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ClinicalTrials.gov public records Last synced Oct 3, 2026, 7:33 PM EDT

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Showing 25–48 of 273 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Tobacco Use Disorder/Cigarette Smoking Clear all
Completed Early Phase 1 Interventional

Compensatory Behavior of E-cig Users in Response to Reduced Nicotine E-liquids

NCT06602492
View directory record Official record
Conditions
Healthy, Nicotine Addiction, Electronic Cigarette Use
Interventions
Lower nicotine e-liquid, Higher nicotine eliquid
Drug
Lead sponsor
Rochester Institute of Technology
Other
Eligibility
21 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 27, 2024 · Synced Oct 3, 2026, 7:33 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Semaglutide for Alcohol Use Disorder

NCT05520775
View directory record Official record
Conditions
Alcohol Use Disorder, Cigarette Smoking
Interventions
Semaglutide, Sham/placebo
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
21 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Oct 3, 2026, 7:33 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Varenicline and Combined NRT for Smoking Cessation

NCT02271919
View directory record Official record
Conditions
Cigarette Smoker, Tobacco Use Disorder
Interventions
Nicotine Lozenge, Nicotine Patch, Placebo, Tobacco Cessation Counseling, Varenicline
Drug · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years to 75 Years
Enrollment
631 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 3, 2026, 7:33 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluating the Relationship Between Tobacco Use, Anxiety Sensitivity, and Panic in Adolescents

NCT00535964
View directory record Official record
Conditions
Panic Disorder
Interventions
Not listed
Lead sponsor
University of Arkansas, Fayetteville
Other
Eligibility
12 Years to 17 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Fayetteville, Arkansas
Source: ClinicalTrials.gov public record
Updated Nov 17, 2022 · Synced Oct 3, 2026, 7:33 PM EDT
Withdrawn Phase 1Phase 2 Interventional

Study of Varencline Effects on Cigarette Smoking Reward and Craving During a Model of Brief Quit Attempt

NCT00571805
View directory record Official record
Conditions
Nicotine Dependence
Interventions
varencline, placebo
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 9, 2015 · Synced Oct 3, 2026, 7:33 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers

A Smoking Intervention Study Using Scheduled Gradual Reduction With Varenicline to Help With Cessation

NCT01772641
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Scheduled Gradual Reduction + Varenicline, Scheduled Gradual Reduction + Placebo Drug, Basic Advice + Varenicline, Basic Advice + Placebo Drug
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 16, 2016 · Synced Oct 3, 2026, 7:33 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Comparisons of Nicotine-free Cigarettes, Extra Low Nicotine Cigarettes vs. Medicinal Nicotine

NCT00777569
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Nicotine free cigarettes, Extra-low nicotine cigarettes, Nicotine Lozenge
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 70 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2006
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 16, 2017 · Synced Oct 3, 2026, 7:33 PM EDT
Recruiting Not applicable Interventional

Implementation of Tobacco Cessation Programming at Community Behavioral Health Sites

NCT06837220
View directory record Official record
Conditions
Nicotine Use Disorder, Smoking Cessation, Smoking Cessation Intervention
Interventions
Enhanced Courage to Quit
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 26 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Oct 3, 2026, 7:33 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

AXS-05 Phase II Trial on Smoking Behavior

NCT03471767
View directory record Official record
Conditions
Smoking Cessation, Smoking, Cigarette, Nicotine Dependence
Interventions
AXS-05, Bupropion SR
Drug
Lead sponsor
James Davis
Other
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 19, 2022 · Synced Oct 3, 2026, 7:33 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

UW Quitting Using Intensive Treatment Study (QUITS)

NCT03176784
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Varenicline, Nicotine patch, Placebo Patch, Placebo Pill
Drug · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
1,251 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
2
States / cities
Madison, Wisconsin • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 23, 2023 · Synced Oct 3, 2026, 7:33 PM EDT
Completed Phase 2 Interventional Results available

18F-FSPG PET/CT in Imaging Patients With Newly Diagnosed Lung Cancer or Indeterminate Pulmonary Nodules

NCT02448225
View directory record Official record
Conditions
Lung Carcinoma, Solitary Pulmonary Nodule, Cigarette Smoking Behavior
Interventions
Computed Tomography, fluorodeoxyglucose F-18, Fluorine F 18 L-glutamate Derivative BAY94-9392, Laboratory Biomarker Analysis, Positron Emission Tomography, Positron Emission Tomography (PET)
Procedure · Radiation · Drug + 1 more
Lead sponsor
Vanderbilt-Ingram Cancer Center
Other
Eligibility
40 Years to 80 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
2
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 19, 2022 · Synced Oct 3, 2026, 7:33 PM EDT
Completed Not applicable Interventional

