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Showing 1–24 of 84 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Usage of Prescription Opioids Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

Safety, Tolerability, and Pharmacokinetics of CSX-1004

NCT06005402
View directory record Official record
Conditions
Opioid Overdose, Opioid Use Disorder
Interventions
CSX-1004, Placebo
Biological
Lead sponsor
Cessation Therapeutics, Inc.
Industry
Eligibility
18 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Aug 20, 2024 · Synced Jul 23, 2026, 8:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

iSTART: A Campus & Community Initiative for Services in Tec-health

NCT05362357
View directory record Official record
Conditions
Substance Use, Binge Drinking, Marijuana Use, Alcohol Drinking, Prescription Opioid Misuse, Illicit Drug Use
Interventions
iSTART Web-app
Behavioral
Lead sponsor
California State University, Northridge
Other
Eligibility
18 Years to 30 Years
Enrollment
1,100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Northridge, California
Source: ClinicalTrials.gov public record
Updated Feb 6, 2024 · Synced Jul 23, 2026, 8:57 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk

NCT05657106
View directory record Official record
Conditions
Opioid-Related Disorders, Hepatitis C (HCV), Human Immunodeficiency Virus (HIV), Drug Overdose, Substance Abuse, Intravenous Drug Usage, Opiate Substitution Treatment, Sexually Transmitted Diseases
Interventions
Harm reduction kiosk
Behavioral
Lead sponsor
April M Young
Other
Eligibility
18 Years and older
Enrollment
752 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jul 23, 2026, 8:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Kentucky Communities and Researchers Engaging to Halt the Opioid Epidemic (CARE2HOPE)

NCT04134767
View directory record Official record
Conditions
Substance Use, HIV Infections, HCV Infection, Sexually Transmitted Infections (Not HIV or Hepatitis), Overdose, Drug, Opioid Use
Interventions
Health Linkage, Overdose Education
Behavioral
Lead sponsor
April M Young
Other
Eligibility
18 Years and older
Enrollment
234 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Dec 20, 2023 · Synced Jul 23, 2026, 8:57 PM EDT
Completed Not applicable Interventional Results available

Primary Care Intervention to Reduce Prescription Opioid Overdoses

NCT02464410
View directory record Official record
Conditions
Pain, Drug Overdose, Opioid Use Disorders
Interventions
Motivational intervention, Psycho-educational control, Long-term opioid therapy informed consent
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
299 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced Jul 23, 2026, 8:57 PM EDT
Completed Not applicable Interventional Results available

STandard Versus No Opioid Prescription After Prolapse and Anti-INcontinence Surgery Trial

NCT04491617
View directory record Official record
Conditions
Postoperative Pain, Opioid Use, Prolapse; Female, Incontinence
Interventions
Standard opioid prescribing, Restrictive opioid prescribing
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 23, 2025 · Synced Jul 23, 2026, 8:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Does Altering Narcotic Prescription Methods Affect Opioid Distribution Following Select Upper Extremity Surgeries?

NCT03570320
View directory record Official record
Conditions
Opioid Use
Interventions
Modification of opioid prescription method
Other
Lead sponsor
John Yanik
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 23, 2020 · Synced Jul 23, 2026, 8:57 PM EDT
Completed Not applicable Interventional

Recovery Initiation and Management After Overdose (RIMO) Experiment

NCT03895827
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Recovery Initiation and Management after Overdose (RIMO), Passive Referral to Treatment Control
Behavioral · Other
Lead sponsor
Chestnut Health Systems
Other
Eligibility
18 Years and older
Enrollment
251 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Jul 23, 2026, 8:57 PM EDT
Active, not recruiting Not applicable Interventional

Community-based Education, Navigation, and Support Intervention for Military Veterans

NCT05343169
View directory record Official record
Conditions
Overdose, Opioid Use Disorder, HIV Infections
Interventions
Overdose Education and Naloxone Distribution, Advanced Education in Safer Substance Use, Treatment, and Self-Care, Social Service and Health Navigation, Peer Social Support
Behavioral
Lead sponsor
New York University
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Jul 23, 2026, 8:57 PM EDT
Completed No phase listed Observational

Quantitative Xylazine Measurement in ED

NCT06949605
View directory record Official record
Conditions
Opioid Overdose, Substance Use Disorders
Interventions
Not listed
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Elmhurst, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Jul 23, 2026, 8:57 PM EDT
Completed Phase 4 Interventional Results available

Rapid Initiation of Drug Treatment Engagement

NCT03908437
View directory record Official record
Conditions
Opioid-use Disorder, Overdose
Interventions
buprenorphine/naloxone
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 2, 2024 · Synced Jul 23, 2026, 8:57 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Kentucky Women's Justice Community Overdose Innovation Network - Phase II

NCT07179614
View directory record Official record
Conditions
Overdose Risk, Opioid Use Disorder, Stimulant Use Disorders
Interventions
Overdose Prevention Intervention Package (OPIP)
Behavioral
Lead sponsor
Michele Staton
Other
Eligibility
18 Years and older · Female only
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Harlan, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Jul 23, 2026, 8:57 PM EDT
Completed Not applicable Interventional Results available

