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Showing 1–24 of 26 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Transgendered Persons Clear all
Completed Early Phase 1 Interventional Accepts healthy volunteers

Comparing Subcutaneous Testosterone to Intramuscular Testosterone in Gender Affirming Care of Transgender Male Adolescents

NCT03864913
View directory record Official record
Conditions
Health Services for Transgender Persons, Transgender Persons
Interventions
Testosterone injection, PedsQL questionnarie, Masculinizing effects questionnaire, Medication experience questionnaire
Drug · Behavioral · Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
14 Years to 19 Years · Female only
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 2, 2024 · Synced Jul 22, 2026, 1:18 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

The Stay Study: A Demonstration Project Advancing PrEP Delivery in the San Francisco Bay Area Transgender Community

NCT03120936
View directory record Official record
Conditions
Transgender Persons, Pre-Exposure Prophylaxis
Interventions
Emtricitabine / Tenofovir Disoproxil Oral Tablet, PrEP support
Drug · Behavioral
Lead sponsor
Public Health Foundation Enterprises, Inc.
Other
Eligibility
18 Years and older
Enrollment
158 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
5
States / cities
Fremont, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 20, 2021 · Synced Jul 22, 2026, 1:18 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Psychotherapy Interventions to Support Transgender, Two-Spirit, and Nonbinary People of Color

NCT05140174
View directory record Official record
Conditions
Mental Health
Interventions
Radical Healing and Internalized Stigma (RHIS) Training
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 30, 2023 · Synced Jul 22, 2026, 1:18 PM EDT
Completed Early Phase 1 Interventional Results available

Transgender Estradiol

NCT04036500
View directory record Official record
Conditions
Transgender Persons
Interventions
Estradiol
Drug
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 10, 2025 · Synced Jul 22, 2026, 1:18 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

PrEPTECH Phase 2 Study of a PrEP Telehealth Intervention

NCT04902820
View directory record Official record
Conditions
Pre-Exposure Prophylaxis, HIV, Telemedicine
Interventions
PrEPTECH website, Online PrEP resource list
Other
Lead sponsor
ETR Associates
Other
Eligibility
15 Years to 27 Years · Male only
Enrollment
229 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Scotts Valley, California
Source: ClinicalTrials.gov public record
Updated Sep 10, 2023 · Synced Jul 22, 2026, 1:18 PM EDT
Active, not recruiting Not applicable Interventional

Forward to Quit: A Person-centered Mobile Technology Intervention for Smoking Cessation Among Transgender Adults

NCT07181551
View directory record Official record
Conditions
Smoking Cessation
Interventions
Forward to Quit (F2Q)
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Jul 22, 2026, 1:18 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

BC Risk Assessment Before Top Surgery

NCT06239766
View directory record Official record
Conditions
Breast Cancer, Risk Reduction
Interventions
Breast Cancer Risk Assessment
Diagnostic Test
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years and older · Female only
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 12, 2024 · Synced Jul 22, 2026, 1:18 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Novel Delivery Method of Transgender Voice Modification Training Using a Mobile Application

NCT05815810
View directory record Official record
Conditions
Transitioning Voice of Transgender and Gender Diverse People
Interventions
Attuned: A mobile application, In-Person Voice Modification Therapy
Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
2
States / cities
Ithaca, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Jul 22, 2026, 1:18 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effect of Testosterone Treatment on Drug Metabolism and Transport

NCT05116293
View directory record Official record
Conditions
Transgender Persons
Interventions
Midazolam oral solution, Digoxin Oral Tablet, Acetaminophen Oral Tablet
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 60 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Jul 22, 2026, 1:18 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Study of Truvada for HIV Pre Exposure Prophylaxis Using Daily Directly Observed Therapy to Look at Potential Interactions Between Truvada and Hormone Therapy

NCT04050371
View directory record Official record
Conditions
HIV Prevention, Transgender Health
Interventions
200 mg emtricitabine and 300 mg tenofovir disoproxil fumarate
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 10, 2021 · Synced Jul 22, 2026, 1:18 PM EDT
Completed No phase listed Observational

Equality in Caregiving: Facilitating Caregiver Mastery Among LGBT Caregivers of PLWD

NCT04394260
View directory record Official record
Conditions
Dementia, Caregiver Burnout
Interventions
Savvy Caregiver Program via Remote Learning, Focus group
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 9, 2023 · Synced Jul 22, 2026, 1:18 PM EDT
Not yet recruiting Not applicable Interventional

Trans STAIR: Implementing an Evidence Based Trauma Treatment With Community Led PrEP Navigation

NCT06724965
View directory record Official record
Conditions
PrEP Uptake Experiences, PrEP Adherence Experiences, Mental Health Symptoms
Interventions
Trans STAIR, PrEP Well
Behavioral
Lead sponsor
San Diego State University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Jul 22, 2026, 1:18 PM EDT
Enrolling by invitation Not applicable Interventional

