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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Trauma and Stressor Related Disorder Clear all
Recruiting Not applicable Interventional

CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy

NCT05467683
View directory record Official record
Conditions
Obsessive-Compulsive Disorder, Post Traumatic Stress Disorder, Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder
Interventions
Exposure-Based Therapy
Behavioral
Lead sponsor
Jasper A. Smits
Other
Eligibility
18 Years to 70 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Boston, Massachusetts • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Jun 26, 2026, 2:24 AM EDT
Completed Phase 2 Interventional Results available

Study Comparing Three Doses of MDMA Along With Therapy in Veterans With Posttraumatic Stress Disorder

NCT01211405
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Low dose MDMA-assisted therapy, Medium dose MDMA-assisted therapy, Full dose MDMA-assisted therapy, Therapy
Drug · Behavioral
Lead sponsor
Resilient Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Mt. Pleasant, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 4, 2025 · Synced Jun 26, 2026, 2:24 AM EDT
Recruiting Not applicable Interventional

Prolonged Exposure Therapy to Treat Posttraumatic Stress Disorder in Pregnant Patients

NCT06670079
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Pregnancy
Interventions
Prolonged exposure therapy + incentives for therapy session attendance
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Jun 26, 2026, 2:24 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Norepinephrine Transporter Availability in PTSD

NCT01799837
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
[C-11]MENET
Drug
Lead sponsor
Emory University
Other
Eligibility
30 Years to 70 Years · Male only
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 10, 2013 · Synced Jun 26, 2026, 2:24 AM EDT
Not yet recruiting Phase 2 Interventional

Remotely Administered tDCS to Improve Cognitive Function in Veterans With mTBI and PTSD Principal Investigator

NCT07414537
View directory record Official record
Conditions
Cognition, Brain Injuries, Stress Disorders, Post-Traumatic
Interventions
Transcranial direct current stimulation (tDCS), Cognitive training
Device · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
20 Years to 75 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Jun 26, 2026, 2:24 AM EDT
Recruiting Phase 4 Interventional

Mismatch vs. Standard Intervention During Memory Reconsolidation Blockade With Propranolol: Effect on Psychophysiological Reactivity During Traumatic Imagery

NCT05853627
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Memory reactivation procedures, Propranolol
Behavioral · Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jun 26, 2026, 2:24 AM EDT
Completed Phase 1 Interventional

Photobiomodulation to Alter Cerebral Blood Flow and to Affect the Emotional Status of Patients With Major Depression

NCT00961454
View directory record Official record
Conditions
Major Depression, Anxiety Disorder, Post-Traumatic Stress Disorder, Substance Abuse Disorder
Interventions
Photobiomodulation with a super-luminous light emitting diode
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 18, 2009 · Synced Jun 26, 2026, 2:24 AM EDT
Completed Phase 2 Interventional Results available

mTBI Mechanisms of Action of HBO2 for Persistent Post-Concussive Symptoms

NCT01611194
View directory record Official record
Conditions
Traumatic Brain Injury With Brief Loss of Consciousness, Post-Concussion Syndrome
Interventions
Hyperbaric oxygen (HBO2) at 1.5 atms, Sham control 1.2 atms
Drug
Lead sponsor
U.S. Army Medical Research and Development Command
Federal
Eligibility
18 Years to 65 Years
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
5
States / cities
Colorado Springs, Colorado • Fort Carson, Colorado • Jacksonville, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 20, 2018 · Synced Jun 26, 2026, 2:24 AM EDT
Completed No phase listed Observational

Patient Participation Beliefs and Post-Traumatic Stress Disorder (PTSD)

NCT01419223
View directory record Official record
Conditions
Post-Traumatic Stress Disorder, Brain Injuries, Traumatic
Interventions
Not listed
Lead sponsor
INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Oct 28, 2013 · Synced Jun 26, 2026, 2:24 AM EDT
Completed Not applicable Interventional

Efficacy of 60-minute Versus 90-minute Sessions in Treating PTSD Using Prolonged Exposure

NCT01911585
View directory record Official record
Conditions
Posttraumatic Stress Disorder, PTSD
Interventions
Prolonged Exposure Therapy
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 16, 2021 · Synced Jun 26, 2026, 2:24 AM EDT
Completed Phase 1 Interventional

Patient-Centered Collaborative Care for Preventing Post-Traumatic Stress Disorder After Traumatic Injury

NCT00270959
View directory record Official record
Conditions
Post-Traumatic Stress Disorder
Interventions
Cognitive Behavioral Therapy, Motivational Interviewing, FDA-Approved Anti-Anxiety Medications, Standard Care Control
Behavioral · Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
207 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Nov 3, 2020 · Synced Jun 26, 2026, 2:24 AM EDT
Completed Not applicable Interventional Results available

Mindfulness Meditation for the Treatment of Women With Comorbid PTSD and SUD

NCT02755103
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Substance-Related Disorders
Interventions
Mindfulness Based Relapse Prevention (MBRP)
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 2, 2023 · Synced Jun 26, 2026, 2:24 AM EDT
Completed Not applicable Interventional Results available

