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ClinicalTrials.gov public records Last synced Oct 14, 2026, 5:47 AM EDT

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Showing 169–192 of 816 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Total Knee Arthroplasty Clear all
Completed Phase 2 Interventional Results available

A Study to Evaluate the Effect of GRF6021 on Postoperative Recovery Following Primary Hip or Knee Arthroplasty

NCT03981419
View directory record Official record
Conditions
Postoperative Recovery
Interventions
GRF6021, Placebo
Biological · Other
Lead sponsor
Alkahest, Inc.
Industry
Eligibility
50 Years to 85 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Mar 13, 2024 · Synced Oct 14, 2026, 5:47 AM EDT
Recruiting Not applicable Interventional

Implementation of Neuromuscular Electrical Stimulation After Total Knee Arthroplasty

NCT06953375
View directory record Official record
Conditions
Total Knee Arthroplasty, Functional Recovery, Aging, Physical Therapy
Interventions
NMES, Usual Care
Procedure · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
3,250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
3
States / cities
Aurora, Colorado • Murray, Utah
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Oct 14, 2026, 5:47 AM EDT
Completed Not applicable Interventional

A Randomized Prospective Trial of Total Knee Arthroplasty Options Comparing Standard Knee Cutting Guides and MRI Generated Patient Specific Custom Cutting Guides

NCT01072019
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Instrument
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 27, 2018 · Synced Oct 14, 2026, 5:47 AM EDT
Terminated Not applicable Interventional

Pharmacogenomics Information in Enhancing Post-operative Total Joint Replacement Pain Management: a Pilot Study

NCT02711592
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Pain, Postoperative
Interventions
Genetic Panel for Analgesics
Genetic
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 25, 2021 · Synced Oct 14, 2026, 5:47 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

The Feasibility of a Comprehensive Behavioral Intervention in Patient Post TKA

NCT01799772
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Comprehensive Behavioral Intervention, Standard of Care Exercise Program
Behavioral · Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
50 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 10, 2014 · Synced Oct 14, 2026, 5:47 AM EDT
Completed No phase listed Observational

Study of Patient Outcomes 5 Years After Partial Knee Replacement

NCT01620892
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Not listed
Lead sponsor
Athens Orthopedic Clinic, P.A.
Other
Eligibility
18 Years and older
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 10, 2019 · Synced Oct 14, 2026, 5:47 AM EDT
Completed No phase listed Observational

A Retrospective Study to Evaluate the ConforMIS iTotal® Posterior Stabilized (PS) Knee Replacement System

NCT03289000
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
iTotal Posterior Stabilized (PS) Knee Replacement System
Device
Lead sponsor
Restor3D
Industry
Eligibility
18 Years and older
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
2
States / cities
Nashville, Tennessee • Huntington, West Virginia
Source: ClinicalTrials.gov public record
Updated Oct 25, 2023 · Synced Oct 14, 2026, 5:47 AM EDT
Terminated Phase 4 Interventional

Celebrex Total Knee Arthroplasty Study

NCT00359151
View directory record Official record
Conditions
Osteoarthritis, Pain
Interventions
Celecoxib, Placebo
Drug
Lead sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
7
States / cities
Aurora, Colorado • Englewood, Colorado • Chicago, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2021 · Synced Oct 14, 2026, 5:47 AM EDT
Active, not recruiting No phase listed Observational

Optetrak Knee System Post Market Clinical Follow-Up

NCT05788757
View directory record Official record
Conditions
Knee Arthroplasty, Total
Interventions
Optetrak Total Knee System
Device
Lead sponsor
Exactech
Industry
Eligibility
18 Years and older
Enrollment
4,588 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2034
U.S. locations
3
States / cities
Worcester, Massachusetts • Las Vegas, Nevada • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 18, 2024 · Synced Oct 14, 2026, 5:47 AM EDT
Active, not recruiting Phase 1 Interventional Accepts healthy volunteers

Oral Steroid Taper After Total Knee Arthroplasty

NCT07070882
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Methylprednisolone
Drug
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Oct 14, 2026, 5:47 AM EDT
Completed Phase 4 Interventional Results available

Dronabinol in Total Knee Arthroplasty (TKA)

NCT04734080
View directory record Official record
Conditions
Total Knee Arthroplasty, Opioid Use
Interventions
Dronabinol 5mg Cap, Placebo oral tablet
Drug · Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 70 Years
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Oct 14, 2026, 5:47 AM EDT
Terminated Phase 4 Interventional

ChloraPrep Versus Betadine for Elective Knee Replacement Surgery

NCT01184196
View directory record Official record
Conditions
Arthroplasty, Knee Replacement, Replacement, Total Knee, Total Knee Replacement
Interventions
Swab area with Betadine, Swab area with ChloraPrep
Drug
Lead sponsor
Central DuPage Hospital
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Winfield, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 16, 2013 · Synced Oct 14, 2026, 5:47 AM EDT
Active, not recruiting Not applicable Interventional

