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ClinicalTrials.gov public records Last synced Oct 20, 2026, 5:32 PM EDT

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Showing 73–96 of 102 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Traumatic Encephalopathy Syndrome Clear all
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy

NCT03554265
View directory record Official record
Conditions
Traumatic Brain Injury, Fatigue, Cognitive Impairment, COVID-19
Interventions
Somatropin
Drug
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years to 70 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 5, 2025 · Synced Oct 20, 2026, 5:32 PM EDT
Recruiting Not applicable Interventional

External Post-Operative Skull Prosthesis to Prevent Sunken Flap Syndrome in Craniectomy Patients

NCT06899711
View directory record Official record
Conditions
Craniectomy, Trephined Syndrome, Traumatic Brain Injury (TBI) Patients, Ischemic Stroke
Interventions
External Cranial Prosthesis
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Oct 20, 2026, 5:32 PM EDT
Completed Not applicable Interventional

Feasibility Testing of Cognitive Strategy Training in Post-Concussive Syndrome

NCT04681742
View directory record Official record
Conditions
Brain Concussion, Post-Concussion Syndrome
Interventions
CO-OP Group
Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 60 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 10, 2023 · Synced Oct 20, 2026, 5:32 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Bright Light Therapy in Mild Traumatic Brain Injury

NCT01747811
View directory record Official record
Conditions
Concussion, Mild, Post-Concussion Symptoms, Sleep Problems
Interventions
wavelength-1 bright light, wavelength-2 bright light
Device
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 1, 2017 · Synced Oct 20, 2026, 5:32 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Bright Light Therapy for Treatment of Sleep Problems Following Mild Traumatic Brain Injury

NCT02374918
View directory record Official record
Conditions
Concussion, Mild, Post-Concussion Symptoms, Sleep Problems
Interventions
mTBI wavelength-1 bright light, mTBI wavelength-2 bright light, HC wavelength-1 bright light, HC wavelength-2 bright light
Device
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 50 Years
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 24, 2021 · Synced Oct 20, 2026, 5:32 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

An fMRI Study of Attention and Effort After Concussion

NCT00653029
View directory record Official record
Conditions
Post Concussive Syndrome
Interventions
Not listed
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 60 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated May 3, 2016 · Synced Oct 20, 2026, 5:32 PM EDT
Recruiting Phase 2 Interventional

HBOT Effects on First Responders' Cognition and Well-Being

NCT07852728
View directory record Official record
Conditions
Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder, Anxiety, Depression, Post Concussion Symptoms
Interventions
Hyperbaric Oxygen Therapy (HBOT)
Drug
Lead sponsor
Summit Hyperbarics and Wellness
Other
Eligibility
18 Years to 75 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Boise, Idaho
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 20, 2026, 5:32 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Examination of Balance, Vestibular, and Ocular Functions and Activity Following Concussion

NCT02317107
View directory record Official record
Conditions
Brain Concussion
Interventions
Not listed
Lead sponsor
Boston Children's Hospital
Other
Eligibility
12 Years to 40 Years
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 4, 2021 · Synced Oct 20, 2026, 5:32 PM EDT
Withdrawn Early Phase 1 Interventional

Use of Adipose-Derived Stem/Stromal Cells in Concussion and Traumatic Brain Injuries

NCT02959294
View directory record Official record
Conditions
Traumatic Encephalopathies, Chronic, Concussion, Mild, Concussion, Intermediate, Concussion, Severe, Concussion, Brain
Interventions
Microcannula Harvest Adipose, Centricyte 1000, Sterile Normal Saline IV deployment AD-cSVF
Procedure · Device
Lead sponsor
Robert W. Alexander, MD, FICS
Industry
Eligibility
16 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Stevensville, Montana
Source: ClinicalTrials.gov public record
Updated Feb 16, 2021 · Synced Oct 20, 2026, 5:32 PM EDT
Completed Not applicable Interventional Results available