MaPGAS Decision Making

NCT06565663
View directory record Official record
Conditions
Gender Dysphoria, Gender Dysphoria, Adult, Gender Incongruence, Transgenderism, Transsexualism, Transgender Persons, Phalloplasty
Interventions
MaPGAS Decision Aid
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
2
States / cities
Hanover, New Hampshire • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 22, 2026 · Synced Jul 22, 2026, 1:18 PM EDT
Active, not recruiting Phase 3 Interventional Accepts healthy volunteers Results available

Study of Lenacapavir for HIV Pre-Exposure Prophylaxis in People Who Are at Risk for HIV Infection

NCT04925752
View directory record Official record
Conditions
Pre-Exposure Prophylaxis of HIV Infection
Interventions
Oral Lenacapavir (LEN), F/TDF, Sub-cutaneous (SC) Lenacapavir (LEN), Placebo SC LEN, PTM F/TDF, PTM Oral LEN, F/TAF (for US participants only)
Drug
Lead sponsor
Gilead Sciences
Industry
Eligibility
16 Years and older
Enrollment
3,292 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2028
U.S. locations
60
States / cities
Birmingham, Alabama • Loma Linda, California • Los Angeles, California + 43 more
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Jul 22, 2026, 1:18 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Psychotherapy Trial With Transgender Clients

NCT03369054
View directory record Official record
Conditions
Transgender Persons, M01.777.500
Interventions
Minority Stress Treatment, Treatment As usual
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 23, 2019 · Synced Jul 22, 2026, 1:18 PM EDT
Completed No phase listed Observational

Trans Health: Evaluation of Markers of Cardio-metabolic Health and Well-being in Transgender Youth

NCT02550431
View directory record Official record
Conditions
Transgendered Persons
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
9 Years to 21 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 4, 2018 · Synced Jul 22, 2026, 1:18 PM EDT
Suspended No phase listed Observational Accepts healthy volunteers

Perspectives on Healthcare Access and Equity of People With Parkinson's Disease Identifying as LGBTQ+

NCT05502055
View directory record Official record
Conditions
Parkinson Disease, Sexual Orientation
Interventions
Individual interviews, Focus Groups, National Survey
Other
Lead sponsor
Creighton University
Other
Eligibility
Not listed
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 5, 2024 · Synced Jul 22, 2026, 1:18 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Navigating Insurance Coverage Expansion (NICE)

NCT04263441
View directory record Official record
Conditions
HIV/AIDS
Interventions
NICE Intervention
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older · Male only
Enrollment
630 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
3
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 15, 2022 · Synced Jul 22, 2026, 1:18 PM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Safety and Effectiveness of HIV-1 DNA Plasmid Vaccine and HIV-1 Recombinant Adenoviral Vector Vaccine in HIV-Uninfected, Circumcised Men and Male-to-Female (MTF) Transgender Persons Who Have Sex With Men

NCT00865566
View directory record Official record
Conditions
HIV Infections
Interventions
DNA plasmid vaccine, Recombinant adenoviral serotype 5 (rAD5) vector vaccine, DNA vaccine placebo, HIV-1 recombinant adenovirus vaccine placebo
Biological
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 50 Years · Male only
Enrollment
2,504 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2017
U.S. locations
22
States / cities
Birmingham, Alabama • Los Angeles, California • San Francisco, California + 15 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2021 · Synced Jul 22, 2026, 1:18 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

TransHealthGUIDE: Transforming Health for Gender-Diverse Young Adults

NCT06177600
View directory record Official record
Conditions
Transgender Persons, Health Services for Transgender Persons, Gender Identity
Interventions
Interactive educational digital platform for transgender and gender-diverse (TGD) young adults and caregivers
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
18 Years to 29 Years
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 19, 2025 · Synced Jul 22, 2026, 1:18 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Evaluating the Safety and Efficacy of the VRC01 Antibody in Reducing Acquisition of HIV-1 Infection Among Men and Transgender Persons Who Have Sex With Men

NCT02716675
View directory record Official record
Conditions
HIV Infections
Interventions
VRC01, Placebo for VRC01
Biological
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 50 Years · Male only
Enrollment
2,699 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
19
States / cities
Birmingham, Alabama • Los Angeles, California • San Francisco, California + 13 more
Source: ClinicalTrials.gov public record
Updated Feb 22, 2022 · Synced Jul 22, 2026, 1:18 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Metabolic and Physiologic Responses to Hormone Therapy in Transgender and Gender Diverse People

NCT06083766
View directory record Official record
Conditions
Effects of GAHT, on Skeletal Muscle in TGD
Interventions
hormone therapy
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 40 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Jul 22, 2026, 1:18 PM EDT
Terminated Early Phase 1 Interventional Accepts healthy volunteers

Effect of Gender Affirming Hormone Therapy on Glucose Metabolism

NCT04515472
View directory record Official record
Conditions
Transgender Persons
Interventions
Botnia Clamp, Withdrawal of Gender Affirming Hormone Therapy (GAHT)
Drug · Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced Jul 22, 2026, 1:18 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Effect of Estrogen Treatment on Drug Metabolism and Transport

NCT05469204
View directory record Official record
Conditions
Transgender Persons
Interventions
Midazolam oral solution, Digoxin Oral Tablet, Acetaminophen Oral Tablet, Midazolam Injectable Solution
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 55 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Jul 22, 2026, 1:18 PM EDT