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ClinicalTrials.gov public records Last synced Oct 15, 2026, 1:48 PM EDT

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Showing 361–384 of 751 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Total Knee Replacements Clear all
Completed Phase 4 Interventional Results available

Pilot Study Evaluating Alterations in Thrombogenicity and Platelet Reactivity Following Lower Extremity Arthroplasty

NCT01809054
View directory record Official record
Conditions
Primary Total Hip and Knee Arthroplasty
Interventions
Arixtra, Pneumatic compression stockings, Aspirin
Drug · Device
Lead sponsor
LifeBridge Health
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 21, 2014 · Synced Oct 15, 2026, 1:48 PM EDT
Completed Not applicable Interventional

Progressive Rehabilitation Following Total Knee Arthroplasty

NCT01537328
View directory record Official record
Conditions
Osteoarthritis
Interventions
Total knee replacement rehabilitation
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 85 Years
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 11, 2018 · Synced Oct 15, 2026, 1:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Home-based Velocity Training in Individuals With Total Knee Replacement

NCT01808781
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Exercises plus walking program, Walking only program
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
40 Years to 75 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 12, 2017 · Synced Oct 15, 2026, 1:48 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cemented vs Cementless TKA

NCT03683992
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Triathlon total knee system
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 75 Years
Enrollment
147 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2023
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 24, 2024 · Synced Oct 15, 2026, 1:48 PM EDT
Completed Not applicable Interventional Results available

Comparing Surgery Versus Standard Physical Therapy in Treating People With a Meniscal Tear and Osteoarthritis

NCT00597012
View directory record Official record
Conditions
Osteoarthritis
Interventions
Arthroscopic partial menisectomy, Standard physical therapy, Postoperative rehabilitative physical therapy
Procedure · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
45 Years and older
Enrollment
351 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2025
U.S. locations
7
States / cities
Chicago, Illinois • Boston, Massachusetts • Rochester, Minnesota + 4 more
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 15, 2026, 1:48 PM EDT
Withdrawn Early Phase 1 Interventional Accepts healthy volunteers

Parabens Flocculation on the Anti Inflammatory Effects of Corticosteroid Injections for Total Knee Arthroplasty

NCT03445611
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
corticosteroid solution with lidocaine containing parabens., corticosteroid solution with lidocaine containing no paraben
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
19 Years to 89 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jun 3, 2021 · Synced Oct 15, 2026, 1:48 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Exparel Use in Adductor Canal Block After Total Knee Arthroplasty

NCT04910165
View directory record Official record
Conditions
Arthritis Knee, Pain, Postoperative, Opioid Use
Interventions
Exparel, Ropivacaine
Drug
Lead sponsor
St. Luke's Hospital, Pennsylvania
Other
Eligibility
18 Years to 99 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Bethlehem, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 20, 2022 · Synced Oct 15, 2026, 1:48 PM EDT
Completed Early Phase 1 Interventional

Pain Control After Total Knee Arthroplasty: Benefit In Adding Single Shot Adductor Canal Block to Existing Pain Regimen Protocol?

NCT02740192
View directory record Official record
Conditions
Pain
Interventions
Adductor Canal Block, Periarticular Injection, Ropivacaine, Bupivacaine
Procedure · Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 30, 2023 · Synced Oct 15, 2026, 1:48 PM EDT
Not listed No phase listed Observational

Return to Physical Activities After Total Knee Arthroplasty

NCT03039907
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Total Knee Arthroplasty
Procedure
Lead sponsor
Cincinnati Sportsmedicine Research and Education Foundation
Other
Eligibility
20 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 8, 2020 · Synced Oct 15, 2026, 1:48 PM EDT
Enrolling by invitation Phase 4 Interventional

Intra-Articular Catheter Total Knee Arthroplasty

NCT06580899
View directory record Official record
Conditions
Continuous Local Infiltration Analgesia, Intra-articular Catheter, Total Knee Arthroplasty
Interventions
Intra-articular catheter, Routine Standard of Care Treatment
Device · Other
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Oct 15, 2026, 1:48 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers

Trial of Essential Amino Acid Supplementation in Protein Deficient Patients Following Total Knee Arthroplasty

NCT02926235
View directory record Official record
Conditions
Quad Atrophy
Interventions
Amino Acid, Placebo
Drug · Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
40 Years to 100 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 8, 2022 · Synced Oct 15, 2026, 1:48 PM EDT
Completed Not applicable Interventional

Three Different Approaches for Ultrasound Guided Femoral Nerve Block for Patients Undergoing Total Knee Arthroplasty

