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ClinicalTrials.gov public records Last synced Oct 10, 2026, 1:34 PM EDT

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Showing 73–96 of 185 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Total Knee Arthroplasty (TKA) Clear all
Terminated Phase 4 Interventional Results available

Minimally Invasive Total Knee Replacement - Navigated Versus Non-navigated Study

NCT00733330
View directory record Official record
Conditions
Osteoarthritis
Interventions
Either P.F.C. Sigma or L.C.S. Complete knee replacement using the conventional surgical approach and manual surgical technique, Either P.F.C. Sigma or L.C.S. Complete knee replacement using minimally invasive surgical approach and computer navigation
Device
Lead sponsor
DePuy International
Industry
Eligibility
18 Years to 80 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
3
States / cities
Newport Beach, California • Winston-Salem, North Carolina • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 15, 2014 · Synced Oct 10, 2026, 1:34 PM EDT
Completed Early Phase 1 Interventional

Anterior Heel Wedge to Treat Flexion Contracture After Total Knee Arthroplasty

NCT07620145
View directory record Official record
Conditions
Knee Flexion Contracture, Total Knee Arthroplasty (TKA)
Interventions
Anterior heel wedge
Device
Lead sponsor
University of North Carolina, Charlotte
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Oct 10, 2026, 1:34 PM EDT
Completed Not applicable Interventional Results available

interACTION: A Portable Joint Function Monitoring and Training System for Remote Rehabilitation Following TKA

NCT02646761
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
InterACTION, Standard of Care Physical Therapy
Device · Other
Lead sponsor
James J. Irrgang
Other
Eligibility
40 Years to 80 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 5, 2019 · Synced Oct 10, 2026, 1:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Preoperative Carbohydrate Rich Drinks on Immediate Postoperative Outcome in Total Knee Arthroplasty

NCT03380754
View directory record Official record
Conditions
Post Operative Nausea and Vomiting
Interventions
Nutricia preOp, Nestle Splash Lemon Flavor Water (Placebo)
Dietary Supplement · Other
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 17, 2020 · Synced Oct 10, 2026, 1:34 PM EDT
Recruiting Phase 4 Interventional

Methadone in the Management of Post-Operative Pain in Total Knee Replacement

NCT07485803
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Methadone
Drug
Lead sponsor
AdventHealth
Other
Eligibility
21 Years to 75 Years
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 10, 2026, 1:34 PM EDT
Withdrawn Phase 2 Interventional

Study to Evaluate a Preop Dose of Brivoligide Injection for Pain After Knee Replacement in Patients With High PCS Scores

NCT03797612
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Brivoligide Injection 660 mg/6 mL, Placebo 6 mL
Drug
Lead sponsor
Adynxx, Inc.
Industry
Eligibility
40 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
2
States / cities
Sheffield, Alabama • Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 13, 2020 · Synced Oct 10, 2026, 1:34 PM EDT
Withdrawn Not applicable Interventional

Utilization of a Knee Brace With Extension Swing

NCT05179044
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Guardian Sport Rehabilitator knee brace
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced Oct 10, 2026, 1:34 PM EDT
Withdrawn Not applicable Interventional

A Prospective Clinical Study Evaluating the Newton™ TKA Protocol

NCT06678750
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
TKA using computer navigation, TKA
Device · Procedure
Lead sponsor
Newton-Wellesley Hospital
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Newton, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Oct 10, 2026, 1:34 PM EDT
Completed Not applicable Interventional

Thigh Pain After Total Knee Arthroplasty (TKA)

NCT02262988
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Total knee replacement
Procedure
Lead sponsor
Fondren Orthopedic Group L.L.P.
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 7, 2022 · Synced Oct 10, 2026, 1:34 PM EDT
Completed Not applicable Interventional Results available

Comparison of 3 Techniques for Ultrasound-guided Femoral Nerve Catheter Insertion

NCT00927368
View directory record Official record
Conditions
Total Knee Replacement Surgery
Interventions
ultrasound guidance alone, ultrasound guidance and needle stimulation, ultrasound guidance and catheter stimulation
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
453 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 31, 2017 · Synced Oct 10, 2026, 1:34 PM EDT
Completed Not applicable Interventional

ROM Outcomes in Patients Undergoing a Primary TKA

NCT04217486
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Patient will be shown a photograph of their knee at 2 weeks postop, Patient will not be shown a photograph of their knee at 2 weeks postop
Other
Lead sponsor
University of Louisville
Other
Eligibility
22 Years to 89 Years
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 16, 2021 · Synced Oct 10, 2026, 1:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preoperative Cognitive Therapy for Improving Health Outcomes After TKA in High-risk Catastrophizing Subjects

NCT01772329
View directory record Official record
Conditions
Catastrophization
Interventions
Cognitive Therapy, Routine Care
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 28, 2022 · Synced Oct 10, 2026, 1:34 PM EDT
Active, not recruiting Not applicable Interventional

Cemented vs Cementless Persona Keel RCT

NCT05630053
View directory record Official record
Conditions
Knee Pain Chronic, Rheumatoid Arthritis, Osteoarthritis, Traumatic Arthritis, Polyarthritis, Avascular Necrosis, Varus Deformity, Valgus Deformity, Flexion Deformity of Knee
Interventions
Cementless Persona Knee System, Cemented Persona Knee System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2032
U.S. locations
7
States / cities
Westminster, Colorado • Chicago, Illinois • Baltimore, Maryland + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Oct 10, 2026, 1:34 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cemented vs Cementless TKA

