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Conditions: Amputation Wound, Traumatic Amputation of Toe, Dysvascular Amputation of Lower Limb
Interventions: Not listed
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 27 Years to 89 Years · Male only
Enrollment: 4,549 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2016
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Traumatic Amputation of Lower Extremity
Interventions: Not listed
Lead sponsor: Major Extremity Trauma Research Consortium; Other
Eligibility: 18 Years to 60 Years
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2021
U.S. locations: 10
States / cities: San Francisco, California • Tampa, Florida • Baltimore, Maryland + 7 more

Conditions: Ankle Fracture, Pilon Fracture
Interventions: ankle or distal tibia surgery; Procedure
Lead sponsor: AO Clinical Investigation and Publishing Documentation; Other
Eligibility: 18 Years and older
Enrollment: 204 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 3
States / cities: Jacksonville, Florida • New York, New York

Conditions: Osteoarthritis (OA) of the Hip, Avascular Necrosis of Bone of Hip, Protrusio Acetabuli, Traumatic Arthropathy-Hip, Slipped Capital Femoral Epiphyses, Fused Hip, Fracture of Pelvis, Diastrophic Variant
Interventions: Vivacit-E Elevated Liners; Device
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 18 Years and older
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: South Bend, Indiana

Conditions: Spasticity
Interventions: Phase 2; Low Dose MYOBLOC (15,000 Units), Phase 2; High Dose MYOBLOC (20,000 Units), Phase 2; Placebo, Phase 3; MYOBLOC, Phase 3; Placebo; Drug
Lead sponsor: Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 4
States / cities: Downey, California • Boise, Idaho • Port Royal, South Carolina + 1 more

Conditions: Amputation, Traumatic, Traumatic Amputation of Lower Extremity, Wounds and Injuries
Interventions: Otto Bock prosthesis, Ossur prosthesis, Freedom Innovations prosthesis; Device
Lead sponsor: VA Eastern Colorado Health Care System; Federal
Eligibility: 18 Years to 55 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: Boulder, Colorado

Conditions: Ankle Fractures, Post-traumatic Osteoarthritis, Osteoarthritis Ankle
Interventions: Carbon Fiber Custom Dynamic Orthosis (CDO); Device
Lead sponsor: University of Iowa; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: ACL Injury, Meniscus Tear, Post-traumatic Osteoarthritis
Interventions: Montelukast, Placebo; Drug
Lead sponsor: Austin V Stone; Other
Eligibility: 25 Years to 50 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Amputation, Amputation, Traumatic, Amputation; Traumatic, Leg, Lower
Interventions: Compliant Adaptive Energy Storage and Return Foot, AllPro; Device
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Osteoarthritis, Knee, Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, Quadriceps Muscle Atrophy
Interventions: Experimental: Whole Body Vibration, Experimental: Local Muscle Vibration, Standard ACL Rehabilitation; Device · Other
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 16 Years to 35 Years
Enrollment: 114 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 2
States / cities: Chapel Hill, North Carolina

Conditions: Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia, Tibial Plateau Fracture, Ankle Fracture (Bimalleolar Equivalent, Bimalleolar, or Trimalleolar), Calcaneus Fractures, Talus Fracture, Wound Infection Deep, Wound Infection Post-Traumatic, Wound Dehiscence, Surgical
Interventions: Nitroglycerin Ointment 2%; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 2
States / cities: Baltimore, Maryland

Conditions: Lower Limb or Combined Lower Limb and Upper Limb Spasticity Due to Stroke or Traumatic Brain Injury
Interventions: NT 201, Placebo; Drug
Lead sponsor: Merz Pharmaceuticals GmbH; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 603 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2027
U.S. locations: 15
States / cities: Birmingham, Alabama • Little Rock, Arkansas • Downey, California + 11 more