Mindfulness Training for Smoking Cessation

NCT01144689
View directory record Official record
Conditions
Cigarette Smoking, Tobacco Smoking, Nicotine Dependence, Smoking Cessation
Interventions
Mindfulness Training, Smoking Cessation Therapy
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 60 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 7, 2016 · Synced Oct 3, 2026, 7:33 PM EDT
Completed Not applicable Interventional Results available

RCT of an Internet Cessation Program Plus Online Social Network for HIV+ Smokers

NCT02781090
View directory record Official record
Conditions
Tobacco Use Disorder, HIV
Interventions
PSFW+, AHA, Nicotine polacrilex
Behavioral · Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
512 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
2
States / cities
Baltimore, Maryland • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 4, 2023 · Synced Oct 3, 2026, 7:33 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Prevention of Postpartum Smoking Relapse and Related Health Consequences by Breastfeeding Promotion

NCT07661550
View directory record Official record
Conditions
Smoking ( Cigarette), Breastfeeding
Interventions
Breastfeeding promotion, Attention placebo control
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years and older · Female only
Enrollment
280 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 3, 2026, 7:33 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Cue Reactivity in Virtual Reality: The Role of Context

NCT00862927
View directory record Official record
Conditions
Smoking
Interventions
Breath Sample, Saliva Sample, Questionnaire, View Virtual Reality Scenes
Other · Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 20, 2012 · Synced Oct 3, 2026, 7:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

COPD E-cigarette Topography Training

NCT05510154
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive, Tobacco Smoking
Interventions
Brief advice, Single Training, Training to Competency
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 27, 2023 · Synced Oct 3, 2026, 7:33 PM EDT
Completed No phase listed Observational

Gene-Environment Interactions in Rheumatoid Arthritis Autoimmunity Disease Severity

NCT00594451
View directory record Official record
Conditions
Rheumatoid Arthritis
Interventions
Not listed
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 1, 2023 · Synced Oct 3, 2026, 7:33 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Beta-Adrenergic Modulation of Drug Cue Reactivity

NCT05587361
View directory record Official record
Conditions
Tobacco Use Disorder, Nicotine Dependence, Cigarette Smoking
Interventions
Propranolol, Nicotine Patch, Placebo Propranolol, Placebo Patch
Drug
Lead sponsor
University of Oklahoma
Other
Eligibility
21 Years to 60 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Oct 3, 2026, 7:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nicotine Withdrawal and Reward Processing

NCT05041959
View directory record Official record
Conditions
Cigarette Smoking, Nicotine Dependence, Nicotine Withdrawal
Interventions
Smoking Abstinence, Ad Lib Smoking
Other
Lead sponsor
University of Oklahoma
Other
Eligibility
21 Years to 55 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated May 8, 2024 · Synced Oct 3, 2026, 7:33 PM EDT
Completed Not applicable Interventional Results available

QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit Attempt

NCT04159571
View directory record Official record
Conditions
Smoking, Smoking Cessation, Craving, Addiction, Addiction Nicotine, Nicotine Dependence, Cigarette Smoking
Interventions
Real TBS to the vmPFC, Sham cTBS to the vmPFC
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 21, 2024 · Synced Oct 3, 2026, 7:33 PM EDT
Recruiting Phase 2 Interventional

A Trial of Varenicline for E-cigarette Cessation

NCT07040566
View directory record Official record
Conditions
E-cigarette Use, Vaping, Nicotine Dependence
Interventions
Varenicline 1mg BID, Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
326 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
2
States / cities
New Haven, Connecticut • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Oct 3, 2026, 7:33 PM EDT
Completed Early Phase 1 Interventional

Nicotine TMS EFT Smoking Pilot Study

NCT03579953
View directory record Official record
Conditions
Smoking, Nicotine Dependence, Addiction, Smoking, Cigarette
Interventions
Real cTBS, Sham cTBS
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 14, 2019 · Synced Oct 3, 2026, 7:33 PM EDT
Withdrawn Phase 2 Interventional

Electronic Nicotine Delivery Systems as a Smoking Cessation Treatment

NCT02487953
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine patch, ENDS, Placebo patch, Placebo ENDS
Drug · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 12, 2018 · Synced Oct 3, 2026, 7:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A High School Program for Preventing Prescription Drug Misuse

NCT03219190
View directory record Official record
Conditions
Prescription Drug Abuse, Substance Abuse, Substance Use (Drugs, Alcohol)
Interventions
LST High School Hybrid
Behavioral
Lead sponsor
National Health Promotion Associates, Inc.
Industry
Eligibility
14 Years to 18 Years
Enrollment
1,804 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Oct 3, 2026, 7:33 PM EDT