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ClinicalTrials.gov public records Last synced Nov 14, 2026, 6:44 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 337–360 of 692 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Tooth Diseases Clear all

Conditions: Edentulous Jaw
Interventions: T3 dental implant system; Device
Lead sponsor: ZimVie; Industry
Eligibility: 18 Years and older
Enrollment: 139 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2026
U.S. locations: 3
States / cities: Gainesville, Florida • Neptune City, New Jersey • Richmond, Virginia

Conditions: Dentine Hypersensitivity
Interventions: 5% Potassium nitrate, 2.5% Potassium nitrate, Sterile water; Drug · Other
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009
U.S. locations: 1
States / cities: Fort Wayne, Indiana

Conditions: Dentin Hypersensitivity
Interventions: Test Toothpaste 1, Test Toothpaste 2, Reference Toothpaste; Drug
Lead sponsor: HALEON; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 254 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Dental Plaque
Interventions: Experimental: U-shaped Power Toothbrush, Placebo Comparator: Soft Manual Toothbrush; Device
Lead sponsor: Lander Enterprises, LLC; Industry
Eligibility: 5 Years to 8 Years
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: Fort Wayne, Indiana

Conditions: Pulp Necroses
Interventions: GentleWave, EdgePro laser irrigation, Irrisafe passive ultrasonic irrigation; Device
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Dental Caries, Pulp Exposure, Dental, Tooth Decay, Dental Decay
Interventions: Vitrebond™ Pulp Protect Liner/Base; Device
Lead sponsor: Solventum US LLC; Industry
Eligibility: 7 Years to 89 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Edentulous Jaw
Interventions: T3 short and restoration (prosthesis), T3 standard length and restoration (prosthesis); Device
Lead sponsor: ZimVie; Industry
Eligibility: 18 Years and older
Enrollment: 106 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 2
States / cities: Boston, Massachusetts • Dearborn Heights, Michigan

Conditions: Jaw, Edentulous, Partially
Interventions: PrimeTaper EV implant; Device
Lead sponsor: Dentsply Sirona Implants and Consumables; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 138 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2029
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Dental Caries
Interventions: Silver Diamine Fluoride 38%, Group 2 (Placebo); Device
Lead sponsor: Justine Kolker; Other
Eligibility: 21 Years to 64 Years
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Sphingosine Phosphate Lyase Insufficiency Syndrome (SPLIS)
Interventions: no intervention; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: Not listed
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Dental Plaque
Interventions: Automated mouthpiece-based toothbrush, Manual toothbrush; Device
Lead sponsor: University of Washington; Other
Eligibility: 5 Years to 17 Years
Enrollment: 42 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Cerebral Palsy (CP), Stroke, Spinal Cord Injury, Traumatic Brain Injury, Charcot Marie Tooth Disease (CMT), Spina Bifida
Interventions: Participate in high intensity exercise of at least 20 minutes in 60 minutes session of RPE greater than 6.; Behavioral
Lead sponsor: University of Hartford; Other
Eligibility: 8 Years to 99 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: West Hartford, Connecticut

Conditions: Periodontitis, Gingivitis, Periodontal Disease, Periodontal Infections, Oral Infections, Periapical Infections, Pneumonia, Diabetes
Interventions: Comprehensive Oral Evaluation, Intraoral Complete Radiographic Series, • Teledentistry-synchronous and asynchronous, Periodontal Therapy, Periodontal Maintenance Procedure, Application of Caries Arresting Medicament, Oral Hygiene Assistance, Referral for Treatment of Acute Oral Infection; Other · Procedure
Lead sponsor: Missouri Department of Health and Senior Services; Other
Eligibility: 60 Years to 100 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Jefferson City, Missouri

Conditions: Dentinal Hypersensitivity, Dental Pain
Interventions: Potassium Nitrate, Placebo; Drug
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009
U.S. locations: 1
States / cities: Fort Wayne, Indiana

Conditions: Dental Caries on Pit and Fissure Surface
Interventions: Isolite System, Cotton Roll Technique; Device · Other
Lead sponsor: University of Iowa; Other
Eligibility: 6 Years to 16 Years
Enrollment: 104 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Gingival Recession, Mucogingival Deformity - Insufficient Keratinized Tissue
Interventions: Modified Coronally Advanced Tunnel with Connective Tissue Graft; Procedure
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Leukodystrophy, White Matter Disease, 4H Syndrome, Adrenoleukodystrophy, AMN, ALD, ALD (Adrenoleukodystrophy), X-linked Adrenoleukodystrophy, X-ALD, Adrenomyeloneuropathy, Aicardi Goutieres Syndrome, AGS, Alexander Disease, Alexanders Leukodystrophy, AxD, ADLD, Canavan Disease, CTX, Cerebrotendinous Xanthomatoses, Krabbe Disease, GALC Deficiency, Globoid Leukodystrophy, TUBB4A-Related Leukodystrophy, H-ABC - Hypomyelination, Atrophy of Basal Ganglia and Cerebellum, HBSL, HBSL - Hypomyelination, Brain Stem, Spinal Cord, Leg Spasticity, LBSL, Leukoencephalopathy With Brain Stem and Spinal Cord Involvement and High Lactate Syndrome (Disorder), Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation, ALSP, CSF1R Gene Mutation, HCC - Hypomyelination and Congenital Cataract, MLC1, Megalencephalic Leukoencephalopathy With Subcortical Cysts 1, MLD, Metachromatic Leukodystrophy, PMD, Pelizaeus-Merzbacher Disease, PLP1 Null Syndrome, PLP1 Gene Duplication &#X7C; Blood or Tissue &#X7C; Mutations, Pelizaeus-Merzbacher-Like Disease, 1, Peroxisomal Biogenesis Disorder, Zellweger Syndrome, Refsum Disease, Salla Disease, Sialic Storage Disease, Sjögren, Sjogren-Larsson Syndrome, Van Der Knapp Disease, Vanishing White Matter Disease, Charcot-Marie-Tooth, CMT, Mct8 (Slc16A2)-Specific Thyroid Hormone Cell Transporter Deficiency, Allan-Herndon-Dudley Syndrome, Cadasil, Cockayne Syndrome, Multiple Sulfatase Deficiency, Gangliosidoses, GM2 Gangliosidosis, BPAN, Labrune Syndrome, LCC, Mucopolysaccharidoses, TBCK-Related Intellectual Disability Syndrome
Interventions: Not listed
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: Up to 18 Years
Enrollment: 236 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2024
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Plaque, Dental
Interventions: Colgate Cavity Protection, TOM's Superior Sensitivity Relief Toothpaste; Drug
Lead sponsor: Colgate Palmolive; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Piscataway, New Jersey

