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ClinicalTrials.gov public records Last synced Oct 15, 2026, 5:24 PM EDT

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Showing 625–648 of 1,791 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Trauma and Stressor Related Disorder Clear all
Recruiting Phase 3 Interventional Accepts healthy volunteers

REVEAL Study - Diagnostic Testing for PTSD Using the Senseye Diagnostic Tool

NCT07280065
View directory record Official record
Conditions
PTSD - Post Traumatic Stress Disorder
Interventions
Senseye Diagnostic Tool (DT), Clinician Administered PTSD Scale for DSM-5, Revised Version
Device · Behavioral
Lead sponsor
Senseye, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,900 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
5
States / cities
Aurora, Colorado • Savannah, Georgia • Meridian, Idaho + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 15, 2026, 5:24 PM EDT
Completed Not applicable Interventional Results available

Veterans Individual Placement and Support Towards Advancing Recovery

NCT01817712
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD)
Interventions
Individual Placement & Support, VA Transitional Work Program
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
541 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
13
States / cities
Birmingham, Alabama • Tuscaloosa, Alabama • San Francisco, California + 10 more
Source: ClinicalTrials.gov public record
Updated Feb 19, 2019 · Synced Oct 15, 2026, 5:24 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Neuromodulation of Trauma Memories in PTSD & Alcohol Dependence

NCT01055171
View directory record Official record
Conditions
Alcohol Dependence, PTSD
Interventions
Propranolol, Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 100 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 8, 2016 · Synced Oct 15, 2026, 5:24 PM EDT
Terminated Phase 1Phase 2 Interventional

Ultrasonic Neuromodulation for Treatment of PTSD

NCT06135064
View directory record Official record
Conditions
PTSD
Interventions
Diadem
Device
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 25, 2025 · Synced Oct 15, 2026, 5:24 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

High-Frequency Repetitive Transcranial Magnetic Stimulation of the Right Dorsolateral Prefrontal Cortex in PTSD

NCT02873299
View directory record Official record
Conditions
PTSD, Post Traumatic Stress Disorder
Interventions
10 Hz rTMS of the right dorsolateral prefrontal cortex, 20 Hz rTMS of the right dorsolateral prefrontal cortex
Other
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 22, 2016 · Synced Oct 15, 2026, 5:24 PM EDT
Terminated Phase 4 Interventional Results available

Antidepressant Response in Older Adults With Comorbid PTSD and MDD

NCT04697693
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Major Depressive Disorder
Interventions
Escitalopram, Duloxetine
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
60 Years to 105 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Oct 15, 2026, 5:24 PM EDT
Recruiting Not applicable Interventional

Mobile Anger Reduction Intervention

NCT06094933
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Anger
Interventions
Mobile Anger Reduction Intervention (MARI), Health Education Condition (HED)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 15, 2026, 5:24 PM EDT
Completed No phase listed Observational

Psychobiological Mechanisms of Resilience to Trauma

NCT00069212
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years and older
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2012
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 9, 2019 · Synced Oct 15, 2026, 5:24 PM EDT
Completed Not applicable Interventional Results available

Mechanisms of Change, Motivation, and Treatment Outcome in Alcohol Dependence - Posttraumatic Stress Disorder

NCT01409707
View directory record Official record
Conditions
Alcohol Dependence, Posttraumatic Stress Disorder
Interventions
Trauma-focused exposure therapy, Motivational enhancement + trauma-focused exposure therapy, Healthy lifestyles sessions
Behavioral
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Mar 10, 2014 · Synced Oct 15, 2026, 5:24 PM EDT
Recruiting Not applicable Interventional

Targeting the Default Mode Network: A TMS-fMRI Study

NCT05646732
View directory record Official record
Conditions
Post Traumatic Stress Disorder, PTSD
Interventions
TMS-fMRI
Device
Lead sponsor
Allyson Rosen
Other
Eligibility
18 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 3, 2024 · Synced Oct 15, 2026, 5:24 PM EDT
Terminated Not applicable Interventional Results available

Feasibility and Acceptability of Stress Induction, Physiological Data Collection, and Mindfulness-Based Stress Reduction Among Combat Veterans With PTSD

NCT05938816
View directory record Official record
Conditions
Ptsd
Interventions
Mindfulness-Based Stress Reduction (MBSR), Health and Wellness Education (HWE)
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 85 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 5, 2024 · Synced Oct 15, 2026, 5:24 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

rTMS for Emotional Difficulties in Verterans

NCT03749967
View directory record Official record
Conditions
Mental Health, Depression, rTMS, Anxiety, PTSD, Psychosocial Impairment
Interventions
Repetitive Transcranial Magnetic Stimulation (rTMS)
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 60 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 9, 2023 · Synced Oct 15, 2026, 5:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Psychophysiologic Predictors of Post-deployment Mental Health Outcomes

NCT00838006
View directory record Official record
Conditions
Post-traumatic Stress Disorder
Interventions
heart rate variability biofeedback, Cognitive bias modification training, Sham Comparator
Device
Lead sponsor
Biomedical Research Foundation
Other
Eligibility
18 Years to 60 Years
Enrollment
426 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
1
States / cities
Blackstone, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 2, 2020 · Synced Oct 15, 2026, 5:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Targeted Strategies to Accelerate Evidence-Based Psychotherapy (EBP) Implementation in Military Settings

