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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Varicose Ulcer Clear all
Completed Phase 1Phase 2 Interventional Results available

Evaluation of Safety and Activity of Celaderm in Healing Venous Leg Ulcers

NCT00399308
View directory record Official record
Conditions
Leg Ulcer, Varicose Ulcer
Interventions
Celaderm (Frozen Cultured Epidermal Allograft), Control (compression bandaging)
Device
Lead sponsor
Shire
Industry
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
9
States / cities
Tamarac, Florida • Niles, Illinois • Boston, Massachusetts + 6 more
Source: ClinicalTrials.gov public record
Updated Jun 10, 2021 · Synced Sep 24, 2026, 3:14 AM EDT
Completed Not applicable Interventional Results available

Clinical Study to Compare 3 Multi-Layered Foam Dressings for the Management of Chronic Wounds

NCT03662997
View directory record Official record
Conditions
Chronic Wound, Venous Leg Ulcer, Diabetic Foot Ulcer
Interventions
Bordered Five-Layer Foam Dressing, Hydropolymer Foam Dressing, Hydrocellular Multi-Layer Foam Dressing
Device
Lead sponsor
Molnlycke Health Care AB
Industry
Eligibility
18 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
5
States / cities
Castro Valley, California • San Francisco, California • Newark, New Jersey + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 31, 2021 · Synced Sep 24, 2026, 3:14 AM EDT
Recruiting Not applicable Interventional

INNOVEN: Efficacy of Porcine Placental Extracellular Matrix Plus Standard of Care (SOC) Versus SOC Alone

NCT06606210
View directory record Official record
Conditions
Wound Heal, Venous Leg Ulcer
Interventions
InnovaMatrix® AC
Device
Lead sponsor
ConvaTec Inc.
Industry
Eligibility
21 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
North Port, Florida
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Sep 24, 2026, 3:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of XCell on Autolytic Debridement of Venous Ulcers

NCT00446823
View directory record Official record
Conditions
Venous Ulcer
Interventions
XCell cellulose wound dressing, Impregnated gauze dressing
Device
Lead sponsor
Xylos Corporation
Industry
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2003
U.S. locations
3
States / cities
Boston, Massachusetts • The Bronx, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 12, 2007 · Synced Sep 24, 2026, 3:14 AM EDT
Recruiting Not applicable Interventional

A Clinical Investigation to Follow the Progress of Exuding Chronic Venous Leg Ulcers Using a Non-Bordered Foam Dressing

NCT05608317
View directory record Official record
Conditions
Wounds, Wound of Skin, Wound Leg, Venous Leg Ulcer
Interventions
ALLEVYN Non-Adhesive
Device
Lead sponsor
Molnlycke Health Care AB
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
3
States / cities
San Francisco, California • Miami, Florida • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 5, 2024 · Synced Sep 24, 2026, 3:14 AM EDT
Completed Phase 1 Interventional

Preliminary Testing of New Treatment for Chronic Leg Wounds

NCT00000431
View directory record Official record
Conditions
Varicose Ulcer
Interventions
PDGF-B/Ad5
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 90 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 12, 2013 · Synced Sep 24, 2026, 3:14 AM EDT
Withdrawn Not applicable Interventional

Compliance of Compression Therapy in Healed Venous Ulcerations

NCT01680809
View directory record Official record
Conditions
Venous Insufficiency
Interventions
Compression stocking 15-20mmHg, Compression stocking 20-30mmHg
Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Richmond Heights, Ohio
Source: ClinicalTrials.gov public record
Updated May 16, 2022 · Synced Sep 24, 2026, 3:14 AM EDT
Terminated Not applicable Interventional Results available

VLU Non-Inferiority Study Comparing a Dual Action Pneumatic Compression Device to Multi-Layer Bandaging

NCT02680834
View directory record Official record
Conditions
Venous Leg Ulcer
Interventions
Dual Action Pneumatic Compression Device, Multi-Layer Bandaging
Device
Lead sponsor
Tactile Medical
Industry
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
18
States / cities
Phoenix, Arizona • Tucson, Arizona • Carlsbad, California + 12 more
Source: ClinicalTrials.gov public record
Updated Feb 18, 2020 · Synced Sep 24, 2026, 3:14 AM EDT
Terminated Not applicable Interventional Results available

