Independent directory Public ClinicalTrials.gov records United States
Clinical Trials Finder
Objective public record navigation
Search Results

Search by objective public record fields.

Search by query text, NCT ID, condition, intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, or age. Results are retrieved from ClinicalTrials.gov and synchronized into the directory. Search pages remain noindex by default.

Clear filters
ClinicalTrials.gov public records Last synced Sep 27, 2026, 5:02 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Valvular Heart Diseases Clear all
Not listed No phase listed Observational

Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study)

NCT01835028
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Echocardiography, Computed tomography, Magnetic resonance imaging, Blood biomarkers, Stress echocardiography
Other
Lead sponsor
Laval University
Other
Eligibility
21 Years to 90 Years
Enrollment
320 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2024
U.S. locations
2
States / cities
Rochester, Minnesota • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 20, 2021 · Synced Sep 27, 2026, 5:02 PM EDT
Not listed No phase listed Observational

Extended Ambulatory Monitoring Improves Risk Stratification in Hypertrophic Cardiomyopathy

NCT03182153
View directory record Official record
Conditions
Hypertrophic Cardiomyopathy
Interventions
Extended Cardiac Monitoring
Device
Lead sponsor
Atlantic Health System
Other
Eligibility
18 Years to 65 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Morristown, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 26, 2018 · Synced Sep 27, 2026, 5:02 PM EDT
Not listed Not applicable Interventional

Balloon vs. Self Expanding Transcatheter Valve for Degenerated Bioprosthesis

NCT04843072
View directory record Official record
Conditions
Valve Heart Disease
Interventions
Evolut R/PRO bioprosthesis, Edwards Sapien S3/Ultra bioprosthesis
Device
Lead sponsor
Erasmus Medical Center
Other
Eligibility
65 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 26, 2022 · Synced Sep 27, 2026, 5:02 PM EDT
Completed Not applicable Interventional Results available

The Medtronic TAVR 2.0 US Clinical Study

NCT02738853
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Medtronic Transcatheter Aortic Valve 2.0 Replacement System
Device
Lead sponsor
Medtronic Cardiovascular
Industry
Eligibility
Not listed
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
8
States / cities
New Haven, Connecticut • Kansas City, Kansas • Boston, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 20, 2023 · Synced Sep 27, 2026, 5:02 PM EDT
Completed Phase 2 Interventional

Use Of SB424323 With Aspirin In Non-Valvular Atrial Fibrillation In Patients At A Low Or Intermediate Risk For Stroke

NCT00240643
View directory record Official record
Conditions
Fibrillation, Atrial, Atrial Fibrillation
Interventions
SB424323
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 75 Years
Enrollment
640 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
9
States / cities
Mobile, Alabama • Troy, Michigan • Akron, Ohio + 6 more
Source: ClinicalTrials.gov public record
Updated Jan 15, 2017 · Synced Sep 27, 2026, 5:02 PM EDT
Recruiting Not applicable Interventional

Bicuspid Aortic Valve Replacement: Evaluation of Transcatheter Versus Surgery-Pilot Trial

NCT06817148
View directory record Official record
Conditions
Aortic Valve Stenosis, Bicuspid Aortic Valve
Interventions
transcatheter aortic valve replacement (TAVR), surgical aortic valve replacement (SAVR)
Procedure
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
50 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2037
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 9, 2025 · Synced Sep 27, 2026, 5:02 PM EDT
Completed Not applicable Interventional

Tricuspid Annuloplasty for Moderate Tricuspid Regurgitation Associated With Miral Operation

NCT01246947
View directory record Official record
Conditions
Cardiac Surgery, Tricuspid Valve Regurgitation
Interventions
Tricuspid valve repair, Mitral surgery alone
Procedure · Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 7, 2023 · Synced Sep 27, 2026, 5:02 PM EDT
Active, not recruiting No phase listed Observational

Perfusion Abnormalities in Hypertrophic Cardiomyopathy

NCT06599229
View directory record Official record
Conditions
Hypertrophic Cardiomyopathy (HCM)
Interventions
myocardial contrast echo
Diagnostic Test
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Sep 27, 2026, 5:02 PM EDT
Completed No phase listed Observational

Williams Syndrome (WS) and Supravalvar Aortic Stenosis (SVAS) DNA and Tissue Bank

