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Showing 1–24 of 66 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Vocal Folds Clear all
Completed Not applicable Interventional

Universal Screening for Vocal Fold Motion Impairment in Children Undergoing Congenital Cardiac Surgery

NCT03882450
View directory record Official record
Conditions
Vocal Fold Palsy, Dysphagia, Congenital Heart Disease in Children
Interventions
Flexible fiberoptic laryngoscopy, Laryngeal ultrasonography
Procedure
Lead sponsor
Emory University
Other
Eligibility
Up to 18 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 13, 2020 · Synced Jul 22, 2026, 3:37 AM EDT
Recruiting Not applicable Interventional

Laryngeal and Vocal Tract Strategies to Reduce Vocal Fold Contact Pressure

NCT06165536
View directory record Official record
Conditions
Mid-membranous Vocal Fold Lesion
Interventions
Resonant voice therapy
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 40 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 14, 2025 · Synced Jul 22, 2026, 3:37 AM EDT
Not yet recruiting Phase 2 Interventional

Bevonescein for Improved Intraoperative Nerve Visualization to Improve Voice Outcomes in Thyroidectomy Patients

NCT07631650
View directory record Official record
Conditions
Head and Neck Disorder, Head and Neck Cancer
Interventions
Bevonescein (ALM 488) Infusion
Drug
Lead sponsor
Matthew Spector
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Jul 22, 2026, 3:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Improving Functional Outcomes in Patients With Unilateral Vocal Cord Paralysis: Assessment of Adaptation Using Functional Magnetic Resonance Imaging

NCT00597844
View directory record Official record
Conditions
Intrathoracic Malignancies, Unilateral Vocal Cord Paralysis
Interventions
voice evaluation and fMRI, undergo voice evaluation and fMRI prior
Other
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 4, 2013 · Synced Jul 22, 2026, 3:37 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Dietary Factors and Disfluency: A Look Into Food Allergies and Other Environmental Triggers Associated With Variations in Severity of Vocal Cord Tension.

NCT02547051
View directory record Official record
Conditions
Vocal Cord Tension, Dysfluency Developmental
Interventions
Food Allergy Testing and Elimination Diet
Other
Lead sponsor
The R2 Institute
Other
Eligibility
16 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 10, 2017 · Synced Jul 22, 2026, 3:37 AM EDT
Terminated Not applicable Interventional

Impact of Duration Of Absolute Voice Rest on Voice Outcome After Phonomicrosurgery

NCT02634957
View directory record Official record
Conditions
Benign Neoplasm of True Vocal Cords
Interventions
absolute voice rest
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 14, 2020 · Synced Jul 22, 2026, 3:37 AM EDT
Recruiting Not applicable Interventional

Deconstructing Voice Therapy: Towards Enhanced Communication Outcomes

NCT07176988
View directory record Official record
Conditions
Dysphonia, Primary Muscle Tension Dysphonia (MTD)
Interventions
Hierarchical method, Non Hierarchical method
Other
Lead sponsor
Emory University
Other
Eligibility
16 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 19, 2025 · Synced Jul 22, 2026, 3:37 AM EDT
Completed Not applicable Interventional

Biofeedback vs Laryngeal Control Therapy in Management of Paradoxical Vocal Fold Motion

NCT05770518
View directory record Official record
Conditions
Paradoxical Vocal Fold Motion, Vocal Cord Dysfunction
Interventions
Biofeedback, Laryngeal control therapy (LCT)
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Jul 22, 2026, 3:37 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Efficacy of Lavender Aromatherapy on Anxiety and Pain Reduction During Awake Otolaryngologic Procedures

NCT07299474
View directory record Official record
Conditions
Inferior Turbinate Hypertrophy, Chronic Rhinosinusitis (CRS), Rhinitis, Vasomotor, Thyroid Nodules, Vocal Fold Immobility
Interventions
Lavender Aromatherapy, Placebo Aromatherapy
Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
184 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Jul 22, 2026, 3:37 AM EDT
Completed Phase 2 Interventional Results available

Controlled Study to Evaluate the Safety and Efficacy of Azficel-T for Vocal Fold Scarring and Age-Related Dysphonia

