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ClinicalTrials.gov public records Last synced Oct 15, 2026, 8:27 PM EDT

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Showing 793–816 of 1,795 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Tobacco Products Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Adolescent Smoking Cessation in Pediatric Primary Care

NCT01312480
View directory record Official record
Conditions
Tobacco Cessation, Media Use
Interventions
5A's Model, Media Use Assessment
Other
Lead sponsor
American Academy of Pediatrics
Other
Eligibility
14 Years to 25 Years
Enrollment
10,967 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2017
U.S. locations
1
States / cities
Elk Grove Village, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 18, 2018 · Synced Oct 15, 2026, 8:27 PM EDT
Completed Phase 4 Interventional Results available

Abstinence Reinforcement Therapy (ART) for Homeless Veteran Smokers

NCT02245308
View directory record Official record
Conditions
Tobacco Use Disorder, Homelessness
Interventions
Nicotine Patches, mobile contingency management (mCM), Smoking cessation counseling, Nicotine rescue method, Bupropion
Drug · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
133 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 4, 2022 · Synced Oct 15, 2026, 8:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pro-Change Smoking Cessation Intervention

NCT02299076
View directory record Official record
Conditions
Tobacco Smoking Cessation, Motivation
Interventions
Behavioral economics incentives, Minimal incentives
Behavioral · Other
Lead sponsor
VAL Health, LLC
Industry
Eligibility
18 Years and older
Enrollment
422 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Old Greenwich, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 2, 2017 · Synced Oct 15, 2026, 8:27 PM EDT
Completed Not applicable Interventional Results available

Tobacco Cessation for Veterans With Post Traumatic Stress Disorder (PTSD)

NCT00908882
View directory record Official record
Conditions
Tobacco Use Cessation, Post Traumatic Stress Disorders
Interventions
Motivation Interviewing Counseling
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 16, 2015 · Synced Oct 15, 2026, 8:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Menthol and Mint Experimental Tobacco Marketplace (ETM) Study

NCT04879225
View directory record Official record
Conditions
Cigarette Smoking, Vaping
Interventions
Tobacco e-liquids, Menthol and Tobacco e-liquids, Mint, Menthol and Tobacco e-liquids, All e-liquid flavors
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 26, 2024 · Synced Oct 15, 2026, 8:27 PM EDT
Recruiting Not applicable Interventional

Harm Reduction for Smokers With Mental Illness

NCT06543407
View directory record Official record
Conditions
Tobacco Dependence
Interventions
SWITCH IT, E-cig Provision Only
Behavioral · Other
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
21 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
2
States / cities
Louisville, Kentucky • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Oct 15, 2026, 8:27 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effects of Nicotine on Brain Activity as Measured by fMRI

NCT01037153
View directory record Official record
Conditions
Nicotine Dependence, Drug Abuse
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 50 Years
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 15, 2026, 8:27 PM EDT
Completed Not applicable Interventional

Development of a Tailored Smoking Cessation Program for Individuals With HIV Infection in Washington, D.C.

NCT04594109
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Tailored behavioral counseling, Standard of Care
Behavioral
Lead sponsor
Colorado State University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 19, 2023 · Synced Oct 15, 2026, 8:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Test-retest Reproducibility of [11C]PHNO PET Using the Constant Infusion Paradigm

NCT01699607
View directory record Official record
Conditions
Nicotine Dependence, Healthy
Interventions
Amphetamine
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 55 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 6, 2020 · Synced Oct 15, 2026, 8:27 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home

NCT06693700
View directory record Official record
Conditions
Smoking, Smoking Cessation, Smoking Reduction, Smoking Habit, Smoking Behaviors, Smoking, Tobacco, Smoking, Cigarette, Smoking (Tobacco) Addiction, Tobacco Use, Tobacco Smoking
Interventions
Indoor Air Quality Monitor AirGradient ONE
Other
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
8
States / cities
Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Oct 15, 2026, 8:27 PM EDT
Completed Not applicable Interventional Results available

Testing the Impact of Smartphone-based Messaging to Support Young Adult Smoking Cessation - Pilot

NCT05991934
View directory record Official record
Conditions
Tobacco Cigarette Smoking
Interventions
Smartphone-based intervention messages
Behavioral
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
18 Years to 30 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 20, 2025 · Synced Oct 15, 2026, 8:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Teens Against Tobacco Use: A Tobacco Prevention Curriculum and Advocacy Initiative

NCT02926339
View directory record Official record
Conditions
Tobacco Smoking Behavior
Interventions
Teens Against Tobacco Use presentation
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
8 Years to 17 Years
Enrollment
639 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Oct 26, 2017 · Synced Oct 15, 2026, 8:27 PM EDT
Recruiting Phase 2 Interventional

Examining the Effects of Cytisinicline on Neural Substrates of Cigarette Cue-reactivity

