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Showing 1–24 of 49 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Unsafe Sex Clear all
Completed Not applicable Interventional

The Young Woman's Reach Project: Trial of an Intervention to Impact Contraceptive Behavior, Unintended Pregnancy, and Sexually Transmitted Infections (STIs) Among Adolescent Females

NCT00230880
View directory record Official record
Conditions
Contraceptive Behavior, Sexually Transmitted Diseases
Interventions
follow-up phone counseling
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
14 Years to 18 Years · Female only
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 4, 2012 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intervention for Substance Use and Sexual Risk Behavior in Homeless Youth

NCT03735784
View directory record Official record
Conditions
Substance Use, Unprotected Sex
Interventions
AWARE
Behavioral
Lead sponsor
RAND
Other
Eligibility
18 Years to 25 Years
Enrollment
276 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
3
States / cities
Hollywood, California • Los Angeles, California • Venice Beach, California
Source: ClinicalTrials.gov public record
Updated Jun 20, 2021 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

MI With Text Messaging to Reduce Sexual Risk and Hazardous Drinking Among MSM

NCT03755661
View directory record Official record
Conditions
Alcohol; Harmful Use, Sex, Unsafe
Interventions
MI&TXT4MSM
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
21 Years to 50 Years · Male only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 5, 2021 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

FASTLANE II: Reducing Sex, Drug, and Mental Health Risk

NCT04109014
View directory record Official record
Conditions
Methamphetamine Abuse, HIV/AIDS, Depression, Sex, Unsafe
Interventions
FASTLANE II
Other
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 8, 2022 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional

HIV/STI Risk Reduction for Incarcerated Women With Interpersonal Violence

NCT01907126
View directory record Official record
Conditions
Unsafe Sex, Physical Violence, Sexual Assault, Sexual Abuse
Interventions
Nutrition Program (NP), Women's Prison CoOp (WPC)
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older · Female only
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
3
States / cities
Framingham, Massachusetts • Cranston, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 19, 2025 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Phase 4 Interventional

The Whole Day First Grade Program

NCT00257088
View directory record Official record
Conditions
Prevention of Drug Abuse and Dependency, Alcohol Abuse and Dependency, High Risk Sex Behavior, Smoking Tobacco, School Failure
Interventions
whole day first grade program
Behavioral
Lead sponsor
American Institutes for Research
Other
Eligibility
Not listed
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2003
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 13, 2008 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Familias Unidas: Preventing Substance Abuse in Hispanic Youth

NCT01038206
View directory record Official record
Conditions
Prevention, Family Function, Substance Use, Sexual Behavior
Interventions
Familias Unidas
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
12 Years and older
Enrollment
746 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 2, 2015 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Network Intervention for Reducing Sexual Risk for HIV With African American Men Who Have Sex With Men (AA MSM)

NCT00691041
View directory record Official record
Conditions
HIV Infections
Interventions
Unity in Diversity
Behavioral
Lead sponsor
Centers for Disease Control and Prevention
Federal
Eligibility
18 Years and older · Male only
Enrollment
233 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 12, 2012 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional

Advanced Provision of Emergency Contraception: Utilizing Technology to Increase Prescription Fill Rates

NCT01401816
View directory record Official record
Conditions
Sexually Active
Interventions
Text Message
Other
Lead sponsor
Boston Medical Center
Other
Eligibility
13 Years to 21 Years · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 9, 2012 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Familias Unidas: Preventing Drug Abuse and HIV in Hispanic First Offenders

NCT01257022
View directory record Official record
Conditions
Substance Use, Unsafe Sexual Behavior
Interventions
Familias Unidas
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
12 Years to 17 Years
Enrollment
242 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Mar 4, 2014 · Synced Jul 20, 2026, 6:41 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Individual and Contextual Factors That Influence Sexual Decisions

NCT03224416
View directory record Official record
Conditions
Binge Drinking, Unsafe Sex, HIV/AIDS, Sexually Transmitted Diseases
Interventions
Alcohol Administration, Placebo Alcohol Administration, No Alcohol Administration
Other
Lead sponsor
Brown University
Other
Eligibility
21 Years to 35 Years · Male only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 20, 2017 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Copper T380 IUD Versus Oral Levonorgestrel for Emergency Contraception vs. Plan B for Emergency Contraception

NCT00669396
View directory record Official record
Conditions
Pregnancy
Interventions
Copper T380 IUD, levonorgestrel
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
West Valley City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 21, 2014 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

No Excuses/Sin Buscar Excusas Intervention to Reduce Latino Men's HIV Risks

NCT00690690
View directory record Official record
Conditions
HIV Infections
Interventions
Video (group-delivered video-based intervention), HCT
Behavioral
Lead sponsor
Centers for Disease Control and Prevention
Federal
Eligibility
18 Years to 49 Years · Male only
Enrollment
370 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 8, 2010 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional

