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Showing 1–24 of 198 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Tooth Decay Clear all
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Comparing Mouth Rinses (and Chewing Gum) in Regard to Streptococcus Mutans Reduction

NCT02598778
View directory record Official record
Conditions
Dental Caries
Interventions
Chlorhexidine gluconate (0.12%), Sodium Fluoride (0.05%), Paraffin wax chewing gum (sugar-free), Deionized water
Drug · Other
Lead sponsor
Montefiore Medical Center
Other
Eligibility
6 Years to 12 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Oct 30, 2022 · Synced Jul 21, 2026, 4:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

BEhavioral EConomics for Oral Health iNnovation Trial

NCT03576326
View directory record Official record
Conditions
Toothbrushing, Dental Plaque, Parent-Child Relations, Oral Hygiene, Dental Caries
Interventions
Drawing Incentive
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Months to 47 Months
Enrollment
244 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Sep 18, 2025 · Synced Jul 21, 2026, 4:47 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Effect of Chewing a Calcium Supplement Before Fluoride Rinse on Salivary Fluoride

NCT04620252
View directory record Official record
Conditions
Dental Caries
Interventions
Inactive supplement, Tricalcium phosphate supplement, Calcium carbonate supplement, Calcium citrate supplement, Inactive supplement and fluoride mouthwash, Calcium carbonate supplement and fluoride mouthwash, Calcium citrate supplement and fluoride mouthwash
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 99 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 8, 2022 · Synced Jul 21, 2026, 4:47 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

DPBRN Longitudinal Study of Repaired or Replaced Dental Restorations

NCT01201395
View directory record Official record
Conditions
Dental Caries
Interventions
Not listed
Lead sponsor
Dental Practice-Based Research Network
Network
Eligibility
6 Years and older
Enrollment
9,813 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
6
States / cities
Birmingham, Alabama • Gainesville, Florida • Minneapolis, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2011 · Synced Jul 21, 2026, 4:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Orthodontic Varnish Microbiology Study

NCT04528134
View directory record Official record
Conditions
Dental Caries, Dental Plaque, Dental White Spot
Interventions
Extended Contact RMGI (Resin-modified Glass Ionomer) Varnish, 5% Sodium Fluoride Varnish
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
12 Years to 27 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Jul 21, 2026, 4:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Oral Hygiene Products in an In Situ Caries Model

NCT02399163
View directory record Official record
Conditions
Dental Caries
Interventions
Fluoride free toothpaste, Fluoride toothpaste, Fluoride mouthwash
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 85 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 11, 2016 · Synced Jul 21, 2026, 4:47 PM EDT
Not yet recruiting Phase 3 Interventional Accepts healthy volunteers

Effectiveness of Toothpaste Tablets on Plaque, Gingival Health and Caries Experiences

NCT07124533
View directory record Official record
Conditions
Gingival Inflammation, Dental Caries
Interventions
Toothpaste Tablet, Conventional Toothpaste
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
2
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Jul 21, 2026, 4:47 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

MI Varnish and MI Paste Plus in a Caries Prevention and Remineralization Study

NCT02424097
View directory record Official record
Conditions
Dental White Spots, Dental Caries
Interventions
CPP-ACP 5% sodium fluoride varnish & 900ppm fluoride paste, 1,100pm F-toothpaste and 0.5%NaF rinse
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
11 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 21, 2020 · Synced Jul 21, 2026, 4:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Using Motivational Interviewing To Reduce Parental Risk-Related Behaviors For Early Childhood Caries

NCT04286256
View directory record Official record
Conditions
Caries,Dental, Caries
Interventions
Motivational Interviewing
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 1, 2020 · Synced Jul 21, 2026, 4:47 PM EDT
Completed Not applicable Interventional

CATCH Healthy Smiles:An Elementary School Oral Health Intervention Trial

NCT04632667
View directory record Official record
Conditions
Caries,Dental
Interventions
Comparison School Group, Intervention School Group
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
5 Years to 9 Years
Enrollment
1,084 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 7, 2025 · Synced Jul 21, 2026, 4:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Waukesha Smiles: Dental Outreach to Low-income Waukesha Children

NCT00703001
View directory record Official record
Conditions
Dental Caries
Interventions
Educational Intervention, Referral Intervention
Behavioral
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
Not listed
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 5, 2010 · Synced Jul 21, 2026, 4:47 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Evaluation of Anti-biofilm Effects of Ferumoxytol (Feraheme) Using an in Situ Biofilm Demineralization Model

NCT03678012
View directory record Official record
Conditions
Dental Caries
Interventions
Ferumoxytol/Hydrogen peroxide, Hydrogen Peroxide, Water
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 85 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
2
States / cities
Indianapolis, Indiana • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 18, 2018 · Synced Jul 21, 2026, 4:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of Kerr SonicFill™ 2 vs 3M ESPE Filtek™ Supreme Ultra Universal Restorative

