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Showing 1–24 of 36 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Vocal Cord Disease Clear all
Completed Not applicable Interventional Results available

Efficacy of a Semi-occluded Mask in the Treatment of Patients With Voice Disorders

NCT03410797
View directory record Official record
Conditions
Voice and Resonance Disorders, Vocal Fold Polyp, Vocal Cord Cyst, Vocal Cord Polyp, Atrophy of Vocal Cord
Interventions
Inclusion of semi-occluded mask in voice therapy
Device
Lead sponsor
Jacqueline Gartner-Schmidt
Other
Eligibility
18 Years to 60 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 4, 2021 · Synced Sep 23, 2026, 9:24 AM EDT
Completed Not applicable Interventional

Universal Screening for Vocal Fold Motion Impairment in Children Undergoing Congenital Cardiac Surgery

NCT03882450
View directory record Official record
Conditions
Vocal Fold Palsy, Dysphagia, Congenital Heart Disease in Children
Interventions
Flexible fiberoptic laryngoscopy, Laryngeal ultrasonography
Procedure
Lead sponsor
Emory University
Other
Eligibility
Up to 18 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 13, 2020 · Synced Sep 23, 2026, 9:24 AM EDT
Withdrawn Not applicable Interventional

Dynamic Laryngotracheal Separation for Aspiration

NCT00580346
View directory record Official record
Conditions
Aspiration Pneumonia
Interventions
Placement of laryngeal implant
Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 20, 2022 · Synced Sep 23, 2026, 9:24 AM EDT
Completed Not applicable Interventional

Dynamic Laryngeal Opening for Bilateral Vocal Fold Paralysis by an Implanted Stimulator

NCT00845442
View directory record Official record
Conditions
Vocal Cord Paralysis
Interventions
pacemaker
Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 21, 2022 · Synced Sep 23, 2026, 9:24 AM EDT
Completed Not applicable Interventional

Silk Protein Microparticle-based Filler for Injection Augmentation

NCT03790956
View directory record Official record
Conditions
Vocal Cord Paralysis Unilateral, Dysphonia, Dysphagia, Oropharyngeal
Interventions
Silk Microparticle Filler Injection
Procedure
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 9, 2023 · Synced Sep 23, 2026, 9:24 AM EDT
Enrolling by invitation No phase listed Observational

Outcomes Tracking in Unilateral Vocal Fold Paralysis (UVFP) and Atrophy After Medialization Laryngeal Surgery

NCT07579364
View directory record Official record
Conditions
Unilateral Vocal Cord Paralysis, Vocal Cord Atrophy
Interventions
Laryngeal Framework Surgery
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
10
States / cities
La Jolla, California • Los Angeles, California • San Francisco, California + 7 more
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Sep 23, 2026, 9:24 AM EDT
Active, not recruiting Phase 2 Interventional

Vocal-cord vs. Complete Laryngeal Radiotherapy for Early Glottic Cancer

NCT03759431
View directory record Official record
Conditions
Cancer Neck, Larynx Cancer, Glottis Tumor
Interventions
Vocal-cord Radiotherapy, Complete Larynx Radiotherapy
Radiation
Lead sponsor
Centre hospitalier de l'Université de Montréal (CHUM)
Other
Eligibility
18 Years and older
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Sep 23, 2026, 9:24 AM EDT
Active, not recruiting No phase listed Observational

Vitamin A Status in Patients With Vocal Fold Leukoplakia

NCT05323292
View directory record Official record
Conditions
Vitamin A, Vitamin A Deficiency, Leukoplakia, Vocal Cord Neoplasm
Interventions
Not listed
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 23, 2026, 9:24 AM EDT
Withdrawn Phase 3 Interventional

Effect of Acid Suppression With Esomeprazole on Vocal Cord Granulomas

NCT00567658
View directory record Official record
Conditions
Larynx Disease
Interventions
Esomeprazole
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 5, 2013 · Synced Sep 23, 2026, 9:24 AM EDT
Not yet recruiting Not applicable Interventional

Assessment of Laryngopharyngeal Sensation: Cancer Survivor Cohort

NCT06078527
View directory record Official record
Conditions
Presbylarynx, Aspiration, Spasmodic Dysphonia, Globus Pharyngeus, Larynx Paralysis, Laryngeal Disease, Vocal Cord Paralysis, Iatrogenic Injury, Sensory Neuropathy
Interventions
Cheung-Bearelly Aesthesiometer, Transnasal Laryngoscopy, Questionnaires
Device · Procedure · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Sep 23, 2026, 9:24 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Detection of Vocal Fold Motion Impairment on Noninvasive Positive Pressure

NCT06406725
View directory record Official record
Conditions
Vocal Cord Dysfunction, Vocal Cord Paralysis, Vocal Cord Paresis, Recurrent Laryngeal Nerve Palsy, Recurrent Laryngeal Nerve Injuries
Interventions
Point-of-Care Ultrasound of the Airway
Diagnostic Test
Lead sponsor
Nemours Children's Clinic
Other
Eligibility
1 Day to 18 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Queens, New York
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 23, 2026, 9:24 AM EDT
Completed Not applicable Interventional

Exercise-induced Paradoxical Vocal Fold Motion Disorder: Clinical Features and Potential Mechanisms

NCT02947009
View directory record Official record
Conditions
Disorder of Vocal Cord
Interventions
Diagnostic Study
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years to 18 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 13, 2017 · Synced Sep 23, 2026, 9:24 AM EDT
Not listed Phase 3 Interventional