An Evaluation of Re:MIX: a Teen Pregnancy Prevention Program With Young Parents as Peer Educators, EngenderHealth

NCT03114410
View directory record Official record
Conditions
Sexual Behavior, Unprotected Sex
Interventions
Re:MIX, a multi-layer comprehensive teen pregnancy prevention intervention aimed at reducing pregnancy and STIs among youth ages 13-17
Behavioral
Lead sponsor
Child Trends
Other
Eligibility
12 Years to 18 Years
Enrollment
621 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 30, 2020 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Project ICARE: Intervening for Community Awareness, Respect, & Empowerment

NCT00712088
View directory record Official record
Conditions
HIV Infections
Interventions
Project ICARE, HCT
Behavioral
Lead sponsor
Centers for Disease Control and Prevention
Federal
Eligibility
18 Years and older · Male only
Enrollment
275 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 10, 2010 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

MyLife MyStyle Evaluation Project

NCT01640392
View directory record Official record
Conditions
Unsafe Sex
Interventions
MyLife MyStyle group-level intervention
Behavioral
Lead sponsor
Los Angeles County Department of Public Health
Government
Eligibility
18 Years to 29 Years · Male only
Enrollment
528 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 14, 2019 · Synced Jul 20, 2026, 6:41 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Evaluation of the SafeSpace App Intervention

NCT06043596
View directory record Official record
Conditions
Health Behavior, Health Care Utilization, Unprotected Sex, Sexually Transmitted Infections
Interventions
SafeSpace Sexual Health, SafeSpace General Health
Behavioral
Lead sponsor
Child Trends
Other
Eligibility
14 Years to 18 Years · Female only
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 20, 2023 · Synced Jul 20, 2026, 6:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Copper T380A IUD vs. Oral Levonorgestrel for Emergency Contraception

NCT00966771
View directory record Official record
Conditions
Pregnancy
Interventions
Copper T380 IUD, Oral levonorgestrel
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 30 Years · Female only
Enrollment
548 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
2
States / cities
Salt Lake City, Utah • West Valley City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 5, 2017 · Synced Jul 20, 2026, 6:41 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Alcohol and "Heat of the Moment" Sexual Decision Making

NCT05729256
View directory record Official record
Conditions
Alcohol Drinking, Sex, Unsafe, Hiv
Interventions
Self-Regulation Intervention, Brief Advice and Information
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older · Male only
Enrollment
354 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Jul 20, 2026, 6:41 PM EDT
Not listed Not applicable Interventional

Evaluating the Many Ways of Being Program

NCT05801601
View directory record Official record
Conditions
Sexual Behavior, Unprotected Sex
Interventions
Many Ways of Being, an innovative sexual health promotion program focused on addressing rigid gender norms and promoting healthy relationships, A career readiness program
Behavioral
Lead sponsor
Child Trends
Other
Eligibility
15 Years to 19 Years
Enrollment
700 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Nov 20, 2023 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Positive Choice: Prevention for Positive Health

NCT00447707
View directory record Official record
Conditions
HIV Infections, Sexual Risk Behavior, Substance Use Risks
Interventions
Positive Choice
Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years and older
Enrollment
497 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2006
U.S. locations
5
States / cities
Oakland, California • San Francisco, California • San Leandro, California
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Project Power: An HIV Risk Reduction Intervention for Black Men Who Have Sex With Men and Women (BMSM/W)

NCT01376895
View directory record Official record
Conditions
Unsafe Sex, Risk Reduction
Interventions
PROJECT POWER, Power Health
Behavioral
Lead sponsor
Nova Southeastern University
Other
Eligibility
18 Years to 60 Years · Male only
Enrollment
211 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 10, 2014 · Synced Jul 20, 2026, 6:41 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Moon and Sun Brothers: A Community Prevention Intervention (Hermanos de Luna y Sol)

NCT07475702
View directory record Official record
Conditions
Help-Seeking Behavior, Pre-exposure Prophylaxis Use, Condomless Sex, Risky Health Behavior
Interventions
Moon and Sun Brothers: A Community Prevention Intervention
Behavioral
Lead sponsor
San Francisco State University
Other
Eligibility
18 Years and older
Enrollment
360 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
2
States / cities
San Francisco, California • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional

Cognitive Processing Intervention for Trauma, HIV/STI Risks, and Substance Use Among Native Women

NCT01849029
View directory record Official record
Conditions
Post Traumatic Stress Disorders, Unsafe Sex, Substance Use Disorders
Interventions
Cognitive Processing Therapy-Cognitive
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Toppenish, Washington
Source: ClinicalTrials.gov public record
Updated Aug 21, 2017 · Synced Jul 20, 2026, 6:41 PM EDT