Helping Families Help Veterans With PTSD and Alcohol Abuse: An RCT of VA-CRAFT

NCT01678196
View directory record Official record
Conditions
PTSD, Alcohol Abuse
Interventions
VA-CRAFT, Control
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 80 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 24, 2016 · Synced Jun 26, 2026, 2:24 AM EDT
Completed Phase 4 Interventional Results available

Atomoxetine in Veterans With Comorbid ADHD/PTSD

NCT02287038
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Attention Deficit Hyperactivity Disorder
Interventions
Atomoxetine 80 MG
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
20 Years to 60 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 2, 2019 · Synced Jun 26, 2026, 2:24 AM EDT
Completed Phase 3 Interventional Results available

Stepped Preventive Care to Reduce the Impact of Acute Pediatric Injury

NCT00451282
View directory record Official record
Conditions
Stress Disorders, Posttraumatic
Interventions
stepped preventive care
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
8 Years to 17 Years
Enrollment
290 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 19, 2015 · Synced Jun 26, 2026, 2:24 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Ketamine and Prolonged Exposure in PTSD

NCT03960658
View directory record Official record
Conditions
Post-traumatic Stress Disorder
Interventions
ketamine-enhanced prolonged exposure
Drug
Lead sponsor
Minneapolis Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 75 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 21, 2021 · Synced Jun 26, 2026, 2:24 AM EDT
Recruiting Phase 3 Interventional

Quetiapine to Reduce Post Concussive Syndrome After Mild Traumatic Brain Injury (mTBI)

NCT06333990
View directory record Official record
Conditions
Mild Traumatic Brain Injury
Interventions
Quetiapine Fumarate, TAU
Drug
Lead sponsor
Foundation for Advancing Veterans' Health Research
Other
Eligibility
18 Years to 65 Years
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
2
States / cities
Albuquerque, New Mexico • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 10, 2025 · Synced Jun 26, 2026, 2:24 AM EDT
Completed Not applicable Interventional Results available

Exposure Therapy For Veterans With PTSD And Panic Attacks

NCT01033136
View directory record Official record
Conditions
PTSD, Panic Attacks
Interventions
Multiple Channel Exposure Therapy - Veterans, Cognitive Processing Therapy
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 75 Years
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 16, 2018 · Synced Jun 26, 2026, 2:24 AM EDT
Recruiting Not applicable Interventional

Intervention to Enhance Coping and Help-seeking Among Youth in Foster Care

NCT06019377
View directory record Official record
Conditions
Adolescent Behavior, Psychosocial Functioning, Coping Behavior, Help-Seeking Behavior, Utilization, Health Care, Depression, Anxiety, Stress Disorders, Post-Traumatic, Emotion Regulation, Child Welfare
Interventions
Stronger Youth Networks and Coping (SYNC)
Behavioral
Lead sponsor
Portland State University
Other
Eligibility
16 Years to 20 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 27, 2025 · Synced Jun 26, 2026, 2:24 AM EDT
Completed Phase 3 Interventional Results available

A 40-week Study to Evaluate TNX-102 SL 5.6 mg Taken Daily at Bedtime in Patients With PTSD

NCT03508700
View directory record Official record
Conditions
PTSD
Interventions
TNX-102 SL 5.6 mg
Drug
Lead sponsor
Tonix Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
16
States / cities
Little Rock, Arkansas • Beverly Hills, California • Oceanside, California + 13 more
Source: ClinicalTrials.gov public record
Updated Feb 4, 2025 · Synced Jun 26, 2026, 2:24 AM EDT
Completed Not applicable Interventional

Multisite Feasibility of Compassion Meditation for Veterans With Posttraumatic Stress Disorder (PTSD)

NCT04793698
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Compassion meditation, Applied relaxation
Other · Behavioral
Lead sponsor
Veterans Medical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
113 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
3
States / cities
Bedford, Massachusetts • Canandaigua, New York • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jun 26, 2026, 2:24 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Nicotine Patch Pretreatment for Smoking Cessation in PTSD

NCT00625131
View directory record Official record
Conditions
Stress Disorders, Posttraumatic, Tobacco Use Disorder
Interventions
Nicotine, Cognitive Behavioral Therapy for Smoking Cessation, Bupropion Sustained Release (SR), Placebo patch
Drug · Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 70 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 19, 2014 · Synced Jun 26, 2026, 2:24 AM EDT
Completed Not applicable Interventional

Study to Promote Innovation in Rural Integrated Telepsychiatry

NCT02738944
View directory record Official record
Conditions
Bipolar Disorder, Posttraumatic Stress Disorder
Interventions
Telepsychiatry Collaborative Care, Telepsychiatry Enhanced Referral
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
1,004 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
13
States / cities
Marianna, Arkansas • Marshall, Arkansas • West Memphis, Arkansas + 10 more
Source: ClinicalTrials.gov public record
Updated Dec 23, 2020 · Synced Jun 26, 2026, 2:24 AM EDT
Recruiting Not applicable Interventional

Enhancing Psychotherapy for Veterans and Service Members With PTSD and Anxiety

NCT05843695
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Anxiety Disorders
Interventions
iTCBT-I, iTCBT-G, TAU
Behavioral
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years and older
Enrollment
306 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Jun 26, 2026, 2:24 AM EDT