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ClinicalTrials.gov public records Last synced Oct 12, 2026, 8:38 AM EDT

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Showing 49–72 of 751 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Total Knee Replacements Clear all
Completed Phase 4 Interventional

Genicular and Anterior Femoral Cutaneous Nerve Blocks for Total Knee Arthroplasty

NCT05980546
View directory record Official record
Conditions
Total Knee Replacement, Genicular Nerve Block, Opioid Use
Interventions
Bupivacaine Injection, Dexamethasone injection, Fentanyl, Mepivacaine
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
244 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Oct 12, 2026, 8:38 AM EDT
Completed Phase 4 Interventional

Systemic Lidocaine Versus Ultrasound-guided Adductor Canal Block for Patients Undergoing Total Knee Arthroplasty

NCT04828083
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Total Knee Arthroplasty
Interventions
Lidocaine IV, Saline IV
Drug
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Oct 12, 2026, 8:38 AM EDT
Active, not recruiting Not applicable Interventional

Persona Ti-Nidium Post-Market Clinical Follow-up

NCT04817969
View directory record Official record
Conditions
Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Varus Deformity, Valgus Deformity, Flexion Deformity of the Knee, Avascular Necrosis, Patellofemoral Osteoarthritis
Interventions
Zimmer Biomet Persona Ti-Nidium Total Knee System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2034
U.S. locations
7
States / cities
Parker, Colorado • Hyattsville, Maryland • Jackson, Mississippi + 4 more
Source: ClinicalTrials.gov public record
Updated Sep 22, 2026 · Synced Oct 12, 2026, 8:38 AM EDT
Not listed Not applicable Interventional

Comparison of TKAs Using Force Plate Analysis

NCT04163445
View directory record Official record
Conditions
Knee Osteoarthritis, Total Knee Arthroplasty, Knee Injuries, Knee Arthritis
Interventions
MicroPort Orthopedics EVOLUTION Medial Pivot TKA, Depuy Synthes ATTUNE PCR TKA
Device
Lead sponsor
Russell Nevins, M.D.
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Aug 6, 2021 · Synced Oct 12, 2026, 8:38 AM EDT
Completed Not applicable Interventional Results available

Prospective Genotyping For Total Hip or Knee Replacement Patients Receiving Warfarin (Coumadin)

NCT00634907
View directory record Official record
Conditions
Venous Thromboembolism, Bleeding
Interventions
Pharmacogenetic-based warfarin dosing, Usual care warfarin dosing
Genetic · Other
Lead sponsor
Gwen McMillin
Other
Eligibility
18 Years and older
Enrollment
263 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 8, 2017 · Synced Oct 12, 2026, 8:38 AM EDT
Completed Phase 1 Interventional

Study Evaluating AGG-523 in Subjects With Severe Osteoarthritis Requiring Total Knee Replacement

NCT00454298
View directory record Official record
Conditions
Osteoarthritis
Interventions
AGG-523 (Aggrecanase Inhibitor)
Drug
Lead sponsor
Wyeth is now a wholly owned subsidiary of Pfizer
Industry
Eligibility
55 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
5
States / cities
Boston, Massachusetts • Newton, Massachusetts • Winchester, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 29, 2009 · Synced Oct 12, 2026, 8:38 AM EDT
Completed Not applicable Interventional Results available

iTotal Pilot Study of ConforMIS Custom Total Knee Implant

NCT02186587
View directory record Official record
Conditions
Knee Arthroplasty, Total
Interventions
ConforMIS custom total knee
Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated May 23, 2023 · Synced Oct 12, 2026, 8:38 AM EDT
Terminated Not applicable Interventional

Netflix Streaming Services in the Operating Room During Total Knee Replacement - a Feasibility Study

NCT04469881
View directory record Official record
Conditions
Surgery
Interventions
VR
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 4, 2023 · Synced Oct 12, 2026, 8:38 AM EDT
Completed Phase 2 Interventional Results available

A Study to Evaluate the Effect of GRF6021 on Postoperative Recovery Following Primary Hip or Knee Arthroplasty

NCT03981419
View directory record Official record
Conditions
Postoperative Recovery
Interventions
GRF6021, Placebo
Biological · Other
Lead sponsor
Alkahest, Inc.
Industry
Eligibility
50 Years to 85 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Mar 13, 2024 · Synced Oct 12, 2026, 8:38 AM EDT
Completed No phase listed Observational

Outcomes Following Total Knee Arthroplasty

NCT02364011
View directory record Official record
Conditions
Osteoarthritis
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
40 Years to 90 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2025
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 18, 2025 · Synced Oct 12, 2026, 8:38 AM EDT
Completed Phase 4 Interventional Results available

The Effects of Arixtra on Wound Drainage Following Total Joint Arthroplasty

NCT00909064
View directory record Official record
Conditions
Total Knee Replacement
Interventions
Fondaparinux Sodium (Arixtra)
Drug
Lead sponsor
Paul Di Cesare,MD
Other
Eligibility
18 Years to 80 Years
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated May 15, 2017 · Synced Oct 12, 2026, 8:38 AM EDT
Active, not recruiting No phase listed Observational

