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ClinicalTrials.gov public records Last synced Oct 5, 2026, 11:23 AM EDT

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Showing 49–72 of 76 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Ventilator-Associated Pneumonia Clear all
Completed Not applicable Interventional Results available

Chlorhexidine Gluconate Oral Care for Adults Experiencing Trauma

NCT01382446
View directory record Official record
Conditions
Ventilator Associated Pneumonia
Interventions
Chlorhexidine gluconate, Toothpaste
Drug · Other
Lead sponsor
St. Joseph's Hospital and Medical Center, Phoenix
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 6, 2017 · Synced Oct 5, 2026, 11:23 AM EDT
Recruiting Not applicable Interventional

Frequent Standardized Oral Care Using Human Milk in the Neonatal Intensive Care Unit

NCT06000761
View directory record Official record
Conditions
Ventilator Associated Pneumonia, Bronchopulmonary Dysplasia, Respiratory Disease
Interventions
Standardized oral Care
Procedure
Lead sponsor
University of Florida
Other
Eligibility
1 Hour to 3 Days
Enrollment
218 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Oct 5, 2026, 11:23 AM EDT
Terminated Phase 4 Interventional Results available

The Duration of Antibiotic Therapy for Early (DATE) Ventilator Associated Pneumonia (VAP): 4 vs. 7 Days

NCT05545735
View directory record Official record
Conditions
Ventilator Associated Pneumonia
Interventions
Standard of Care Antibiotic Therapy
Drug
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jan 16, 2026 · Synced Oct 5, 2026, 11:23 AM EDT
Active, not recruiting Not applicable Interventional

Frequent Standardized Oral Care to Improve Health Outcomes in Premature Infants in the Neonatal Intensive Care Unit

NCT05167318
View directory record Official record
Conditions
Microbial Colonization, Ventilator Associated Pneumonia
Interventions
frequent standardized oral care
Other
Lead sponsor
University of Florida
Other
Eligibility
12 Hours to 72 Hours
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 5, 2026, 11:23 AM EDT
Not listed No phase listed Observational

Airway Microbiome Changes After Artificial Airway Exchange in Critically-ill Pediatric Patients.

NCT06201130
View directory record Official record
Conditions
Tracheostomy, Endotracheal Tube, Ventilator Associated Pneumonia, Tracheitis, Microbial Colonization, Pediatric Infectious Disease, Pediatrics
Interventions
Suctioning of artificial airway
Diagnostic Test
Lead sponsor
Northwell Health
Other
Eligibility
0 Years to 18 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Queens, New York
Source: ClinicalTrials.gov public record
Updated Jan 17, 2024 · Synced Oct 5, 2026, 11:23 AM EDT
Recruiting Not applicable Interventional

Macrophage Programing in Acute Lung Injury: MiniBAL

NCT05767671
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome, Ventilator Associated Pneumonia
Interventions
Non-Bronchoscopic Mini Bronchoalveolar Lavage
Other
Lead sponsor
William Janssen, MD
Other
Eligibility
18 Years to 99 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 6, 2026 · Synced Oct 5, 2026, 11:23 AM EDT
Completed Not applicable Interventional Results available

Safe Critical Care: Testing Improvement Strategies

NCT00975923
View directory record Official record
Conditions
Central Line-associated Bloodstream Infection (CLABSI), Ventilator Associated Pneumonia
Interventions
Collaborative Group, Tool Kit
Behavioral
Lead sponsor
Vanderbilt University
Other
Eligibility
1 Year and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 12, 2016 · Synced Oct 5, 2026, 11:23 AM EDT
Completed Not applicable Interventional

CDC Prevention Epicenters Wake Up and Breathe Collaborative

NCT01583413
View directory record Official record
Conditions
Ventilator-associated Pneumonia
Interventions
Daily SAT & SBT
Procedure
Lead sponsor
Harvard Pilgrim Health Care
Other
Eligibility
Not listed
Enrollment
3,342 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
5
States / cities
Chicago, Illinois • Salem, Massachusetts • St Louis, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 11, 2013 · Synced Oct 5, 2026, 11:23 AM EDT
Terminated Phase 3 Interventional Results available

A Safety and Tolerability Study of Doripenem Compared With Cefepime in Hospitalized Children With Bacterial Pneumonia

NCT01110421
View directory record Official record
Conditions
Pneumonia, Bacterial, Community-Acquired Infections, Nosocomial Infection, Pneumonia, Ventilator-Associated
Interventions
Cefepime placebo, Cefepime, Doripenem, Doripenem placebo, Amoxicillin/clavulanate potassium
Drug
Lead sponsor
Janssen Research & Development, LLC
Industry
Eligibility
3 Months to 18 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
4
States / cities
Little Rock, Arkansas • Cleveland, Ohio • Toledo, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 15, 2014 · Synced Oct 5, 2026, 11:23 AM EDT
Completed Phase 2 Interventional

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Cefiderocol in Hospitalized Neonates and Infants

NCT06086626
View directory record Official record
Conditions
Gram-Negative Bacterial Infections
Interventions
Cefiderocol, Standard of Care
Drug
Lead sponsor
Shionogi
Industry
Eligibility
Up to 3 Months
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
2
States / cities
Little Rock, Arkansas • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Oct 5, 2026, 11:23 AM EDT
Completed Not applicable Interventional Results available

Trial of 2% Chlorhexidine Bathing on Nosocomial Infections in the Surgical Intensive Care Unit

NCT01640925
View directory record Official record
Conditions
Cross Infection, Pneumonia, Ventilator-associated, Catheter-related Infections, Infection Due to Indwelling Urinary Catheter, Surgical Wound Infection
Interventions
Chlorhexidine gluconate, Standard bathing
Drug · Other
Lead sponsor
Joshua Swan
Other
Eligibility
18 Years and older
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 27, 2018 · Synced Oct 5, 2026, 11:23 AM EDT
Completed Phase 4 Interventional