Efficacy Study of the Application of Low Level Laser Light to Treat Venous Stasis Ulcers

NCT01376050
View directory record Official record
Conditions
Venous Stasis Ulcer
Interventions
Erchonia ML Scanner (MLS), Placebo Laser
Device
Lead sponsor
Erchonia Corporation
Industry
Eligibility
40 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 10, 2015 · Synced Sep 24, 2026, 3:14 AM EDT
Withdrawn Not applicable Interventional

Clinical Evaluation of the SNaP Wound Care System

NCT01113658
View directory record Official record
Conditions
Acute and Chronic Wounds, Pressure Ulcers, Trauma Wounds, Diabetic Foot Ulcers, Venous Stasis Ulcers
Interventions
SNaP Wound Care System
Device
Lead sponsor
3M
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
2
States / cities
Daly City, California
Source: ClinicalTrials.gov public record
Updated Jul 31, 2022 · Synced Sep 24, 2026, 3:14 AM EDT
Completed Not applicable Interventional

Physical Activity Interventions for Leg Ulcer Patients

NCT02632695
View directory record Official record
Conditions
Leg Ulcers, Venous Ulcers, Varicose Ulcers
Interventions
FOOTFIT
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
55 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Spartanburg, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 6, 2018 · Synced Sep 24, 2026, 3:14 AM EDT
Enrolling by invitation Not applicable Interventional

A Modified Platform Trial of Multiple CAMPs for the Management of Diabetic Foot Ulcers and Venous Leg Ulcers

NCT06453187
View directory record Official record
Conditions
Diabetic Foot Ulcer, Venous Leg Ulcer
Interventions
Urinary Bladder Matrix (UBM) sheet device for Venous Leg Ulcers, Urinary Bladder Matrix (UBM) sheet device for Diabetic Foot Ulcers, AmnioExcel Plus for Venous Leg Ulcers, AmnioExcel Plus for Diabetic Foot Ulcers, Standard of Care
Device · Procedure
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
18 Years to 80 Years
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
13
States / cities
Los Angeles, California • San Francisco, California • Vista, California + 9 more
Source: ClinicalTrials.gov public record
Updated Jul 26, 2026 · Synced Sep 24, 2026, 3:14 AM EDT
Suspended Not applicable Interventional

Effect of Hyaluronic Acid ECM on Venous Ulcers

NCT02930499
View directory record Official record
Conditions
Venous Ulcers
Interventions
Hyalomatrix extra-cellular matrix, Mepilex wound dressing
Device
Lead sponsor
Calvary Hospital, Bronx, NY
Other
Eligibility
21 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 29, 2017 · Synced Sep 24, 2026, 3:14 AM EDT
Terminated Phase 2 Interventional Results available

Safety and Efficacy of Gaseous Nitric Oxide on Venous Stasis Leg Ulcers

NCT00545298
View directory record Official record
Conditions
Venous Ulcers
Interventions
Nitric Oxide - same dose 6 wks, Nitric Oxide modified treatment
Drug
Lead sponsor
Nitric BioTherapeutics, Inc
Industry
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 18, 2012 · Synced Sep 24, 2026, 3:14 AM EDT
Recruiting Not applicable Interventional

Prospective Case Series Evaluating the Efficacy and Safety of NeoThelium FT for Venous Leg Ulcers

NCT07061613
View directory record Official record
Conditions
Venous Leg Ulcer
Interventions
NeoThelium FT (HCT/P 361)
Other
Lead sponsor
NuScience Medical Biologics, LLC
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Metairie, Louisiana • Slidell, Louisiana
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 24, 2026, 3:14 AM EDT
Not listed Not applicable Interventional

Outcomes of Sclerotherapy of the Ulcer Bed Compared to a Combination of Ablation and Injections

NCT05633277
View directory record Official record
Conditions
Venous Reflux, Venous Insufficiency, Venous Ulcer, Venous Disease
Interventions
Polidocanol
Procedure
Lead sponsor
ProMedica Health System
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 30, 2022 · Synced Sep 24, 2026, 3:14 AM EDT
Completed Not applicable Interventional Results available

Developing Strategies for Effective Debridement in Patients for Venous Leg Ulcers