NCT01763814
View directory record Official record
Conditions
Knee Arthroplasty
Interventions
Femoral nerve block, Femoral nerve block non stimulating catheter, Femoral nerve block stimulating catheter
Procedure
Lead sponsor
Chicago Anesthesia Pain Specialists
Other
Eligibility
18 Years to 90 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 7, 2019 · Synced Oct 15, 2026, 1:48 PM EDT
Completed Not applicable Interventional Results available

Optimizing Physical Activity Outcomes After Total Knee Arthroplasty

NCT03226106
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteoarthritis
Interventions
Physical Activity Behavior Intervention, Attention Control
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years to 85 Years
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 16, 2024 · Synced Oct 15, 2026, 1:48 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Mepivacaine vs. Bupivacaine Spinal Anesthetic in Total Knee Arthroplasty

NCT02980926
View directory record Official record
Conditions
Anesthesia, Spinal, Arthroplasty, Replacement, Knee, Pain Management, Early Ambulation, Ambulatory Surgical Procedures
Interventions
Mepivacaine, Bupivacaine
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
40 Years to 90 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
West Bloomfield, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 27, 2017 · Synced Oct 15, 2026, 1:48 PM EDT
Suspended Phase 4 Interventional Accepts healthy volunteers

Effect of Colchicine on Range of Motion After Manipulation Under Anesthesia for the Stiff Total Knee Replacement

NCT02926248
View directory record Official record
Conditions
Manipulation Under Anesthesia
Interventions
Colchicine, Placebo
Drug · Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years and older
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 28, 2020 · Synced Oct 15, 2026, 1:48 PM EDT
Completed Phase 2 Interventional

Perioperative Intervention to Improve Post-TKR Support and Function

NCT00566826
View directory record Official record
Conditions
Osteoarthritis, Arthroplasty, Replacement, Knee
Interventions
Patient support sessions, Treatment as usual
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
21 Years and older
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 6, 2023 · Synced Oct 15, 2026, 1:48 PM EDT
Recruiting Not applicable Interventional

ARVIS TKA vs Conventional TKA

NCT06663384
View directory record Official record
Conditions
Osteoarthritis
Interventions
Evaluation of Augmented Reality technology in TKA compared to standard TKA
Other
Lead sponsor
Foundation for Orthopaedic Research and Education
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 15, 2026, 1:48 PM EDT
Not yet recruiting Phase 4 Interventional

Doxepin Alone or Combined With Ramelteon Versus Placebo for Improving Sleep Quality After Primary Total Knee Arthroplasty

NCT07598734
View directory record Official record
Conditions
Sleep Quality Post-TKA, Postoperative Knee Function, Quality of Life After Primary TKA
Interventions
Doxepin 6 mg, Ramelteon 8 mg, Placebo Tablets
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 80 Years
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 20, 2026 · Synced Oct 15, 2026, 1:48 PM EDT
Recruiting Not applicable Interventional

Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes

NCT06298721
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Arthropathy, Surgery
Interventions
Personalized outcome prediction tool + targeted interventions, Standard of Care TKA
Behavioral
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Oct 15, 2026, 1:48 PM EDT
Recruiting Not applicable Interventional

Developing an Opioid Taper Intervention Before Total Joint Arthroplasty

NCT05788016
View directory record Official record
Conditions
Arthritis Knee, Arthritis Hip, Chronic Pain
Interventions
opioid taper
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 15, 2026, 1:48 PM EDT
Recruiting Not applicable Interventional

Observation of Wheeled Device Use After TKA

NCT06080152
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Mobility Tool
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 99 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Oct 15, 2026, 1:48 PM EDT
Terminated Not applicable Interventional

Medial Peel Release Technique TKA Randomized Clinical Trial

NCT05154058
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteoarthritis, Knee
Interventions
Medial Subperiosteal Release with Sharp Dissection, Medial Subperiosteal Release with Electrocautery
Procedure
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 27, 2023 · Synced Oct 15, 2026, 1:48 PM EDT
Completed Phase 4 Interventional Results available

Adductor Canal Block Versus Periarticular Bupivicaine Injection in Total Knee Arthroplasty

NCT02777749
View directory record Official record
Conditions
Osteoarthritis
Interventions
Bupivacaine
Drug
Lead sponsor
Columbia University
Other
Eligibility
Not listed
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 20, 2019 · Synced Oct 15, 2026, 1:48 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Effect of Oral Pregabalin on Spinal Neurotransmitters in Patients Undergoing Knee Replacement

NCT00729690
View directory record Official record
Conditions
PAIN
Interventions
Pregabalin, Placebo
Drug
Lead sponsor
Asokumar Buvanendran
Other
Eligibility
55 Years to 75 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 19, 2012 · Synced Oct 15, 2026, 1:48 PM EDT