NCT03032705
View directory record Official record
Conditions
Dental Caries
Interventions
SonicFill™ 2, Filtek™ Supreme
Device
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 12, 2021 · Synced Jul 21, 2026, 4:47 PM EDT
Completed Phase 3 Interventional Results available

TREXIMA and RELPAX Gastric Scintigraphy Inside and Outside a Migraine

NCT00385008
View directory record Official record
Conditions
Migraine Disorders
Interventions
Combination Product (sumatriptan succinate / naproxen sodium), RELPAX(eletriptan) 40mg Tablet
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 11, 2018 · Synced Jul 21, 2026, 4:47 PM EDT
Terminated Phase 3 Interventional Accepts healthy volunteers

Caries Transmission Prevention in Alaska Native Infants

NCT00067340
View directory record Official record
Conditions
Dental Caries
Interventions
Chlorhexidine mouth rinse, Xylitol chewing gum
Drug · Other
Lead sponsor
University of Washington
Other
Eligibility
Female only
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2006
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 1, 2015 · Synced Jul 21, 2026, 4:47 PM EDT
Withdrawn Not applicable Interventional

Raltegravir Activity In Lymphoid Tissues

NCT00863668
View directory record Official record
Conditions
HIV Infection, HIV Infections
Interventions
Efavirenz + Tenofovir DF/Emtricitabine, Raltegravir + Tenofovir DF/Emtricitabine, Colonoscopy with biopsies, Inguinal Lymph Node Excision
Drug · Procedure
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 17, 2015 · Synced Jul 21, 2026, 4:47 PM EDT
Completed Not applicable Interventional

Clinical Performance of Posterior Composite Tooth Fillings in Adults

NCT03175627
View directory record Official record
Conditions
Dental Caries, Dental Restoration Failure
Interventions
Filtek One, Filtek Z250
Device
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Jun 27, 2021 · Synced Jul 21, 2026, 4:47 PM EDT
Completed Not applicable Interventional Results available

Clinical Performance of Chairside CAD/CAM Restorations

NCT04279574
View directory record Official record
Conditions
Dental Cements, Caries,Dental
Interventions
Lithium disilicate onlays (IPS emaxCAD/Ivoclar), Chairside zirconia crowns (3M)
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
18 Years to 89 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 23, 2025 · Synced Jul 21, 2026, 4:47 PM EDT
Not listed No phase listed Observational

Diagnostic Ability of Near Infrared Transillumination Detecting Interproximal Caries as Compared to Conventional Bitewing Radiographs

NCT05362461
View directory record Official record
Conditions
Caries,Dental
Interventions
Near Infrared Transillumination
Diagnostic Test
Lead sponsor
University of Colorado, Denver
Other
Eligibility
5 Years to 9 Years
Enrollment
50 participants
Timeline
2022 – 2023
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 31, 2022 · Synced Jul 21, 2026, 4:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

BEhavioral EConomics for Oral Health iNnovation Pilot Trial

NCT03862443
View directory record Official record
Conditions
Toothbrushing, Dental Plaque, Parent-Child Relations, Oral Hygiene, Dental Caries
Interventions
Fixed Incentive, Drawing Incentive
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Months to 42 Months
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Mar 4, 2019 · Synced Jul 21, 2026, 4:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Family Access to Dentist Study

NCT02395120
View directory record Official record
Conditions
Dental Caries
Interventions
Standard letter, Intervention letter, Reduced intervention letter, DIG, Reduced DIG
Behavioral
Lead sponsor
Case Western Reserve University
Other
Eligibility
5 Years to 10 Years
Enrollment
1,305 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
2
States / cities
Cleveland, Ohio • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 15, 2022 · Synced Jul 21, 2026, 4:47 PM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

Evaluation of Implants Placed Immediately or Delayed Into Extraction Sites

NCT00067392
View directory record Official record
Conditions
Dental Caries
Interventions
Dental Implant
Procedure
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
21 Months to 65 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2009
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Nov 8, 2010 · Synced Jul 21, 2026, 4:47 PM EDT
Completed Not applicable Interventional Results available

Scotchbond Universal Plus Compared to Scotchbond Universal for Posterior Class I & II Restorations With Filtek Universal

NCT05248204
View directory record Official record
Conditions
Cavities of Teeth, Dental Decay
Interventions
Scotchbond™ Universal Plus Adhesive, Scotchbond™ Universal Adhesive
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
18 Years to 70 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Jul 21, 2026, 4:47 PM EDT
Completed Not applicable Interventional Results available

TetricCAD Crown Clinical Study

NCT03716817
View directory record Official record
Conditions
Fractured Tooth, Decayed Tooth, Unsatisfactory Restoration of Tooth
Interventions
Tetric CAD
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Jul 21, 2026, 4:47 PM EDT