NCT02706639
View directory record Official record
Conditions
Williams Syndrome, Supravalvular Aortic Stenosis, Cardiovascular Disease
Interventions
Not listed
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
1 Day to 85 Years
Enrollment
305 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
3
States / cities
Bethesda, Maryland • St Louis, Missouri • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 27, 2026, 5:02 PM EDT
Not listed Phase 1 Interventional

VIVID - Valvular and Ventricular Improvement Via iCoapsys Delivery - Feasibility Study

NCT00512005
View directory record Official record
Conditions
Mitral Valve Regurgitation, Left Ventricular Dysfunction, Heart Failure, Mitral Insufficiency, Mitral Incompetence, Ischemic Heart Disease
Interventions
Percutaneous mitral valve repair
Device
Lead sponsor
Myocor
Industry
Eligibility
18 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
4
States / cities
Atlanta, Georgia • Evanston, Illinois • Shawnee Mission, Kansas + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 23, 2009 · Synced Sep 27, 2026, 5:02 PM EDT
Completed No phase listed Observational Results available

The Comparative Safety and Effectiveness of Dabigatran, Versus Rivaroxaban, and Apixaban Utilized in the Department of Defense Non-Valvular Atrial Fibrillation Patient Population: A Retrospective Database Analysis

NCT03026556
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Dabigatran vs. Rivaroxaban, Dabigatran vs. Apixaban
Drug
Lead sponsor
Boehringer Ingelheim
Industry
Eligibility
18 Years and older
Enrollment
42,534 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Princeton, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 2, 2019 · Synced Sep 27, 2026, 5:02 PM EDT
Recruiting No phase listed Observational

Integration of Telemedicine and Home-Based Cardiac Rehabilitation: Feasibility, Efficacy, and Adherence

NCT05972070
View directory record Official record
Conditions
Myocardial Infarction, Percutaneous Transluminal Coronary Angioplasty, Coronary Artery Bypass, Stable Angina, Heart Failure, Valve Disease, Heart, Cardiac Rehabilitation, Stent
Interventions
ROMTech Portable Connect
Device
Lead sponsor
ROM Technologies, INC
Industry
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Brookfield, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Sep 27, 2026, 5:02 PM EDT
Recruiting Not applicable Interventional

ATLAS (AltaValve) Pivotal Trial

NCT06465745
View directory record Official record
Conditions
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence
Interventions
AltaValve System.
Device
Lead sponsor
4C Medical Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2031
U.S. locations
36
States / cities
Phoenix, Arizona • Tucson, Arizona • La Jolla, California + 30 more
Source: ClinicalTrials.gov public record
Updated Aug 2, 2026 · Synced Sep 27, 2026, 5:02 PM EDT
Recruiting Not applicable Interventional

Study of the Clinical Impact of Surgical Correction of Tricuspid Insufficiency in Implantable LVAD Patients

NCT02537769
View directory record Official record
Conditions
Tricuspid Regurgitation, Heart Failure NYHA Class III, Heart Failure NYHA Class IV
Interventions
Left ventricular assist device (LVAD), Tricuspid Valve Repair (TVR)
Device · Procedure
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 22, 2021 · Synced Sep 27, 2026, 5:02 PM EDT
Active, not recruiting Not applicable Interventional Results available

PERIGON Pivotal Trial

NCT02088554
View directory record Official record
Conditions
Aortic Stenosis
Interventions
Model 400 aortic valve bioprosthesis
Device
Lead sponsor
Medtronic Cardiac Surgery
Industry
Eligibility
18 Years and older
Enrollment
1,312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2035
U.S. locations
20
States / cities
Los Angeles, California • Aurora, Colorado • Hartford, Connecticut + 16 more
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Sep 27, 2026, 5:02 PM EDT
Active, not recruiting No phase listed Observational

Post Market Clinical Follow-Up Study in Patients Treated With the On-X Ascending Aortic Prosthesis (AAP)

NCT05082454
View directory record Official record
Conditions
Aortic Valve Disease
Interventions
Open repair
Device
Lead sponsor
JOTEC GmbH
Industry
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2029
U.S. locations
3
States / cities
Danville, Pennsylvania • Houston, Texas • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 4, 2025 · Synced Sep 27, 2026, 5:02 PM EDT
Recruiting No phase listed Observational

