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ClinicalTrials.gov public records Last synced Oct 4, 2026, 12:56 PM EDT

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Showing 73–96 of 157 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Varicose Veins Leg Clear all
Completed No phase listed Observational Accepts healthy volunteers

Obtaining and Storing Standard of Care Wound Biopsies for Immediate or Future Wound-Related Scientific Study

NCT00759889
View directory record Official record
Conditions
Diabetic Foot, Leg Ulcer, Decubitus Ulcer
Interventions
Not listed
Lead sponsor
Southwest Regional Wound Care Center
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2018
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Jan 14, 2019 · Synced Oct 4, 2026, 12:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of XCell on Autolytic Debridement of Venous Ulcers

NCT00446823
View directory record Official record
Conditions
Venous Ulcer
Interventions
XCell cellulose wound dressing, Impregnated gauze dressing
Device
Lead sponsor
Xylos Corporation
Industry
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2003
U.S. locations
3
States / cities
Boston, Massachusetts • The Bronx, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 13, 2007 · Synced Oct 4, 2026, 12:56 PM EDT
Recruiting Phase 4 Interventional

Evaluating Several Cellular, Acellular, and Matrix-like Products (CAMPs) and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot and Venous Leg Ulcers.

NCT06826339
View directory record Official record
Conditions
Venous Leg Ulcer, Venous Leg, Diabetic Foot, Diabetic Foot Ulcer, Foot Ulcer, Diabetic, Ulcer Foot, Leg Ulcer, Ulcer Venous, Ulcer
Interventions
ACApatch™, caregraFT™, Standard of Care
Other
Lead sponsor
Tiger Biosciences, LLC.
Industry
Eligibility
21 Years and older
Enrollment
340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Monroeville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 22, 2026 · Synced Oct 4, 2026, 12:56 PM EDT
Terminated Not applicable Interventional Results available

Intravascular Ultrasound-Guided Intervention for Venous Leg Ulcers (IGuideU)

NCT04696354
View directory record Official record
Conditions
Venous Ulcer of Leg
Interventions
IVUS, Continued Compression Therapy/Stockings
Diagnostic Test · Other
Lead sponsor
Philips Clinical & Medical Affairs Global
Industry
Eligibility
18 Years to 85 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
8
States / cities
Darien, Connecticut • Winter Park, Florida • Chicago, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Oct 4, 2026, 12:56 PM EDT
Active, not recruiting No phase listed Observational

Observational Study to Investigate the Use of Sterilized Porcine Placental Tissue in the Treatment of Chronic VLU

NCT06400875
View directory record Official record
Conditions
Ulcer Venous, Wound Heal
Interventions
InnovaMatrix® AC Sterilized, Porcine Placental Extracellular Matrix (ECM)
Device
Lead sponsor
ConvaTec Inc.
Industry
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 29, 2025 · Synced Oct 4, 2026, 12:56 PM EDT
Withdrawn Not applicable Interventional

Efficacy of Vasculera in Prevention on Post-op Pain and Edema Following Lower Extremity Venous Treatment in the Outpatient Setting

NCT02936271
View directory record Official record
Conditions
Venous Insufficiency of Leg, Venous Reflux, Varicose Veins, Lower Extremity Edema Chronic
Interventions
Vasculera, Placebo
Other
Lead sponsor
Corewell Health West
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 23, 2022 · Synced Oct 4, 2026, 12:56 PM EDT
Enrolling by invitation Not applicable Interventional

A Modified Platform Trial of Multiple CAMPs for the Management of Diabetic Foot Ulcers and Venous Leg Ulcers

NCT06453187
View directory record Official record
Conditions
Diabetic Foot Ulcer, Venous Leg Ulcer
Interventions
Urinary Bladder Matrix (UBM) sheet device for Venous Leg Ulcers, Urinary Bladder Matrix (UBM) sheet device for Diabetic Foot Ulcers, AmnioExcel Plus for Venous Leg Ulcers, AmnioExcel Plus for Diabetic Foot Ulcers, Standard of Care
Device · Procedure
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
18 Years to 80 Years
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
13
States / cities
Los Angeles, California • San Francisco, California • Vista, California + 9 more
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 4, 2026, 12:56 PM EDT
Completed Phase 1 Interventional

Preliminary Testing of New Treatment for Chronic Leg Wounds

NCT00000431
View directory record Official record
Conditions
Varicose Ulcer
Interventions
PDGF-B/Ad5
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 90 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 13, 2013 · Synced Oct 4, 2026, 12:56 PM EDT
Not listed Not applicable Interventional