Conditions: Initial Caries, Arrested Dental Caries, Cavitated Caries, Dental Caries, Dental Caries in Children
Interventions: Curodont Repair Fluoride Plus, Silver Diamine Fluoride, Glass Ionomer Sealant, Fluoride varnish, Fluoride toothpaste; Drug · Device
Lead sponsor: CareQuest Institute for Oral Health; Other
Eligibility: 4 Years and older
Enrollment: 744 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 4
States / cities: Dothan, Alabama • Westborough, Massachusetts • Bend, Oregon + 1 more

Conditions: Jaw, Edentulous
Interventions: ASTRA TECH Implant System, OsseoSpeed™, all dimensions.; Device
Lead sponsor: Dentsply Sirona Implants and Consumables; Industry
Eligibility: 20 Years and older
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2012
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Brain Trauma
Interventions: Plasma Neurofilament Light (NF-L), Omega-3 Index, HeadCount Questionnaire; Other
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 18 Years to 25 Years · Female only
Enrollment: 27 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 2
States / cities: Kansas City, Missouri

Conditions: Recession, Gingival
Interventions: Mandibular Incisor root coverage procedure; Procedure
Lead sponsor: Case Western Reserve University; Other
Eligibility: 18 Years and older
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Tooth Demineralization
Interventions: MI Paste Plus, PreviDent Fluoride Varnish, Normal Home Care; Procedure
Lead sponsor: University of Washington; Other
Eligibility: 12 Years to 20 Years
Enrollment: 240 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Teeth Staining
Interventions: Toothpaste; Other
Lead sponsor: Boka LLC; Industry
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Fort Wayne, Indiana

Search by objective public record fields.

An Observational Clinical Study of the T3 Dental Implant System

Efficacy of Potassium Nitrate Solution in Reducing Dentinal Hypersensitivity

A Study to Investigate the Tooth Whitening and Dentin Hypersensitivity Effectiveness of Two Experimental Toothpastes

Plaque Removal Efficacy of a U-Shaped Sonic Power Toothbrush in Children

Bacterial Load Reduction by GentleWave and EdgePro Irrigation Systems in Mandibular Necrotic Molars

Clinical Study Evaluating Solventum™ Vitrebond™ Pulp Protect Liner/Base for Direct Capping of Pulpal Exposure

A Clinical Study of the T3 Short Dental Implant System

Multicenter Study to Evaluate the Clinical Outcome of PrimeTaper EV Implant in Single Tooth Restorations

Silver Diamine Fluoride Pilot Study (SDF)

Natural History of Sphingosine Phosphate Lyase Insufficiency Syndrome (SPLIS)

Efficacy of Plaque Removal of a Novel Brushing Device

High Intensity Exercise and Improving Physical Activity Among People With Neurologic Dysfunction

Extending Dental Care to Nursing Home Residents to Reduce Mouth Infections and Incidence of Pneumonia and Improve Diabetic Glucose Control

The Effects of Potassium Nitrate in Reducing Dentinal Hypersensitivity

A Clinical Trial Comparing Isolite® vs. Cotton Roll Isolation in the Placement of Dental Sealants

Modified Coronally Advanced Tunnel for Mandibular Lingual Root Coverage

LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies

Arginine Plaque Metabolism Pilot Clinical Study

Early Caries Lesion Management Observational Study

Study on ASTRA TECH Implant System, OsseoSpeed™ Implants in Patients Missing All Teeth in the Upper Jaw, Restored With Provisional Teeth Within 24 Hours

Plasma Neurofilament Light and Its Relationship With Omega-3 Status and Soccer Heading in Women Soccer Players

Comparison of Two Methods of Covering a Single Lower Front Tooth With Receded Gums

Study of Treatments Used for White Spot Lesions After Orthodontic Treatment.

The Purpose of This Research Study is to Compare the Effectiveness of a Non-fluoride Sensitive Whitening Toothpaste, Containing 5% KNO3 (Test) to That of a Non-whitening Fluoride Toothpaste (Negative Control) in Improving Tooth Whiteness (Removal of Extrinsic Stains Over 4 Weeks of Unsupervised Use.