- Conditions
- Total Knee Arthroplasty Postoperative Pain, Opioid Reduction After TKA
- Interventions
- NEUROCUPLE™ Patch, Sham patch, Enhanced Recovery After Surgery (ERAS) Standard of Care
- Device · Other
- Lead sponsor
- Jacques E. Chelly
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 274 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2027
- U.S. locations
- 3
- States / cities
- Pittsburgh, Pennsylvania
Search Results
Search by objective public record fields.
Search by query text, NCT ID, condition, intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, or age. Results come from ClinicalTrials.gov. When the live registry is unavailable, a clearly labeled stored copy may be shown.
These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Showing 1–24
of 141
matching trials from the live ClinicalTrials.gov search.
- Conditions
- Opioid Use, Arthropathy of Knee, Pain, Postoperative
- Interventions
- RelieVRx headset, multi-modality pain management
- Device · Drug
- Lead sponsor
- AppliedVR Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 63 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2023
- U.S. locations
- 3
- States / cities
- Danville, Pennsylvania • Wilkes-Barre, Pennsylvania
- Conditions
- Anesthesia, Local, Pain, Postoperative
- Interventions
- Short-term ON-Q, Short-term ON-Q, Long-term ON-Q, Long-term ON-Q
- Device · Drug
- Lead sponsor
- AdventHealth
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 50 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2017 – 2019
- U.S. locations
- 1
- States / cities
- Orlando, Florida
- Conditions
- Arthritis Knee, Postoperative Nausea, Postoperative Pain
- Interventions
- Dexamethasone, Placebo
- Drug
- Lead sponsor
- Henry Ford Health System
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 109 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2022
- U.S. locations
- 1
- States / cities
- Grosse Pointe Farms, Michigan
- Conditions
- Pain, Postoperative, Osteo Arthritis Knee
- Interventions
- Exparel
- Drug
- Lead sponsor
- Campbell Clinic
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 10 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024 – 2025
- U.S. locations
- 1
- States / cities
- Germantown, Tennessee
- Conditions
- Total Knee Arthroplasty (Postoperative Pain), Total Hip Arthroplasty (Postoperative Pain)
- Interventions
- Transcranial Direct Current Stimulation, Cognitive-Behavioral (CB) intervention
- Device · Behavioral
- Lead sponsor
- VA Office of Research and Development
- Federal
- Eligibility
- 18 Years to 90 Years
- Enrollment
- 106 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2026
- U.S. locations
- 1
- States / cities
- Charleston, South Carolina
- Conditions
- Osteoarthritis, Knee
- Interventions
- Dronabinol, Placebo
- Drug · Other
- Lead sponsor
- Colorado Joint Replacement
- Other
- Eligibility
- 21 Years to 75 Years
- Enrollment
- 460 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2025
- U.S. locations
- 1
- States / cities
- Denver, Colorado
- Conditions
- Post-Operative Pain, Total Knee Arthroplasty
- Interventions
- Total knee arthroplasty (TKA), Cryoablation
- Procedure · Device
- Lead sponsor
- NYU Langone Health
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 215 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2027
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Osteoarthritis, Osteoarthritis, Knee, Arthritis, Degenerative, Osteoarthrosis, Osteoarthrosis Deformans
- Interventions
- Bupivacaine Liposome Injection, Indwelling femoral nerve block
- Drug
- Lead sponsor
- United States Naval Medical Center, San Diego
- Federal
- Eligibility
- 18 Years and older
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015
- U.S. locations
- 1
- States / cities
- San Diego, California
- Conditions
- Surgical Stress Response, Stress Physiological, Stress Physiology, Stress Psychological, Breathing Techniques, Breathing Exercises, Hypothalamic Pituitary Adrenal, Relaxation, Relaxation Therapy, Cortisol, Postoperative Pain, Postoperative Anxiety, Postoperative Depression, Quality of Recovery (QoR-15)
- Interventions
- A 5-minute Asynchronous Breathwork Intervention, A 5-minute Asynchronous Card Game Video
- Behavioral
- Lead sponsor
- University of Arizona
- Other
- Eligibility
- 65 Years and older
- Enrollment
- 32 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2026
- U.S. locations
- 1
- States / cities
- Tucson, Arizona
- Conditions
- Post-surgical Pain, Total Knee Arthroplasty, Foot/Ankle Surgery, Catheterization for Postop Analgesia
- Interventions
- ropivacaine 0.2%
- Drug
- Lead sponsor
- University of California, San Diego
