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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Unsafe Sex Clear all
Completed Not applicable Interventional Accepts healthy volunteers

The Evaluation of Pulse: A Mobile Health App and Teen Pregnancy Prevention Program

NCT04043130
View directory record Official record
Conditions
Unprotected Sex, Contraceptive Usage
Interventions
Pulse
Behavioral
Lead sponsor
Child Trends
Other
Eligibility
18 Years to 20 Years · Female only
Enrollment
2,317 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 15, 2020 · Synced Jul 21, 2026, 6:46 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Education and Employment Support for HIV Prevention in Young Adults (ENSPIRE)

NCT06096324
View directory record Official record
Conditions
Economic Hardship, Condomless Sex, Utilization, Health Care
Interventions
Job announcements plus HIV prevention text messages, educational sessions, economic resources, and mentoring., Job announcements
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 24 Years
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Jul 21, 2026, 6:46 AM EDT
Completed Not applicable Interventional

AWARE Intervention: Feasibility and Efficacy Trial at Three University Health Services Centers

NCT03961633
View directory record Official record
Conditions
Depression, Anxiety, PTSD, Suicidal Ideation, Substance Use Disorders, Unsafe Sex, Coping Behavior
Interventions
AWARE intervention
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years to 35 Years · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
Boston, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 22, 2019 · Synced Jul 21, 2026, 6:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Manhood 2.0: A Community-Based Teen Pregnancy Prevention Program for Young Men

NCT04962802
View directory record Official record
Conditions
Sexual Behavior, Unprotected Sex
Interventions
Manhood 2.0, Post-High School Readiness
Behavioral
Lead sponsor
Child Trends
Other
Eligibility
15 Years to 18 Years · Male only
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jul 26, 2021 · Synced Jul 21, 2026, 6:46 AM EDT
Not listed Not applicable Interventional

Telephone Counseling to Enhance the Quality and Safety of Romantic and Sexual Relationships in People Living and Aging With HIV

NCT03004170
View directory record Official record
Conditions
HIV Seropositivity
Interventions
Telephone-Administered Motivational Interviewing Plus Behavioral Skills Training, Telephone-Administered Coping Effectiveness Training
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
50 Years and older
Enrollment
343 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 8, 2021 · Synced Jul 21, 2026, 6:46 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Evaluating a Digital Intervention to Improve Adolescent Condom Use and Communication

NCT06878755
View directory record Official record
Conditions
Condomless Sex, Sexual Assault
Interventions
Promoting Assertive Communication among Teens (PACT), Healthy Minds
Other
Lead sponsor
North Carolina Agriculture & Technical State University
Other
Eligibility
14 Years to 17 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Greensboro, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jul 21, 2026, 6:46 AM EDT
Terminated Not applicable Interventional

Targeting Non-virally Suppressed Adults With Alcohol Use Disorder in HIV Primary Care

NCT04280068
View directory record Official record
Conditions
Alcohol Dependence, HIV/AIDS
Interventions
Clinician Guide (CG), Clinician Guide plus HealthCall
Behavioral
Lead sponsor
Research Foundation for Mental Hygiene, Inc.
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Oct 8, 2020 · Synced Jul 21, 2026, 6:46 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Young Adult Education on Alcohol & Health

NCT05620849
View directory record Official record
Conditions
Sexual Behavior, Alcohol Drinking, Condomless Sex
Interventions
Online program
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 24 Years · Female only
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 8, 2024 · Synced Jul 21, 2026, 6:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Addressing Substance Use Through CVCT

NCT03125915
View directory record Official record
Conditions
Sex, Unsafe, Drug Use
Interventions
Communication skills training video, substance use module, Couples HIV Testing and Counseling
Behavioral
Lead sponsor
Hunter College of City University of New York
Other
Eligibility
18 Years to 60 Years · Male only
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 14, 2021 · Synced Jul 21, 2026, 6:46 AM EDT
Completed Phase 3 Interventional Results available

Safety and Efficacy of CDB-2914 for Emergency Contraception

NCT00411684
View directory record Official record
Conditions
Emergency Contraception
Interventions
CDB-2914
Drug
Lead sponsor
HRA Pharma
Industry
Eligibility
18 Years and older · Female only
Enrollment
1,623 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
17
States / cities
San Jose, California • Denver, Colorado • Miami, Florida + 14 more
Source: ClinicalTrials.gov public record
Updated Sep 20, 2021 · Synced Jul 21, 2026, 6:46 AM EDT
Completed No phase listed Observational

Quick Start of Highly Effective Contraception

NCT02076217
View directory record Official record
Conditions
IUD, Contraceptive Implant, Contraception, Birth Control, Emergency Contraception
Interventions
Copper T-380 IUD, LNG IUD, Contraceptive implant Nexplanon, Depo-Provera
Drug · Device
Lead sponsor
University of Utah
Other
Eligibility
15 Years to 45 Years · Female only
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
West Valley City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Jul 21, 2026, 6:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Protecting Our Future Generation: Promotion of Protective Sexual Health Practices Among Native American Youth and Young Adults Through an Assets-based Self-care Intervention

NCT03895320
View directory record Official record
Conditions
Sexual Behavior, Unprotected Sex, Gonorrhea, Chlamydia, Trichomonas, Sexually Transmitted Diseases, Adolescent Behavior, Self Evaluation
Interventions
Sexual Health Risk Assessment, Sexual Health Score, Sexual Health Messaging, Water SSB Quiz, Water SSB Score, Water SSB Messaging, STI Screening
Behavioral
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
14 Years to 26 Years
Enrollment
219 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Whiteriver, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 22, 2024 · Synced Jul 21, 2026, 6:46 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

