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ClinicalTrials.gov public records Last synced Oct 7, 2026, 9:15 PM EDT

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Showing 97–120 of 157 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Varicose Veins Leg Clear all
Terminated Not applicable Interventional Results available

Perforator Vein Injection for Symptomatic Venous Disease

NCT03363633
View directory record Official record
Conditions
Venous Disease
Interventions
sodium tetradecyl sulfate, Compression
Drug · Device
Lead sponsor
Ellen Dillavou
Other
Eligibility
18 Years to 100 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 23, 2018 · Synced Oct 7, 2026, 9:15 PM EDT
Terminated Not applicable Interventional Results available

A Comparative Evaluation of a MPS Dressing and a CMC Dressing on Subjects With Lower Extremity Venous Ulcers

NCT03903692
View directory record Official record
Conditions
Venous Leg Ulcer
Interventions
Marine polysaccharide dressing, Carboxymethylcellulose dressing
Device
Lead sponsor
Medline Industries
Industry
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
5
States / cities
Fresno, California • Selma, California • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 25, 2024 · Synced Oct 7, 2026, 9:15 PM EDT
Terminated Phase 1 Interventional

Study of Individualized Wound Prevention Instruction to Prevent Venous Ulcer Development

NCT00727701
View directory record Official record
Conditions
Varicose Ulcer
Interventions
Aftercare summary
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 26, 2015 · Synced Oct 7, 2026, 9:15 PM EDT
Completed Phase 2 Interventional

A Study to Evaluate the Safety and the Efficacy of EscharEx (EX-02 Formulation) in Debridement of Venous Leg Ulcers

NCT03588130
View directory record Official record
Conditions
Venous Leg Ulcer
Interventions
EscharEx (5% EX-02 formulation), Gel Vehicle, Non-surgical standard of care (NSSOC)
Drug
Lead sponsor
MediWound Ltd
Industry
Eligibility
18 Years to 90 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
21
States / cities
Carlsbad, California • Fresno, California • Los Angeles, California + 17 more
Source: ClinicalTrials.gov public record
Updated Nov 14, 2022 · Synced Oct 7, 2026, 9:15 PM EDT
Completed Phase 2 Interventional

Subjects With Non-Healing Venous Leg Ulcers Treated With Standard Care Plus Cryopreserved Human Umbilical Cord (TTAX01)

NCT03818828
View directory record Official record
Conditions
Venous Leg Ulcer
Interventions
TTAX01, Profore Compression Therapy, Cadexomer Iodine dressing
Biological · Other
Lead sponsor
BioTissue Holdings, Inc
Industry
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
6
States / cities
Carlsbad, California • Sylmar, California • North Chicago, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 3, 2020 · Synced Oct 7, 2026, 9:15 PM EDT
Completed Not applicable Interventional

Testing Fish Oil Derivatives In Healing Of Chronic Venous Leg Ulcers

NCT01754506
View directory record Official record
Conditions
Venous Stasis Ulcers
Interventions
Fish Oil
Dietary Supplement
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 85 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 16, 2015 · Synced Oct 7, 2026, 9:15 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Efficacy and Safety of Artacent™ for Treatment Resistant Lower Extremity Venous and Diabetic Ulcers

NCT02838784
View directory record Official record
Conditions
Venous Ulcer, Foot Ulcer, Diabetic
Interventions
Artacent Human Amniotic Membrane, Standard of Care
Other · Procedure
Lead sponsor
Tides Medical
Industry
Eligibility
18 Years and older
Enrollment
134 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
7
States / cities
Arcadia, California • New Iberia, Louisiana • New Orleans, Louisiana + 4 more
Source: ClinicalTrials.gov public record
Updated Oct 13, 2017 · Synced Oct 7, 2026, 9:15 PM EDT
Completed Phase 2 Interventional

A Trial to Assess the Safety and Activity of Nexagon® for the Treatment of Venous Leg Ulcers (The NOVEL Study)

NCT00820196
View directory record Official record
Conditions
Venous Ulcer
Interventions
Nexagon®, Nexagon® vehicle
Drug
Lead sponsor
OcuNexus Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
4
States / cities
San Francisco, California • Stockton, California • Erie, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2012 · Synced Oct 7, 2026, 9:15 PM EDT
Terminated Not applicable Interventional Results available