NCT03683992
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Triathlon total knee system
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 75 Years
Enrollment
147 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2023
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 24, 2024 · Synced Oct 10, 2026, 1:34 PM EDT
Recruiting Phase 2 Interventional

Yale Steroid Enhanced Versus Exparel Nerveblock TKA Part 2

NCT05736549
View directory record Official record
Conditions
Total Knee Replacement, Knee Arthroplasty
Interventions
Bupivacaine-Liposomal Bupivacaine, Bupivacaine -Dexamethasone Sodium Phosphate-Methylprednisolone Acetate
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 10, 2026, 1:34 PM EDT
Terminated Early Phase 1 Interventional Accepts healthy volunteers

Continuous Femoral and Tibial Nerve Blocks in TKA Patients

NCT01680692
View directory record Official record
Conditions
Analgesia in Total Knee Arthroplasty
Interventions
Ropivicaine, Continuous Femoral Nerve Catheter, Continuous Tibial Nerve Catheter
Drug · Device
Lead sponsor
Texas Tech University Health Sciences Center, El Paso
Other
Eligibility
18 Years to 85 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Apr 25, 2018 · Synced Oct 10, 2026, 1:34 PM EDT
Completed No phase listed Observational Results available

Analysis of Competitive Posterior Cruciate Retaining (PCR) and Posterior Stabilized (PS) Total Knee Arthroplasty (TKA)

NCT04321356
View directory record Official record
Conditions
Knee Osteoarthritis, Total Knee Arthroplasty, Knee
Interventions
Triathlon PCR TKA, Triathlon PS TKA, Persona PCR TKA, Persona PS TKA
Device
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
2
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Oct 10, 2026, 1:34 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Continuous Adductor Canal Blocks Vs. Low Dose Femoral Nerve Blocks For Early Rehabilitation After Total Knee Arthroplasty

NCT02453321
View directory record Official record
Conditions
Pain, Postoperative, Total Knee Arthroplasty (TKA)
Interventions
Continuous Femoral Nerve Block, Nerve Block, Continuous Adductor Canal, Continuous Sciatic Nerve Block, Bupivacaine
Procedure · Drug
Lead sponsor
Kevin King, DO
Other
Eligibility
18 Years to 75 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 27, 2018 · Synced Oct 10, 2026, 1:34 PM EDT
Completed Not applicable Interventional Results available

Controlled Study of Kneehab XP for Patients Undergoing Total Knee Replacement

NCT01548040
View directory record Official record
Conditions
Total Knee Replacement
Interventions
Kneehab XP, Quadriceps TENS
Device
Lead sponsor
Theragen Inc.
Industry
Eligibility
40 Years and older
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 11, 2018 · Synced Oct 10, 2026, 1:34 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Stryker Triathlon® Cruciate Substituting vs. Posterior Stabilized Outcomes Study

NCT01367925
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Stryker Triathlon® CS Tibial Insert, Stryker Triathlon® PS Tibial Insert
Device
Lead sponsor
Spokane Joint Replacement Center
Other
Eligibility
20 Years to 80 Years
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2016
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Dec 13, 2017 · Synced Oct 10, 2026, 1:34 PM EDT
Completed Not applicable Interventional Results available

Zimmer POLAR - Total Knee Arthroplasty (TKA)

NCT01859130
View directory record Official record
Conditions
Osteoarthritis, RheumatoId Arthritis, Traumatic Arthritis, Polyarthritis
Interventions
Zimmer Persona Total Knee System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years to 75 Years
Enrollment
299 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2021
U.S. locations
4
States / cities
Naperville, Illinois • Egg Harbor, New Jersey • Durham, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 13, 2023 · Synced Oct 10, 2026, 1:34 PM EDT
Completed Not applicable Interventional Results available

Electrical Stimulation for the Treatment of Pain Following Total Knee Arthroplasty (TKA) Using the SPRINT System

NCT02468934
View directory record Official record
Conditions
Total Knee Replacement, Total Knee Arthroplasty, Pain, Postoperative Pain, Orthopedic Disorders
Interventions
SPRINT Peripheral Nerve Stimulation (PNS) System
Device
Lead sponsor
SPR Therapeutics, Inc.
Industry
Eligibility
21 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
3
States / cities
La Jolla, California • Durham, North Carolina • New Albany, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 4, 2018 · Synced Oct 10, 2026, 1:34 PM EDT
Terminated Not applicable Interventional Results available

Evaluating Edema and Range of Motion Using Negative Pressure Therapy vs. Standard Surgical Dressing in Bilateral TKA

NCT04712019
View directory record Official record
Conditions
Surgical Wound, Bilateral Total Knee Arthroplasty, Wounds and Injuries, Joint Diseases, Musculoskeletal Diseases, Edema Leg, Joint Pain, Arthritis Knee
Interventions
Closed Incision Negative Pressure Therapy (ciNPT), Standard Silver-containing Dressing
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
22 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
6
States / cities
Annapolis, Maryland • Baltimore, Maryland • Columbia, Maryland + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Oct 10, 2026, 1:34 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Peripheral Nerve Blocks vs Periarticular Local Anesthetic Injection for Total Knee Arthroplasty (TKA)

NCT02223364
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Peripheral nerve blocks with Bupivacaine, Intra articular injection with Ropivacaine, Intra articular injection with liposomal bupivacaine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 31, 2017 · Synced Oct 10, 2026, 1:34 PM EDT