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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:16 AM EST

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Showing 49–72 of 86 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Total Joint Replacement Surgery Clear all

Conditions: Osteoarthritis of the Knee
Interventions: Total Knee Arthroplasty with Custom Cutting Blocks, Total Knee Arthroplasty via Computer Assisted Surgery; Procedure
Lead sponsor: Foundation for Southwest Orthopedic Research; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 2
States / cities: Houston, Texas

Conditions: Hyperglycemia
Interventions: Metformin, Placebo; Drug · Other
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years to 99 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Osteoarthritis, Hip
Interventions: Hip Resurfacing, Total Hip Arthroplasty; Device
Lead sponsor: Spokane Joint Replacement Center; Other
Eligibility: 20 Years to 80 Years
Enrollment: 31 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2018
U.S. locations: 1
States / cities: Spokane, Washington

Conditions: Osteoarthritis
Interventions: Not listed
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years and older
Enrollment: 30,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2031
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Postoperative Pain, Delirium, Confusion, Sleep
Interventions: Melatonin, Placebo; Drug
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 90 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Total Hip Arthroplasty (THA), Total Hip Arthroplasty \(THA\), Total Hip Replacement, Total Hip Replacement Surgery, Total Hip Replacements, Total Hip Replacement Arthroplasty, Suzetrigine, Pain Management, Pain, Nav 1.8, JOURNAVX, Opioid Cessation, Opioid Consumption, Postoperative, Multimodal Analgesia, Randomized Controlled Trial, Randomized Controlled Study, Randomized Controlled Trials
Interventions: Suzetrigine, Placebo; Drug · Other
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 80 Years
Enrollment: 210 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: New York, New York

Conditions: Arthroplasty, Replacement, Knee
Interventions: Depodur, sciatic nerve block; Drug · Procedure
Lead sponsor: University of Louisville; Other
Eligibility: 18 Years to 70 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Louisville, Kentucky

Conditions: Hip Arthroplasty
Interventions: Not listed
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years and older
Enrollment: 3,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Post-Traumatic Osteoarthritis of Hip
Interventions: Not listed
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 20 Years to 75 Years
Enrollment: 81 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 5
States / cities: Sacramento, California • Denver, Colorado • Winston-Salem, North Carolina + 2 more

Conditions: Knee Osteoarthritis, Knee Rheumatism
Interventions: Obturator nerve regional block, Adductor canal regional block, Saline; Drug
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years to 85 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Hip Fracture, Osteoarthritis, Femur Head Necrosis
Interventions: Essential amino acid supplement, Ketoconazole, Placebo; Drug
Lead sponsor: University of Arkansas; Other
Eligibility: 30 Years to 80 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2012
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Knee Total Joint Replacement, Hip Total Joint Replacement
Interventions: Education on disposal of opioids; Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Scottsdale, Arizona

Conditions: Hip Arthropathy, Knee Arthropathy, Vitamin D Deficiency
Interventions: Vitamin D3; Dietary Supplement
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 900 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Osteoarthritis, Knee
Interventions: Exercise; Behavioral
Lead sponsor: Helen Hayes Hospital; Other
Eligibility: 60 Years to 89 Years
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: West Haverstraw, New York

Conditions: Osteoarthritis
Interventions: GUIDED IMAGERY, PLACEBO; Behavioral
Lead sponsor: Kent State University; Other
Eligibility: 18 Years and older
Enrollment: 82 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Akron, Ohio

Conditions: Osteoarthritis, Blood Loss, Surgical, Blood Loss, Postoperative
Interventions: Tranexamic Acid (Oral), Tranexamic Acid (Intravenous); Drug
Lead sponsor: The New England Baptist Hospital; Other
Eligibility: 18 Years and older
Enrollment: 118 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Prosthetic Joint Infection, Surgical Skin Infection
Interventions: Integuseal; Device
Lead sponsor: Rothman Institute Orthopaedics; Other
Eligibility: 18 Years to 80 Years
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Osteoarthritis, Knee
Interventions: Digital hand-held surgical navigation system, Conventional tibial extramedullary alignment system; Device
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: Not listed
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Osteoarthritis of Knee, Edema, Wounds and Injuries
Interventions: ODIN1, Standard Care, Diagnostic Device Testing; Device · Other
Lead sponsor: Bioelectric Research Corporation; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016
U.S. locations: 2
States / cities: Las Vegas, Nevada

Conditions: Arthroplasty
Interventions: Biomet TMJ Replacement System; Device
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 18 Years and older
Enrollment: 93 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 4
States / cities: Indianapolis, Indiana • West Bloomfield, Michigan • Philadelphia, Pennsylvania + 1 more

Conditions: Osteoarthritis, Sarcopenia
Interventions: Total knee replacement surgery; Procedure
Lead sponsor: University of Florida; Other
Eligibility: 60 Years and older
Enrollment: 18 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Pain Management, Opioid Consumption
Interventions: Placebo, Oxycodone 5 mg, Multimodal Non-Opioid Analgesia; Drug · Other
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Pain, Postoperative
Interventions: Caffeine, Placebo oral tablet; Drug
Lead sponsor: Rothman Institute Orthopaedics; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Egg Harbor, New Jersey

Conditions: Lumbar Spine Degeneration
Interventions: MOTUS Total Joint Replacement; Device
Lead sponsor: 3Spine; Industry
Eligibility: 21 Years to 80 Years
Enrollment: 158 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2029
U.S. locations: 14
States / cities: Los Angeles, California • Steamboat Springs, Colorado • Deerfield Beach, Florida + 11 more

Search by objective public record fields.

A Comparative Study of Knee Systems

Metformin Use in Patients Undergoing Total Joint Replacement Surgery

Dual Energy X-ray Absorptiometry (DXA) Comparison Hip Resurfacing Versus Total Hip Arthroplasty (THA)

FORCE-TJR: Improving Orthopedic Outcomes Through a National TJR Registry

Study of Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery

Suzetrigine in Total Hip Arthroplasty

Combination of Peripheral Nerve Block and DepoDur in Total Knee Joint Replacement

Hospital for Special Surgery Hip Arthroplasty Cohort

Ceramic On Ceramic (COC) 36mm PAS IDE Rollover Subjects; Ceramic Acetabular Bearing With Ceramic Femoral Head in Total Hip Replacement

Does Adding an Additional Numbing Medication Injection in the Thigh Help With Pain Control After Knee Replacement Surgery?

Effectiveness of Two Types of Treatment in Restoring Muscle After Hip or Knee Surgery

Increasing Awareness of Opioid Disposal in the Orthopedic Patient Population

Effect of Vitamin D Status and Repletion on Postoperative Total Joint Arthroplasty Complications

A Comparative Analysis of Two Types of Exercise on Outcomes Following Total Knee Arthroplasty

Guided Imagery Response in Total Knee Replacement

Non-inferiority Trial of Oral Tranexamic Acid vs. Intravenous Tranexamic Acid in Joint Replacement Surgery

Efficacy of InteguSeal for Surgical Skin Preparation in Patients Undergoing Total Joint Replacement

Conventional Alignment System Versus Surgical Navigation System in Total Knee Arthroplasty

Microcurrent Stimulation Reduces Post-Operative Swelling and Healing Time Following Knee Replacement Surgery

Total Temporomandibular Joint Replacement System Post Approval Study

The Strong Brain Study

Opioid-Sparing Joint Replacement

Caffeine Study for Pain Control Following Total Joint Replacement

MOTUS Total Joint Replacement Investigational Device Exemption Study