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ClinicalTrials.gov public records Last synced Nov 7, 2026, 1:16 PM EST

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Showing 1–24 of 45 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Unilateral Hearing Loss Clear all
Completed Phase 1 Interventional

OTO-104 for Meniere's Disease

NCT01084525
View directory record Official record
Conditions
Meniere's Disease
Interventions
OTO-104 (steroid) 3 mg, Placebo, OTO-104 (steroid) 12 mg
Drug
Lead sponsor
Otonomy, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
15
States / cities
Los Angeles, California • San Diego, California • Colorado Springs, Colorado + 12 more
Source: ClinicalTrials.gov public record
Updated Jun 8, 2011 · Synced Nov 7, 2026, 1:16 PM EST
Terminated Phase 3 Interventional Results available

Efficacy and Safety of AM-111 as Acute Sudden Sensorineural Hearing Loss Treatment

NCT02809118
View directory record Official record
Conditions
Hearing Loss, Idiopathic Sudden Sensorineural
Interventions
AM-111 0.4 mg/ml, AM-111 0.8 mg/ml, Placebo
Drug · Other
Lead sponsor
Auris Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
38
States / cities
Birmingham, Alabama • Escondido, California • Fresno, California + 34 more
Source: ClinicalTrials.gov public record
Updated Aug 7, 2020 · Synced Nov 7, 2026, 1:16 PM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Single-Sided Deafness in the Medicare Population

NCT05250414
View directory record Official record
Conditions
Hearing Loss, Unilateral
Interventions
MED-EL Cochlear Implant System
Device
Lead sponsor
Med-El Corporation
Industry
Eligibility
65 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
2
States / cities
Iowa City, Iowa • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Nov 7, 2026, 1:16 PM EST
Terminated Not applicable Interventional Results available

Cochlear Implantation for Treatment of Single-sided Deafness

NCT02532972
View directory record Official record
Conditions
Total Unilateral Deafness, Unilateral Partial Deafness
Interventions
Med-el MAESTRO Cochlear Implant with Flex 28 electrode array
Device
Lead sponsor
Dr. Daniel Lee
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 5, 2020 · Synced Nov 7, 2026, 1:16 PM EST
Completed Not applicable Interventional

CROS Application in CI

NCT03243097
View directory record Official record
Conditions
Hearing Loss
Interventions
Phase I - Standard Microphone Cros Input, Phase II - Automatic directional microphone Cros Input, Phase III - No Cros Input
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 27, 2023 · Synced Nov 7, 2026, 1:16 PM EST
Active, not recruiting Not applicable Interventional

Investigation to Evaluate the Safety and Effectiveness of Cochlear Implantation in Children and Adults With Unilateral Hearing Loss/Single-sided Deafness

NCT05318417
View directory record Official record
Conditions
Hearing Loss, Unilateral, Deafness, Unilateral
Interventions
The Cochlear™ Nucleus® Cochlear Implant (CI) System
Device
Lead sponsor
Cochlear
Industry
Eligibility
5 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
6
States / cities
Palo Alto, California • Englewood, Colorado • Iowa City, Iowa + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Nov 7, 2026, 1:16 PM EST
Completed No phase listed Observational Accepts healthy volunteers

Efficacy of the Bone-anchored Hearing Aid for Unilateral Deafness

NCT00201617
View directory record Official record
Conditions
Unilateral Deafness
Interventions
Bone-anchored hearing aid
Device
Lead sponsor
The New York Eye & Ear Infirmary
Other
Eligibility
18 Years to 70 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 14, 2015 · Synced Nov 7, 2026, 1:16 PM EST
Recruiting Phase 1Phase 2 Interventional

Anti-VEGF Gene Therapy Trial for Vestibular Schwannoma

NCT06517888
View directory record Official record
Conditions
Vestibular Schwannoma
Interventions
AAVAnc80-antiVEGF via Akouos Delivery Device
Combination Product
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
4
States / cities
Baltimore, Maryland • Rochester, Minnesota • Nashville, Tennessee + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 4, 2026 · Synced Nov 7, 2026, 1:16 PM EST
Completed No phase listed Observational