The GORE Viabahn Endoprosthesis for the Treatment of Venous Occlusions and Stenoses

NCT01406795
View directory record Official record
Conditions
Venous Thrombosis
Interventions
Gore Viabahn Heparin Coated Stent
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Feb 27, 2017 · Synced Oct 7, 2026, 9:15 PM EDT
Completed Phase 2 Interventional Results available

Dose-response Relationship Study of S42909 on Leg Ulcer Healing

NCT03077165
View directory record Official record
Conditions
Venous Leg Ulcer
Interventions
S42909 100 mg, S42909 200 mg, S42909 400 mg, S42909 800 mg, S42909 1200 mg, Placebo Oral Tablet
Drug
Lead sponsor
Ilkos Therapeutic Inc.
Industry
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
14
States / cities
Carlsbad, California • Carmichael, California • Castro Valley, California + 10 more
Source: ClinicalTrials.gov public record
Updated Oct 8, 2020 · Synced Oct 7, 2026, 9:15 PM EDT
Not listed Phase 2 Interventional

Safety and Preliminary Efficacy of PalinGen Flow Amniotic Tissue Allograft in Chronic Ulcers of the Lower Extremities

NCT04667416
View directory record Official record
Conditions
Chronic Ulcer of Lower Extremity
Interventions
PalinGen Flow Amniotic Tissue Allograft
Biological
Lead sponsor
Amnio Technology, LLC
Industry
Eligibility
18 Years and older
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
7
States / cities
Carmichael, California • Castro Valley, California • Fresno, California + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 20, 2024 · Synced Oct 7, 2026, 9:15 PM EDT
Not yet recruiting Phase 1 Interventional

LUT017 Gel for Venous Leg Ulcers and Chronic Non-Healing Skin Wounds in Adults

NCT07463365
View directory record Official record
Conditions
Venous Leg Ulcer, Chronic Non-Healing Cutaneous Wounds, VLU
Interventions
LUT017 gel
Drug
Lead sponsor
Antoni Ribas
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 7, 2026, 9:15 PM EDT
Recruiting Not applicable Interventional

Evaluation of the Efficacy of Hyalomatrix® in the Healing of Chronic Venous Leg Ulcers

NCT07335861
View directory record Official record
Conditions
Venous Leg Ulcer, Chronic Wounds
Interventions
Hyalomatrix, Standard of Care
Device · Other
Lead sponsor
NuScience Medical Biologics, LLC
Industry
Eligibility
18 Years and older
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
4
States / cities
Alexandria, Louisiana • Pineville, Louisiana • Vidalia, Louisiana + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Oct 7, 2026, 9:15 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Non-Invasive Management of Chronic Venous Insufficiency

NCT00950378
View directory record Official record
Conditions
Venous Insufficiency
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
40 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 29, 2013 · Synced Oct 7, 2026, 9:15 PM EDT
Terminated Not applicable Interventional Results available

VenaSeal Spectrum: Global Post-Market Randomized Controlled Trial

NCT03820947
View directory record Official record
Conditions
Venous Reflux
Interventions
VenaSeal™ System, Endothermal Ablation (ETA), Surgical Stripping
Device · Procedure
Lead sponsor
Medtronic Endovascular
Industry
Eligibility
18 Years and older
Enrollment
506 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
12
States / cities
Prescott Valley, Arizona • Tucson, Arizona • Fresno, California + 9 more
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Oct 7, 2026, 9:15 PM EDT
Terminated Phase 2 Interventional

Safety and Efficacy of Gaseous Nitric Oxide on Venous Stasis Leg Ulcers

NCT00613808
View directory record Official record
Conditions
Venous Ulcers
Interventions
Nitric Oxide 200ppm Group B
Drug
Lead sponsor
Nitric BioTherapeutics, Inc
Industry
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
2
States / cities
Denver, Colorado • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 25, 2012 · Synced Oct 7, 2026, 9:15 PM EDT
Completed Phase 3 Interventional Results available

Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers >12 cm2 to ≤ 36 cm2

NCT01737762
View directory record Official record
Conditions
Venous Leg Ulcers
Interventions
HP802-247, Vehicle
Biological
Lead sponsor
Healthpoint
Industry
Eligibility
18 Years and older
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
37
States / cities
Phoenix, Arizona • Carlsbad, California • Castro Valley, California + 32 more
Source: ClinicalTrials.gov public record
Updated Jul 26, 2017 · Synced Oct 7, 2026, 9:15 PM EDT
Completed Phase 1 Interventional

Bioengineered Skin and Wound Healing

NCT00007280
View directory record Official record
Conditions
Leg Ulcers
Interventions
Bioengineered skin
Device
Lead sponsor
Roger Williams Medical Center
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2005
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 2, 2013 · Synced Oct 7, 2026, 9:15 PM EDT
Completed Not applicable Interventional

Randomized Controlled 8-week Crossover Evaluation of Compression Bandage Systems for Venous Leg Ulcers

NCT00301496
View directory record Official record
Conditions
Venous Ulcer
Interventions
Coban 2 Layer Compression System
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
21 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
5
States / cities
Montgomery, Alabama • Castro Valley, California • Lawrenceville, Georgia + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 2, 2024 · Synced Oct 7, 2026, 9:15 PM EDT
Active, not recruiting Not applicable Interventional Results available

The GORE® VIABAHN® FORTEGRA Venous Stent IVC Study

NCT05409976
View directory record Official record
Conditions
Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis, Venous Ulcer, Venous Stenosis, Venous Occlusion, Vein Thrombosis, Vein Occlusion, Vein Disease
Interventions
GORE® VIAFORT Vascular Stent
Device
Lead sponsor
W.L.Gore & Associates
Industry
Eligibility
18 Years and older
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2030
U.S. locations
8
States / cities
Stanford, California • Washington D.C., District of Columbia • Chicago, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Oct 7, 2026, 9:15 PM EDT
Recruiting Phase 4 Interventional

A Non-Randomized Open Label Clinical Trial Evaluating DermaBind TL

NCT07172893
View directory record Official record
Conditions
Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU)
Interventions
DermaBind TL
Biological
Lead sponsor
HealthTech Wound Care
Industry
Eligibility
18 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
10
States / cities
DeLand, Florida • Palm Beach Gardens, Florida • Sweetwater, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Oct 7, 2026, 9:15 PM EDT
Active, not recruiting No phase listed Observational

Geko™ Cross Therapy Registry - Wound

NCT05007301
View directory record Official record
Conditions
Wound, Venous Leg Ulcer, Diabetic Foot Ulcer, Arterial Leg Ulcer
Interventions
geko device
Device
Lead sponsor
Firstkind Ltd
Industry
Eligibility
18 Years and older
Enrollment
2,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 7, 2026, 9:15 PM EDT
Not listed No phase listed Observational

Venous Leg Ulcer and Lymphedema Registry

NCT02813187
View directory record Official record
Conditions
Venous Stasis Ulcer, Quality of Patient Care
Interventions
cellular and tissue based therapy, debridement, advanced wound therapy, Nutritional screening
Biological · Procedure · Dietary Supplement
Lead sponsor
U.S. Wound Registry
Other
Eligibility
Not listed
Enrollment
10,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
1
States / cities
The Woodlands, Texas
Source: ClinicalTrials.gov public record
Updated Apr 25, 2018 · Synced Oct 7, 2026, 9:15 PM EDT
Enrolling by invitation Not applicable Interventional

A Modified Platform Trial of Multiple CAMPs for the Management of Diabetic Foot Ulcers and Venous Leg Ulcers

NCT06453187
View directory record Official record
Conditions
Diabetic Foot Ulcer, Venous Leg Ulcer
Interventions
Urinary Bladder Matrix (UBM) sheet device for Venous Leg Ulcers, Urinary Bladder Matrix (UBM) sheet device for Diabetic Foot Ulcers, AmnioExcel Plus for Venous Leg Ulcers, AmnioExcel Plus for Diabetic Foot Ulcers, Standard of Care
Device · Procedure
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
18 Years to 80 Years
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
13
States / cities
Los Angeles, California • San Francisco, California • Vista, California + 9 more
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 7, 2026, 9:15 PM EDT