- Conditions
- Total Knee Replacement, Total Knee Arthroplasty, Pain, Postoperative Pain, Orthopedic Disorders
- Interventions
- SPRINT Peripheral Nerve Stimulation (PNS) System
- Device
- Lead sponsor
- SPR Therapeutics, Inc.
- Industry
- Eligibility
- 21 Years and older
- Enrollment
- 24 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2017
- U.S. locations
- 3
- States / cities
- La Jolla, California • Durham, North Carolina • New Albany, Ohio
Search Results
Search by objective public record fields.
Search by query text, NCT ID, condition, intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, or age. Results are retrieved from ClinicalTrials.gov and synchronized into the directory. Search pages remain noindex by default.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Showing 25–48
of 24
matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
- Conditions
- Postoperative Pain
- Interventions
- Not listed
- Lead sponsor
- Massachusetts General Hospital
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 174 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2014 – 2017
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Pain
- Interventions
- Femoral perineural infusion
- Drug
- Lead sponsor
- National Institute of General Medical Sciences (NIGMS)
- NIH
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 50 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2005 – 2008
- U.S. locations
- 2
- States / cities
- La Jolla, California • Gainesville, Florida
- Conditions
- Osteoarthritis (OA) of the Knee
- Interventions
- oral suzetrigine, oral Oxycodone
- Drug
- Lead sponsor
- University of Louisville
- Other
- Eligibility
- 21 Years to 89 Years
- Enrollment
- 140 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2027
- U.S. locations
- 1
- States / cities
- Louisville, Kentucky
- Conditions
- Osteo Arthritis Knee
- Interventions
- Isotonic saline, Ketamine Injectable Solution
- Drug
- Lead sponsor
- Rothman Institute Orthopaedics
- Other
- Eligibility
- Not listed
- Enrollment
- 75 participants
- Timeline
- 2016 – 2019
- U.S. locations
- 1
- States / cities
- Philadelphia, Pennsylvania
- Conditions
- Pain, Postoperative, Total Knee Arthroplasty
- Interventions
- Duloxetine, Placebos
- Drug
- Lead sponsor
- Rush University Medical Center
- Other
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 241 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2021 – 2025
- U.S. locations
- 1
- States / cities
- Chicago, Illinois
- Conditions
- Arthropathy of Knee, Post Operative Pain, Opioid Use, Opioid Abuse, Opioid Misuse
- Interventions
- Opioid education in person, Opioid education via video
- Other
- Lead sponsor
- Hospital for Special Surgery, New York
- Other
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 42 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2023
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Opioid Use, Opioid Dependence, Knee Pain Chronic, Knee Osteoarthritis
- Interventions
- Improved Opioid-Tapering Instructions, Clinical Patient Educator
- Drug · Behavioral
- Lead sponsor
- Brigham and Women's Hospital
- Other
- Eligibility
- 18 Years and older
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2022 – 2024
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Total Knee Arthroplasty Postoperative Pain, Opioid Reduction After TKA
- Interventions
- NEUROCUPLE™ Patch, Sham patch, Enhanced Recovery After Surgery (ERAS) Standard of Care
- Device · Other
- Lead sponsor
- Jacques E. Chelly
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 274 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2027
- U.S. locations
- 3
- States / cities
- Pittsburgh, Pennsylvania
- Conditions
- Osteoarthritis, Knee
- Interventions
- Intracapsular Injection, Periarticular Injection
- Procedure
- Lead sponsor
- Broward Health
- Other
- Eligibility
- 18 Years to 90 Years
- Enrollment
- 50 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2014 – 2016
- U.S. locations
- 1
- States / cities
- Fort Lauderdale, Florida
- Conditions
- Multimodal Analgesia, Nonsteroidal Anti-inflammatory Drugs
- Interventions
- Ibuprofen 600 mg, standard oxycodone/acetaminophen
- Drug
- Lead sponsor
- NYU Langone Health
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 77 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2016 – 2017
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Total Knee Arthroplasty, Osteoarthritis, Post Operative Pain Control
- Interventions
- 20ml bolus of 0.5% ropivicaine, 0.2% Ropivicaine at 8 milliliter/hour, 5ml bolus of 0.5% ropivicaine
- Drug
- Lead sponsor
- University of Pennsylvania
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 159 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2017
- U.S. locations
- 1
- States / cities
- Philadelphia, Pennsylvania
- Conditions
- Post-surgical Pain
- Interventions
- AYX1 Injection 660 mg/6 mL, Placebo Injection 6 mL
- Drug
- Lead sponsor
- Adynxx, Inc.
