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ClinicalTrials.gov public records Last synced Oct 13, 2026, 2:11 AM EDT

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Showing 73–96 of 746 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Total Knee Replacement Arthroplasty Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Treatment With Iovera° for Total Knee Arthroplasty (TKA) Post-Operative Pain

NCT03327220
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
iovera°
Device
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
22 Years to 79 Years
Enrollment
124 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Germantown, Tennessee
Source: ClinicalTrials.gov public record
Updated May 21, 2021 · Synced Oct 13, 2026, 2:11 AM EDT
Completed Phase 4 Interventional

Tranexamic Acid for Total Knee Arthroscopy

NCT04443920
View directory record Official record
Conditions
Blood Loss, Surgical
Interventions
Tranexamic acid (TXA), Placebo Normal Saline (NS)
Drug
Lead sponsor
The Miriam Hospital
Other
Eligibility
18 Years and older
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 22, 2023 · Synced Oct 13, 2026, 2:11 AM EDT
Completed Not applicable Interventional Results available

Preoperative Acupuncture for Total Knee or Hip Arthroplasty

NCT06099223
View directory record Official record
Conditions
Knee Arthropathy, Hip Arthropathy, Anxiety
Interventions
Acupuncture needles
Device
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 26, 2025 · Synced Oct 13, 2026, 2:11 AM EDT
Not listed Not applicable Interventional

Home PT vs FORCE PT

NCT02911389
View directory record Official record
Conditions
Osteoarthritis
Interventions
Home PT via web-based platform, Home PT via paper manual, outpatient PT
Other
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 22, 2016 · Synced Oct 13, 2026, 2:11 AM EDT
Completed No phase listed Observational

Study of Surgical Technique With Use of Single-radius Prosthesis in Total Knee Replacement

NCT01505452
View directory record Official record
Conditions
Arthritis of Knee
Interventions
Not listed
Lead sponsor
Athens Orthopedic Clinic, P.A.
Other
Eligibility
18 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 9, 2019 · Synced Oct 13, 2026, 2:11 AM EDT
Completed Phase 4 Interventional Results available

Comparing Post-Op Narcotic Usage in Patients Receiving Periarticular Exparel vs. Standard Periarticular Joint Inj

NCT02682498
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
(Bupivacaine Liposome Injectable Suspension), Standard Preparation
Drug
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Jul 7, 2017 · Synced Oct 13, 2026, 2:11 AM EDT
Completed Phase 4 Interventional Results available

Abaloparatide Before Total Knee Arthroplasty

NCT04167163
View directory record Official record
Conditions
Osteoporosis, Arthroplasties, Knee Replacement
Interventions
Abaloparatide
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
55 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 5, 2026 · Synced Oct 13, 2026, 2:11 AM EDT
Completed No phase listed Observational Results available

In Vivo Kinematics Comparison of Stryker or Zimmer Total Knee Arthroplasty

NCT01864434
View directory record Official record
Conditions
Knee Prosthesis
Interventions
Stryker posterior cruciat retaining (PCR) total knee arthroplasty (TKA), Zimmer PCR TKA
Device
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
40 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
4
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 10, 2019 · Synced Oct 13, 2026, 2:11 AM EDT
Completed Not applicable Interventional

Impact of a POPOP on Preoperative Health, Eligibility, and Clinical & Patient-Reported Outcomes in TJA

NCT04910048
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteoarthritis, Hip, Avascular Necrosis, Rheumatoid Arthritis
Interventions
POPOP (preoperative patient optimization program), SOC (standard of care)
Other
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 80 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 13, 2026, 2:11 AM EDT
Completed Not applicable Interventional Results available

Triathlon® Cruciate Retaining (CR) Total Knee System Outcomes Study

NCT00957723
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Triathlon® CR Total Knee System
Device
Lead sponsor
Stryker Orthopaedics
Industry
Eligibility
21 Years to 80 Years
Enrollment
419 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2017
U.S. locations
11
States / cities
Phoenix, Arizona • Miami, Florida • Columbus, Georgia + 8 more
Source: ClinicalTrials.gov public record
Updated Oct 12, 2018 · Synced Oct 13, 2026, 2:11 AM EDT
Completed Not applicable Interventional Results available

Triathlon Total Stabilizer (TS) Outcomes Study

NCT00958789
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Triathlon TS Knee System
Device
Lead sponsor
Stryker Orthopaedics
Industry
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2019
U.S. locations
12
States / cities
Phoenix, Arizona • Jacksonville, Florida • Chicago, Illinois + 9 more
Source: ClinicalTrials.gov public record
Updated Oct 22, 2021 · Synced Oct 13, 2026, 2:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Unipolar vs. Bipolar Hemostasis in Total Knee Arthroplasty: A Prospective Randomized Trial