Effect of Fetal Aortic Valvuloplasty on Outcomes

NCT05386173
View directory record Official record
Conditions
Congenital Heart Disease, Aortic Valve Stenosis, Fetal Cardiac Disorder, Hypoplastic Left Heart Syndrome
Interventions
Fetal aortic balloon dilatation
Procedure
Lead sponsor
Queen Silvia Children's Hospital, Gothenburg, Sweden
Other
Eligibility
23 Weeks to 31 Weeks
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2029
U.S. locations
2
States / cities
San Francisco, California • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Sep 27, 2026, 5:02 PM EDT
Recruiting No phase listed Observational

Cardiovascular Multimodality Imaging Study

NCT06610019
View directory record Official record
Conditions
Non-ischemic Cardiomyopathy, Cardiomyopathies, Hypertrophic Cardiomyopathy, Right Ventricular Arrhythmogenic Cardiomyopathy, Cardiac Amyloidosis, Anderson Fabry Disease, Sarcoidosis, Cancer Therapy-related Cardiac Dysfunction, Ventricular Arrythmia, Heart Failure
Interventions
Not listed
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
10,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2031
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 9, 2026 · Synced Sep 27, 2026, 5:02 PM EDT
Recruiting No phase listed Observational

Abbott Structural Heart Device Registry

NCT06590467
View directory record Official record
Conditions
Heart Diseases, ASD - Atrial Septal Defect, VSD - Muscular Ventricular Septal Defect, PFO - Patent Foramen Ovale, PIVSD - Post Infarct Muscular Ventricular Septal Defect, Valvular Heart Disease
Interventions
Amplatzer™ Occlusion Devices, Epic™ Surgical Tissue Heart Valve devices
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
Not listed
Enrollment
2,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2039
U.S. locations
13
States / cities
Los Angeles, California • Washington D.C., District of Columbia • Miami, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 27, 2026, 5:02 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Association of Insulin Resistance and FGF21 on Cardiac Function in Pediatric Dilated Cardiomyopathy

NCT04222101
View directory record Official record
Conditions
Cardiomyopathy, Dilated, Cardiomyopathy, Hypertrophic, Insulin Resistance
Interventions
Oral glucose tolerance test
Diagnostic Test
Lead sponsor
Le Bonheur Children's Hospital
Other
Eligibility
13 Years to 18 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 19, 2021 · Synced Sep 27, 2026, 5:02 PM EDT
Terminated No phase listed Observational

Three Dimensional Imaging and Wireless Technologies to Enhance Medical Care in Space

NCT00598767
View directory record Official record
Conditions
Aortic Valve Insufficiency, Aortic Stenosis
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 27, 2026, 5:02 PM EDT
Recruiting Not applicable Interventional

Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

NCT04097145
View directory record Official record
Conditions
Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease
Interventions
Edwards PASCAL System, Optimal Medical Therapy
Device · Drug
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
1,270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2031
U.S. locations
73
States / cities
Phoenix, Arizona • Tucson, Arizona • Irvine, California + 59 more
Source: ClinicalTrials.gov public record
Updated Sep 13, 2026 · Synced Sep 27, 2026, 5:02 PM EDT
Recruiting Phase 1 Interventional

The HALT Biomarker Study

NCT04552275
View directory record Official record
Conditions
Aortic Stenosis, Hypo-attenuated Leaflet Thickening, Bioprosthetic Valve Degeneration
Interventions
Proteomics Analysis
Diagnostic Test
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
65 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2035
U.S. locations
3
States / cities
Boston, Massachusetts • Minneapolis, Minnesota • Manchester, New Hampshire
Source: ClinicalTrials.gov public record
Updated Nov 9, 2021 · Synced Sep 27, 2026, 5:02 PM EDT
Completed No phase listed Observational

Prospective Balloon Aortic Valvuloplasty

NCT02122900
View directory record Official record
Conditions
Aortic Stenosis
Interventions
Not listed
Lead sponsor
Baylor Research Institute
Other
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
2
States / cities
Dallas, Texas • Plano, Texas
Source: ClinicalTrials.gov public record
Updated Jun 11, 2017 · Synced Sep 27, 2026, 5:02 PM EDT