conditions
Smoking
Interventions
Surgeon General's Warning, Graphic Warning
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
2,149 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
2
States / cities
Oakland, California • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 14, 2016 · Synced Oct 15, 2026, 12:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Cigarette Pack Constituent Disclosures

NCT02785484
View directory record Official record
Conditions
Cigarette Smoking Behavior
Interventions
Label with constituent disclosure message, Label with litter message
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
21 Years and older
Enrollment
784 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2017 · Synced Oct 15, 2026, 12:45 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effects of Intranasal Oxytocin on Cigarette Smoking

NCT02595749
View directory record Official record
Conditions
Nicotine Dependence, Tobacco Smoking
Interventions
Oxytocin, Placebo
Drug
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 40 Years
Enrollment
83 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 15, 2021 · Synced Oct 15, 2026, 12:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Just Kwit: Mobile Intervention for Tobacco Cessation

NCT03538678
View directory record Official record
Conditions
Smoking Cessation
Interventions
Kwit smartphone app
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 30 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 18, 2021 · Synced Oct 15, 2026, 12:45 AM EDT
Recruiting Not applicable Interventional

Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine

NCT07202039
View directory record Official record
Conditions
Tobacco-flavored EC, Sweet-Cooling EC, Sweet Non-cooling EC
Interventions
Brief individual counseling sessions
Behavioral
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
21 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Oct 15, 2026, 12:45 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Multi-Modal Investigation of the Smoking Cessation Medication Varenicline: Dopaminergic Modulation of Reward Processing and Cognitive Control

NCT00830739
View directory record Official record
Conditions
Tobacco Use Disorder, Nicotine Dependence
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 55 Years
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 5, 2018 · Synced Oct 15, 2026, 12:45 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Biomarker Feedback to Motivate Cessation in Pregnancy

NCT02431611
View directory record Official record
Conditions
Nicotine Dependence, Pregnancy
Interventions
Biomarker feedback (phone based smoking cessation counseling), Control condition (phone based smoking cessation counseling)
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Anchorage, Alaska
Source: ClinicalTrials.gov public record
Updated Dec 19, 2017 · Synced Oct 15, 2026, 12:45 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban

NCT00511134
View directory record Official record
Conditions
Insomnia, Nicotine Dependence
Interventions
Eszopiclone, Bupropion
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 9, 2022 · Synced Oct 15, 2026, 12:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Computerized Risk Assessment in an Employee Population

NCT00153335
View directory record Official record
Conditions
Healthy
Interventions
patient-provider interaction
Behavioral
Lead sponsor
Centers for Disease Control and Prevention
Federal
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2007
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Feb 26, 2010 · Synced Oct 15, 2026, 12:45 AM EDT