Allograft Adipose Injectable for Vocal Fold Paralysis

NCT04700566
View directory record Official record
Conditions
Vocal Fold Palsy
Interventions
Renuva Allograft Adipose Matrix
Biological
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 5, 2023 · Synced Sep 23, 2026, 9:24 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Patient Augmented Reality and Vibratory Array Otorhinolaryngology Procedures

NCT06227039
View directory record Official record
Conditions
Pain, Acute, Vocal Fold Polyp, Vocal Cord Paralysis, Laryngeal Neoplasms
Interventions
Vibroacoustic stimulation on, Augmented Reality on, Vibroacoustic stimulation off, Augmented reality off
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 25, 2024 · Synced Sep 23, 2026, 9:24 AM EDT
Terminated Phase 3 Interventional

Surgery for Vocal Cord Paralysis

NCT00064571
View directory record Official record
Conditions
Unilateral Vocal Cord Paralysis
Interventions
vocal fold medialization, vocal fold reinnervation
Procedure
Lead sponsor
National Institute on Deafness and Other Communication Disorders (NIDCD)
NIH
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
12
States / cities
Birmingham, Alabama • Irvine, California • Washington D.C., District of Columbia + 9 more
Source: ClinicalTrials.gov public record
Updated Apr 23, 2006 · Synced Sep 23, 2026, 9:24 AM EDT
Not yet recruiting Not applicable Interventional

PhoRTE® Therapy Efficacy: In-Person Versus Telehealth

NCT06934265
View directory record Official record
Conditions
Atrophy of Vocal Cord, Presbyphonia, Dysphonia, Glottic Insufficiency, Voice Change, Voice Disorder, Adults, Aging, Speech Therapy, Voice Alteration
Interventions
exuberant voice therapy
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
54 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
4
States / cities
Arcadia, California • Beverly Hills, California • Glendale, California + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Sep 23, 2026, 9:24 AM EDT
Completed Not applicable Interventional

Biofeedback vs Laryngeal Control Therapy in Management of Paradoxical Vocal Fold Motion

NCT05770518
View directory record Official record
Conditions
Paradoxical Vocal Fold Motion, Vocal Cord Dysfunction
Interventions
Biofeedback, Laryngeal control therapy (LCT)
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Sep 23, 2026, 9:24 AM EDT
Completed No phase listed Observational

Cough in Reduced True Vocal Fold Mobility

NCT02407301
View directory record Official record
Conditions
Unilateral Vocal Cord Paresis, Unilateral Vocal Cord Paralysis
Interventions
cough airflow measure, vocal tasks, true vocal fold movement, spirometry test, maximum expiratory pressure (MEP)
Other
Lead sponsor
University of Florida
Other
Eligibility
40 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated May 12, 2016 · Synced Sep 23, 2026, 9:24 AM EDT
Completed Not applicable Interventional

Serial Platelet-Rich Plasma Injections for Vocal Fold Atrophy, Scar, and/or Sulcus Vocalis

NCT03749863
View directory record Official record
Conditions
Presbylarynx, Atrophy; Larynx, Dysphonia, Vocal Cord Atrophy, Presbylarynges, Vocal Fold Scar, Sulcus Vocalis of Vocal Cord
Interventions
Serial PRP injections
Procedure
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 9, 2023 · Synced Sep 23, 2026, 9:24 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Characteristics of Idiopathic Familial Voice Disorders

NCT00001552
View directory record Official record
Conditions
Laryngeal Disease, Spastic Dysphonia, Voice Disorder
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
270 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 1996
U.S. locations
2
States / cities
Iowa City, Iowa • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 23, 2026, 9:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Histological Study Evaluating Silk Voice and Crosslinked Hyaluronic Acid

NCT04315415
View directory record Official record
Conditions
Vocal Fold Palsy, Vocal Cord Paralysis, Vocal Cord Atrophy
Interventions
Silk Voice
Device
Lead sponsor
Sofregen Medical, Inc.
Industry
Eligibility
22 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 19, 2022 · Synced Sep 23, 2026, 9:24 AM EDT
Completed Not applicable Interventional

Comparison of Office-based KTP and CO2 Laser Outcomes in Patients With Vocal Cord Lesions.

NCT04575142
View directory record Official record
Conditions
Laryngeal Diseases
Interventions
CO2 laser
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 88 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 23, 2024 · Synced Sep 23, 2026, 9:24 AM EDT
Completed No phase listed Observational

Evaluating the Use of a Device Called Impulse Oscillometry in Participants With Vocal Cord Disorders or Asthma

NCT05246930
View directory record Official record
Conditions
Breathing, Mouth, Lung Function Decreased, Vocal Cord Dysfunction, Laryngeal Obstruction, Asthma
Interventions
Impulse Oscillometer
Device
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
43 participants
Timeline
2022 – 2024
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Dec 17, 2024 · Synced Sep 23, 2026, 9:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prevention and Treatment of Laryngospasm and Hypoxemia Based on Risk Factors in Adult Outpatients Undergoing EGD

NCT04159116
View directory record Official record
Conditions
Laryngospasm, Hypoxemia
Interventions
Prophylactic suctioning when clinically indicated
Other
Lead sponsor
Envision Healthcare Scientific Intelligence, Inc.
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Moon Township, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 16, 2021 · Synced Sep 23, 2026, 9:24 AM EDT