Optetrak Knee System Post Market Clinical Follow-Up

NCT05788757
View directory record Official record
Conditions
Knee Arthroplasty, Total
Interventions
Optetrak Total Knee System
Device
Lead sponsor
Exactech
Industry
Eligibility
18 Years and older
Enrollment
4,588 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2034
U.S. locations
3
States / cities
Worcester, Massachusetts • Las Vegas, Nevada • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 18, 2024 · Synced Oct 12, 2026, 8:38 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Prospective Clinical Study Evaluating Tibiofemoral Rotational Alignment Using Intraoperative Sensing During Total Knee Arthroplasty (TKA)

NCT02286739
View directory record Official record
Conditions
Osteoarthritis
Interventions
TKA with "Verasense", TKA without "Verasense"
Device · Procedure
Lead sponsor
Orthosensor, Inc.
Industry
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
6
States / cities
Weston, Florida • Atlanta, Georgia • Morton Grove, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 19, 2024 · Synced Oct 12, 2026, 8:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Home-based Velocity Training in Individuals With Total Knee Replacement

NCT01808781
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Exercises plus walking program, Walking only program
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
40 Years to 75 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 12, 2017 · Synced Oct 12, 2026, 8:38 AM EDT
Enrolling by invitation Phase 4 Interventional

Antibiotic Prophylaxis in High-Risk Arthroplasty Patients

NCT04297592
View directory record Official record
Conditions
Infections Joint Prosthetic, Overweight or Obesity, MSSA Colonization, MRSA, Chronic Kidney Diseases, Diabetes, Autoimmune Diseases, Inflammatory Disease, Tobacco Use
Interventions
Cephalexin, Doxycycline, Cefadroxil
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 99 Years
Enrollment
4,618 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
2
States / cities
Iowa City, Iowa • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 12, 2026, 8:38 AM EDT
Withdrawn No phase listed Observational

Preop Cooled Radiofrequency Ablation for Total Knee Replacement

NCT03893292
View directory record Official record
Conditions
Postoperative Pain, Knee Osteoarthritis
Interventions
Total knee replacement, COOLIEF
Procedure · Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
65 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 13, 2020 · Synced Oct 12, 2026, 8:38 AM EDT
Completed Early Phase 1 Interventional

Pain Control After Total Knee Arthroplasty: Benefit In Adding Single Shot Adductor Canal Block to Existing Pain Regimen Protocol?

NCT02740192
View directory record Official record
Conditions
Pain
Interventions
Adductor Canal Block, Periarticular Injection, Ropivacaine, Bupivacaine
Procedure · Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 30, 2023 · Synced Oct 12, 2026, 8:38 AM EDT
Completed Phase 4 Interventional

Platelet Rich Plasma (PRP) in Total Knee Replacement

NCT00826098
View directory record Official record
Conditions
Osteoarthritis, Inflammatory Arthritis
Interventions
Platelet Rich Plasma
Biological
Lead sponsor
Exactech
Industry
Eligibility
Not listed
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
2
States / cities
Lewiston, Maine • Salisbury, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 1, 2022 · Synced Oct 12, 2026, 8:38 AM EDT
Terminated Not applicable Interventional

Cemented vs. Cementless TKA

NCT04597684
View directory record Official record
Conditions
Total Knee Arthroplasty (TKA)
Interventions
Cementless Total Knee Arthroplasty, Cemented Total Knee Arthroplasty
Procedure
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 8, 2022 · Synced Oct 12, 2026, 8:38 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

The Feasibility of a Comprehensive Behavioral Intervention in Patient Post TKA

NCT01799772
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Comprehensive Behavioral Intervention, Standard of Care Exercise Program
Behavioral · Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
50 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 10, 2014 · Synced Oct 12, 2026, 8:38 AM EDT
Completed Not applicable Interventional

Adductor Canal Blocks With Bupivacaine and Magnesium After Same-day Discharge Total Knee Arthroplasty Improve Post-operative Pain Relief and Decrease Opioid Consumption: a Prospective Randomized Controlled Trial

NCT05004636
View directory record Official record
Conditions
Post-operative Pain, Acute
Interventions
Adding Magnesium as an adjuvant to the adductor canal Block (ACB) for same-day discharge total knee arthroplasty
Drug
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 100 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Pontiac, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 13, 2021 · Synced Oct 12, 2026, 8:38 AM EDT
Completed Not applicable Interventional Results available

Adductor Canal Catheter Effectiveness and Safety Study

NCT04639128
View directory record Official record
Conditions
Total Knee Replacement Surgery
Interventions
Adductor Canal Catheter
Device
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
San Leandro, California
Source: ClinicalTrials.gov public record
Updated Apr 25, 2024 · Synced Oct 12, 2026, 8:38 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Analysis of Standard Versus Barbed Sutures in Primary Total Knee Arthroplasty.

NCT01320371
View directory record Official record
Conditions
Arthropathy of Knee
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 80 Years
Enrollment
363 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
4
States / cities
Durham, North Carolina • New Albany, Ohio • Temple, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 4, 2014 · Synced Oct 12, 2026, 8:38 AM EDT
Completed Phase 2 Interventional

Safety and Activity of F14 for Management of Pain Following Total Knee Replacement

NCT03541655
View directory record Official record
Conditions
Total Knee Replacement, Postoperative Pain
Interventions
Bupivacaine HCl, F14 (celecoxib)
Drug
Lead sponsor
Arthritis Innovation Corporation
Industry
Eligibility
45 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
3
States / cities
Denver, Colorado • Dayton, Ohio • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 10, 2020 · Synced Oct 12, 2026, 8:38 AM EDT