Single-sided Deafness and Cochlear Implantation

NCT05052944
View directory record Official record
Conditions
Hearing Loss, Hearing Loss, Sensorineural, Hearing Loss, Unilateral, Hearing Loss, Sudden, Hearing Loss, Cochlear, Hearing Loss in Left Ear, Hearing Loss in Right Ear, Labyrinthitis
Interventions
Cochlear implantation
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
5
States / cities
Baltimore, Maryland • Bethesda, Maryland • Lutherville-Timonium, Maryland + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 13, 2023 · Synced Nov 7, 2026, 1:16 PM EST
Completed No phase listed Observational

Cochlear Implantation Among Adults and Older Children With Unilateral or Asymmetric Hearing Loss

NCT02105441
View directory record Official record
Conditions
Severe Unilateral Sensorineural Hearing Loss
Interventions
Cochlear implant
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
7 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Nov 7, 2026, 1:16 PM EST
Active, not recruiting Not applicable Interventional

Single-Sided Deafness and Asymmetric Hearing Loss

NCT04506853
View directory record Official record
Conditions
Hearing Loss, Unilateral, Hearing Loss, Sensorineural
Interventions
MED-EL Cochlear Implant System
Device
Lead sponsor
Med-El Corporation
Industry
Eligibility
5 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
4
States / cities
Iowa City, Iowa • New York, New York • Chapel Hill, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 20, 2026 · Synced Nov 7, 2026, 1:16 PM EST
Completed No phase listed Observational Results available

Cross-sectional Evaluation of the Subjective Performance and Satisfaction With Ponto Sound Processors

NCT05356221
View directory record Official record
Conditions
Hearing Loss, Hearing Loss, Conductive, Hearing Loss, Unilateral
Interventions
Ponto Sound processor
Device
Lead sponsor
Oticon Medical
Industry
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Somerset, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 17, 2025 · Synced Nov 7, 2026, 1:16 PM EST
Completed Not applicable Interventional Results available

Use of Amplification in Children With Unilateral Hearing Loss

NCT02269124
View directory record Official record
Conditions
Unilateral Hearing Loss
Interventions
Hearing aid
Device
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
6 Years to 12 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 11, 2021 · Synced Nov 7, 2026, 1:16 PM EST
Completed Not applicable Interventional Results available

Evaluation of Unilateral vs Bilateral Hearing Aids for the Treatment of Age-related Hearing Loss

NCT04739436
View directory record Official record
Conditions
Hearing Loss
Interventions
Hearing amplification
Device
Lead sponsor
Duke University
Other
Eligibility
50 Years and older
Enrollment
278 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
2
States / cities
Durham, North Carolina • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 10, 2025 · Synced Nov 7, 2026, 1:16 PM EST
Enrolling by invitation Not applicable Interventional

Impact of Anatomy-Based Cochlear Implant Programming on Early Performance

NCT06734039
View directory record Official record
Conditions
Hearing Loss, Unilateral, Cochlear Implants, Hearing Loss, Sensorineural, Single-Sided Deafness (SSD), Asymmetric Hearing Loss
Interventions
Programming of cochlear implant audio processor frequency settings
Device
Lead sponsor
Med-El Corporation
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
6
States / cities
Iowa City, Iowa • Kansas City, Kansas • Chapel Hill, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Nov 7, 2026, 1:16 PM EST
Recruiting No phase listed Observational

Pilot Study to Evaluate the Long-term Chronic Care of Patients Who Could or do Utilize an Osseointegrated Device (OID)

NCT04899037
View directory record Official record
Conditions
Hearing Loss, Conductive, Hearing Loss, Mixed, Deafness, Unilateral
Interventions
No intervention
Other
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Nov 7, 2026, 1:16 PM EST
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Phase I/IIa Study Evaluating Safety and Efficacy of an Intratympanic Dose of PIPE-505 in Subjects With Hearing Loss