NCT01003080
View directory record Official record
Conditions
Knee Arthroplasty
Interventions
Aquamantys Device, Standard of care treatment for hemostasis during a total knee arthroplasty.
Device · Other
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
2
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Sep 21, 2018 · Synced Oct 13, 2026, 2:11 AM EDT
Completed No phase listed Observational Results available

Journey 2 Multi Center Kinematic Study

NCT05107414
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Total Knee Arthroplasty
Device
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years to 85 Years
Enrollment
201 participants
Timeline
2021 – 2024
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Oct 13, 2026, 2:11 AM EDT
Completed Not applicable Interventional

Anterior Referencing Versus Posterior Referencing in Minimally Invasive Total Knee Arthroplasty

NCT01135030
View directory record Official record
Conditions
Osteoarthritis
Interventions
Total knee
Procedure
Lead sponsor
Heekin Orthopedic Research Institute
Other
Eligibility
21 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 6, 2012 · Synced Oct 13, 2026, 2:11 AM EDT
Completed Not applicable Interventional

Study to Evaluate ACB Versus FNB Early Postoperative Period Functional Outcomes After TKA

NCT02218814
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Nerve Block
Interventions
Adductor Canal Block, Bupivacaine, Femoral Nerve Block, Bupivacaine
Procedure
Lead sponsor
George Macrinici
Other
Eligibility
40 Years to 80 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Joliet, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 2, 2016 · Synced Oct 13, 2026, 2:11 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Xperience™ vs Normal Saline Irrigation Solution for Decreasing Bioburden After Primary Total Hip and Knee Arthroplasty

NCT05577936
View directory record Official record
Conditions
Total Knee Replacement Surgery, Total Hip Replacement Surgery
Interventions
XPERIENCE Advanced Surgical Irrigation, Standard of Care Irrigation
Device · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 28, 2023 · Synced Oct 13, 2026, 2:11 AM EDT
Completed Phase 4 Interventional

Dilute Betadine Lavage in the Prevention of Postoperative Infection

NCT01175044
View directory record Official record
Conditions
Prosthesis-Related Infections, Arthroplasty
Interventions
Betadine Lavage, Saline Lavage
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
505 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2019
U.S. locations
2
States / cities
Chicago, Illinois • Winfield, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 17, 2021 · Synced Oct 13, 2026, 2:11 AM EDT
Completed No phase listed Observational

Prediction of Outcomes Following Total Knee Replacement

NCT01370421
View directory record Official record
Conditions
Osteoarthritis
Interventions
Not listed
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
45 Years and older
Enrollment
248 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 2, 2022 · Synced Oct 13, 2026, 2:11 AM EDT
Completed No phase listed Observational

Physical Therapy Components for Maximum TKR Outcome

NCT03120052
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Replacement
Interventions
Not listed
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years to 99 Years
Enrollment
161 participants
Timeline
2018 – 2020
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 12, 2021 · Synced Oct 13, 2026, 2:11 AM EDT
Recruiting Not applicable Interventional

ARVIS TKA vs Conventional TKA

NCT06663384
View directory record Official record
Conditions
Osteoarthritis
Interventions
Evaluation of Augmented Reality technology in TKA compared to standard TKA
Other
Lead sponsor
Foundation for Orthopaedic Research and Education
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 13, 2026, 2:11 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Non-Ablative Fractional Resurfacing of Total Knee Replacement Scars

NCT02166138
View directory record Official record
Conditions
Epidermal Thickening, Unspecified
Interventions
Non-Abilative Laser treatment
Procedure
Lead sponsor
Charles Cornell, MD
Other
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 20, 2015 · Synced Oct 13, 2026, 2:11 AM EDT
Completed Not applicable Interventional

Regenexx™ SD Versus Exercise Therapy for Treatment of Knee Osteoarthritis With Historical Comparison to TKA

NCT02034032
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Regenexx SD, Exercise Therapy
Procedure · Behavioral
Lead sponsor
Regenexx, LLC
Industry
Eligibility
18 Years to 70 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Des Plaines, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 4, 2019 · Synced Oct 13, 2026, 2:11 AM EDT
Terminated Not applicable Interventional

Visionaire: A Prospective Study

NCT01937572
View directory record Official record
Conditions
Osteoarthritis
Interventions
Visionaire system (Knee MRI), No Knee MRI
Other
Lead sponsor
The Hawkins Foundation
Other
Eligibility
18 Years to 100 Years
Enrollment
149 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 5, 2018 · Synced Oct 13, 2026, 2:11 AM EDT
Completed No phase listed Observational

Stated-Preferences in Knee Arthroplasty

NCT03058380
View directory record Official record
Conditions
Arthritis, Knee Osteoarthritis, Arthropathy of Knee
Interventions
Stated-Preferences Evaluation Instrument
Other
Lead sponsor
Duke University
Other
Eligibility
40 Years to 80 Years
Enrollment
348 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 17, 2019 · Synced Oct 13, 2026, 2:11 AM EDT