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Conditions: Venous Ulcer of Leg
Interventions: IVUS, Continued Compression Therapy/Stockings; Diagnostic Test · Other
Lead sponsor: Philips Clinical & Medical Affairs Global; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 8
States / cities: Darien, Connecticut • Winter Park, Florida • Chicago, Illinois + 5 more

Conditions: Leg Ulcer
Interventions: Multi-layer compression therapy, Application of dHACM; Procedure · Other
Lead sponsor: MiMedx Group, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 128 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 15
States / cities: Phoenix, Arizona • Carlsbad, California • Castro Valley, California + 12 more

Conditions: Venous Leg Ulcer
Interventions: Marine polysaccharide dressing, Carboxymethylcellulose dressing; Device
Lead sponsor: Medline Industries; Industry
Eligibility: 18 Years and older
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 5
States / cities: Fresno, California • Selma, California • Boston, Massachusetts + 2 more

Conditions: Venous Disease, Venous Vascular Diseases and Syndromes, Venous Insufficiency, Venous Ulcers
Interventions: Cryotherapy: Cooling gel wrap, Usual care; Procedure
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 197 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 2
States / cities: Charleston, South Carolina • Spartanburg, South Carolina

Conditions: Venous Leg Ulcer (VLU)
Interventions: Amnion-Intermediate-Chorion, Standard of Care (SOC); Other · Procedure
Lead sponsor: Cellution Biologics; Industry
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Rocky Mount, North Carolina

Conditions: Diabetic Foot Ulcer, Venous Ulcer
Interventions: Low Frequency, Low Intensity Ultrasound, Sham Applicator; Device
Lead sponsor: Drexel University; Other
Eligibility: 18 Years and older
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2023
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Crohn Disease, Ulcerative Colitis, Venous Thromboembolism
Interventions: Aspirin 81Mg Ec Tab, Standard of Care; Drug
Lead sponsor: Stefan Holubar MD MS FACS, FASCRS; Other
Eligibility: 18 Years to 100 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Venous Leg Ulcer
Interventions: Granexin; Drug
Lead sponsor: Xequel Bio, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 3
States / cities: Augusta, Georgia • Spartanburg, South Carolina • Salem, Virginia

Conditions: Diabetic Foot Ulcer, Venous Leg Ulcer, Pressure Ulcer, Wound, Non-Healed
Interventions: DETEC® pH; Diagnostic Test
Lead sponsor: Progenitec Inc.; Industry
Eligibility: 21 Years and older
Enrollment: 450 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 2
States / cities: Lake Success, New York • Arlington, Texas

Conditions: Chronic Wounds, Diabetes, Venous Stasis Ulcers
Interventions: FGF-1; Drug
Lead sponsor: Venturis Therapeutics, Inc.; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2006
U.S. locations: 1
States / cities: Warren, Pennsylvania

Conditions: Partial Thickness Wound, Pressure Ulcer, Venous Ulcer, Diabetic Ulcer, Surgical Wounds, Trauma Wounds, Draining Wounds, Chronic Vascular Ulcer
Interventions: PuraPly™ Antimicrobial Wound Matrix; Device
Lead sponsor: Organogenesis; Industry
Eligibility: 18 Years and older
Enrollment: 310 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 15
States / cities: Prescott Valley, Arizona • Jupiter, Florida • Miami, Florida + 12 more

Conditions: Venous Leg Ulcer
Interventions: Summus Laser, Summus Laser Sham; Device
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2027
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Venus Leg Ulcers
Interventions: EscharEx (EX-03), Placebo (Gel vehicle), Non-surgical standard of care (NSSOC); Drug · Other
Lead sponsor: MediWound Ltd; Industry
Eligibility: 18 Years and older
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2029
U.S. locations: 1
States / cities: Maimi, Florida

Conditions: Post Thrombotic Syndrome
Interventions: complex lymphedema therapy; Other
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Venous Leg Ulcer
Interventions: Membrane Wrap™, Standard of Care; Device · Other
Lead sponsor: BioLab Holdings; Industry
Eligibility: 50 Years to 85 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 9
States / cities: Mesa, Arizona • San Franciso, California • DeLand, Florida + 6 more

Conditions: Venous Stasis Ulcers
Interventions: Novel Dressing; Device
Lead sponsor: Hollister Incorporated; Industry
Eligibility: 18 Years and older
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 8
States / cities: Phoenix, Arizona • Miami, Florida • Elk Grove Village, Illinois + 4 more

Conditions: Venous Leg Ulcer, Venous Stasis Ulcer
Interventions: No HP802 Treatment, No HP802 Vehicle Treatment; Biological · Other
Lead sponsor: Healthpoint; Industry
Eligibility: 18 Years and older
Enrollment: 206 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 29
States / cities: Tucson, Arizona • Castro Valley, California • Encinitas, California + 26 more

