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ClinicalTrials.gov public records Last synced Oct 19, 2026, 4:17 PM EDT

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Showing 73–96 of 305 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Vaping Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Quit Nicotine: E-Cig Cessation Intervention

NCT04898075
View directory record Official record
Conditions
E-Cig Use
Interventions
Remote Contingency Management (CM) for nicotine abstinence, Control
Behavioral · Other
Lead sponsor
Yale University
Other
Eligibility
13 Years to 20 Years
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 10, 2025 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Potential Effects of Electronic Nicotine Delivery System Flavor Regulations on African American Menthol Smokers

NCT05023096
View directory record Official record
Conditions
Electronic Nicotine Delivery System Flavors
Interventions
Tobacco product administration and assessment
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years and older
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Oct 19, 2026, 4:17 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Secondhand Effects of Hookah (i.e., Waterpipe) Smoke and Aerosol

NCT04661683
View directory record Official record
Conditions
Hookah Smoking, Secondhand Aerosol, Vascular Stiffness, Vaping
Interventions
Combustible Hookah Smoke, Electronic Hookah Aerosol, Clean Room Air
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 49 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Exploratory Study of Switching From Combustible Cigarettes to the BIDI E-cigarette

NCT05855343
View directory record Official record
Conditions
Smoking Cessation
Interventions
BIDI Stick e-cigarette
Other
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 19, 2024 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use Behavior, Nicotine Uptake, and Subjective Effects Comparison of Tobacco and Menthol e-Liquids by ENDS Consumers

NCT05134415
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
RELX ENDS Tobacco Flavor 1, RELX ENDS Tobacco Flavor 2, RELX ENDS Menthol Flavor 1, RELX ENDS Menthol Flavor 2
Other
Lead sponsor
Cheerain HK Limited
Industry
Eligibility
22 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Burbank, California
Source: ClinicalTrials.gov public record
Updated Dec 13, 2021 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Not applicable Interventional

Influencer Marketing: a Survey-based Experiment

NCT06433466
View directory record Official record
Conditions
Vaping
Interventions
Videos featuring influencers promoting e-cigarettes alongside healthy lifestyle activities
Other
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 24 Years
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 29, 2024 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Developing E-liquid Product Standards (Sweet Spot Study)

NCT05864586
View directory record Official record
Conditions
Nicotine, Nicotine Vaping, E-cigarette Use
Interventions
Vaping study EC A, Vaping study EC B, Vaping study EC C, Vaping study EC D, Vaping study EC E, Vaping study EC F, Vaping study EC G, Vaping study EC H, Vaping study EC I, Vaping study EC J
Behavioral
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 50 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 10, 2025 · Synced Oct 19, 2026, 4:17 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

A Virtual Reality E-cigarette Prevention and Emotion Regulation Intervention for Adolescents

NCT07460622
View directory record Official record
Conditions
E-cigarette Use/Vaping Prevention, Nicotine Dependence Prevention, Adolescent Mental Health
Interventions
Virtual Reality E-Cigarette Prevention Program
Behavioral
Lead sponsor
Yale University
Other
Eligibility
11 Years to 15 Years
Enrollment
1,251 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Short-Term Cardiovascular Effects of E-Cigarettes: Influence of E-Liquid pH

NCT04449510
View directory record Official record
Conditions
Cardiovascular Risk Factor, Nicotine Dependence
Interventions
Electronic Cigarette
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 70 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 15, 2025 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Not applicable Interventional

Social Media Vaping Cessation Pilot With Peer Mentors

NCT07437196
View directory record Official record
Conditions
Vaping, Social Support
Interventions
Quit the Hit (QTH) Program with Peer Mentoring
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
13 Years to 29 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Understanding the Impact of Cartridge-Based Electronic Cigarettes and Generated Aerosols on Cardiopulmonary Health

NCT05199480
View directory record Official record
Conditions
E-Cig Use
Interventions
Tobacco flavored liquid type 1, Tobacco flavored liquid type 2
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years and older
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 1, 2025 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dual Use of ENDS and Combustible Cigarettes

NCT05280535
View directory record Official record
Conditions
Smoking, Cigarette, Electronic Cigarette Use
Interventions
Cue Reactivity Task, Computerized Visual Dot Probe, Choice Task
Behavioral
Lead sponsor
Brown University
Other
Eligibility
21 Years to 34 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 18, 2025 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluating New Nicotine Standards for Cigarettes - Project 3