NCT04462198
View directory record Official record
Conditions
Sensorineural Hearing Loss
Interventions
PIPE-505, Placebo
Drug
Lead sponsor
Contineum Therapeutics
Industry
Eligibility
18 Years to 75 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
8
States / cities
Torrance, California • Boca Raton, Florida • New Albany, Indiana + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2025 · Synced Nov 7, 2026, 1:16 PM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Wide Diameter Bone Anchored Implant Study

NCT01671176
View directory record Official record
Conditions
Conductive Hearing Loss, Conductive and Sensori-neural Hearing Loss in the Same Ear, Unilateral, Profound Sensori-neural Hearing Loss
Interventions
Wide diameter bone anchored implant
Device
Lead sponsor
Oticon Medical
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
2
States / cities
Sarasota, Florida • Farmington Hills, Michigan
Source: ClinicalTrials.gov public record
Updated May 7, 2018 · Synced Nov 7, 2026, 1:16 PM EST
Completed No phase listed Observational Accepts healthy volunteers

Determine the Incidence of Long QT Amongst a Large Cohort of Subjects Diagnosed With Unilateral or Bilateral Sensorineural Hearing Loss.

NCT02082431
View directory record Official record
Conditions
Sensorineural Hearing Loss, Long QT Syndrome
Interventions
Not listed
Lead sponsor
Pediatrix
Other
Eligibility
1 Day to 90 Days
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2020
U.S. locations
12
States / cities
Anchorage, Alaska • Phoenix, Arizona • Waterford, Connecticut + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 5, 2020 · Synced Nov 7, 2026, 1:16 PM EST
Not listed Phase 4 Interventional

Evaluation of Benefit for Treatment of Single Sided Deafness (SSD) Between Two Bone Conduction Prosthetic Devices; Osseointegrated Implant Versus Maxilla Anchored Removable Oral Appliance ("SoundBite")

NCT01933386
View directory record Official record
Conditions
Single Sided Deafness
Interventions
SoundBite
Device
Lead sponsor
Sonitus Medical Inc
Industry
Eligibility
18 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
3
States / cities
Phoenix, Arizona • Novi, Michigan • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Oct 29, 2013 · Synced Nov 7, 2026, 1:16 PM EST
Completed Not applicable Interventional Results available

Implantation of the Cochlear® Nucleus® System in Adults With Single-Sided Deafness

NCT01670006
View directory record Official record
Conditions
Single Sided Deafness
Interventions
Cochlear Nucleus Cochlear Implant System
Device
Lead sponsor
Cochlear
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 22, 2022 · Synced Nov 7, 2026, 1:16 PM EST
Completed Phase 1Phase 2 Interventional Results available

Safety, Tolerability and Efficacy for CGF166 in Patients With Unilateral or Bilateral Severe-to-profound Hearing Loss

NCT02132130
View directory record Official record
Conditions
Unilateral Severe to Profound Hearing Loss OR Bilateral Severe to Profound Hearing Loss
Interventions
CGF166
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years to 75 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
4
States / cities
Kansas City, Kansas • Baltimore, Maryland • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 8, 2021 · Synced Nov 7, 2026, 1:16 PM EST
Completed Not applicable Interventional Results available

Evaluation of the Baha SoundArc in Pediatric Patients

NCT03333577
View directory record Official record
Conditions
Hearing Loss, Conductive, Hearing Loss, Mixed, Hearing Loss, Unilateral
Interventions
SoundArc
Device
Lead sponsor
Cochlear
Industry
Eligibility
5 Years to 12 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
3
States / cities
Chandler, Arizona • San Diego, California • Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Apr 30, 2019 · Synced Nov 7, 2026, 1:16 PM EST
Completed Not applicable Interventional Results available

Long Term Safety of the Sonitus SoundBite System

NCT01108406
View directory record Official record
Conditions
Hearing Loss, Unilateral Hearing Loss, Total Unilateral Deafness
Interventions
Sonitus SoundBite System, SoundBite Hearing System
Device
Lead sponsor
Sonitus Medical Inc
Industry
Eligibility
18 Years to 80 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
San Jose, California
Source: ClinicalTrials.gov public record
Updated Oct 20, 2014 · Synced Nov 7, 2026, 1:16 PM EST