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Conditions: DFU, VLU, Surgical Wound, Wounds, Pressure Injuries
Interventions: cureVision cV; Diagnostic Test
Lead sponsor: Capsicure, LLC; Network
Eligibility: 22 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 5
States / cities: San Diego, California • Coral Gables, Florida • Miami, Florida + 1 more

Conditions: Venous Leg Ulcer
Interventions: TTAX01, Profore Compression Therapy, Cadexomer Iodine dressing; Biological · Other
Lead sponsor: BioTissue Holdings, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 6
States / cities: Carlsbad, California • Sylmar, California • North Chicago, Illinois + 3 more

Conditions: Venous Leg Ulcer, Venous Ulcer, Venous Stasis Ulcer, Venous Stasis, Wound Heal, Wound, Venous Insufficiency of Leg, Non-healing Wound
Interventions: TR987 0.1% gel + Standard of Care, Standard of care; Drug · Other
Lead sponsor: TR Therapeutics; Industry
Eligibility: 18 Years and older
Enrollment: 312 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 4
States / cities: Jacksonville, Florida • Clinton Twp, Michigan • Lake Success, New York + 1 more

Conditions: Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU), Pressure Ulcer (PU)
Interventions: dHPT, AIC; Biological
Lead sponsor: Cellution Biologics; Industry
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Venous Leg Ulcer, Venous Ulcer, Venous Stasis Ulcer, Venous Stasis, Wound Heal, Wounds, Venous Insufficiency of Leg, Non-healing Wound
Interventions: TR987 0.1% gel + Standard of Care, Standard of care; Drug · Other
Lead sponsor: TR Therapeutics; Industry
Eligibility: 18 Years and older
Enrollment: 312 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 33
States / cities: Tucson, Arizona • Castro Valley, California • Fresno, California + 27 more

Conditions: Non-Diabetic Patients, Wound Leg, Chronic Ulcer Leg/Foot
Interventions: Not listed
Lead sponsor: Chandan Sen; Other
Eligibility: 30 Years and older
Enrollment: 54 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2023
U.S. locations: 3
States / cities: Indianapolis, Indiana • Columbus, Ohio

Conditions: Wound, Foot, Diabetic Foot Ulcer (DFU), Venus Leg Ulcer
Interventions: Microlyte®, IP 1: Membrane Wrap - Hydro; Device
Lead sponsor: Capsicure, LLC; Network
Eligibility: 18 Years and older
Enrollment: 147 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 7
States / cities: San Diego, California • Coral Gables, Florida • Miami, Florida + 3 more

Conditions: Venous Leg Ulcer (VLU)
Interventions: Topical Wound Oxygen Therapy, Sham Control Topical Wound Oxygen; Device
Lead sponsor: AOTI Ltd.; Industry
Eligibility: 18 Years and older
Enrollment: 212 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: New York, New York

Conditions: Venous Ulcer of Leg
Interventions: IVUS, Continued Compression Therapy/Stockings; Diagnostic Test · Other
Lead sponsor: Philips Clinical & Medical Affairs Global; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 8
States / cities: Darien, Connecticut • Winter Park, Florida • Chicago, Illinois + 5 more

Conditions: Venous Leg Ulcer
Interventions: Varithena; Drug
Lead sponsor: Boston Scientific Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 76 participants
Timeline: 2017 – 2020
U.S. locations: 13
States / cities: Palo Alto, California • Sacramento, California • Darien, Connecticut + 10 more

Conditions: Venous Leg Ulcer (VLU)
Interventions: EscharEx (EX-03), Placebo (Gel vehicle); Drug
Lead sponsor: MediWound Ltd; Industry
Eligibility: 18 Years and older
Enrollment: 216 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 19
States / cities: Phoenix, Arizona • Fresno, California • Los Angeles, California + 15 more

Conditions: Venous Leg Ulcer, Venous Stasis, Venous Stasis Ulcer
Interventions: Human Autologous Homologous Skin Construct, Additional Outer Dressing Application, Fibracol Wound Dressing; Other
Lead sponsor: PolarityTE; Industry
Eligibility: 18 Years and older
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 2
States / cities: Martinsville, Virginia • Roanoke, Virginia

Conditions: Diabetic Foot Ulcer, Venous Leg Ulcer
Interventions: Amnion-Intermediate-Chorion, Amnion-Chorion-Amnion, Standard of Care; Other · Procedure
Lead sponsor: Cellution Biologics; Industry
Eligibility: 18 Years to 98 Years
Enrollment: 292 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 4
States / cities: Jacksonville, Florida • Cincinnati, Ohio • Weslaco, Texas + 1 more

Conditions: Venous Leg Ulcers
Interventions: NuShield®; Other
Lead sponsor: Organogenesis; Industry
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Pickerington, Ohio

Conditions: Determine Effectiveness of Theraskin in the Treatment of DFU and VLU
Interventions: Human Allograft (Theraskin); Other
Lead sponsor: Solsys Medical LLC; Industry
Eligibility: 18 Years and older
Enrollment: 188 participants
Timeline: 2003 – 2009
U.S. locations: 1
States / cities: Fairfax, Virginia

Conditions: Venous Leg Ulcer, Diabetic Foot Ulcer
Interventions: EscharEx (EX-02 formulation); Drug
Lead sponsor: MediWound Ltd; Industry
Eligibility: 18 Years to 90 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 3
States / cities: Tamarac, Florida • Las Vegas, Nevada • Chapel Hill, North Carolina

