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ClinicalTrials.gov public records Last synced Oct 8, 2026, 2:32 AM EDT

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Showing 145–168 of 1,821 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Trauma and Stress Related Disorders Clear all
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Intensive 7-day Treatment for PTSD Combining Ketamine With Exposure Therapy

NCT02727998
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Ketamine, Midazolam
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 75 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 17, 2022 · Synced Oct 8, 2026, 2:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Violence Prevention for Adolescent Girls With Prior Maltreatment

NCT02765048
View directory record Official record
Conditions
PTSD, Depression, Aggression, Victimization
Interventions
GAIN Program
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
12 Years and older
Enrollment
312 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
3
States / cities
Arnold, Missouri • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 6, 2016 · Synced Oct 8, 2026, 2:32 AM EDT
Not listed Not applicable Interventional

Delivery of Self Training and Education for Stressful Situations-Telephone Version

NCT01502449
View directory record Official record
Conditions
PTSD
Interventions
DESTRESS-T, Optimized Usual Care (OUC)
Behavioral · Other
Lead sponsor
Uniformed Services University of the Health Sciences
Federal
Eligibility
18 Years to 65 Years
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Columbus, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 12, 2012 · Synced Oct 8, 2026, 2:32 AM EDT
Recruiting Phase 3 Interventional

Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression

NCT07226232
View directory record Official record
Conditions
Major Depression
Interventions
Psilocybin
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 75 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
5
States / cities
Birmingham, Alabama • Tuscaloosa, Alabama • Portland, Oregon + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Oct 8, 2026, 2:32 AM EDT
Active, not recruiting Not applicable Interventional

TMS-fNIRS Personalized Dosing

NCT05916417
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Traumatic Brain Injury
Interventions
TMS-fNIRS over the dl-PFC
Device
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Oct 8, 2026, 2:32 AM EDT
Not yet recruiting Phase 2 Interventional

Ketamine Treatment for PTSD and MDD in TBI

NCT06228391
View directory record Official record
Conditions
PTSD, Post Traumatic Stress Disorder, Major Depressive Disorder, Traumatic Brain Injury
Interventions
IV ketamine, Midazolam
Drug
Lead sponsor
Minneapolis Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 29, 2024 · Synced Oct 8, 2026, 2:32 AM EDT
Completed No phase listed Observational

Yoga as a Therapy for Traumatic Experiences

NCT00269490
View directory record Official record
Conditions
Post-Traumatic Stress Disorder
Interventions
Yoga Nidra
Behavioral
Lead sponsor
Samueli Institute for Information Biology
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jan 28, 2008 · Synced Oct 8, 2026, 2:32 AM EDT
Completed Not applicable Interventional

Optimal Dose of Early Intervention to Prevent PTSD

NCT01959620
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
1-Session Exposure Therapy, 3-Session Exposure Therapy
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years to 65 Years
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 21, 2017 · Synced Oct 8, 2026, 2:32 AM EDT
Terminated Not applicable Interventional Results available

Transcranial Infrared Laser Stimulation (TILS) of Prefrontal Cognition in Post-traumatic Stress Disorder (PTSD)

NCT03209882
View directory record Official record
Conditions
Post-traumatic Stress Disorder (PTSD)
Interventions
TILS, sham
Device
Lead sponsor
The University of Texas at Arlington
Other
Eligibility
18 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Arlington, Texas
Source: ClinicalTrials.gov public record
Updated Jul 23, 2021 · Synced Oct 8, 2026, 2:32 AM EDT
Completed Phase 2 Interventional Results available

Combined Treatment for Alcohol-Dependent Individuals With PTSD

NCT00262223
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Alcohol Abuse, Substance-Related Disorders
Interventions
Seeking Safety, Sertraline, Pill placebo
Behavioral · Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 3, 2020 · Synced Oct 8, 2026, 2:32 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Monoamine Transporters Genotypes: Risk of PTSD and Related Comorbidities

NCT00403455
View directory record Official record
Conditions
PTSD
Interventions
Paroxetine
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2011
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 2, 2018 · Synced Oct 8, 2026, 2:32 AM EDT
Completed Phase 2 Interventional Results available

Ganaxolone in Posttraumatic Stress Disorder (PTSD)

NCT01339689
View directory record Official record
Conditions
PTSD
Interventions
Ganaxolone, Placebo
Drug
Lead sponsor
Marinus Pharmaceuticals
Industry
Eligibility
18 Years to 55 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
8
States / cities
San Diego, California • Washington D.C., District of Columbia • Boston, Massachusetts + 5 more
Source: ClinicalTrials.gov public record
Updated Dec 29, 2022 · Synced Oct 8, 2026, 2:32 AM EDT
Recruiting Not applicable Interventional

