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Conditions: Venous Reflux, Venous Insufficiency, Venous Ulcer, Venous Disease
Interventions: Polidocanol; Procedure
Lead sponsor: ProMedica Health System; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Toledo, Ohio

Conditions: Venous Leg Ulcer
Interventions: Marine polysaccharide dressing, Carboxymethylcellulose dressing; Device
Lead sponsor: Medline Industries; Industry
Eligibility: 18 Years and older
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 5
States / cities: Fresno, California • Selma, California • Boston, Massachusetts + 2 more

Conditions: Venous Leg Ulcers
Interventions: Unite Biomatrix; Device
Lead sponsor: Baxter Healthcare Corporation; Industry
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 3
States / cities: San Diego, California • Miami, Florida • Warren, Pennsylvania

Conditions: Venous Leg Ulcer, Chronic Wounds
Interventions: Hyalomatrix, Standard of Care; Device · Other
Lead sponsor: NuScience Medical Biologics, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 122 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 4
States / cities: Alexandria, Louisiana • Pineville, Louisiana • Vidalia, Louisiana + 1 more

Conditions: Diabetic Foot Ulcer, Venous Leg Ulcer, Pressure Ulcer
Interventions: DETEC® Esterase; Diagnostic Test
Lead sponsor: Progenitec Inc.; Industry
Eligibility: 21 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Arlington, Texas

Conditions: Venous Leg Ulcer
Interventions: PICO Negative Pressure Wound Therapy, Compression Dressing; Device · Procedure
Lead sponsor: Northwell Health; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Staten Island, New York

Conditions: Venous Leg Ulcer (VLU)
Interventions: Omeza OCM™ Wound Matrix, Routine Care; Device · Procedure
Lead sponsor: Omeza, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 254 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Lake Success, New York

Conditions: Compression; Vein, Compression; Artery, Sedentary Behavior, DVT of Legs
Interventions: Lower extremity compression garments, Active break; Device · Behavioral
Lead sponsor: New York Institute of Technology; Other
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Old Westbury, New York

Conditions: Venous Disease
Interventions: sodium tetradecyl sulfate, Compression; Drug · Device
Lead sponsor: Ellen Dillavou; Other
Eligibility: 18 Years to 100 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Venous Stasis Ulcers
Interventions: Fish Oil; Dietary Supplement
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years to 85 Years
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Venous Leg Ulcers
Interventions: Aurix; Device
Lead sponsor: Nuo Therapeutics; Industry
Eligibility: 18 Years and older
Enrollment: 640 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 23
States / cities: Arcadia, California • Montebello, California • Visalia, California + 16 more

Conditions: Pulmonary Arterial Hypertension
Interventions: QCC374, Placebo Matching; Drug
Lead sponsor: Novartis Pharmaceuticals; Industry
Eligibility: 18 Years and older
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Venous Leg Ulcer
Interventions: allo-APZ2-CVU, Placebo; Drug
Lead sponsor: RHEACELL GmbH & Co. KG; Industry
Eligibility: 18 Years and older
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 4
States / cities: Hialeah, Florida • Miami, Florida • Boston, Massachusetts + 1 more

Conditions: Lower Extremity Edema, Congestive Heart Failure(CHF), Chronic Venous Insufficiency (CVI), Kidney Disease
Interventions: Pedal Pump, Pedal Pump Sham; Device
Lead sponsor: David McVay; Industry
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Diabetic Foot Ulcer, Foot Ulcer Chronic, DFU, Ulcer Foot, Venous Leg Ulcer (VLU), Venous Leg Ulcer, Venous Ulcer, Leg Ulcers, Ulcer
Interventions: Tri-Membrane Wrap™ DFU, Membrane Wrap™ DFU, Membrane Wrap-Lite™ DFU, Membrane Wrap-Hydro™ DFU, Tri-Membrane Wrap™ VLU, Membrane Wrap™ VLU, Membrane Wrap-Lite™ VLU, Membrane Wrap-Hydro™ VLU; Other
Lead sponsor: BioLab Holdings; Industry
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Philidelphia, Pennsylvania

Conditions: Peripheral Arterial Disease
Interventions: L-N^G monomethyl arginine (L-NMMA); Drug
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Partial Thickness Wound, Pressure Ulcer, Venous Ulcer, Diabetic Ulcer, Surgical Wounds, Trauma Wounds, Draining Wounds, Chronic Vascular Ulcer
Interventions: PuraPly™ Antimicrobial Wound Matrix; Device
Lead sponsor: Organogenesis; Industry
Eligibility: 18 Years and older
Enrollment: 310 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 15
States / cities: Prescott Valley, Arizona • Jupiter, Florida • Miami, Florida + 12 more

Conditions: Deep Vein Thrombosis, Venous Stasis, Venous Insufficiency, Venous Leg Ulcer, Venous Reflux, Post Thrombotic Syndrome
Interventions: Stents; Device
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 225 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2026
U.S. locations: 29
States / cities: Orange, California • San Francisco, California • New Haven, Connecticut + 23 more