The ROle of Compression StocKings in Heart Failure Patients

NCT06350695
View directory record Official record
Conditions
Heart Failure，Congestive, Leg Edema, Venous Insufficiency, Venous Ulcers
Interventions
low grade compression stockings (10-15 mmHg), high grade compression stockings (20-30 mmHg)
Device
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 2, 2024 · Synced Oct 4, 2026, 12:56 PM EDT
Terminated Not applicable Interventional Results available

A Prospective, Open Label, Multicenter Trial for Evaluating the Efficacy of Treating and Managing Wounds in Elderly Population in Specialized Nursing Facilities Using RD1

NCT04577183
View directory record Official record
Conditions
Diabetic Foot Ulcer, Pressure Ulcer, Venous Leg Ulcer, Trauma Injury, Skin Tear, Chronic Ulcer
Interventions
RD1 System
Device
Lead sponsor
RedDress Ltd.
Industry
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Butler, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 2, 2024 · Synced Oct 4, 2026, 12:56 PM EDT
Completed Phase 3 Interventional Results available

Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers

NCT01656889
View directory record Official record
Conditions
Venous Leg Ulcers
Interventions
HP-802-247, Vehicle
Biological
Lead sponsor
Healthpoint
Industry
Eligibility
18 Years and older
Enrollment
447 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
45
States / cities
Glendale, Arizona • Phoenix, Arizona • Tucson, Arizona + 37 more
Source: ClinicalTrials.gov public record
Updated Mar 14, 2016 · Synced Oct 4, 2026, 12:56 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Evaluation of the OsciPulse Rapid Cycling Compression Device Effects on Venous Blood Flow

NCT05087108
View directory record Official record
Conditions
Venous Thromboses, Venous Stasis
Interventions
OsciPulse system, Reference Therapy 1, Refence Therapy 2
Device
Lead sponsor
OsciFlex LLC
Industry
Eligibility
40 Years to 90 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 9, 2023 · Synced Oct 4, 2026, 12:56 PM EDT
Not listed No phase listed Observational

Safety Study Providing 12 Months Follow-up From First Exposure to HP802-247 in Subjects With Venous Leg Ulcer

NCT01658618
View directory record Official record
Conditions
Venous Leg Ulcer
Interventions
HP802-247
Biological
Lead sponsor
Healthpoint
Industry
Eligibility
18 Years and older
Enrollment
440 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
44
States / cities
Glendale, Arizona • Phoenix, Arizona • Tucson, Arizona + 36 more
Source: ClinicalTrials.gov public record
Updated Feb 3, 2014 · Synced Oct 4, 2026, 12:56 PM EDT
Not listed Not applicable Interventional

The Omeza Protocol for Chronic Ulcers

NCT04198441
View directory record Official record
Conditions
Venous Leg Ulcer, Diabetic Foot Ulcer
Interventions
Wound dressing
Device
Lead sponsor
Omeza, LLC
Industry
Eligibility
21 Years to 80 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
4
States / cities
Jacksonville, Florida • Newark, New Jersey • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 9, 2021 · Synced Oct 4, 2026, 12:56 PM EDT
Completed Phase 4 Interventional

Study Comparing VERSAJET With Conventional Surgical Procedures in the Removal of Unhealthy Tissue From Lower Limb Ulcers

NCT00521027
View directory record Official record
Conditions
Diabetic Foot, Varicose Ulcer, Pressure Ulcer
Interventions
Versajet Hydrosurgery System, Conventional surgical debridement techniques
Device · Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
1
States / cities
Belleville, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 19, 2018 · Synced Oct 4, 2026, 12:56 PM EDT
Terminated Phase 4 Interventional Results available

Flexitouch Compression System for Venous Stasis Ulcer

NCT00534937
View directory record Official record
Conditions
Venous Stasis Ulcer
Interventions
Compression wrapping, Flexitouch compression pump
Procedure
Lead sponsor
West Penn Allegheny Health System
Other
Eligibility
18 Years to 90 Years
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
2
States / cities
Cleveland, Ohio • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 1, 2013 · Synced Oct 4, 2026, 12:56 PM EDT
Completed Not applicable Interventional

Omeza Combination Therapy With Standard of Care to Standard of Care Alone for Chronic Venous Leg Ulcers

