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ClinicalTrials.gov public records Last synced Sep 30, 2026, 5:41 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 287 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Treatment for Opioid Use Disorder Clear all
Active, not recruiting Phase 4 Interventional

Pain Self-Management and Patient-Oriented Dosing for Pain and in Retention Opioid Treatment

NCT06367387
View directory record Official record
Conditions
Opioid Use Disorder, Chronic Pain
Interventions
Patient-Oriented Dosing (POD), Pain Self-Management (PSM), Usual Care, Standard Buprenorphine Dosing Condition
Drug · Behavioral
Lead sponsor
Erin Winstanley
Other
Eligibility
18 Years and older
Enrollment
273 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
13
States / cities
Baltimore, Maryland • Dundalk, Maryland • Hagerstown, Maryland + 6 more
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 30, 2026, 5:41 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

COVID-19-Related Opioid Treatment Policy Evaluation

NCT05028998
View directory record Official record
Conditions
Opioid-use Disorder, Alcohol Use Disorder
Interventions
Not listed
Lead sponsor
Boston VA Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 1, 2023 · Synced Sep 30, 2026, 5:41 PM EDT
Not yet recruiting Not applicable Interventional

Real World Evaluation of the Effectiveness and Implementation of a Digital Health Therapeutic for OUD

NCT07348796
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
KIOS App
Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 30, 2026, 5:41 PM EDT
Recruiting Phase 2Phase 3 Interventional

Efficacy of Buprenorphine and XR-Naltrexone Combination for Relapse Prevention in Opioid Use Disorder

NCT05011266
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Buprenorphine/naloxone, Placebo
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
2
States / cities
Rockville, Maryland • New York, New York
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Sep 30, 2026, 5:41 PM EDT
Completed Not applicable Interventional Results available

FOREward Together: Training Peer Recovery Coaches to Promote Retention and Adherence to MOUD

NCT05098795
View directory record Official record
Conditions
Opioid Use
Interventions
Behavioral Activation (BA)
Behavioral
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 14, 2025 · Synced Sep 30, 2026, 5:41 PM EDT
Recruiting Not applicable Interventional

Novel Telemedicine-Delivered Prolonged Exposure Therapy for Treating PTSD in Individuals With OUD

NCT06288711
View directory record Official record
Conditions
Opioid Use Disorder, Posttraumatic Stress Disorder
Interventions
Prolonged exposure therapy, Financial incentives, Treatment as usual
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Sep 30, 2026, 5:41 PM EDT
Completed Not applicable Interventional

Feasibility of Mobile and Technology Assisted Aftercare Services for Crisis Stabilization Units

NCT04899934
View directory record Official record
Conditions
Substance Abuse, Criminal Behavior, Mental Disorder
Interventions
mobile and technology assisted aftercare, Treatment as usual
Behavioral · Other
Lead sponsor
Florida State University
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Jun 5, 2023 · Synced Sep 30, 2026, 5:41 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders

NCT02322047
View directory record Official record
Conditions
Alcohol Use Disorder, Posttraumatic Stress Disorder (PTSD)
Interventions
Prazosin, Naltrexone, Placebo (Prazosin), Placebo (Naltrexone)
Drug
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years to 80 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 29, 2020 · Synced Sep 30, 2026, 5:41 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Comparing Home, Office, and Telehealth Induction for Medication Assisted Treatment for Opioid Use Disorder

NCT04664062
View directory record Official record
Conditions
Opioid-use Disorder, Opioid Dependence
Interventions
Medication Assisted Treatment
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
16 Years to 89 Years
Enrollment
303 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
2
States / cities
Denver, Colorado • Leawood, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 9, 2024 · Synced Sep 30, 2026, 5:41 PM EDT
Completed No phase listed Observational

Technology for MAT in Primary Care - Phase 1

NCT05006846
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Opioid Addiction Recovery Support Software Platform
Other
Lead sponsor
Q2i, LLC
Industry
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 16, 2021 · Synced Sep 30, 2026, 5:41 PM EDT
Recruiting Phase 2 Interventional

Ketamine for Opioid Use Disorder

NCT06943859
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Treatment with Ketamine, Treatment with Very Low Dose Ketamine
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 30, 2026, 5:41 PM EDT
Completed No phase listed Observational

Evaluating the Efficacy of a Digital Platform to Deliver Comprehensive Treatment for Opioid Use Disorder

NCT05529225
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Not listed
Lead sponsor
Boulder Care
Industry
Eligibility
18 Years and older
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
2
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Sep 30, 2026, 5:41 PM EDT
Not yet recruiting Not applicable Interventional