NC Young Women's CoOp

NCT02965014
View directory record Official record
Conditions
Condomless Sex, Human Immunodeficiency Virus (HIV), Sexually Transmitted Infection (STI), Alcohol and Drug Use
Interventions
Face-to-Face Young Women's CoOp (YWC), mHealth Young Women's CoOp (YWC), HIV Counseling and Testing
Behavioral
Lead sponsor
RTI International
Other
Eligibility
18 Years to 25 Years · Female only
Enrollment
652 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
4
States / cities
Durham, North Carolina • Greensboro, North Carolina • High Point, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2025 · Synced Jul 21, 2026, 6:46 AM EDT
Completed Not applicable Interventional Results available

Health-E You: Reducing Unintended Pregnancies Among Hispanic Adolescents

NCT02847858
View directory record Official record
Conditions
Unprotected Sex, Unsafe Sex
Interventions
Health-E You: a computer-based intervention to improve the use of effective contraception among Hispanic adolescents
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
14 Years to 18 Years · Female only
Enrollment
1,360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 22, 2019 · Synced Jul 21, 2026, 6:46 AM EDT
Completed Not applicable Interventional Results available

Brief Interventions in the Emergency Department for Alcohol and HIV/Sexual Risk

NCT01351389
View directory record Official record
Conditions
Alcohol Consumption, Unsafe Sex
Interventions
Brief Motivational Intervention (BMI), Brief Advice
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 65 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
3
States / cities
Pawtucket, Rhode Island • Providence, Rhode Island • Warwick, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 18, 2025 · Synced Jul 21, 2026, 6:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Trial of an Adapted STD Screening and Risk Reduction Intervention

NCT02513225
View directory record Official record
Conditions
Alcohol Use, Drug Use, Diagnostic Self Evaluation, Gonorrhea, Unprotected Sex, Chlamydia, Trichomonas
Interventions
Project EMPWR, Optimized Standard Care (OSC)
Behavioral · Other
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
18 Years to 49 Years
Enrollment
350 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Fort Apache, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced Jul 21, 2026, 6:46 AM EDT
Completed No phase listed Observational

Evaluation of Implementation of the Phoenix PrEP (Pre-Exposure Prophylaxis) Access Project for Youth Aged 13-24

NCT03637322
View directory record Official record
Conditions
Unsafe Sex, IV Drug Usage
Interventions
Not listed
Lead sponsor
Phoenix Children's Hospital
Other
Eligibility
13 Years to 24 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 30, 2023 · Synced Jul 21, 2026, 6:46 AM EDT
Completed Not applicable Interventional

Reducing Unsafe Alcohol Use in HIV-Positive Individuals

NCT00371969
View directory record Official record
Conditions
Alcohol Abuse
Interventions
Enhanced Motivational Interview, Standard Motivational Interview or viewing DVD
Behavioral
Lead sponsor
Research Foundation for Mental Hygiene, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
254 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 29, 2015 · Synced Jul 21, 2026, 6:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Evaluation of Pulse: A Mobile Health App and Teen Pregnancy Prevention Program

NCT03253783
View directory record Official record
Conditions
Unprotected Sex, Contraceptive Usage, Reproductive and Sexual Health Care Utilization
Interventions
Pulse
Behavioral
Lead sponsor
Healthy Teen Network
Other
Eligibility
18 Years to 20 Years · Female only
Enrollment
1,304 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 22, 2018 · Synced Jul 21, 2026, 6:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Protect and Connect: Couple HIV Prevention for Drug Involved Male Offenders

NCT01690494
View directory record Official record
Conditions
Sexually Transmitted Diseases, Unsafe Sex, Substance-Related Disorders
Interventions
PACT, TAU
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
480 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 17, 2018 · Synced Jul 21, 2026, 6:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Couple-Based Relationship Strengthening HIV Intervention for Young Parents

NCT01643005
View directory record Official record
Conditions
HIV
Interventions
Relationship Strengthening HIV Prevention Intervention, Parenting Program Intervention
Behavioral
Lead sponsor
Yale University
Other
Eligibility
14 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2020
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 25, 2020 · Synced Jul 21, 2026, 6:46 AM EDT
Completed Phase 1 Interventional

Telephone-delivered Behavioral Interventions to Reduce Risky Sexual Behavior in HIV-positive Late Middle-age and Older Adults

NCT01499706
View directory record Official record
Conditions
Unsafe Sex
Interventions
1-session of telephone-administered motivational interviewing, 4-session telephone-administered motivational interviewing
Behavioral
Lead sponsor
Ohio University College of Osteopathic Medicine
Other
Eligibility
45 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 25, 2011 · Synced Jul 21, 2026, 6:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Respecting the Circle of Life on Pregnancy Prevention Outcomes Among American Indian Adolescents

NCT02904629
View directory record Official record
Conditions
Sex, Unprotected Sex, Contraception, Alcohol Use, Drug Use, Pregnancy
Interventions
Respecting the Circle of Life (RCL), Control Program
Behavioral · Other
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
11 Years and older
Enrollment
1,072 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Whiteriver, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 18, 2022 · Synced Jul 21, 2026, 6:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Proyecto SOL: A Risk Reduction Intervention for Hispanic Men Who Have Sex With Men (MSM)

NCT00690976
View directory record Official record
Conditions
HIV Infections
Interventions
Proyecto SOL, HCT
Behavioral
Lead sponsor
Centers for Disease Control and Prevention
Federal
Eligibility
18 Years to 49 Years · Male only
Enrollment
220 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Mar 10, 2010 · Synced Jul 21, 2026, 6:46 AM EDT