Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 14, 2026, 12:31 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 86 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Total Joint Replacement Surgery Clear all

Conditions: Rheumatoid Arthritis, Degenerative Arthritis, Post Traumatic Arthritis
Interventions: Integra Cadence Total Ankle System; Device
Lead sponsor: Smith & Nephew, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 132 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2025
U.S. locations: 9
States / cities: San Francisco, California • Sarasota, Florida • Buffalo, New York + 5 more

Conditions: Osteoarthritis: Joint Replacement Surgery
Interventions: CLARIX FLO, Saline; Other
Lead sponsor: BioTissue Holdings, Inc; Industry
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Orange Park, Florida

Conditions: Total Joint Replacement Surgery
Interventions: SPARTA force plate; Device
Lead sponsor: Derek Amanatullah; Other
Eligibility: 18 Years to 99 Years
Enrollment: 55 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Stanford, California

Conditions: Drainage
Interventions: Duraprep Surgical Solution; Drug
Lead sponsor: Rothman Institute Orthopaedics; Other
Eligibility: 18 Years to 80 Years
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Muscular Atrophy
Interventions: LY2495655, Placebo; Drug
Lead sponsor: Eli Lilly and Company; Industry
Eligibility: 50 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 16
States / cities: Tucson, Arizona • Laguna Hills, California • Lakewood, Colorado + 13 more

Conditions: Post-Traumatic Osteoarthritis of Ankle, Ankle Osteoarthritis, Ankle Injuries
Interventions: Osteochondral allograft ankle; Procedure
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 18 Years to 55 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Post-traumatic Arthritis
Interventions: Ceramax Acetabular System; Device
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: Not listed
Enrollment: 185 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2019
U.S. locations: 12
States / cities: Sacramento, California • Denver, Colorado • Fort Collins, Colorado + 8 more

Conditions: Osteoarthritis
Interventions: Customized patient instruments, Traditional Metal Instruments; Device
Lead sponsor: Medacta USA; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 5
States / cities: Marrero, Louisiana • Billings, Montana • Meadville, Pennsylvania + 2 more

Conditions: Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\), Total Knee Replacement, Total Knee Replacement Surgery, Total Knee Replacements, Total Knee Replacement Arthroplasty, Suzetrigine, Pain Management, Pain, Nav 1.8, JOURNAVX, Opioid Cessation, Opioid Consumption, Postoperative, Multimodal Analgesia, Randomized Controlled Trial, Randomized Controlled Study, Randomized Controlled Trials
Interventions: Placebo, Suzetrigine; Other · Drug
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 80 Years
Enrollment: 148 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: New York, New York

Conditions: Degenerative Joint Disease, Osteoarthritis
Interventions: PEAK PlasmaBlade 4.0, Traditional Electrosurgery with scalpel; Device
Lead sponsor: Medtronic Surgical Technologies; Industry
Eligibility: 21 Years to 80 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 2
States / cities: Rochester Hills, Michigan • Arlington, Texas

Conditions: Knee Osteoarthritis, Musculoskeletal Disease, Surgery
Interventions: PAI, PAI + steroid, PAI + zilretta; Drug
Lead sponsor: Walter Reed National Military Medical Center; Federal
Eligibility: 18 Years and older
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Total Knee Arthroplasty, Total Knee Arthroplasty Recovery
Interventions: Intra-articular Posteromedial Surgeon Administered (IPSA) Block with LIA, Local Infiltration Analgesia (LIA), Bupivacaine liposome injectable suspension (IPSA block), Bupivacaine liposome injectable suspension (LIA); Procedure · Drug
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
Interventions: Stereotactic guidance system; Device
Lead sponsor: Ormonde M. Mahoney, MD; Other
Eligibility: 45 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Athens, Georgia

Conditions: Osteoarthritis, Knee
Interventions: Navio™ Robotics-assisted Surgical System; Device
Lead sponsor: Columbia University; Other
Eligibility: 40 Years to 85 Years
Enrollment: 99 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2026
U.S. locations: 1
States / cities: New York, New York