Persona Ti-Nidium Post-Market Clinical Follow-up

NCT04817969
View directory record Official record
Conditions
Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Varus Deformity, Valgus Deformity, Flexion Deformity of the Knee, Avascular Necrosis, Patellofemoral Osteoarthritis
Interventions
Zimmer Biomet Persona Ti-Nidium Total Knee System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2034
U.S. locations
7
States / cities
Parker, Colorado • Hyattsville, Maryland • Jackson, Mississippi + 4 more
Source: ClinicalTrials.gov public record
Updated Sep 22, 2026 · Synced Oct 14, 2026, 5:47 AM EDT
Recruiting Phase 4 Interventional

Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty

NCT06784882
View directory record Official record
Conditions
Acute Postoperative Pain, Surgery
Interventions
continuous peripheral nerve block with OnQ pump, single injection nerve block
Device · Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jun 17, 2025 · Synced Oct 14, 2026, 5:47 AM EDT
Recruiting Phase 2 Interventional

Optimal Dosing For Low-Dose Aspirin Chemoprophylaxis For VTE Following Total Joint Arthroplasty

NCT04295486
View directory record Official record
Conditions
Venous Thromboembolism
Interventions
Aspirin
Drug
Lead sponsor
University of Miami
Other
Eligibility
19 Years and older
Enrollment
5,478 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Oct 14, 2026, 5:47 AM EDT
Completed No phase listed Observational

Costs and Benefits of ConforMIS iTotal® Knee Replacement System Versus Standard Total Knee

NCT01899417
View directory record Official record
Conditions
Osteoarthritis,Knee
Interventions
ConforMIS iTotal® Knee Replacement
Device
Lead sponsor
Restor3D
Industry
Eligibility
19 Years and older
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Atlantis, Florida
Source: ClinicalTrials.gov public record
Updated Oct 25, 2023 · Synced Oct 14, 2026, 5:47 AM EDT
Completed Not applicable Interventional

Opioid Education in Total Knee Arthroplasty

NCT05593341
View directory record Official record
Conditions
Arthropathy of Knee, Post Operative Pain, Opioid Use, Opioid Abuse, Opioid Misuse
Interventions
Opioid education in person, Opioid education via video
Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 27, 2024 · Synced Oct 14, 2026, 5:47 AM EDT
Completed Not applicable Interventional

The Study of Physical Activity Rewards After Knee Surgery

NCT01970631
View directory record Official record
Conditions
Osteoarthritis, Degenerative Joint Disease
Interventions
Motivational Interviewing (MI), Financial Incentives
Behavioral · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
40 Years and older
Enrollment
202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 18, 2018 · Synced Oct 14, 2026, 5:47 AM EDT
Terminated Phase 2Phase 3 Interventional Accepts healthy volunteers

Adductor Canal Block

NCT04513145
View directory record Official record
Conditions
Osteoarthritis, Total Knee Replacement
Interventions
Ropivacaine injection, Saline Injection, Total Knee Arthroplasty
Drug · Procedure
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
30 Years to 85 Years
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Oct 14, 2026, 5:47 AM EDT
Completed Phase 4 Interventional

Genicular and Anterior Femoral Cutaneous Nerve Blocks for Total Knee Arthroplasty

NCT05980546
View directory record Official record
Conditions
Total Knee Replacement, Genicular Nerve Block, Opioid Use
Interventions
Bupivacaine Injection, Dexamethasone injection, Fentanyl, Mepivacaine
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
244 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Oct 14, 2026, 5:47 AM EDT
Withdrawn Phase 2Phase 3 Interventional

Intraoperative Liposomal Bupivacaine Injection in Primary Total Knee Arthroplasty

NCT02341079
View directory record Official record
Conditions
Osteoarthritis, Osteoarthritis, Knee, Arthritis, Degenerative, Osteoarthrosis, Osteoarthrosis Deformans
Interventions
Bupivacaine Liposome Injection, Indwelling femoral nerve block
Drug
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 10, 2017 · Synced Oct 14, 2026, 5:47 AM EDT
Completed Not applicable Interventional Results available

Study to Compare Negative Pressure Wound Therapy or Standard Dressings After Orthopedic Surgery

NCT02064270
View directory record Official record
Conditions
Wound of Knee, Wound of Hip
Interventions
Single-Use Negative Pressure Wound Therapy, Standard postsurgical dressings
Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
526 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 17, 2018 · Synced Oct 14, 2026, 5:47 AM EDT
Terminated Early Phase 1 Interventional

Multimodal Pain Management Following Primary TKA

NCT02369523
View directory record Official record
Conditions
Pain
Interventions
Exparel, Ropivacaine cocktail (PIC), Bupivacaine
Drug
Lead sponsor
University of Utah
Other
Eligibility
40 Years to 90 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 15, 2023 · Synced Oct 14, 2026, 5:47 AM EDT
Completed Phase 2 Interventional Results available

Dose-Ranging Study for Prolonged Postoperative Analgesia in Subject Undergoing Total Knee Arthroplasty

NCT00485693
View directory record Official record
Conditions
Postoperative Pain
Interventions
Bupivacaine HCl, SKY0402
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years to 75 Years
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
6
States / cities
Birmingham, Alabama • Davis, California • Laguna Hills, California + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 28, 2022 · Synced Oct 14, 2026, 5:47 AM EDT