Testing a Scalable Model of Care to Improve Patients Access to Mental Health Services After Traumatic Injury

NCT05497115
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Depression
Interventions
Trauma Resilience and Recovery Program
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
16 Years and older
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Washington, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 8, 2026, 2:32 AM EDT
Withdrawn Not applicable Interventional

Mindful Yoga Therapy for Veterans With PTSD and Pain

NCT01957371
View directory record Official record
Conditions
PTSD, Chronic Pain
Interventions
Mindful Yoga Therapy
Behavioral
Lead sponsor
VA Connecticut Healthcare System
Federal
Eligibility
18 Years to 45 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 9, 2014 · Synced Oct 8, 2026, 2:32 AM EDT
Not listed Not applicable Interventional

Stress-Reducing Interventions in HIV+ Patients: Pilot

NCT00599599
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, HIV Infections
Interventions
Prolonged Exposure Therapy
Behavioral
Lead sponsor
Kent State University
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
2
States / cities
Akron, Ohio • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 5, 2009 · Synced Oct 8, 2026, 2:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pilot Testing of an Equity Focused and Trauma-informed Communication Intervention During Family-centered Rounds

NCT05618652
View directory record Official record
Conditions
Hospitalism in Children, Post Traumatic Stress Disorder
Interventions
Equity Focused and Trauma-Informed Communication Intervention
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 5, 2026 · Synced Oct 8, 2026, 2:32 AM EDT
Completed Not applicable Interventional

Mindfulness-Based Stress Reduction and the Microbiome

NCT01619384
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Irritable Bowel Syndrome
Interventions
Mindfulness-Based Stress Reduction
Behavioral
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Nov 19, 2014 · Synced Oct 8, 2026, 2:32 AM EDT
Completed Not applicable Interventional

Chaplain Family Project Trial

NCT03702634
View directory record Official record
Conditions
Anxiety, PTSD, Depression, Communication, Satisfaction
Interventions
Spiritual Care Assessment and Intervention (SCAI) framework
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
2
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 28, 2022 · Synced Oct 8, 2026, 2:32 AM EDT
Completed Phase 3 Interventional

Integrated Cognitive Behavioral Therapy (ICBT) for Posttraumatic Stress Disorder (PTSD) and Substance Use Disorders

NCT01457404
View directory record Official record
Conditions
Stress Disorder, Post-Traumatic, Substance-Related Disorders
Interventions
Integrated Cognitive Behavioral Therapy, Treatment-as-usual
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 26, 2015 · Synced Oct 8, 2026, 2:32 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Ketone Supplementation in Individuals With PTSD

NCT04083352
View directory record Official record
Conditions
PTSD, Ketosis
Interventions
Pruvit Ketomax Ketone Salt, Placebo
Dietary Supplement
Lead sponsor
Augusta University
Other
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 18, 2019 · Synced Oct 8, 2026, 2:32 AM EDT
Completed Not applicable Interventional Results available

Trial to Evaluate Efficacy of Magnetic Resonant Therapy (MRT) in PTSD

NCT02268084
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Magnetic EEG/ECG-guided Resonance Therapy, Sham
Device
Lead sponsor
Wave Neuroscience
Industry
Eligibility
18 Years to 55 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 1, 2021 · Synced Oct 8, 2026, 2:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Exercise and Therapeutic Exposure

NCT05177458
View directory record Official record
Conditions
PTSD
Interventions
Experimental, Active Control
Behavioral
Lead sponsor
Thomas Adams
Other
Eligibility
21 Years to 50 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Aug 30, 2024 · Synced Oct 8, 2026, 2:32 AM EDT
Completed Phase 2 Interventional Results available

NAC for Treating Comorbid PTSD and SUD

NCT02911285
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Alcohol Use Disorder (AUD), Substance Use Disorder (SUD)
Interventions
N-acetylcysteine, Placebo, Cognitive behavioral therapy
Drug · Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 75 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 19, 2021 · Synced Oct 8, 2026, 2:32 AM EDT
Active, not recruiting Not applicable Interventional

Consulting After Combat: Interviewing Veterans to Develop a Therapy to Restore Functioning and Reintegration After Moral Injury Events

NCT05020587
View directory record Official record
Conditions
Moral Injury, Functional Impairment
Interventions
Open pilot trial of a group therapy manual.
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Temple, Texas
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Oct 8, 2026, 2:32 AM EDT