Common Canister Protocol for Inhaler Administration in Mechanically Ventilated Patients

NCT01935388
View directory record Official record
Conditions
Ventilator Associated Pneumonia
Interventions
Common canister
Other
Lead sponsor
Barnes-Jewish Hospital
Other
Eligibility
18 Years and older
Enrollment
354 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 7, 2016 · Synced Oct 5, 2026, 11:23 AM EDT
Completed Phase 4 Interventional

A Peri-intubation Oral Intervention to Reduce Oral Flora and VAP

NCT00248300
View directory record Official record
Conditions
Pneumonia
Interventions
Chlorhexidine
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 11, 2015 · Synced Oct 5, 2026, 11:23 AM EDT
Terminated Phase 4 Interventional Results available

Early Antibiotics After Aspiration in ICU Patients

NCT05079620
View directory record Official record
Conditions
Aspiration, Aspiration Pneumonia
Interventions
Ceftriaxone, Amoxicillin clavulanic acid, Cefepime, Vancomycin, Levofloxacin
Drug
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 30, 2025 · Synced Oct 5, 2026, 11:23 AM EDT
Completed No phase listed Observational

MASTERMIND-Pneumonia Study (Also Known as Pneumonia Direct Pilot)

NCT06181669
View directory record Official record
Conditions
Pneumonia, Bacterial, Ventilator Associated Pneumonia
Interventions
Pathogen and Host Directed testing
Diagnostic Test
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
173 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
4
States / cities
Detroit, Michigan • Royal Oak, Michigan • St Louis, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Oct 5, 2026, 11:23 AM EDT
Withdrawn Not applicable Interventional

Preoperative Optimization to Improve Functional Status

NCT04566172
View directory record Official record
Conditions
Pulmonary Atelectasis, Pneumonia, Ventilator-Associated
Interventions
Inspiratory Muscle Training (IMT)
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
65 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 21, 2024 · Synced Oct 5, 2026, 11:23 AM EDT
Completed No phase listed Observational

Removing Fluid Above Breathing Tubes in the Operating Room

NCT01110109
View directory record Official record
Conditions
Pneumonia, Ventilator-Associated
Interventions
Not listed
Lead sponsor
Medtronic - MITG
Industry
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Oct 26, 2010 · Synced Oct 5, 2026, 11:23 AM EDT
Completed Early Phase 1 Interventional

Reduction of Bacterial Resistance With Inhaled Antibiotics in the Intensive Care Unit

NCT01878643
View directory record Official record
Conditions
Respiratory Infection, Bacterial Resistance, Respiratory Failure
Interventions
vancomycin or gentamicin, Placebo
Drug
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2002
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jun 17, 2013 · Synced Oct 5, 2026, 11:23 AM EDT
Enrolling by invitation No phase listed Observational

A Multi-Center Diagnostic Stewardship Program to Improve Respiratory Culture Utilization in Critically Ill Children

NCT04987840
View directory record Official record
Conditions
Ventilator Associated Pneumonia, Tracheobronchitis
Interventions
Not listed
Lead sponsor
Johns Hopkins University
Other
Eligibility
Not listed
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
8
States / cities
Baltimore, Maryland • Boston, Massachusetts • Minneapolis, Minnesota + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 5, 2026, 11:23 AM EDT
Completed Early Phase 1 Interventional Results available

Study of Biotene OralBalance Gel for Oral Care in Critically-Ill Mechanically Ventilated Neonates

NCT01314742
View directory record Official record
Conditions
Ventilator-associated Pneumonia
Interventions
Biotene OralBalance® gel, Sterile Water moisten cotton tipped applicator
Drug · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
7 Days and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
2
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 11, 2018 · Synced Oct 5, 2026, 11:23 AM EDT
Completed Phase 3 Interventional

Silver-Coated Endotracheal Tube to Reduce Ventilator Associated Pneumonia (VAP)

NCT00148642
View directory record Official record
Conditions
Respiratory Failure
Interventions
silver salts coated endotracheal tube, uncoated endotracheal tube
Device
Lead sponsor
C. R. Bard
Industry
Eligibility
18 Years and older
Enrollment
2,003 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2006
U.S. locations
5
States / cities
San Diego, California • Oak Park, Illinois • Rochester, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 18, 2017 · Synced Oct 5, 2026, 11:23 AM EDT
Completed Phase 2 Interventional Results available

Effect of Improved Oral Hygiene to Prevent Pneumonia in Hospitalized Patients

NCT00123123
View directory record Official record
Conditions
Pneumonia
Interventions
chlorhexidine gluconate oral rinse (0.12%), placebo
Drug
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years and older
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated May 5, 2021 · Synced Oct 5, 2026, 11:23 AM EDT
Completed Not applicable Interventional Results available

Endotracheal Tubes for Prevention of Ventilator-associated Pneumonia

NCT01744483
View directory record Official record
Conditions
Ventilator-acquired Pneumonia
Interventions
PVC ETT, PUC ETT, PUC-CASS ETT
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 26, 2017 · Synced Oct 5, 2026, 11:23 AM EDT
Terminated Phase 3 Interventional

Pivotal Study in VAP Suspected or Confirmed to be Due to Pseudomonas Aeruginosa

NCT03409679
View directory record Official record
Conditions
Pneumonia
Interventions
Murepavadin, Two anti-pseudomonal antibiotics
Drug
Lead sponsor
Polyphor Ltd.
Industry
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
3
States / cities
Chicago, Illinois • Springfield, Missouri • Greensboro, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 28, 2019 · Synced Oct 5, 2026, 11:23 AM EDT