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ClinicalTrials.gov public records Last synced Oct 26, 2026, 2:17 AM EDT

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Showing 1–24 of 42 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Trigeminal Neuropathy Clear all
Completed Not applicable Interventional

Randomized Study of L-Baclofen in Patients With Refractory Trigeminal Neuralgia

NCT00004431
View directory record Official record
Conditions
Trigeminal Neuralgia
Interventions
L-baclofen
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 1999
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 25, 2015 · Synced Oct 26, 2026, 2:17 AM EDT
Completed No phase listed Observational

Observational Study of the the Use of a Trigeminal Vagal Nerve Stimulator in the Routine Care of Native Americans With Diabetic Neuropathy Pain. Pain Scores, Drug Use and Glucose Measurements Will be Assessed

NCT07025356
View directory record Official record
Conditions
Diabetic Neuropathy With Neurologic Complication
Interventions
Implantation of a trigeminal Vagus cervical nerve stimulator system, Implantation of a neurostimulator system for trigeminal vagal cervical nerve stimulation
Drug · Device
Lead sponsor
Vagus Nerve Society
Other
Eligibility
18 Years to 89 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Pine Ridge, South Dakota
Source: ClinicalTrials.gov public record
Updated Jun 17, 2025 · Synced Oct 26, 2026, 2:17 AM EDT
Completed Phase 4 Interventional Results available

Anti-CGRP for Inflammation and Pain Modulation in Small Fiber Neuropathy/Fibromyalgia

NCT04158752
View directory record Official record
Conditions
Trigeminal Neuralgia, Glossopharyngeal Neuralgia
Interventions
Galcanezumab
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 80 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Oct 26, 2026, 2:17 AM EDT
Withdrawn Phase 2Phase 3 Interventional

Efficacy and Safety of ATNC05 in Treatment of Atypical Facial Pain

NCT01920087
View directory record Official record
Conditions
Atypical Facial Pain, Persistent Idiopathic Facial Pain, Atypical Trigeminal Neuralgia, Neuropathic Orofacial Pain, Neuropathic Facial Pain
Interventions
ATNC05, Placebo
Drug
Lead sponsor
Allodynic Therapeutics, Inc
Industry
Eligibility
18 Years to 89 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
North Miami, Florida
Source: ClinicalTrials.gov public record
Updated Mar 13, 2014 · Synced Oct 26, 2026, 2:17 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Trigeminal Neuralgia Electrophysiology

NCT05269472
View directory record Official record
Conditions
Trigeminal Neuralgia
Interventions
Trigeminal Electrophysiology
Procedure
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Oct 26, 2026, 2:17 AM EDT
Active, not recruiting Not applicable Interventional

RAD 1501: A Trial of Virtual Cone Trigeminal Neuralgia Radiosurgery

NCT02708810
View directory record Official record
Conditions
Trigeminal Neuralgia
Interventions
Unframed Virtual Cone, 80 Gy Radiation
Device · Radiation
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 99 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 16, 2025 · Synced Oct 26, 2026, 2:17 AM EDT
Terminated Phase 3 Interventional Results available

A Study of Amifostine for Prevention of Facial Numbness in Radiosurgery Treatment of Trigeminal Neuralgia

NCT01364259
View directory record Official record
Conditions
Trigeminal Neuralgia
Interventions
Amifostine, CyberKnife stereotactic radiosurgery
Drug · Procedure
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2015
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 4, 2017 · Synced Oct 26, 2026, 2:17 AM EDT
Completed Phase 2 Interventional

Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain

NCT00001725
View directory record Official record
Conditions
Facial Neuralgia, Pain, Trigeminal Neuralgia
Interventions
Dextromethorphan
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 26, 2026, 2:17 AM EDT
Recruiting Phase 4 Interventional

OnabotulinumtoxinA for Trigeminal Neuralgia

NCT06216886
View directory record Official record
Conditions
Trigeminal Neuralgia
Interventions
OnabotulinumtoxinA 100 UNT [Botox], Sodium Chloride 0.9% for Injection, Preservative Free
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Oct 26, 2026, 2:17 AM EDT
Not yet recruiting No phase listed Observational

Post-Operative Trigeminal Pain After Microvascular Decompression for Trigeminal Neuralgia

NCT07216547
View directory record Official record
Conditions
Trigeminal Neuralgia, Microvascular Decompression Surgery, Post-operative Pain
Interventions
Not listed
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 26, 2026, 2:17 AM EDT
Terminated Phase 2 Interventional Results available

Trial for Treatment Refractory Trigeminal Neuralgia

NCT03941834
View directory record Official record
Conditions
Trigeminal Neuralgia
Interventions
Rimegepant, Placebo
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
20
States / cities
Gilbert, Arizona • La Jolla, California • Palo Alto, California + 10 more
Source: ClinicalTrials.gov public record
Updated Jun 10, 2024 · Synced Oct 26, 2026, 2:17 AM EDT
Completed Not applicable Interventional Results available

Research Study to Test Safety and Effectiveness of Investigational Drug in Patients With Trigeminal Neuralgia

NCT00203229
View directory record Official record
Conditions
Trigeminal Neuralgia
Interventions
lamotrigine, Placebo
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
15 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2006
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 3, 2014 · Synced Oct 26, 2026, 2:17 AM EDT
Completed Phase 2 Interventional