- Industry
- Eligibility
- 40 Years and older
- Enrollment
- 210 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2017
- U.S. locations
- 9
- States / cities
- Birmingham, Alabama • Sheffield, Alabama • Phoenix, Arizona + 6 more
- Conditions
- Arthroplasty, Replacement, Knee, Pain, Postoperative
- Interventions
- Genetic Panel for Analgesics
- Genetic
- Lead sponsor
- TriHealth Inc.
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 4 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016 – 2019
- U.S. locations
- 1
- States / cities
- Cincinnati, Ohio
- Conditions
- Total Knee Replacement, Primary Knee Arthroplasty
- Interventions
- Fentanyl, Ropivacaine
- Drug
- Lead sponsor
- University of South Florida
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 60 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2011 – 2012
- U.S. locations
- 1
- States / cities
- Tampa, Florida
- Conditions
- Osteoarthritis
- Interventions
- Placebo saline injection, Ropivicaine 0.5%
- Other · Drug
- Lead sponsor
- Duke University
- Other
- Eligibility
- Not listed
- Enrollment
- 67 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2007 – 2008
- U.S. locations
- 1
- States / cities
- Durham, North Carolina
- Conditions
- Post Operative Pain
- Interventions
- F14, 0.25 % Bupivacaine HCl, Acetaminophen, Methocarbamol
- Drug
- Lead sponsor
- Arthritis Innovation Corporation
- Industry
- Eligibility
- 45 Years to 80 Years
- Enrollment
- 151 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2024
- U.S. locations
- 7
- States / cities
- Little Rock, Arkansas • Tamarac, Florida • Tulsa, Oklahoma + 4 more
- Conditions
- Analgesia
- Interventions
- F14 (sustained release celecoxib)
- Drug
- Lead sponsor
- Arthritis Innovation Corporation
- Industry
- Eligibility
- 45 Years to 80 Years
- Enrollment
- 100 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2027 – 2028
- U.S. locations
- 2
- States / cities
- Denver, Colorado • San Antonio, Texas
- Conditions
- Postoperative Pain
- Interventions
- Nerve block
- Procedure
- Lead sponsor
- Johns Hopkins University
- Other
- Eligibility
- 21 Years to 80 Years
- U.S. locations
- 1
- States / cities
- Baltimore, Maryland
- Conditions
- Pain, Postoperative
- Interventions
- Not listed
- Lead sponsor
- Washington University School of Medicine
- Other
- Eligibility
- 18 Years to 85 Years
- Enrollment
- 300 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2015 – 2018
- U.S. locations
- 1
- States / cities
- St Louis, Missouri
- Conditions
- Post-operation Pain
- Interventions
- MDT-10013
- Drug
- Lead sponsor
- Medtronic Spinal and Biologics
- Industry
- Eligibility
- 18 Years and older
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016
- U.S. locations
- 3
- States / cities
- Birmingham, Alabama • DeLand, Florida • Altoona, Pennsylvania
- Conditions
- Persistent Postsurgical Pain
- Interventions
- Not listed
- Lead sponsor
- Rush University Medical Center
- Other
- Eligibility
- 18 Years to 85 Years
- Enrollment
- 311 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2011 – 2018
- U.S. locations
- 1
- States / cities
- Chicago, Illinois
- Conditions
- Knee Osteoarthritis, Blood Loss, Pain, Postoperative
- Interventions
- Tranexamic Acid Pill, Placebo
- Drug
- Lead sponsor
- Campbell Clinic
- Other
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 46 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2021 – 2024
- U.S. locations
- 1
- States / cities
- Germantown, Tennessee
- Conditions
- Total Knee Arthroplasty
- Interventions
- NEUROCUPLE™ Patch, Placebo Patch
- Device
- Lead sponsor
- nCap Medical
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 156 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024 – 2025
- U.S. locations
- 1
- States / cities
- Pittsburgh, Pennsylvania