NCT03663452
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Targeted Assessment and Context-Tailored Implementation of Change Strategies (TACTICS), Prolonged exposure training
Behavioral
Lead sponsor
Palo Alto Veterans Institute for Research
Other
Eligibility
Not listed
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
8
States / cities
Fairbanks, Alaska • Fairfield, California • Jacksonville, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Oct 15, 2026, 5:24 PM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

Outcomes Mandate National Integration With Cannabis as Medicine

NCT03944447
View directory record Official record
Conditions
Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma, Fibromyalgia, Seizures, Hepatitis C, Cancer, Crohn Disease, HIV/AIDS, Multiple Sclerosis, Traumatic Brain Injury, Sickle Cell Disease, Post Traumatic Stress Disorder, Tourette Syndrome, Ulcerative Colitis, Glaucoma, Epilepsy, Inflammatory Bowel Diseases, Parkinson Disease, Amyotrophic Lateral Sclerosis, Chronic Traumatic Encephalopathy, Anxiety, Depression, Insomnia, Autism, Opioid-use Disorder, Bipolar Disorder, Covid19, SARS-CoV Infection, COVID-19, Corona Virus Infection, Coronavirus
Interventions
Cannabis, Medical, RYAH-Medtech Inhaler
Drug · Device
Lead sponsor
OMNI Medical Services, LLC
Network
Eligibility
7 Years and older
Enrollment
200,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2025
U.S. locations
17
States / cities
Boca Raton, Florida • Bradenton, Florida • Fort Lauderdale, Florida + 13 more
Source: ClinicalTrials.gov public record
Updated Jun 2, 2022 · Synced Oct 15, 2026, 5:24 PM EDT
Recruiting Not applicable Interventional

Cognitive Rehabilitation for Treatment of Anger in Veterans With TBI and PTSD

NCT07227987
View directory record Official record
Conditions
Traumatic Brain Injury (TBI), Posttraumatic Stress Disorder (PTSD)
Interventions
CALM (Cognitive Apps for Life Management), Psychoeducation
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 15, 2026, 5:24 PM EDT
Not yet recruiting Not applicable Interventional

Treatment of Fibromyalgia and PTSD With Live and Inactive Vagus Nerve Stimulation With PEPC

NCT07718984
View directory record Official record
Conditions
Fibromyalgia (FM), Posttraumatic Stress Disorder (PTSD)
Interventions
tAN plus PEPC, sham plus PEPC
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 15, 2026, 5:24 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

K08 VR Fear Conditioning

NCT07216222
View directory record Official record
Conditions
Anxiety and Fear, PTSD, Veteran
Interventions
Deep Brain Stimulation
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 70 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 15, 2026, 5:24 PM EDT
Completed Phase 2 Interventional

Oxytocin to Enhance Integrated Treatment for AUD and PTSD

NCT04523922
View directory record Official record
Conditions
PTSD, Alcohol Use Disorder
Interventions
40 IU Intranasal Oxytocin, Placebo, Concurrent Treatment of PTSD and Substance Use Disorders using Prolonged Exposure
Drug · Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 70 Years
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 15, 2026, 5:24 PM EDT
Withdrawn Phase 4 Interventional

Ramelteon for Complex Insomnia in Veterans With PTSD

NCT03265951
View directory record Official record
Conditions
Insomnia
Interventions
Ramelteon, Usual Care
Drug · Other
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Apr 9, 2021 · Synced Oct 15, 2026, 5:24 PM EDT
Terminated Phase 1 Interventional

A Trial to Assess the Effects of Prazosin or Propranolol on Blood Pressure in the Presence of Brexpiprazole/Sertraline

NCT05189977
View directory record Official record
Conditions
Post-traumatic Stress Disorder (PTSD)
Interventions
Propranolol, Prazosin
Drug
Lead sponsor
Otsuka Pharmaceutical Development & Commercialization, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Princeton, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Oct 15, 2026, 5:24 PM EDT
Recruiting Not applicable Interventional

Microbiome Modulation With Prebiotics in PTSD and Cirrhosis

NCT06464952
View directory record Official record
Conditions
Cirrhosis, PTSD
Interventions
Resistant potato starch, Powdered cellulose
Dietary Supplement
Lead sponsor
Hunter Holmes Mcguire Veteran Affairs Medical Center
Federal
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 9, 2026 · Synced Oct 15, 2026, 5:24 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Cooperative Studies Program #563 - Prazosin and Combat Trauma PTSD

NCT00532493
View directory record Official record
Conditions
PTSD, Sleep Disorders
Interventions
prazosin, placebo
Drug · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
304 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
15
States / cities
Loma Linda, California • Long Beach, California • Palo Alto, California + 12 more
Source: ClinicalTrials.gov public record
Updated May 1, 2018 · Synced Oct 15, 2026, 5:24 PM EDT
Completed Not applicable Interventional

Evaluation of Telehealth Interventions for Post-Trauma Stress

NCT00350584
View directory record Official record
Conditions
Post Traumatic Stress Disorders
Interventions
Mindfulness Telehealth Intervention, Psychoeducation Telehealth Intervention
Behavioral
Lead sponsor
VA Boston Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 29, 2011 · Synced Oct 15, 2026, 5:24 PM EDT