NCT03796793
View directory record Official record
Conditions
Venous Leg Ulcer
Interventions
Wound Edge Debridement, Standard of Care Treatment
Procedure · Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 24, 2026, 3:14 AM EDT
Not listed Not applicable Interventional

Amnioband and Standard of Care vs. Standard of Care Alone in the Treatment of Venous Leg Ulcers

NCT02609594
View directory record Official record
Conditions
Venous Leg Ulcers
Interventions
Weekly application of Amnioband, Biweekly application of Amnioband, Standard of Care
Other
Lead sponsor
SerenaGroup, Inc.
Network
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
8
States / cities
Boston, Massachusetts • Brick, New Jersey • Elmer, New Jersey + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 6, 2018 · Synced Sep 24, 2026, 3:14 AM EDT
Terminated Not applicable Interventional Results available

Assessment of Wound Closure Comparing Synthetic Hybrid-Scale Fiber Matrix With Standard of Care in Treating Diabetic Foot Ulcers (DFU) and With Living Cellular Skin Substitute in Treating Venous Leg Ulcers (VLU)

NCT04927702
View directory record Official record
Conditions
Diabetic Foot Ulcer, Venous Leg Ulcer
Interventions
Synthetic Hybrid-Scale Fiber Matrix, Standard of Care, Living Cellular Skin Substitute
Device
Lead sponsor
Acera Surgical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
6
States / cities
Vista, California • Jacksonville, Florida • Miami Beach, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 24, 2026, 3:14 AM EDT
Completed Not applicable Interventional Results available

Effect of Intermittent Pneumatic Compression on Ulcer Healing in Subjects With Secondary Lymphedema

NCT01079299
View directory record Official record
Conditions
Lymphedema
Interventions
Intermittent, gradient, pneumatic compression device
Device
Lead sponsor
Calvary Hospital, Bronx, NY
Other
Eligibility
21 Years to 95 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 9, 2012 · Synced Sep 24, 2026, 3:14 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Efficacy and Safety of Artacent™ for Treatment Resistant Lower Extremity Venous and Diabetic Ulcers

NCT02838784
View directory record Official record
Conditions
Venous Ulcer, Foot Ulcer, Diabetic
Interventions
Artacent Human Amniotic Membrane, Standard of Care
Other · Procedure
Lead sponsor
Tides Medical
Industry
Eligibility
18 Years and older
Enrollment
134 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
7
States / cities
Arcadia, California • New Iberia, Louisiana • New Orleans, Louisiana + 4 more
Source: ClinicalTrials.gov public record
Updated Oct 12, 2017 · Synced Sep 24, 2026, 3:14 AM EDT
Completed Phase 1Phase 2 Interventional

Cooling Lower Leg Skin to Prevent Venous Leg Ulcers in Patients With Poor Vein Circulation

NCT01509599
View directory record Official record
Conditions
Venous Disease, Venous Vascular Diseases and Syndromes, Venous Insufficiency, Venous Ulcers
Interventions
Cryotherapy: Cooling gel wrap, Usual care
Procedure
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
197 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
2
States / cities
Charleston, South Carolina • Spartanburg, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 4, 2016 · Synced Sep 24, 2026, 3:14 AM EDT
Terminated Phase 2 Interventional Results available

A Phase 2 Exploratory Pharmacodynamic Study of HP802-247 in Venous Leg Ulcers

NCT02154087
View directory record Official record
Conditions
Venous Leg Ulcers
Interventions
HP802-247
Biological
Lead sponsor
Healthpoint
Industry
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 2, 2016 · Synced Sep 24, 2026, 3:14 AM EDT
Not listed No phase listed Observational

Negative Pressure Wound Therapy Registry

NCT02467998
View directory record Official record
Conditions
Diabetic Foot Ulcers, Venous Stasis Ulcer, Pressure Ulcer, Surgical Wound Dehiscence, Burns, Other Types of Chronic Non Healing Wounds
Interventions
NPWT
Device
Lead sponsor
U.S. Wound Registry
Other
Eligibility
Not listed
Enrollment
50,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2005
U.S. locations
1
States / cities
The Woodlands, Texas
Source: ClinicalTrials.gov public record
Updated Apr 30, 2018 · Synced Sep 24, 2026, 3:14 AM EDT