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ClinicalTrials.gov public records Last synced Oct 16, 2026, 10:05 PM EDT

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Showing 625–648 of 818 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Total Knee Arthroplasty Clear all
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Metal Ion Concentrations After Total Knee Arthroplasty

NCT06447922
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Total Knee Replacement, Blood Metal Ion Concentration
Interventions
Metal ion level testing
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 100 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 16, 2026, 10:05 PM EDT
Active, not recruiting No phase listed Observational

Functional Recovery After Total Knee Arthroplasty

NCT06821269
View directory record Official record
Conditions
Arthritis Knee
Interventions
Robotic assisted total knee arthroplasty, Manual total knee arthroplasty, Robotic assisted revision total knee arthroplasty, Manual revision total knee arthroplasty
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
40 Years to 90 Years
Enrollment
30 participants
Timeline
2023 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 16, 2026, 10:05 PM EDT
Completed Not applicable Interventional

Minimally Invasive Surgical Approaches In Total Knee Arthroplasty

NCT01461356
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Minimally invasive total knee replacement, Standard approach total knee replacement
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
45 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 28, 2011 · Synced Oct 16, 2026, 10:05 PM EDT
Withdrawn Not applicable Interventional

Pain Control With Pre-operative Cryoneurolysis Following TKA

NCT03818022
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Cryoneurolysis (Iovera)
Procedure
Lead sponsor
Fondren Orthopedic Group L.L.P.
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 23, 2024 · Synced Oct 16, 2026, 10:05 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Post-Market Retrospective Study on Revision Total Knee Arthroplasty Using Medacta GMK® Revision Prosthesis

NCT02912351
View directory record Official record
Conditions
Osteoarthritis
Interventions
Patient record review, Radiographs, and questionaires.
Other
Lead sponsor
Medacta USA
Industry
Eligibility
Not listed
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Boise, Idaho
Source: ClinicalTrials.gov public record
Updated Apr 1, 2022 · Synced Oct 16, 2026, 10:05 PM EDT
Completed Not applicable Interventional

Obturator Nerve Block With Femoral and Sciatic Block

NCT01409460
View directory record Official record
Conditions
Nerve Block; Pain Medication
Interventions
Oburator Nerve block, Sham Injection in pectineus muscle.
Procedure
Lead sponsor
Trinity Health Of New England
Other
Eligibility
18 Years to 85 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 4, 2011 · Synced Oct 16, 2026, 10:05 PM EDT
Not listed No phase listed Observational

Quantitative Assessment of Walking (Squawk) With the Canary canturioTM te (CTE) Tibial Extension

NCT05693818
View directory record Official record
Conditions
Arthritis Knee
Interventions
Clinical Limping Evalution
Other
Lead sponsor
Canary Medical
Industry
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Spartanburg, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 21, 2023 · Synced Oct 16, 2026, 10:05 PM EDT
Not listed Not applicable Interventional

Trial of Unicompartmental Versus Total Knee Arthroplasty

NCT03385759
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Unicompartmental knee arthroplasty, Total knee arthroplasty
Procedure
Lead sponsor
Anderson Orthopaedic Research Institute
Other
Eligibility
18 Years to 75 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
2
States / cities
Chicago, Illinois • Alexandria, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 14, 2022 · Synced Oct 16, 2026, 10:05 PM EDT
Completed No phase listed Observational Results available

Diagnostic Utility of a Novel Point-of-Care Test of Calprotectin for Revision Total Knee Arthroplasty

NCT03694925
View directory record Official record
Conditions
Prosthetic Joint Infection
Interventions
Calprotectin test
Diagnostic Test
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
2
States / cities
Weston, Florida • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 17, 2020 · Synced Oct 16, 2026, 10:05 PM EDT
Completed Not applicable Interventional Results available

Does Radiofrequency Ablation of the Articular Nerves of the Knee Prior to Total Knee Replacement Improve Pain Outcomes

NCT02746874
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Radiofrequency Ablation (RFA), Simulated Radiofrequency Ablation (RFA)
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
30 Years to 80 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 2, 2021 · Synced Oct 16, 2026, 10:05 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

UKA Manual Versus UKA MAKO Robotic

NCT03447626
View directory record Official record
Conditions
Arthritis
Interventions
MAKO Robotic UKA
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 75 Years
Enrollment
486 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 9, 2024 · Synced Oct 16, 2026, 10:05 PM EDT
Terminated Phase 2 Interventional Results available

Safety of Buprenorphine Transdermal System (BTDS) in Subjects With Acute Postoperative Pain After Total Knee Replacement

NCT00403234
View directory record Official record
Conditions
Postoperative Pain
Interventions
Buprenorphine transdermal patch, Placebo BTDS
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
5
States / cities
Phoenix, Arizona • San Clemente, California • Orlando, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 3, 2012 · Synced Oct 16, 2026, 10:05 PM EDT
Completed Not applicable Interventional Results available