Conditions: Wounds and Injuries, Burns, Mohs Surgery, Diabetic Foot Ulcer Mixed, Venous Leg Ulcer, Non-healing Wound, Trauma Injury, Injury and Wounds, Degloving Injuries, Pressure Ulcers, Bedsores, Decubitus Ulcer
Interventions: Various types of wound care treatments; Combination Product
Lead sponsor: Siddhey LLC; Industry
Eligibility: 18 Years and older
Enrollment: 5,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2030
U.S. locations: 12
States / cities: Scottsdale, Arizona • Tempe, Arizona • Tucson, Arizona + 8 more

Conditions: Venous Insufficiency, Venous Reflux, Lower Extremity Ulcer
Interventions: MIST Therapy; Device
Lead sponsor: Celleration, Inc.; Industry
Eligibility: 18 Years to 90 Years
Enrollment: 156 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Weymouth, Massachusetts

Conditions: Diabetic Foot Ulcer, Venous Leg Ulcer
Interventions: PelloGraft, SanoGraft; Other
Lead sponsor: Surgenex; Industry
Eligibility: 18 Years and older
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 2
States / cities: Vista, California • Tulsa, Oklahoma

Conditions: Venous Leg Ulcers
Interventions: HP802-247, Vehicle; Biological
Lead sponsor: Healthpoint; Industry
Eligibility: 18 Years and older
Enrollment: 155 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 37
States / cities: Phoenix, Arizona • Carlsbad, California • Castro Valley, California + 32 more

Conditions: Ulcers
Interventions: MEBO Wound Ointment (MEBO), Standard of Care; Drug · Procedure
Lead sponsor: Skingenix, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 2
States / cities: Castro Valley, California • Miami, Florida

Conditions: Diabetic Foot Ulcer (DFU), Venous Leg Ulcer, Wound; Foot
Interventions: IP1: BioLab Membrane Wrap Lite IP2: BioLab Tri-Membrane Wrap, IP2: BioLab Tri-Membrane Wrap; Other
Lead sponsor: Capsicure, LLC; Network
Eligibility: 18 Years and older
Enrollment: 165 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 7
States / cities: Oxnard, California • Coral Gables, Florida • Miami, Florida + 4 more

Conditions: Diabetic Foot Ulcer, Venous Leg Ulcer
Interventions: Synthetic Hybrid-Scale Fiber Matrix, Standard of Care, Living Cellular Skin Substitute; Device
Lead sponsor: Acera Surgical, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 6
States / cities: Vista, California • Jacksonville, Florida • Miami Beach, Florida + 3 more

Conditions: Diabetic Foot Ulcer (DFU), Venous Leg Ulcers (VLUs), Pressure Ulcers, Bedsores, Decubitus Ulcer
Interventions: Not listed
Lead sponsor: Dynamic Medical Services dba Acesso Biologics; Industry
Eligibility: 18 Years and older
Enrollment: 2,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 2
States / cities: Novi, Michigan • Murfreesboro, Tennessee

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BIO-SEE: Bioburden Imaging Outcome Study for Equivalence Evaluation

Subjects With Non-Healing Venous Leg Ulcers Treated With Standard Care Plus Cryopreserved Human Umbilical Cord (TTAX01)

Tissue Repair Gel in Venous Leg Ulcers in AU/US

Evaluation of the Safety and Efficacy of Dehydrated Human Placenta Tissue (dHPT) for Wound Healing

Tissue Repair Gel in Venous Leg Ulcers (US)

Role of Tissue Oxygenation and the miR-210 Gene In Wound Healing

CAMPR-II RWE TRIAL: A Saline-hydrated Allogeneic Dual-layer Amniotic Membrane Product or a Synthetic, Resorbable Polymeric Wound Matrix to a Coarsened Exact Matched Retrospective Control Cohort of Hard to Heal DFUs and VLUs

Trial to Evaluate Cyclical Topical Wound Oxygen Therapy in the Treatment of Chronic Venous Leg Ulcers

Intravascular Ultrasound-Guided Intervention for Venous Leg Ulcers (IGuideU)

Effect of VarIthena on Wound Healing in Venous Leg Ulcers (VLU)

A Double Blind Study Performed to Evaluate the Efficacy and the Safety of EscharEx in Debridement of VLU (VALUE)

SkinTE® in the Treatment of Venous Leg Wounds

Study Evaluating Several CAMPs in Nonhealing Diabetic Foot and Venous Leg Ulcers

Clinical Trial Evaluating NuShield® Plus Standard of Care (SOC) Versus Standard of Care (SOC) Alone in the Management of Non-Healing Venous Leg Ulcers (VLUs)

Clinical Trial to Examine Effectiveness of a Human Allograft for Treatment of DFU and VLU

A Study to Evaluate the Clinical Performance, Safety and Pharmacology Effect of EscharEx in Patients With Lower Leg Ulcers

Clinical Registry Collecting Real World Evidence on Wound Care Treatments

Effects of Non Contact Low Frequency Ultrasound in Healing Venous Leg Ulcers

Study Assessing Complete Wound Healing by Comparing Surgenex® PelloGraft in Treating DFU and SanoGraft® in Treating VLU to SOC

Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers >12 cm2 to ≤ 36 cm2

A Clinical Study of the Safety and Efficacy of MEBO Wound Ointment in Subjects With Venous Leg Ulcers

CAMP RWE Trial: Amnion Grafts for Healing Hard-to-Heal Ulcers in RW Populations

Assessment of Wound Closure Comparing Synthetic Hybrid-Scale Fiber Matrix With Standard of Care in Treating Diabetic Foot Ulcers (DFU) and With Living Cellular Skin Substitute in Treating Venous Leg Ulcers (VLU)

HEAL-4: Real-World Effectiveness of 4 Amniotic Allografts Adjunctive to Standard Care in DFU, VLU, and PU