Conditions: Smoking, Smoking Cessation
Interventions: Comprehensive Relapse Prevention Intervention, Standard Treatment Counseling, Nicotine Replacement Therapy (NRT); Behavioral · Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 100 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Hip Osteoarthritis, Knee Osteoarthritis
Interventions: Educational intervention; Other
Lead sponsor: West Virginia University; Other
Eligibility: 45 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Morgantown, West Virginia

Conditions: Total Hip Replacement, Total Knee Replacement
Interventions: post op communication software; Device
Lead sponsor: Concentra AI, inc; Industry
Eligibility: 22 Years to 80 Years
Enrollment: 652 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 3
States / cities: Phoenix, Arizona • Wichita, Kansas • Baltimore, Maryland

Conditions: Knee Osteoarthritis
Interventions: Femoral Nerve Catheters, Single Shot Femoral Nerve Blocks; Drug
Lead sponsor: Eastern Maine Medical Center; Other
Eligibility: 18 Years to 80 Years
Enrollment: 99 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Bangor, Maine

Conditions: Osteoarthritis, Knee
Interventions: Total knee replacement; Procedure
Lead sponsor: Fondren Orthopedic Group L.L.P.; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Total Knee Arthroplasty; Total Hip Arthroplasty
Interventions: Health Partner, Standard Care; Behavioral
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 18 Years and older
Enrollment: 127 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Plainsboro, New Jersey

Conditions: Osteoarthritis, Degenerative Joint Disease
Interventions: Motivational Interviewing (MI), Financial Incentives; Behavioral · Other
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 40 Years and older
Enrollment: 202 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Knee Replacement Surgery, Osteoarthritis
Interventions: Standard of Care, FLOSEAL Hemostatic Matrix + Standard of care; Procedure · Drug
Lead sponsor: Baxter Healthcare Corporation; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 137 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 12
States / cities: Los Angeles, California • Redwood City, California • Englewood, Colorado + 8 more

Conditions: Shoulder Arthroplasty
Interventions: Not listed
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years and older
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Arthritis
Interventions: Reverse Shoulder Arthroplasty, Total Shoulder Arthroplasty; Device
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 70 Years to 95 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: St Louis, Missouri

Search by objective public record fields.

Clinical Evaluation of Integra® Cadence™ Total Ankle System in Primary Ankle Joint Replacement (CADENCE)

Amniotic Umbilical Cord Particulate During Total Knee Arthroplasty

A Rehabilitation Tool to Determine Patient's Stay in Hospital After Joint Replacement

Evaluating the Effectiveness of 2 Surgical Skin Preparation Methods in Reducing Surgical Wound Drainage After Total Hip or Knee Replacement

A Study of LY2495655 in Older Participants Undergoing Elective Total Hip Replacement

Indications for Osteochondral Allograft Transplantation

28mm Ceramic-on-Ceramic Total Hip Replacement Study

Single-use Efficiency Instruments With Patient Specific Technique (MyKnee®) Versus Traditional Metal Instruments With Conventional Surgical Technique

Suzetrigine in TKA

PEAK PlasmaBlade 4.0 Versus Traditional Electrosurgery in Total Knee Replacement.

Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.

Pilot Study on EXPAREL as an Intra-articular Posteromedial Surgeon Administered (IPSA) Block vs. Local Infiltration Analgesia in Knee Replacement Surgery

Total Knee Arthroplasty Guidance Systems Study

Navio Robotic Versus Conventional Total Knee Arthroplasty

Preventing Smoking Relapse After Total Joint Replacement Surgery

Leisure Expectations About Physical Activity Study

An Open Label Data Collection Study of My Connect Post-Op, a Post-Operative Communication Tool

Comparing Femoral Nerve Catheters to Single Shot Femoral Nerve Blocks for Total Knee Replacement Surgery

Thigh Pain After Total Knee Arthroplasty (TKA)

Health Partner Evaluation at Princeton

The Study of Physical Activity Rewards After Knee Surgery

Efficacy and Safety of FLOSEAL for Hemostasis in Total Knee Arthroplasty

Hospital for Special Surgery Shoulder Arthroplasty Cohort

Total vs. Reverse Shoulder Replacement: Pain Relief Two Years After Surgery