Postoperative Knee Strength Following Total Knee Replacement: A Double-Blinded Randomized Comparison Study

NCT01620047
View directory record Official record
Conditions
Total Knee Replacement, Primary Knee Arthroplasty
Interventions
Fentanyl, Ropivacaine
Drug
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Nov 11, 2013 · Synced Oct 16, 2026, 10:05 PM EDT
Completed Phase 1 Interventional

First-in-human Single Ascending Dose Study of LNA043 in Patients Scheduled for Total Knee Replacement

NCT02491281
View directory record Official record
Conditions
Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery
Interventions
LNA043, Placebo
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
50 Years to 75 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Dec 11, 2020 · Synced Oct 16, 2026, 10:05 PM EDT
Completed Not applicable Interventional

Shared Decision Making in Patients With Osteoarthritis of the Hip and Knee

NCT01492257
View directory record Official record
Conditions
Hip Osteoarthritis, Knee Osteoarthritis
Interventions
Shared Decision Making Intervention
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
2
States / cities
Redwood City, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 13, 2012 · Synced Oct 16, 2026, 10:05 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Gait and Functional Improvement in Total Knee Arthroplasty With the Use of Verasense for Soft Tissue Balancing

NCT02290119
View directory record Official record
Conditions
Osteoarthritis
Interventions
Sensor-assisted TKR (Verasense), Control - Without the use of Verasense
Device · Procedure
Lead sponsor
Orthosensor, Inc.
Industry
Eligibility
45 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 6, 2023 · Synced Oct 16, 2026, 10:05 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Xperience™ vs Normal Saline Irrigation Solution for Decreasing Bioburden After Primary Total Hip and Knee Arthroplasty

NCT05577936
View directory record Official record
Conditions
Total Knee Replacement Surgery, Total Hip Replacement Surgery
Interventions
XPERIENCE Advanced Surgical Irrigation, Standard of Care Irrigation
Device · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 28, 2023 · Synced Oct 16, 2026, 10:05 PM EDT
Completed Phase 1 Interventional

Study Evaluating AGG-523 in Subjects With Severe Osteoarthritis Requiring Total Knee Replacement

NCT00454298
View directory record Official record
Conditions
Osteoarthritis
Interventions
AGG-523 (Aggrecanase Inhibitor)
Drug
Lead sponsor
Wyeth is now a wholly owned subsidiary of Pfizer
Industry
Eligibility
55 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
5
States / cities
Boston, Massachusetts • Newton, Massachusetts • Winchester, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 29, 2009 · Synced Oct 16, 2026, 10:05 PM EDT
Completed Phase 4 Interventional Results available

TXA vs. Amicar in Total Knee and Hip Arthroplasty

NCT02030821
View directory record Official record
Conditions
Blood Loss, Hip Arthritis, Knee Arthritis
Interventions
Amicar, TXA
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
246 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 5, 2018 · Synced Oct 16, 2026, 10:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Efficacy of Surgical Preparation Solutions in Knee Surgery

NCT01857349
View directory record Official record
Conditions
Arthroplasty, Replacement
Interventions
Chlora Prep, Dura Prep
Other
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
18 Years to 89 Years
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2020
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Oct 20, 2020 · Synced Oct 16, 2026, 10:05 PM EDT
Completed Phase 2 Interventional

Effectiveness of Adding Morphine to Intraosseous Vancomycin for Pain Control in Total Knee Arthroplasty

NCT06716749
View directory record Official record
Conditions
Primary Total Knee Arthroplasty, Intraosseous Morphine Injection, Knee Osteoarthritis
Interventions
Morphine, Vancomycin
Drug
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Oct 16, 2026, 10:05 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Telemedicine in Total Knee Arthroplasty Using Wearable Technology

NCT03406455
View directory record Official record
Conditions
Knee Arthritis
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
60 Years to 80 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 24, 2019 · Synced Oct 16, 2026, 10:05 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Fixed Bearing Versus Mobile Bearing Patient Satisfaction and Clinical Outcome Study

NCT02633085
View directory record Official record
Conditions
Osteoarthritis
Interventions
Fixed Bearing or Mobile Bearing UKA
Device
Lead sponsor
Medacta USA
Industry
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
1
States / cities
Leesburg, Florida
Source: ClinicalTrials.gov public record
Updated Mar 24, 2023 · Synced Oct 16, 2026, 10:05 PM EDT
Completed Not applicable Interventional

Combined NMES and BFR Training After TKA

NCT04347343
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Standard Rehabilitation + Neuromuscular Electrical Stimulation and Blood Flow Restriction
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 85 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 7, 2022 · Synced Oct 16, 2026, 10:05 PM EDT