Musical Mindfulness for Pain in the ED Waiting Room

NCT07391891
View directory record Official record
Conditions
Music Therapy for Pain and Sedation, Neck Pain Musculoskeletal, Back Pain
Interventions
Music intervention
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Feb 6, 2026 · Synced Sep 30, 2026, 5:41 PM EDT
Completed Not applicable Interventional

Adaptive Decision Support for Addiction Treatment (ADAPT) Serial Randomized Testing for Usability, Round 2

NCT07602218
View directory record Official record
Conditions
Opioid Use Disorder, Clinical Decision Support
Interventions
Refined EMBED CDS, Provider alert to order consultation with addiction counselor
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
379 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
3
States / cities
Guilford, Connecticut • New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 30, 2026, 5:41 PM EDT
Completed Phase 1 Interventional

Medication-Assisted Treatment for Youth With Substance Use Disorders

NCT02593474
View directory record Official record
Conditions
Opioid Use Disorder, Opioid Dependence
Interventions
Naltrexone
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
16 Years to 25 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 31, 2018 · Synced Sep 30, 2026, 5:41 PM EDT
Completed Phase 2Phase 3 Interventional

EXHIT ENTRE Comparative Effectiveness Trial

NCT04345718
View directory record Official record
Conditions
Substance Use Disorder, Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe
Interventions
Extended Release Buprenorphine, Treatment as Usual
Drug
Lead sponsor
Gavin Bart
Other
Eligibility
18 Years and older
Enrollment
344 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
6
States / cities
New Haven, Connecticut • Baltimore, Maryland • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Sep 30, 2026, 5:41 PM EDT
Active, not recruiting Not applicable Interventional

Developing a Telehealth Model to Improve Treatment Access for Rural Veterans With Substance Use Disorders

NCT05348317
View directory record Official record
Conditions
Substance Use, Substance Use Disorders, Substance Dependence, Veterans
Interventions
VetReach
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Sep 30, 2026, 5:41 PM EDT
Completed Not applicable Interventional

Effectiveness of a CBT-based mHealth Intervention Targeting MOUD Retention, Adherence, and Opioid Use

NCT04808479
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
imFREE mCBT, mHealth ED
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Tarzana, California
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Sep 30, 2026, 5:41 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Mirtazapine for the Treatment of Methamphetamine Use in Opioid Use Disorder Patients Receiving Medication Assisted Treatment

NCT06323837
View directory record Official record
Conditions
Stimulant Use Disorder
Interventions
Mirtazapine, Placebo
Drug
Lead sponsor
Washington State University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Jul 2, 2026 · Synced Sep 30, 2026, 5:41 PM EDT
Completed Phase 3 Interventional Results available

Bunionectomy Study for Postoperative Analgesia (EPOCH 1)

NCT03295721
View directory record Official record
Conditions
Postoperative Pain
Interventions
HTX-011, Saline Placebo, Bupivacaine HCl, Luer-lock applicator, Vial access device
Drug · Device
Lead sponsor
Heron Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
412 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
15
States / cities
Mobile, Alabama • Mesa, Arizona • Phoenix, Arizona + 11 more
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Sep 30, 2026, 5:41 PM EDT
Recruiting Phase 1 Interventional

Study to Assess the Use of Tezampanel for Opioid Withdrawal Syndrome in Treatment-Seeking Patients With Opioid Use Disorder

NCT06538558
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Tezampanel, Placebo
Drug
Lead sponsor
Proniras Corporation
Industry
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Sep 30, 2026, 5:41 PM EDT
Completed Not applicable Interventional Results available

Optimization and Multi-Site Feasibility of Yoga for Chronic Pain in People in YOGAMAT-II - Phase I

NCT04646148
View directory record Official record
Conditions
Opioid Use, Chronic Pain
Interventions
Yoga classes
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
2
States / cities
Boston, Massachusetts • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 14, 2022 · Synced Sep 30, 2026, 5:41 PM EDT
Completed Not applicable Interventional Results available

Mobile Medication Adherence Platform for Buprenorphine-Naloxone During Treatment of Opioid Use Disorder: Phase I Study

NCT04656899
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Reminders messages to improve adherence.
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
18 Years to 60 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Mar 14, 2023 · Synced Sep 30, 2026, 5:41 PM EDT
Withdrawn Not applicable Interventional

Virtual MOUD Treatment- Virtual POC Toxicology

NCT05448118
View directory record Official record
Conditions
Substance Use Disorder
Interventions
Virtual POC Toxicology Test
Diagnostic Test
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
2
States / cities
West Haven, Connecticut • Leeds, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 27, 2023 · Synced Sep 30, 2026, 5:41 PM EDT