NCT02120781
View directory record Official record
Conditions
Dysphonia Resulting From Vocal Fold Scarring, Age-related Dysphonia
Interventions
Azficel-T (autologous fibroblasts), Placebo
Biological · Drug
Lead sponsor
Castle Creek Biosciences, LLC.
Industry
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
3
States / cities
Los Angeles, California • Stanford, California • New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 2, 2021 · Synced Jul 22, 2026, 3:37 AM EDT
Terminated Not applicable Interventional Results available

Expiratory Muscle Strength Training and Phonation Resistance Training Exercises For Elderly Patients With Vocal Fold Atrophy

NCT03696576
View directory record Official record
Conditions
Voice Disorder, Vocal Cord Atrophy, Presbyphonia
Interventions
EMST, PhoRTE
Device · Behavioral
Lead sponsor
Emory University
Other
Eligibility
65 Years to 95 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
2
States / cities
Atlanta, Georgia • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 29, 2021 · Synced Jul 22, 2026, 3:37 AM EDT
Terminated No phase listed Observational

Neurogenic Dysphonia/Dysphagia Registry

NCT02493491
View directory record Official record
Conditions
Neurogenic Dysphonia, Neurogenic Dysphagia
Interventions
Not listed
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years and older
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
12
States / cities
La Jolla, California • Sacramento, California • Augusta, Georgia + 8 more
Source: ClinicalTrials.gov public record
Updated Sep 8, 2016 · Synced Jul 22, 2026, 3:37 AM EDT
Not listed Phase 3 Interventional

Allograft Adipose Injectable for Vocal Fold Paralysis

NCT04700566
View directory record Official record
Conditions
Vocal Fold Palsy
Interventions
Renuva Allograft Adipose Matrix
Biological
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 5, 2023 · Synced Jul 22, 2026, 3:37 AM EDT
Active, not recruiting No phase listed Observational

Clinical Markers of Dysphagia in Cardiac Surgical Patients

NCT05304416
View directory record Official record
Conditions
Cardiovascular Diseases, Dysphagia
Interventions
Fiberoptic Endoscopic Evaluation of Swallowing, Simultaneous FEES and Videofluoroscopy instrumental swallowing exam, Videofluoroscopy instrumental swallowing exam (VFSS), Voluntary Cough Peak Expiratory Flow (PEF) Testing, Reflex Cough Screen, Lingual Pressure Testing, Speech Testing
Diagnostic Test · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 90 Years
Enrollment
347 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
2
States / cities
Gainesville, Florida • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Jul 22, 2026, 3:37 AM EDT
Completed No phase listed Observational

Evaluating the Use of a Device Called Impulse Oscillometry in Participants With Vocal Cord Disorders or Asthma

NCT05246930
View directory record Official record
Conditions
Breathing, Mouth, Lung Function Decreased, Vocal Cord Dysfunction, Laryngeal Obstruction, Asthma
Interventions
Impulse Oscillometer
Device
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
43 participants
Timeline
2022 – 2024
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Dec 17, 2024 · Synced Jul 22, 2026, 3:37 AM EDT
Active, not recruiting No phase listed Observational

Vitamin A Status in Patients With Vocal Fold Leukoplakia

NCT05323292
View directory record Official record
Conditions
Vitamin A, Vitamin A Deficiency, Leukoplakia, Vocal Cord Neoplasm
Interventions
Not listed
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Jul 22, 2026, 3:37 AM EDT
Completed No phase listed Observational

Dysphagia in Thoracic Surgical Patients

NCT04487028
View directory record Official record
Conditions
Thoracic Diseases
Interventions
Fiberoptic Endoscopic Evaluation of Swallowing
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 90 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
3
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 23, 2021 · Synced Jul 22, 2026, 3:37 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

APrevent-VOIS-Implant-002 - a Two-Part, Open-Label, Non-Randomized Multicenter Study

NCT05119842
View directory record Official record
Conditions
Paralysis, Unilateral, Vocal Cord
Interventions
APrevent® VOIS-Implant
Device
Lead sponsor
APrevent Biotech GmbH
Industry
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
4
States / cities
Phoenix, Arizona • Baltimore, Maryland • Cleveland, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2025 · Synced Jul 22, 2026, 3:37 AM EDT
Active, not recruiting Phase 2 Interventional