Conditions: Venous Leg Ulcer
Interventions: PICO Negative Pressure Wound Therapy, Compression Dressing; Device · Procedure
Lead sponsor: Northwell Health; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Staten Island, New York

Conditions: Wound Care, Venous Ulcer Care, Wound Cleansing, Chronic Wound Care
Interventions: Prontosan wound irrigation solution; Device
Lead sponsor: Calvary Hospital, Bronx, NY; Other
Eligibility: 18 Years to 95 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Chronic Venous Hypertension With Ulcer
Interventions: Standard Multi-layered Compression dressing, Standard Multi-layered Compression dressing with a cryopreserved skin allograft (TheraSkin); Procedure
Lead sponsor: Solsys Medical LLC; Industry
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Fairfax, Virginia

Conditions: Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis, Venous Ulcer, Venous Stenosis, Venous Occlusion, Vein Thrombosis, Vein Occlusion, Vein Disease
Interventions: GORE® VIAFORT Vascular Stent; Device
Lead sponsor: W.L.Gore & Associates; Industry
Eligibility: 18 Years and older
Enrollment: 165 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2031
U.S. locations: 24
States / cities: Stanford, California • Darien, Connecticut • New Haven, Connecticut + 20 more

Conditions: Venous Leg Ulcer, Chronic Wounds
Interventions: Hyalomatrix, Standard of Care; Device · Other
Lead sponsor: NuScience Medical Biologics, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 122 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 4
States / cities: Alexandria, Louisiana • Pineville, Louisiana • Vidalia, Louisiana + 1 more

Conditions: Diabetic Foot Ulcer (DFU), Venous Leg Ulcer, Wound; Foot
Interventions: IP1: BioLab Membrane Wrap Lite IP2: BioLab Tri-Membrane Wrap, IP2: BioLab Tri-Membrane Wrap; Other
Lead sponsor: Capsicure, LLC; Network
Eligibility: 18 Years and older
Enrollment: 165 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 7
States / cities: Oxnard, California • Coral Gables, Florida • Miami, Florida + 4 more

Conditions: Post Thrombotic Syndrome, Deep Vein Thrombosis, Venous Stasis Syndrome, Venous Insufficiency, Postphlebitic Syndrome
Interventions: VeinOPlus; Device
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

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Intravascular Ultrasound-Guided Intervention for Venous Leg Ulcers (IGuideU)

Use of dHACM in the Treatment of Venous Leg Ulcers

A Comparative Evaluation of a MPS Dressing and a CMC Dressing on Subjects With Lower Extremity Venous Ulcers

Cooling Lower Leg Skin to Prevent Venous Leg Ulcers in Patients With Poor Vein Circulation

Nonhealing Venous Leg Ulcers Treated With a Standard of Care (SoC) Alone or Standard of Care and Dehydrated Human Placenta Tissue (dHPT) With Crossover

Enhanced Ultrasound Treatment of Chronic Wounds With Monitoring of Healing and Quality of Life Outcomes

SAVES-IBD: Safety & Efficacy of Aspirin vs. Standard of Care for VTE Prophylaxis After IBD Surgery

Safety Study to Examine the Systemic Exposure of Granexin® Gel After Topical Application to Venous Leg Ulcers

DETEC® pH Point of Care Wound Diagnostic Test

FGF-1 for Topical Administration for the Treatment of Diabetic or Venous Stasis Ulcers

The RESPOND Registry

Randomized Controlled Trial for Treatment of Pain and Assessment of Wound Healing in Chronic Venous Leg Ulcers Using Near Infrared Laser Therapy

Controlled Study, Performed to Evaluate the Safety and Efficacy of EscharEx and Its Placebo (Gel Vehicle) Compared to Non-surgical Standard of Care in Participants With Venous Leg Ulcers (VLU)

Treatment Trial for Post-Thrombotic Syndrome

Human Amniotic Membrane On Venous Leg Ulcers In an Elderly Population

Wound Fluid Protease Levels During Use of Novel Wound Dressing

Safety Follow-Up to HP 802-247-09-015

Pilot Study Comparing Negative Pressure Dressings to Conventional Dressings

Effect of Prontosan Wound Irrigation Solution on Venous Ulcers

Standard Compression Therapy With/Without Application of Skin Allograft (Theraskin) for Venous Leg Ulcer Treatment

The GORE® VIABAHN® FORTEGRA Venous Stent Iliofemoral Study

Evaluation of the Efficacy of Hyalomatrix® in the Healing of Chronic Venous Leg Ulcers

CAMP RWE Trial: Amnion Grafts for Healing Hard-to-Heal Ulcers in RW Populations

Pilot Study for VeinoPlus to Improve Symptoms of Postthrombotic Syndrome (PTS)