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ClinicalTrials.gov public records Last synced Oct 20, 2026, 4:54 PM EDT

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Showing 1–24 of 83 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Traumatic Amputation Clear all
Completed Not applicable Interventional

SoftHand Comparison Study

NCT05328934
View directory record Official record
Conditions
Upper Extremity Injury, Upper Extremity Deformities, Congenital, Amputation, Traumatic, Amputation, Congenital
Interventions
SoftHand Pro, Ossur i-Limb
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 99 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
2
States / cities
Tempe, Arizona • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 12, 2026 · Synced Oct 20, 2026, 4:54 PM EDT
Withdrawn Not applicable Interventional

To Validate Point Mini User Needs

NCT06504667
View directory record Official record
Conditions
Amputation; Traumatic, Hand, Amputation, Congenital
Interventions
Point Mini
Device
Lead sponsor
Point Designs
Industry
Eligibility
5 Years to 15 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
2
States / cities
Aurora, Colorado • Lafayette, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Oct 20, 2026, 4:54 PM EDT
Completed Not applicable Interventional Results available

Interface Kinematics of Transhumeral Prosthetic Sockets Using XROMM

NCT01546675
View directory record Official record
Conditions
Traumatic Amputation of Arm
Interventions
Skeletal Stabilization
Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
New York, New York • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Nov 24, 2014 · Synced Oct 20, 2026, 4:54 PM EDT
Completed Not applicable Interventional

Low Cost Socket for Lower Limb Amputees

NCT04725461
View directory record Official record
Conditions
Amputation, Amputation; Traumatic, Limb, Amputation, Traumatic
Interventions
Low cost lower limb prosthetic socket
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 95 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 17, 2025 · Synced Oct 20, 2026, 4:54 PM EDT
Completed No phase listed Observational

Retrospective Evaluation of Ketamine Effectiveness for the Treatment of Acute Battlefield Related Pain

NCT04057989
View directory record Official record
Conditions
Pain, Acute, Analgesia, Amputation, Traumatic, Post Traumatic Stress Disorder, Trauma, Brain
Interventions
ketamine
Drug
Lead sponsor
Defense and Veterans Center for Integrative Pain Management
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 15, 2019 · Synced Oct 20, 2026, 4:54 PM EDT
Completed Not applicable Interventional Results available

Telehealth Pain Self-Management for Employed Adults

NCT04248725
View directory record Official record
Conditions
Chronic Pain, Brain Injuries, Traumatic, Multiple Sclerosis, Spinal Cord Injuries, Amputation
Interventions
E-TIPS
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 24, 2025 · Synced Oct 20, 2026, 4:54 PM EDT
Completed Not applicable Interventional

Comparison of Pattern Recognition Control and Direct Control in TMR

NCT03097978
View directory record Official record
Conditions
Amputation, Amputation; Traumatic, Arm, Upper
Interventions
Commercial system, RIC arm system, Direct Control, Pattern Recognition
Device · Other
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 95 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 23, 2018 · Synced Oct 20, 2026, 4:54 PM EDT
Recruiting Not applicable Interventional

Effects of Myoelectric Channel Count and Targeting for Upper Limb Prosthetic Control

NCT07011420
View directory record Official record
Conditions
Amputation, Amputation, Traumatic, Amputation, Congenital, Prosthesis User, Upper Limb Amputation Below Elbow (Injury), Amputation; Traumatic, Arm: Forearm, Between Elbow and Wrist
Interventions
Experimental socket with 4 untargeted channels active, Experimental socket with 8 untargeted channels active, Experimental socket with up to 16 untargeted channels active, Experimental socket with 8 targeted channels active, Coapt EMG Cuff
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Chicago, Illinois • Holliston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 3, 2025 · Synced Oct 20, 2026, 4:54 PM EDT
Recruiting Not applicable Interventional

Improving Mobility and Function Following Transfemoral Amputation: A Novel Approach to Reverse Volumetric Muscle Loss

NCT05929508
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity
Interventions
Ischemic Preconditioning
Other
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Oct 20, 2026, 4:54 PM EDT
Completed Not applicable Interventional

Study to Determine if Different Prosthetic Sockets Effect How Much Oxygen is in the Tissue of Lower Limb Amputees While They Are Walking

NCT00985842
View directory record Official record
Conditions
Amputation, Diabetes Complications, Leg Injuries, Traumatic Amputation
Interventions
Pe-Lite and sleeve suspension socket, Total Surface bearing a socket with a sleeve suspension but without suction, Total surface bearing suction socket with a pin lock suspension, Total surface bearing suction socket with a sleeve suspension, Vacuum-assisted socket system (Harmony System, Otto Bock)
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 29, 2018 · Synced Oct 20, 2026, 4:54 PM EDT
Active, not recruiting No phase listed Observational

Kinematics of Ewing Amputees

NCT06371209
View directory record Official record
Conditions
Lower Extremity Amputation, Trans-Tibial Amputation, Traumatic Lower Extremity Amputation, Agonist-Antagonist Myoneural Interface
Interventions
Modified Amputation, Standard Amputation
Procedure
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 20, 2026, 4:54 PM EDT
Completed Not applicable Interventional