Vocal-cord vs. Complete Laryngeal Radiotherapy for Early Glottic Cancer

NCT03759431
View directory record Official record
Conditions
Cancer Neck, Larynx Cancer, Glottis Tumor
Interventions
Vocal-cord Radiotherapy, Complete Larynx Radiotherapy
Radiation
Lead sponsor
Centre hospitalier de l'Université de Montréal (CHUM)
Other
Eligibility
18 Years and older
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Jul 22, 2026, 3:37 AM EDT
Completed Not applicable Interventional

Comparison of Office-based KTP and CO2 Laser Outcomes in Patients With Vocal Cord Lesions.

NCT04575142
View directory record Official record
Conditions
Laryngeal Diseases
Interventions
CO2 laser
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 88 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 23, 2024 · Synced Jul 22, 2026, 3:37 AM EDT
Completed Phase 1 Interventional Results available

Bevacizumab for Treatment of Recurrent Respiratory Papillomatosis (RRP)

NCT01020747
View directory record Official record
Conditions
Recurrent Respiratory Papillomatosis
Interventions
Avastin® (bevacizumab), Saline
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 19, 2012 · Synced Jul 22, 2026, 3:37 AM EDT
Not listed No phase listed Observational

The PIONEER Initiative: Precision Insights On N-of-1 Ex Vivo Effectiveness Research Based on Individual Tumor Ownership (Precision Oncology)

NCT03896958
View directory record Official record
Conditions
Cancer, All Types, Cancer of Liver, Cancer of Stomach, Cancer of Head and Neck, Cancer of Rectum, Cancer of Kidney, Cancer of Esophagus, Cancer of Colon, Cancer Skin, Cancer of Cervix, Cancer, Metastatic, Cancer of Larynx, Cancer of Neck, Cancer of Lung, Cancer of Brain and Nervous System, Cancer of Vulva, Disseminated, Cancer of Pancreas, Sarcoma, GIST, Small-cell Lung Cancer, Adenocarcinoma Lung, Cancer of Prostate, Cancer, Advanced, Adrenal Cancer, Testicular Cancer, Uterine Cancer, Bronchoalveolar Cell Lung Cancer, Cancer Unknown Primary, Glioblastoma Multiforme, Oligodendroglioma, Breast Cancer, Renal Cell Carcinoma, Hepatocellular Carcinoma, Cholangiocarcinoma, Squamous Cell Carcinoma, Transitional Cell Carcinoma, Cancer, Other, Cancer, Anal, Melanoma, Cancer, Bile Duct, Cancer, Bladder, Cancer Cords Vocal, Cancers Cell Neuroendocrine, Cancer Differentiated Poorly, Cancer, Anaplastic Thyroid
Interventions
Not listed
Lead sponsor
SpeciCare
Industry
Eligibility
1 Month to 99 Years
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Gainesville, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 3, 2020 · Synced Jul 22, 2026, 3:37 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Modeling the Effects of Vocal Cord Atrophy on Airflow and Voice Quality in Elderly Individuals

NCT03458104
View directory record Official record
Conditions
Vocal Cord Atrophy
Interventions
Cone Beam Computed Tomography, Acoustic/Auerodynamic testing, Laryngovideostroboscopy
Other · Diagnostic Test
Lead sponsor
Duke University
Other
Eligibility
65 Years to 80 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 6, 2020 · Synced Jul 22, 2026, 3:37 AM EDT
Completed No phase listed Observational

Cough in Reduced True Vocal Fold Mobility

NCT02407301
View directory record Official record
Conditions
Unilateral Vocal Cord Paresis, Unilateral Vocal Cord Paralysis
Interventions
cough airflow measure, vocal tasks, true vocal fold movement, spirometry test, maximum expiratory pressure (MEP)
Other
Lead sponsor
University of Florida
Other
Eligibility
40 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated May 12, 2016 · Synced Jul 22, 2026, 3:37 AM EDT