Nasal Carbon Dioxide for the Symptomatic Treatment of Classical Trigeminal Neuralgia

NCT02473016
View directory record Official record
Conditions
Trigeminal Neuralgia
Interventions
Carbon Dioxide Drug Delivery System (CDDS)
Drug
Lead sponsor
Capnia, Inc.
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
6
States / cities
Los Angeles, California • Tampa, Florida • New York, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Nov 17, 2017 · Synced Oct 26, 2026, 2:17 AM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Risk of Nerve Damage After Administration of Local Anesthesia

NCT06564987
View directory record Official record
Conditions
Inferior Alveolar Nerve Injuries
Interventions
4% Articaine with 1:200,000 epinephrine, 2% lidocaine with 1:100,000 epinephrine
Drug
Lead sponsor
Cleveland Dental Institute
Other
Eligibility
18 Years to 55 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Akron, Ohio • Ashtabula, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 26, 2024 · Synced Oct 26, 2026, 2:17 AM EDT
Completed Phase 2 Interventional Results available

Efficacy of Guanfacine and Lidocaine Combination in Trigeminal Nerve Block for Pain Management in Trigeminal Neuropathy

NCT03865940
View directory record Official record
Conditions
Trigeminal Neuralgia
Interventions
Lidocaine, Guanfacine
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 30, 2025 · Synced Oct 26, 2026, 2:17 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Trigeminal Evoked Responses to Improve Rhizotomy

NCT05738096
View directory record Official record
Conditions
Trigeminal Neuralgia, Rhizotomy
Interventions
TSEP + rhizotomy surgery, TSEPs recording only
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 26, 2025 · Synced Oct 26, 2026, 2:17 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

The Will Erwin Headache Research Center - Cluster Headache Study

NCT02910323
View directory record Official record
Conditions
Cluster Headache, Cluster Headaches and Other Trigeminal Autonomic Cephalgias, Paroxysmal Hemicrania, SUNCT, Hemicrania Continua, Trigeminal Neuralgia
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
1,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2035
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Oct 26, 2026, 2:17 AM EDT
Recruiting Phase 1 Interventional

Safety of Cultured Allogeneic Adult Umbilical Cordor Placental Derived Stem Cells Exosomes for Trigeminal Neuralgia

NCT05152368
View directory record Official record
Conditions
Peripheral Neuropathy, Trigeminal Neuralgia
Interventions
cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes
Biological
Lead sponsor
The Foundation for Orthopaedics and Regenerative Medicine
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Naples, Florida
Source: ClinicalTrials.gov public record
Updated Oct 20, 2026 · Synced Oct 26, 2026, 2:17 AM EDT
Terminated Not applicable Interventional

Corneal Neurotization as a Treatment for Neurotrophic Keratopathy

NCT05809245
View directory record Official record
Conditions
Neurotrophic Corneal Ulcer, Neurotrophic Keratitis, Cranial Nerve V Diseases
Interventions
Corneal neurotization
Procedure
Lead sponsor
Stanford University
Other
Eligibility
Not listed
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 12, 2023 · Synced Oct 26, 2026, 2:17 AM EDT
Completed No phase listed Observational

Diffusion Tensor Imaging Magnetic Resonance Imaging (DTI MRI) as a Correlate to Pain Relief and Facial Numbness in Patients Following Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia

NCT01364272
View directory record Official record
Conditions
Trigeminal Neuralgia
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 28, 2021 · Synced Oct 26, 2026, 2:17 AM EDT
Completed Phase 4 Interventional Results available

(Botox) Mechanisms of Action in Altering the Molecular Environment in Which Pain Fibers Exist

NCT03381261
View directory record Official record
Conditions
Migraine
Interventions
Botulinum toxin type A
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 24, 2025 · Synced Oct 26, 2026, 2:17 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Platelet-rich Fibrin and Grooving for Sagittal Split Osteotomy

NCT04706182
View directory record Official record
Conditions
Inferior Alveolar Nerve Injury, Nerve Injury, Neurosensory Disorder, Mandibular Nerve Injury
Interventions
Platelet-rich fibrin (PRF), Proximal segment grooving (PSG)
Procedure
Lead sponsor
Jesse Han
Other
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 12, 2021 · Synced Oct 26, 2026, 2:17 AM EDT
Withdrawn No phase listed Observational

Comorbid Painful TMD Among Trigeminal Neuralgia

NCT05914558
View directory record Official record
Conditions
Trigeminal Neuralgia, Temporomandibular Disorder, Myofascial Pain, Trigeminal Neuropathy
Interventions
Clinical appointment
Diagnostic Test
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
2
States / cities
Baltimore, Maryland • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 31, 2025 · Synced Oct 26, 2026, 2:17 AM EDT
Recruiting No phase listed Observational

RSSearch Patient Registry-Long Term Study of Use of SRS/SBRT

NCT01885299
View directory record Official record
Conditions
Neoplasms, Arteriovenous Malformation of Central Nervous System, Trigeminal Neuralgia
Interventions
SRS/SBRT
Radiation
Lead sponsor
The Radiosurgery Society
Other
Eligibility
Not listed
Enrollment
50,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2030
U.S. locations
13
States / cities
Colorado Springs, Colorado • Miami, Florida • Brunswick, Georgia + 10 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 26, 2026, 2:17 AM EDT