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ClinicalTrials.gov public records Last synced Oct 9, 2026, 8:59 AM EDT

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Showing 121–144 of 2,070 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Tobacco Smoking Behavior Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Project RESIST: Increasing Resistance to Tobacco Marketing Among Young Adult Sexual Minority Women Using Inoculation Message Approaches

NCT04812795
View directory record Official record
Conditions
Cigarette Smoking Behavior
Interventions
Culturally tailored anti-smoking messages, Non-culturally tailored interventions
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
18 Years to 30 Years
Enrollment
2,214 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Stanford, California • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 15, 2023 · Synced Oct 9, 2026, 8:59 AM EDT
Completed No phase listed Observational

Endothelial Progenitor Cells and Risk Factors for Coronary Artery Disease

NCT00013975
View directory record Official record
Conditions
Coronary Arteriosclerosis
Interventions
Not listed
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
Not listed
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2003
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 9, 2026, 8:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Exercise or Relaxation for Smoking Cessation

NCT00921388
View directory record Official record
Conditions
Nicotine Dependence, Smoking Cessation
Interventions
Varenicline and smoking cessation counseling, Exercise or relaxation treatment
Other · Behavioral
Lead sponsor
UConn Health
Other
Eligibility
45 Years and older · Female only
Enrollment
301 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2017
U.S. locations
2
States / cities
Farmington, Connecticut • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 31, 2017 · Synced Oct 9, 2026, 8:59 AM EDT
Recruiting Not applicable Interventional

Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+)

NCT07711691
View directory record Official record
Conditions
Lung Cancer Screening, Lung Neoplasms, Smoking ( Cigarette), Early Detection of Cancer
Interventions
Empower LCS, Call+ Telephone Navigation, Usual Care, Education
Behavioral · Other
Lead sponsor
University of California, Irvine
Other
Eligibility
50 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
57
States / cities
Anaheim, California • Costa Mesa, California • Irvine, California + 27 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 9, 2026, 8:59 AM EDT
Completed Phase 1 Interventional

Tobacco Cessation in Postmenopausal Women (Part II) - 2

NCT00061074
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Nicotrol
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
40 Years to 79 Years · Female only
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
1993 – 2000
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 2, 2015 · Synced Oct 9, 2026, 8:59 AM EDT
Completed Not applicable Interventional Results available

Effects of Cigarette and E-cigarette Flavors on Substitutability in the ETM

NCT06910202
View directory record Official record
Conditions
Cigarette Smoking Behavior
Interventions
Manipulation of nicotine/tobacco product price and availability
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Oct 9, 2026, 8:59 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Tobacco Cessation Via Public Health Dental Clinics

NCT00683839
View directory record Official record
Conditions
Smoking
Interventions
Brief tobacco counseling
Behavioral
Lead sponsor
Oregon Research Institute
Other
Eligibility
18 Years and older
Enrollment
2,637 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
3
States / cities
Jackson, Mississippi • New York, New York • Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 26, 2011 · Synced Oct 9, 2026, 8:59 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Project HOPES: Healthy Options for Pain and Ending Smoking. A Program for Cancer Survivors.

NCT06029907
View directory record Official record
Conditions
Smoking Cessation, Pain
Interventions
Smoking cessation and pain management intervention, Varenicline
Other · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Oct 9, 2026, 8:59 AM EDT
Completed Phase 2 Interventional Results available

Formoterol Dose Ranging Study (ACHIEVE Duaklir USA Phase IIb)

NCT02796651
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease - COPD
Interventions
Formoterol fumarate (6 μg), Formoterol furmarate (20 μg), Placebo for formoterol fumarate, Formoterol fumarate (12 μg), Formoterol fumarate (40 μg)
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
40 Years to 130 Years
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
20
States / cities
Glendale, Arizona • Phoenix, Arizona • Tempe, Arizona + 17 more
Source: ClinicalTrials.gov public record
Updated Feb 7, 2018 · Synced Oct 9, 2026, 8:59 AM EDT
Completed Not applicable Interventional

Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health Settings

NCT05030272
View directory record Official record
Conditions
Tobacco Use Disorder, Mental Illness, Recurring Major Depressive Disorder, Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, Persistent Depressive Disorder
Interventions
Quit on the Go App (formerly "Learn to Quit " App), Brief advice, Nicotine patch, Smartphone coaching, Nicotine gum, Nicotine Lozenges
Device · Behavioral · Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
343 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
3
States / cities
Buffalo, New York • Durham, North Carolina • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 9, 2026, 8:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Capitalizing on a Teachable Moment to Promote Smoking Cessation

NCT02276664
View directory record Official record
Conditions
Smoking Cessation
Interventions
Self-Help (SHI), Usual Care (UC)
Behavioral
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Aug 13, 2020 · Synced Oct 9, 2026, 8:59 AM EDT
Completed Phase 4 Interventional