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 117 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2018
- U.S. locations
- 1
- States / cities
- San Diego, California
- Conditions
- Total Knee Arthroplasty
- Interventions
- NEUROCUPLE™ Patch, Placebo Patch
- Device
- Lead sponsor
- nCap Medical
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 156 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024 – 2025
- U.S. locations
- 1
- States / cities
- Pittsburgh, Pennsylvania
- Conditions
- Pain, Joint Stiffness
- Interventions
- Total Knee Arthroplasty
- Procedure
- Lead sponsor
- Hospital for Special Surgery, New York
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 179 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2018
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Multimodal Analgesia, Nonsteroidal Anti-inflammatory Drugs
- Interventions
- Ibuprofen 600 mg, standard oxycodone/acetaminophen
- Drug
- Lead sponsor
- NYU Langone Health
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 77 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2016 – 2017
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Pain, Postoperative, Arthroplasty Complications
- Interventions
- Ketamine
- Drug
- Lead sponsor
- Dartmouth-Hitchcock Medical Center
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 200 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2024
- U.S. locations
- 1
- States / cities
- Lebanon, New Hampshire
- Conditions
- Osteo Arthritis Knee
- Interventions
- Isotonic saline, Ketamine Injectable Solution
- Drug
- Lead sponsor
- Rothman Institute Orthopaedics
- Other
- Eligibility
- Not listed
- Enrollment
- 75 participants
- Timeline
- 2016 – 2019
- U.S. locations
- 1
- States / cities
- Philadelphia, Pennsylvania
- Conditions
- Arthritis Knee, Knee Osteoarthritis, Pain, Postoperative
- Interventions
- Methylprednisolone 4 milligram Tab, Dexamethasone injection
- Drug
- Lead sponsor
- F. Johannes Plate
- Other
- Eligibility
- 18 Years and older
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2027
- U.S. locations
- 2
- States / cities
- Monroeville, Pennsylvania • Pittsburgh, Pennsylvania
- Conditions
- Pain, Postoperative
- Interventions
- ACB, ACB + iPACK
- Other
- Lead sponsor
- Cedars-Sinai Medical Center
- Other
- Eligibility
- 18 Years to 90 Years
- Enrollment
- 42 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2017 – 2023
- U.S. locations
- 1
- States / cities
- Los Angeles, California
- Conditions
- Pain
- Interventions
- EXPAREL, Bupivacaine
- Drug
- Lead sponsor
- Pacira Pharmaceuticals, Inc
- Industry
- Eligibility
- 18 Years and older · Male only
- Enrollment
- 140 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016 – 2017
- U.S. locations
- 17
- States / cities
- Fremont, California • Loma Linda, California • Fort Lauderdale, Florida + 13 more
- Conditions
- Opioid Use, Pain, Postoperative, Sleep, Delirium
- Interventions
- Melatonin, Placebo
- Dietary Supplement
- Lead sponsor
- Scripps Health
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 120 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2028
- U.S. locations
- 1
- States / cities
- La Jolla, California
- Conditions
- Osteoarthritis of Knee, Edema, Wounds and Injuries
- Interventions
- ODIN1, Standard Care, Diagnostic Device Testing
- Device · Other
- Lead sponsor
- Bioelectric Research Corporation
- Industry
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 40 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2016
- U.S. locations
- 2
- States / cities
- Las Vegas, Nevada
- Conditions
- Osteoarthritis (OA) of the Knee
- Interventions
- oral suzetrigine, oral Oxycodone
- Drug
- Lead sponsor
- University of Louisville
- Other
- Eligibility
- 21 Years to 89 Years
- Enrollment
- 140 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2027
- U.S. locations
- 1
- States / cities
- Louisville, Kentucky
- Conditions
- Pain
- Interventions
- Femoral perineural infusion
- Drug
- Lead sponsor
- National Institute of General Medical Sciences (NIGMS)
- NIH
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 50 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2005 – 2008
- U.S. locations
- 2
- States / cities
- La Jolla, California • Gainesville, Florida
- Conditions
- Total Knee Arthroplasty (Postoperative Pain)
- Interventions
- ATX101, bupivacaine hydrochloride, saline placebo
- Drug
- Lead sponsor
- Allay Therapeutics, Inc.
- Industry
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 226 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025
- U.S. locations
- 11
- States / cities
- Little Rock, Arkansas • Tamarac, Florida • Atlanta, Georgia + 7 more