HIRREM Developmental Study

NCT02709369
View directory record Official record
Conditions
Sleep Initiation and Maintenance Disorders, Anxiety, Post-Traumatic Stress Disorder, Hot Flashes, Headache, Traumatic Brain Injury, Post Concussion Symptoms
Interventions
HIRREM
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
11 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 24, 2019 · Synced Oct 20, 2026, 5:32 PM EDT
Recruiting Not applicable Interventional

Targeting Neuroplasticity for Persistent Post-Concussive Cognitive Symptoms

NCT07246993
View directory record Official record
Conditions
Persistent Post Concussion Syndrome, Mild Traumatic Brain Injury
Interventions
Active tDCS, Sham tDCS
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Oct 20, 2026, 5:32 PM EDT
Recruiting Phase 1Phase 2 Interventional

Low-Tech Treatments for Obstructive Sleep Apnea

NCT07301710
View directory record Official record
Conditions
Obstructive Sleep Apnea (OSA), Traumatic Brain Injury (TBI)
Interventions
High-Resistance Breathing and Drinking Exercises, Low-Resistance Breathing and Drinking Exercises
Behavioral
Lead sponsor
Uniformed Services University of the Health Sciences
Federal
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 20, 2026, 5:32 PM EDT
Not listed Phase 2 Interventional

Growth Hormone Replacement Therapy for Retried Professional Football Players

NCT04121780
View directory record Official record
Conditions
TBI (Traumatic Brain Injury), Concussion, Brain, Sport Injury, Anterior Pituitary Hyposecretion Syndrome, Hypopituitarism, Growth Hormone Deficiency
Interventions
Growth Hormone, Placebo
Biological · Other
Lead sponsor
Center for Neurological Studies
Other
Eligibility
18 Years to 76 Years · Male only
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Dearborn, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Oct 20, 2026, 5:32 PM EDT
Completed Phase 2 Interventional Results available

mTBI Mechanisms of Action of HBO2 for Persistent Post-Concussive Symptoms

NCT01611194
View directory record Official record
Conditions
Traumatic Brain Injury With Brief Loss of Consciousness, Post-Concussion Syndrome
Interventions
Hyperbaric oxygen (HBO2) at 1.5 atms, Sham control 1.2 atms
Drug
Lead sponsor
U.S. Army Medical Research and Development Command
Federal
Eligibility
18 Years to 65 Years
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
5
States / cities
Colorado Springs, Colorado • Fort Carson, Colorado • Jacksonville, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 21, 2018 · Synced Oct 20, 2026, 5:32 PM EDT
Completed Not applicable Interventional Results available

Clinical Trial Comparing Two Non-Surgical Treatments for Severe Blepharoptosis

NCT04678115
View directory record Official record
Conditions
Blepharoptosis, Ptosis, Eyelid, Myasthenia Gravis, Stroke, Traumatic Brain Injury, Chronic Progressive External Ophthalmoplegia
Interventions
Magnetic Levator Prosthesis (MLP), Kinesiotape Frontalis Sling (KTFS)
Device
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
5 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 22, 2025 · Synced Oct 20, 2026, 5:32 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Cerebral Blood Flow Regulation and Concussions

NCT02754206
View directory record Official record
Conditions
Brain Concussion, Post-Concussion Syndrome
Interventions
Not listed
Lead sponsor
Southern Methodist University
Other
Eligibility
18 Years to 30 Years
Enrollment
79 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 14, 2021 · Synced Oct 20, 2026, 5:32 PM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Sildenafil Treatment for Mild TBI

NCT03598140
View directory record Official record
Conditions
Vascular System Injuries, Concussion, Brain, Post-Concussion Syndrome
Interventions
Sildenafil Citrate, Placebo oral capsule
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 35 Years · Male only
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 19, 2020 · Synced Oct 20, 2026, 5:32 PM EDT
Not listed Not applicable Interventional

Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study

NCT03724136
View directory record Official record
Conditions
Alzheimer Disease, Alzheimer Dementia, Vascular Dementia, Lewy Body Disease, Lewy Body Dementia With Behavioral Disturbance (Disorder), Dementia, Mixed, Parkinson-Dementia Syndrome, Chronic Traumatic Encephalopathy, Huntington's Dementia, Wernicke Korsakoff Syndrome, Traumatic Brain Injury, Dementia, Multi-Infarct, Autism, Autism Spectrum Disorder, Autistic Behavior, Autistic Disorder, Current or Active State, Cadasil, LATE Limbic-predominant Age-related TDP-43 Encephalopathy
Interventions
Intravenous Bone Marrow Stem Cell (BMSC) Fraction, Intranasal Topical Bone Marrow Stem Cell (BMSC) Fraction, Near Infrared Light
Procedure
Lead sponsor
MD Stem Cells
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
2
States / cities
Westport, Connecticut • Coral Springs, Florida
Source: ClinicalTrials.gov public record
Updated Apr 15, 2024 · Synced Oct 20, 2026, 5:32 PM EDT
Completed Phase 2 Interventional

Hyperbaric Oxygen for Traumatic and Non-traumatic Brain Injury

NCT01986205
View directory record Official record
Conditions
Brain Injury, Chronic
Interventions
Hyperbaric Oxygen, Minimal pressure air
Combination Product
Lead sponsor
Lindell Weaver
Other
Eligibility
18 Years to 70 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
2
States / cities
Murray, Utah • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 4, 2022 · Synced Oct 20, 2026, 5:32 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

"Interactive Metronome Technology for Blast-Related Traumatic Brain Injury"

NCT01248390
View directory record Official record
Conditions
Traumatic Brain Injury, Post-Concussion Syndrome
Interventions
Interactive metronome
Behavioral
Lead sponsor
The Defense and Veterans Brain Injury Center
Federal
Eligibility
18 Years to 55 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2016
U.S. locations
1
States / cities
Colorado Springs, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 20, 2017 · Synced Oct 20, 2026, 5:32 PM EDT
Active, not recruiting Not applicable Interventional

Neurotechnology Following Traumatic Brain Injury

NCT03649958
View directory record Official record
Conditions
Post-Concussion Symptoms, Insomnia, Pain, Chronic, Depressive Symptoms
Interventions
HIRREM-SOP or Cereset, Cereset 2x
Device
Lead sponsor
Brain State Technologies, LLC
Industry
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
2
States / cities
Bethesda, Maryland • Fort Bragg, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 14, 2023 · Synced Oct 20, 2026, 5:32 PM EDT
Recruiting Phase 2 Interventional

Long-Term Outcomes Following HBOT

NCT07732374
View directory record Official record
Conditions
Traumatic Brain Injury, Post-Concussive Symptoms, Post-Traumatic Stress Disorder
Interventions
Hyperbaric Oxygen Therapy (HBOT)
Drug
Lead sponsor
Summit Hyperbarics and Wellness
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Boise, Idaho
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Oct 20, 2026, 5:32 PM EDT
Active, not recruiting Not applicable Interventional

Mobile Subthreshold Exercise Program for Concussion--R01

NCT04688255
View directory record Official record
Conditions
Concussion, Brain, Concussion, Mild, Brain Injuries, Traumatic, Persistent Post Traumatic Headache, Post-Concussion Syndrome, Post-Concussive Syndrome, Chronic
Interventions
MSTEP, Stretching
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
11 Years to 18 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 16, 2025 · Synced Oct 20, 2026, 5:32 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline

NCT07044596
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Post Concussion Syndrome
Interventions
Functional near-infrared spectroscopy (fNIRS), V1 stimulation electrodes, Magnetic Resonance Imaging (MRI), MAGNUS scanner
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
20 Years to 85 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 20, 2026, 5:32 PM EDT