Dissemination of Tobacco Tactics for Hospitalized Smokers

NCT01309217
View directory record Official record
Conditions
Smoking Cessation
Interventions
Tobacco Tactics Intervention, Usual Care
Behavioral · Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
1,528 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
6
States / cities
Grand Rapids, Michigan • Livonia, Michigan • Muskegon, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 18, 2014 · Synced Oct 9, 2026, 8:59 AM EDT
Completed Phase 1 Interventional

Smoking Termination / Anxiety Reduction Treatment (ST/ART)

NCT01789125
View directory record Official record
Conditions
Smoking, Anxiety Disorders
Interventions
Nicotine Patch, Smoking Termination and Anxiety Reduction Treatment, Education-Supportive Psychotherapy
Drug · Behavioral
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 23, 2019 · Synced Oct 9, 2026, 8:59 AM EDT
Completed Not applicable Interventional

Web-Delivered Acceptance & Commitment Therapy for Smokers With Bipolar Disorder

NCT02750904
View directory record Official record
Conditions
Smoking, Bipolar Disorder
Interventions
Experimental plus Nicotine Replacement Therapy, Control plus Nicotine Replacement Therapy
Behavioral
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
4
States / cities
Palo Alto, California • Denver, Colorado • Bedford, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2019 · Synced Oct 9, 2026, 8:59 AM EDT
Completed Not applicable Interventional Results available

Abstinence Reinforcement Therapy (ART) for Rural Veteran Smokers

NCT01723163
View directory record Official record
Conditions
Veteran, Smoking Cessation
Interventions
Abstinence Reinforcement Therapy (ART), Telephone Counseling and NRT
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
310 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 1, 2019 · Synced Oct 9, 2026, 8:59 AM EDT
Suspended No phase listed Observational Accepts healthy volunteers

Patients' Attitudes Toward and Experiences With Buprenorphine Treatment

NCT05121428
View directory record Official record
Conditions
Opioid-use Disorder, Acceptability of Health Care, Opioid-Related Disorders
Interventions
Not listed
Lead sponsor
Cambridge Health Alliance
Other
Eligibility
18 Years and older
Enrollment
817 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 11, 2025 · Synced Oct 9, 2026, 8:59 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Abuse Liability of IQOS Heated Tobacco Products Among Adults Who Smoke

NCT07688304
View directory record Official record
Conditions
Tobacco
Interventions
Smoking Behavioral Research (IQOS), Smoking Behavioral Research (UBC)
Behavioral
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 9, 2026, 8:59 AM EDT
Completed Phase 4 Interventional Results available

The END Perioperative Smoking Pilot Study

NCT02482233
View directory record Official record
Conditions
Smoking, Nicotine Addiction, Surgery
Interventions
ENDD (NJOY), NRT (NicoDerm CQ), telephone counseling, brief advice, brochure
Behavioral · Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 9, 2022 · Synced Oct 9, 2026, 8:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Electronic Cigarettes (E-cigarettes) as a Harm Reduction Strategy

NCT02628964
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking
Interventions
e-cigarettes
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years to 35 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 24, 2020 · Synced Oct 9, 2026, 8:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Mechanisms of Mindfulness for Smoking Cessation

NCT02943499
View directory record Official record
Conditions
Smoking Cessation
Interventions
App/Training, Smartphone
Behavioral · Device
Lead sponsor
Brown University
Other
Eligibility
21 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 19, 2019 · Synced Oct 9, 2026, 8:59 AM EDT
Completed Not applicable Interventional

Comparative Effectiveness of Two Tobacco Cessation Interventions for Employees of Partners HealthCare, Inc.

NCT02601521
View directory record Official record
Conditions
Smoking Cessation, Tobacco Use Disorder
Interventions
Internal tobacco coach, External tobacco coach
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 24, 2021 · Synced Oct 9, 2026, 8:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD190501: A Study to Determine Subject Puffing Patterns of an Electronic Nicotine Delivery System in an Ambulatory Setting

NCT04226404
View directory record Official record
Conditions
Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
Interventions
CSD1905-11, CSD1905-12, CSD1905-13, CSD1905-14, CSD1905-15, CSD1905-16, CSD1905-17
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 25, 2020 · Synced Oct 9, 2026, 8:59 AM EDT
Not listed Phase 2Phase 3 Interventional Accepts healthy volunteers

Efficacy and Safety of Combination EMB-001 as a Potential Smoking Cessation Treatment

NCT04868253
View directory record Official record
Conditions
Smoking Cessation, Tobacco Use Disorder
Interventions
EMB-01
Drug
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
21 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated May 28, 2021 · Synced Oct 9, 2026, 8:59 AM EDT
Recruiting Not applicable Interventional

Optimizing Tobacco Treatment Delivery for People Living With HIV

NCT05019495
View directory record Official record
Conditions
Hiv, Smoking, Cigarette
Interventions
PrOMOTE
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Oct 9, 2026, 8:59 AM EDT