Conditions: Venous Embolism of Lower Extremities (Diagnosis), Arterial Embolism and Thrombosis, Acute DVT of Lower Extremity, Chronic DVT of Lower Extremity, DVT, Deep Vein Thrombosis Leg, Thrombus in the Peripheral Venous Vasculature, Peripheral Arterial Disease, Acute Limb Ischemia, Lower Extremity Acute Limb Ischemia, LE ALI
Interventions: Liberant Thrombectomy System; Device
Lead sponsor: Medtronic Endovascular; Industry
Eligibility: 22 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 4
States / cities: Washington D.C., District of Columbia • Naples, Florida • New York, New York + 1 more

Conditions: Leg Ulcer
Interventions: ICXP007; Drug
Lead sponsor: Intercytex; Industry
Eligibility: 18 Years and older
Enrollment: 396 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2005
U.S. locations: 31
States / cities: Montgomery, Alabama • Phoenix, Arizona • Tucson, Arizona + 26 more

Conditions: Leg Veins
Interventions: Right leg treated with Glycerin compounded with 1% Lidocaine and Epinephrine, Left leg treated with Glycerin compounded with 1% Lidocaine and Epinephrine; Drug
Lead sponsor: Goldman, Butterwick, Fitzpatrick and Groff; Other
Eligibility: 20 Years to 75 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: San Diego, California

Conditions: Deep Vein Thrombosis (DVT), Thrombus in the Peripheral Venous Vasculature, Venous Embolism, Thrombus in the Central and Peripheral Circulatory System, Including Saphenous Vein Grafts
Interventions: Aspiration thrombectomy system; Device
Lead sponsor: Argon Medical Devices; Industry
Eligibility: 18 Years and older
Enrollment: 185 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 4
States / cities: Fort Lauderdale, Florida • Tampa, Florida • Edgewood, Kentucky + 1 more

Conditions: Venous Insufficiency, Leg Ulcer
Interventions: Bilayered Cellular Matrix (OrCel); Device
Lead sponsor: Ortec International; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2005
U.S. locations: 10
States / cities: Montgomery, Alabama • Phoenix, Arizona • Castro Valley, California + 7 more

Conditions: Venous Leg Ulcer, Chronic Venous Insufficiency, Venous Stasis Ulcer, Venous Ulcer, Venous Insufficiency
Interventions: Dual Action Pneumatic Compression; Device
Lead sponsor: Tactile Medical; Industry
Eligibility: 18 Years and older
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 6
States / cities: San Francisco, California • Miami, Florida • Boston, Massachusetts + 2 more

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Outcomes of Sclerotherapy of the Ulcer Bed Compared to a Combination of Ablation and Injections

A Comparative Evaluation of a MPS Dressing and a CMC Dressing on Subjects With Lower Extremity Venous Ulcers

The Mechanism of Action of Unite Biomatrix in Venous Leg Ulcers

Evaluation of the Efficacy of Hyalomatrix® in the Healing of Chronic Venous Leg Ulcers

DETEC® Esterase for Screening Wound Infection at Point of Care

Pilot Study Comparing Negative Pressure Dressings to Conventional Dressings

OCM™ Treatment With Routine Care in Venous Leg Ulcers Compared to Routine Care Treatment Alone.

Lower Leg Compression in Extended Video Game Play: A Pilot Study

Perforator Vein Injection for Symptomatic Venous Disease

Testing Fish Oil Derivatives In Healing Of Chronic Venous Leg Ulcers

Effectiveness of Aurix Therapy in Venous Leg Ulcers

Safety, Pharmacokinetics and Efficacy Study of QCC374 in PAH Patients

Allogeneic ABCB5-positive Dermal Mesenchymal Stromal Cells for Treatment of Therapy-resistant CVU (Phase III)

Pedal Pump Clinical Trial on Edema V1

A Multicenter, Prospective, Controlled Modified Multi-Platform Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers.

Endothelial Function in Lower Extremity Bypass Grafts

The RESPOND Registry

Chronic Venous Thrombosis: Relief With Adjunctive Catheter-Directed Therapy (The C-TRACT Trial)

Case-Specific Health Care Professional Clinical Survey of Liberant™ Thrombectomy System

Safety and Efficacy Study of ICXP007 With Compression Bandaging for the Treatment of Non-Infected Venous Leg Ulcers

Study Comparing Glycerin With 1% Lidocaine and Epinephrine Versus Glycerin With 1% Lidocaine Without Epinephrine for the Sclerotherapy of Leg Telangiectasias

Cleaner Long-tErm Assessment Registry - Venous Insights and Efficacy With eXtended Tracking

The Evaluation of OrCel for the Treatment of Venous Ulcers

Evaluation of a Dual Action Pneumatic Compression System: Tolerance and Comfort in Patients With Venous Leg Ulcers (VLUs)