NCT03194256
View directory record Official record
Conditions
Smoking, Cigarette, Electronic Cigarettes
Interventions
Spectrum Research Cigarettes
Behavioral
Lead sponsor
Brown University
Other
Eligibility
15 Years to 20 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 18, 2023 · Synced Oct 19, 2026, 4:17 PM EDT
Recruiting Not applicable Interventional

Vaping and Smoking Project in People With Schizophrenia

NCT06944847
View directory record Official record
Conditions
Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)
Interventions
Acute (24-hour) abstinence, Ad libitum smoking/vaping
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
21 Years to 50 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Phase 4 Interventional Results available

The END Perioperative Smoking Pilot Study

NCT02482233
View directory record Official record
Conditions
Smoking, Nicotine Addiction, Surgery
Interventions
ENDD (NJOY), NRT (NicoDerm CQ), telephone counseling, brief advice, brochure
Behavioral · Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 9, 2022 · Synced Oct 19, 2026, 4:17 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Evaluation of Acute and Subacute Effects of Nicotine Free Electronic Cigarette(NCFE) Vapors

NCT02585791
View directory record Official record
Conditions
Healthy Lifetime Non-smokers
Interventions
Propylene Glycol, vegetable glycerin, PG+VG
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jan 14, 2020 · Synced Oct 19, 2026, 4:17 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Nicotine Regulation for Dual Users of E-cigarettes and Cigarettes

NCT06614504
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Varying the nicotine content of cigarettes, Varying the nicotine content of e-cigarettes
Other
Lead sponsor
University of Vermont
Other
Eligibility
21 Years and older
Enrollment
308 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
2
States / cities
Providence, Rhode Island • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jun 27, 2025 · Synced Oct 19, 2026, 4:17 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

A Text Messaging Trial to Test Vaping Health Messages Optimized to Young Adults' Vaping Status

NCT07038317
View directory record Official record
Conditions
Vaping Behaviors, Message Exposure, Young Adults
Interventions
Intervention, Control
Other
Lead sponsor
University of Hawaii
Other
Eligibility
18 Years to 24 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Honolulu, Hawaii
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 19, 2026, 4:17 PM EDT
Recruiting Not applicable Interventional

Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy

NCT06948058
View directory record Official record
Conditions
Smoking Cessation, Obesity and Obesity-related Medical Conditions
Interventions
Electronic Cigarettes (EC), Nicotine replacement therapy (NRT)
Other
Lead sponsor
Brown University
Other
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of e-Cigarettes on Perceptions and Behavior - Substudy 2

NCT05958966
View directory record Official record
Conditions
Electronic Cigarette Use, E-Cig Use, Cigarette Smoking, Cigarette Use, Electronic
Interventions
E-cigarette e-liquid self-administration
Other
Lead sponsor
University of Southern California
Other
Eligibility
21 Years and older
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 25, 2023 · Synced Oct 19, 2026, 4:17 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Survey to Test the Nicotine Concentration and Nicotine Flux Labels for E-cigarettes

NCT07553585
View directory record Official record
Conditions
Nicotine Labeling for E-cigarettes
Interventions
Updated Labeling
Other
Lead sponsor
Yale University
Other
Eligibility
14 Years and older
Enrollment
2,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Not applicable Interventional Results available

Incentive-based and Media Literacy Informed Approaches to Improve Vaping Cessation

NCT05586308
View directory record Official record
Conditions
Behavior, Health Risk, Implementation Science, E Cigarette Use, Cessation, Smoking, Incentives, Engagement, Patient, Peer Support, Media Literacy
Interventions
Text-massaging suport, Financial incentive, Media literacy
Behavioral
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 29 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Oct 19, 2026, 4:17 PM EDT
Terminated No phase listed Observational

Adolescent Vaping Characterization and Parent Views on Adolescent Vaping Protocol

NCT05669716
View directory record Official record
Conditions
Healthy Volunteers, Vaping Teens
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
13 Years to 120 Years
Enrollment
726 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Oct 19, 2026, 4:17 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Electronic Cigarettes or Nicotine Inhaler for Smoking Cessation

NCT02004171
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
electronic cigarette, nicotine inhaler
Other · Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 60 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 19, 2016 · Synced Oct 19, 2026, 4:17 PM EDT