NCT05291169
View directory record Official record
Conditions
Venous Leg Ulcer
Interventions
Omeza® OCM™
Device
Lead sponsor
Omeza, LLC
Industry
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
7
States / cities
Los Angeles, California • Hollywood, Florida • North Port, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 6, 2024 · Synced Oct 4, 2026, 12:56 PM EDT
Completed Not applicable Interventional

Clinical Effectiveness of DermACELL AWM in Subjects With Chronic Venous Leg Ulcers

NCT03589586
View directory record Official record
Conditions
Venous Leg Ulcer
Interventions
DermACELL AWM
Other
Lead sponsor
LifeNet Health
Industry
Eligibility
21 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
7
States / cities
Tucson, Arizona • Fresno, California • Los Angeles, California + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 18, 2021 · Synced Oct 4, 2026, 12:56 PM EDT
Withdrawn Phase 4 Interventional

Effect of PEM Treatment of Superficial Axial and Tributary Vein Reflux on Improvement of Wound Healing in VLUs

NCT02988063
View directory record Official record
Conditions
Leg Ulcer, Veins, Varicose, Venous Ulcer, Reflux, Venous Reflux, Venous Leg Ulcer, Varicose Veins, Varicose Ulcer, Varicose Veins Leg
Interventions
Polidocanol Endovenous Microfoam (PEM)
Drug
Lead sponsor
OhioHealth
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 15, 2017 · Synced Oct 4, 2026, 12:56 PM EDT
Completed Phase 2 Interventional Results available

Cooling Leg and Foot Ulcer Skin Post Healing to Prevent Ulcer Recurrence

NCT02626156
View directory record Official record
Conditions
Venous Hypertension Ulcers, Venous Stasis Ulcer, Venous Ulcer, Venous Insufficiency, Leg Ulcer, Foot Ulcer, Varicose Ulcer, Diabetic Foot
Interventions
Cooling gel pack, Cooling cotton pack
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
50 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
2
States / cities
Charleston, South Carolina • Spartanburg, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 30, 2021 · Synced Oct 4, 2026, 12:56 PM EDT
Completed No phase listed Observational

The RESPOND Registry

NCT03286452
View directory record Official record
Conditions
Partial Thickness Wound, Pressure Ulcer, Venous Ulcer, Diabetic Ulcer, Surgical Wounds, Trauma Wounds, Draining Wounds, Chronic Vascular Ulcer
Interventions
PuraPly™ Antimicrobial Wound Matrix
Device
Lead sponsor
Organogenesis
Industry
Eligibility
18 Years and older
Enrollment
310 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
15
States / cities
Prescott Valley, Arizona • Jupiter, Florida • Miami, Florida + 12 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2019 · Synced Oct 4, 2026, 12:56 PM EDT
Completed Not applicable Interventional Results available

Clinical Study to Compare 3 Multi-Layered Foam Dressings for the Management of Chronic Wounds

NCT03662997
View directory record Official record
Conditions
Chronic Wound, Venous Leg Ulcer, Diabetic Foot Ulcer
Interventions
Bordered Five-Layer Foam Dressing, Hydropolymer Foam Dressing, Hydrocellular Multi-Layer Foam Dressing
Device
Lead sponsor
Molnlycke Health Care AB
Industry
Eligibility
18 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
5
States / cities
Castro Valley, California • San Francisco, California • Newark, New Jersey + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2021 · Synced Oct 4, 2026, 12:56 PM EDT
Recruiting Phase 2 Interventional

MTX-001 for the Treatment of Non-Healing Venous Stasis Ulcers

NCT04647240
View directory record Official record
Conditions
Venous Stasis Ulcer, Venous Leg Ulcer
Interventions
MTX-001 (human amniotic fluid)
Biological
Lead sponsor
Merakris Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
12
States / cities
Tucson, Arizona • Castro Valley, California • Los Angeles, California + 8 more
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 4, 2026, 12:56 PM EDT
Completed Phase 2 Interventional Results available

Dose-response Relationship Study of S42909 on Leg Ulcer Healing

NCT03077165
View directory record Official record
Conditions
Venous Leg Ulcer
Interventions
S42909 100 mg, S42909 200 mg, S42909 400 mg, S42909 800 mg, S42909 1200 mg, Placebo Oral Tablet
Drug
Lead sponsor
Ilkos Therapeutic Inc.
Industry
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
14
States / cities
Carlsbad, California • Carmichael, California • Castro Valley, California + 10 more
Source: ClinicalTrials.gov public record
Updated Oct 8, 2020 · Synced Oct 4, 2026, 12:56 PM EDT