Expectations and Pain Control Advancement In surgeRy: The REPAIR Trial

NCT03726476
View directory record Official record
Conditions
Abuses Over-The-Counter/Prescription Medications, Pain, Postoperative, Opioid Use, Physical Activity, Patient Dependence on
Interventions
Patient centered pre-op education, routine preop education
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Enrollment
174 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
2
States / cities
Albuquerque, New Mexico • Rio Rancho, New Mexico
Source: ClinicalTrials.gov public record
Updated Jul 17, 2024 · Synced Jul 23, 2026, 8:57 PM EDT
Completed Not applicable Interventional

Program for Pain & Prescription Opioid Use in Pregnancy

NCT02804152
View directory record Official record
Conditions
Pain, Opioid Abuse, Pregnancy
Interventions
CBT for Chronic Pain in Pregnancy
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 5, 2022 · Synced Jul 23, 2026, 8:57 PM EDT
Recruiting Not applicable Interventional

The ENHANCE Project Toolkit

NCT07649278
View directory record Official record
Conditions
Substance Related Disorder, Drug Overdose, eHealth
Interventions
Connections mHealth Application
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Jul 23, 2026, 8:57 PM EDT
Completed No phase listed Observational Results available

User Acceptability of a Device-Based Opioid Overdose Intervention

NCT04530591
View directory record Official record
Conditions
Opioid Overdose, Opioid-use Disorder, Substance Use Disorders
Interventions
Survey, Interview
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years and older
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 6, 2021 · Synced Jul 23, 2026, 8:57 PM EDT
Completed Not applicable Interventional Results available

Opioid Use After Thyroid and Parathyroid Surgeries

NCT04955444
View directory record Official record
Conditions
Thyroidectomy, Parathyroidectomy, Opioid Use, Pain, Postoperative
Interventions
Quality improvement bundle
Other
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 4, 2023 · Synced Jul 23, 2026, 8:57 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Patient Reported Outcomes for Opioid Use Disorder

NCT03985163
View directory record Official record
Conditions
Opioid-use Disorder, Overdose of Opiate, Patient Participation
Interventions
Patient Reported Outcomes Electronic Survey
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 15, 2024 · Synced Jul 23, 2026, 8:57 PM EDT
Recruiting Not applicable Interventional

Machine-Learning Prediction and Reducing Overdoses With EHR Nudges

NCT06806163
View directory record Official record
Conditions
Opioid Overdose, Opioid Use, Opioid Use Disorder, Opioids
Interventions
EHR-Embedded Elevated-Risk Flag, EHR-Embedded Elevated-Risk Flag with Behavioral Nudges, Usual Care
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
1,350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Jul 23, 2026, 8:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Increasing Implementation of Post-Operative Opioid Prescribing Guidelines

NCT05358522
View directory record Official record
Conditions
Surgery, Opioid Use, Opioid Misuse, Prescription Opioid Misuse
Interventions
Opioid Prescribing Report Cards
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
Not listed
Enrollment
26,562 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 27, 2024 · Synced Jul 23, 2026, 8:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Opioid Prescribing Nudge

NCT04069403
View directory record Official record
Conditions
Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent), Prescription Drug Abuse and Dependency, Health Behavior, Benzodiazepine Abuse, Benzodiazepine Dependent
Interventions
Automated Reports on prescription patterns for their patients
Other
Lead sponsor
Duke University
Other
Eligibility
Not listed
Enrollment
427 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 29, 2020 · Synced Jul 23, 2026, 8:57 PM EDT
Not yet recruiting Phase 4 Interventional

A Bundled Intervention to End Opioid Overdoses

NCT07485335
View directory record Official record
Conditions
Opioid Use Disorder, Opioid Overdose
Interventions
Bundled intervention (Experimental), control group, Buprenorphine (Experimental), Scheduled Peer Support Specialist (Experimental), Telemedicine Buprenorphine Treatment
Other · Drug · Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Jul 23, 2026, 8:57 PM EDT
Not listed Not applicable Interventional

Using Mobile Devices for Neurofeedback to Reduce Opioid Use in Chronic Pain

NCT04838925
View directory record Official record
Conditions
Chronic Pain, Opioid Use
Interventions
Mobile Neurofeedback App
Device
Lead sponsor
CrossComm, Inc.
Industry
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 23, 2023 · Synced Jul 23, 2026, 8:57 PM EDT
Completed No phase listed Observational

Development of a Risk Prediction Screening Tool for Opioid-Prescription Injury (STOP Injury) in Older Adults Initiated on Opioids From the Emergency Department

NCT03836235
View directory record Official record
Conditions
Opioid Use
Interventions
Not listed
Lead sponsor
University of Florida
Other
Eligibility
50 Years to 120 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 13, 2020 · Synced Jul 23, 2026, 8:57 PM EDT