NCT06617312
View directory record Official record
Conditions
Smoking Cessation, Tobacco Use Disorder
Interventions
Cytisinicline, Placebo Oral Capsule
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 3, 2025 · Synced Oct 15, 2026, 8:27 PM EDT
Recruiting Not applicable Interventional

Opioids, Low Nicotine Cigarettes, and Chronic Pain

NCT06747871
View directory record Official record
Conditions
Chronic Pain, Tobacco Use, Opioid Substitution Treatment
Interventions
Very Low Nicotine Cigarettes (VLNC), Normal Nicotine Cigarettes (NNC)
Behavioral
Lead sponsor
Duke University
Other
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 9, 2026 · Synced Oct 15, 2026, 8:27 PM EDT
Enrolling by invitation No phase listed Observational

Developing Evidence to Inform Regulatory Policy on Nicotine Content in E-Liquids

NCT06619964
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Not listed
Lead sponsor
Rochester Institute of Technology
Other
Eligibility
21 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Oct 15, 2026, 8:27 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Knowledge and Perception of Smoking Risks/Consequences

NCT00686101
View directory record Official record
Conditions
Cigarette Smoking, Schizophrenia
Interventions
Not listed
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 65 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 4, 2019 · Synced Oct 15, 2026, 8:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Environmental Emissions From Electronic Cigarettes and Tobacco-Burning Cigarettes

NCT02185898
View directory record Official record
Conditions
Smoking
Interventions
Leading U.S. non-menthol cigarette, Leading U.S. menthol cigarette, Electronic cigarette #1, Electronic cigarette #2, Electronic cigarette #3, U.S. Market-sample electronic cigarettes
Other
Lead sponsor
R.J. Reynolds Vapor Company
Industry
Eligibility
21 Years to 99 Years
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Stockbridge, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 1, 2018 · Synced Oct 15, 2026, 8:27 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Control Systems Approach to Predicting Individualized Dynamics of Nicotine Cravings

NCT02643914
View directory record Official record
Conditions
Nicotine Addiction, Cigarette Smoking
Interventions
Nicotine, MR Compatible Nicotine Delivery Device
Drug · Device
Lead sponsor
Stony Brook University
Other
Eligibility
21 Years to 65 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 15, 2026, 8:27 PM EDT
Completed No phase listed Observational

Room Air Levels of Harmful and Potentially Harmful Constituents After Heated Tobacco Product Use and Cigarettes

NCT06476405
View directory record Official record
Conditions
Tobacco Smoking, Tobacco Use
Interventions
Not listed
Lead sponsor
Altria Client Services LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Stockbridge, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Oct 15, 2026, 8:27 PM EDT
Completed Phase 4 Interventional Results available

Mobile Health Technology to Enhance Abstinence in Smokers With Schizophrenia

NCT02420015
View directory record Official record
Conditions
Schizophrenia, Cigarette Smoking
Interventions
Nicotine replacement therapy, Bupropion, cognitive-behavioral smoking cessation counseling, Mobile Contingency Management, Stay Quit Coach, SMS text messaging
Drug · Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 70 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 10, 2019 · Synced Oct 15, 2026, 8:27 PM EDT
Not listed Phase 4 Interventional

Safety and Efficacy of the Novel Selective Nicotinic Receptor Partial Agonist, CHANTIX (Varenicline) in Patients With Acute Coronary Syndrome

NCT01170338
View directory record Official record
Conditions
Smoking, Acute Coronary Syndrome
Interventions
Varenicline 100 mg by mouth twice daily, control
Drug
Lead sponsor
Newark Beth Israel Medical Center
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2008
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 27, 2010 · Synced Oct 15, 2026, 8:27 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Intensive Behavioral Training Program on Impulsivity and Inhibitory Control in Smokers

NCT01314378
View directory record Official record
Conditions
Tobacco Smoking, Nicotine Dependence, Impulsivity, Addiction, Substance Dependence
Interventions
Mindfulness Training, Cognitive-Behavioral Therapy
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 2, 2012 · Synced Oct 15, 2026, 8:27 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Treating Smokers With Mental Illness

NCT03822416
View directory record Official record
Conditions
Smoking Cessation, Cigarette Smoking, Schizophrenia, Psychotic Disorders, Major Depressive Disorder, Bipolar Disorder I, Bipolar II Disorder, Mental Illness
Interventions
Nicotine patch, Nicotine lozenge, Therapy, Information
Drug · Behavioral · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 25, 2021 · Synced Oct 15, 2026, 8:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Addressing Tobacco Use Disparities in Rural Older Adults Through an Innovative Mobile Phone Intervention

NCT02510716
View directory record Official record
Conditions
Tobacco Cessation
Interventions
SGR, Support message only
Behavioral
Lead sponsor
Duke University
Other
Eligibility
60 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 21, 2016 · Synced Oct 15, 2026, 8:27 PM EDT