Conditions: Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, Knee Osteoarthritis, Osteo Arthritis Knee, Knee Injuries, Cartilage, Articular, Gait
Interventions: Real-time gait biofeedback, Sham real-time gait biofeedback; Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 16 Years to 35 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Ankle Fractures, Post-traumatic Osteoarthritis, Osteoarthritis Ankle
Interventions: Custom Carbon Fiber Dynamic Orthosis (CDO); Device
Lead sponsor: University of Iowa; Other
Eligibility: 18 Years to 65 Years
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Post-Traumatic Osteoarthritis of Ankle, Ankle Osteoarthritis, Ankle Injuries
Interventions: Osteochondral allograft ankle; Procedure
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 18 Years to 55 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Amputation, Amputation; Traumatic, Limb, Amputation, Traumatic
Interventions: Low cost lower limb prosthetic socket; Device
Lead sponsor: Shirley Ryan AbilityLab; Other
Eligibility: 18 Years to 95 Years
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2025
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Traumatic Brain Injury
Interventions: Exercise Only, Exercise + Non-Immersive Virtual Reality, Exercise + Immersive Virtual Reality; Behavioral
Lead sponsor: Kessler Foundation; Other
Eligibility: 18 Years to 65 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: East Hanover, New Jersey

Conditions: Amputation, Diabetes, Leg Injuries, Traumatic Amputations
Interventions: Total Surface Bearing Suction Socket, Vacuum assisted socket system; Device
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Leg Spasticity
Interventions: Botulinum toxin type A, Placebo; Biological · Drug
Lead sponsor: Ipsen; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 388 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 17
States / cities: Scottsdale, Arizona • Downey, California • Oxnard, California + 12 more

Conditions: Chronic Lower Leg Ulcer, Diabetic Lower Extremity Ulcers, Pressure Injuries, Traumatic Wounds and Injuries, Surgical Wounds
Interventions: Motion NPWT; Device
Lead sponsor: West Boca Center for Wound Healing; Other
Eligibility: Not listed
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Coconut Creek, Florida

Conditions: Diabetes Mellitus, Leg Injuries, Traumatic Amputation
Interventions: Transverse plane rotation adaptor pylon, Rigid pylon; Device
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Tibial Shaft Fracture, Tibial Plateau Fracture
Interventions: Acute injury without compartment syndrome, Acute injury with compartment syndrome, Exertional compartment syndrome; Procedure
Lead sponsor: University of Utah; Other
Eligibility: 18 Years to 90 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2028
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Anterior Cruciate Ligament Injuries, Post-Traumatic Osteoarthritis of Knee, Bone Marrow Aspirate Concentrate, ACL Injury
Interventions: Concentrated Bone Marrow Aspirate Injection, Sham Incision, Revision Anterior Cruciate Ligament Reconstruction; Biological · Procedure
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 55 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 2
States / cities: Atlanta, Georgia • New York, New York

Conditions: Diabetic Foot Ulcer, Pressure Injury, Pressure Ulcer, Surgical Wound, Acute Wound, Traumatic Wound, Dehiscence, Edema
Interventions: Invia Motion Endure NPWT system; Device
Lead sponsor: Medela AG; Industry
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 2
States / cities: Augusta, Georgia • Austell, Georgia

Search by objective public record fields.

Longitudinal Study of Weight Change Following Lower Limb Amputation

Prosthetic Fit Assessment in Transtibial Amputees Secondary to Trauma

Trauma Expectation Factor Trauma Outcome Measure

MDR Vivacit-E Elevated Study

Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Lower Limb Spasticity

What is the Optimal Stiffness and Height of a Running-specific Prosthesis?

Custom Dynamic Orthoses to Reduce Articular Contact Stress

MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)

No Power Bionic Lower Extremity Prosthesis

Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury

Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging.

Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury

Gait Rehabilitation to Treat FastOA

Iterative Design of Custom Dynamic Orthoses to Reduce Articular Contact Stress

Indications for Osteochondral Allograft Transplantation

Low Cost Socket for Lower Limb Amputees

The Environment's Impact on Thinking When Added to Leg Cycling in People With TBI: VITAL

Vacuum Suspension: Effects on Tissue Oxygenation, Activity and Fit

Dysport® Adult Lower Limb Spasticity Study

Use of Hydroprep Wound Therapy With Motion Negative Pressure Therapy for Treatment of Chronic Lower Extremity Wounds

Prosthetic Components and Stability in Amputee Gait

Gene Expression in Lower Extremity Acute Traumatic Compartment Syndrome

Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction

A Dual-center Study Evaluating Clinical Acceptance of a NPWT Wound Care System