Pattern Recognition Prosthetic Control

NCT04272593
View directory record Official record
Conditions
Prosthesis User, Congenital Amputation of Upper Limb, Amputation; Traumatic, Limb
Interventions
EMG-Pattern Recognition Controller
Device
Lead sponsor
Coapt, LLC
Industry
Eligibility
18 Years to 70 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 20, 2022 · Synced Oct 20, 2026, 4:54 PM EDT
Completed Not applicable Interventional

Tap Dance for Adults With Lower Limb Amputation

NCT06334146
View directory record Official record
Conditions
Amputation; Traumatic, Leg, Lower
Interventions
Tap dance program
Other
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Oct 15, 2024 · Synced Oct 20, 2026, 4:54 PM EDT
Completed Not applicable Interventional Results available

A Comparative Assessment of Transfemoral Prosthetic Sockets

NCT04038580
View directory record Official record
Conditions
Amputation, Amputation; Traumatic, Leg, Lower
Interventions
Laminated Socket, Quatro, Infinite Socket, CJ Socket
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
2
States / cities
Chicago, Illinois • Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Oct 20, 2026, 4:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Outcomes With Passive MPKs vs. Powered Prosthetic Knees

NCT05267639
View directory record Official record
Conditions
Amputation, Amputation; Traumatic, Leg, Lower, Limb; Absence, Congenital, Lower, Prosthesis User, Lower Limb Amputation Above Knee (Injury), Amputation; Traumatic, Leg: Thigh, Between Hip and Knee
Interventions
Power Knee
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
2
States / cities
Holliston, Massachusetts • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Oct 20, 2026, 4:54 PM EDT
Completed Not applicable Interventional Results available

Home Study of an Advanced Upper Limb Prosthesis

NCT01551420
View directory record Official record
Conditions
Traumatic Amputation of Arm
Interventions
Advanced upper limb prosthetic device IMU controlled, Advanced upper limb prosthetic EMG-PR controlled
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
4
States / cities
Tampa, Florida • New York, New York • Providence, Rhode Island + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 30, 2019 · Synced Oct 20, 2026, 4:54 PM EDT
Completed Phase 4 Interventional

Chronic Pain After Amputation

NCT00006427
View directory record Official record
Conditions
Amputation, Traumatic, Pain, Postoperative Pain
Interventions
Amitriptyline
Drug
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years to 65 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1996
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 26, 2016 · Synced Oct 20, 2026, 4:54 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

EMG-Based Hand-Wrist Control: Study B Mirrored

NCT04692571
View directory record Official record
Conditions
Amputation, Amputation; Traumatic, Hand, Amputation, Congenital, Prosthesis User
Interventions
PSICON Measurement Apparatus
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
2
States / cities
Holliston, Massachusetts • Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 5, 2021 · Synced Oct 20, 2026, 4:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Comparison of External Mechanical Work Between Different Prosthetic Feet

NCT01340807
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity
Interventions
Specialized Functional Prosthetic Training
Other
Lead sponsor
Miami VA Healthcare System
Federal
Eligibility
40 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 25, 2011 · Synced Oct 20, 2026, 4:54 PM EDT
Completed Not applicable Interventional Results available

Validation of User Needs of the Point Digit With Partial Hand Amputees

NCT04763278
View directory record Official record
Conditions
Amputation; Traumatic, Hand
Interventions
Point Digit
Device
Lead sponsor
Point Designs
Industry
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
2
States / cities
Aurora, Colorado • Lafayette, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 27, 2024 · Synced Oct 20, 2026, 4:54 PM EDT
Completed Not applicable Interventional Results available

Cryoanalgesia to Treat Phantom Limb Pain Following Above-Knee Amputation

NCT06071715
View directory record Official record
Conditions
Amputation, Surgical, Amputation, Traumatic, Phantom Limb Pain, Phantom Pain Following Amputation of Lower Limb
Interventions
ACTIVE cryoneurolysis, SHAM cryoneurolysis
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Oct 20, 2026, 4:54 PM EDT
Completed Not applicable Interventional

Spinal Root and Spinal Cord Stimulation for Restoration of Function in Lower-Limb Amputees

NCT03027947
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity, Phantom Limb Pain
Interventions
Spinal cord stimulator
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 70 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 12, 2022 · Synced Oct 20, 2026, 4:54 PM EDT
Active, not recruiting Not applicable Interventional Results available

Optimizing Rehabilitation for Phantom Limb Pain Using Mirror Therapy and Transcranial Direct Current Stimulation (tDCS)

NCT02487966
View directory record Official record
Conditions
Phantom Limb Pain, Amputation, Traumatic
Interventions
transcranial Direct Current Stimulation (tDCS): active (Soterix ©), Mirror Therapy: active, transcranial Direct Current Stimulation (tDCS): sham (Soterix ©), Mirror Therapy: Sham
Device · Behavioral
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2026
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Oct 20, 2026, 4:54 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Study to Identify the Genetic Variations Associated With Phantom Limb Pain

NCT01462448
View directory record Official record
Conditions
Phantom Limb
Interventions
Blood Draw
Procedure
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years and older
Enrollment
726 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2023
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Oct 20, 2026, 4:54 PM EDT