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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Vocal Folds Clear all
Completed Not applicable Interventional

Dynamic Laryngeal Opening for Bilateral Vocal Fold Paralysis by an Implanted Stimulator

NCT00845442
View directory record Official record
Conditions
Vocal Cord Paralysis
Interventions
pacemaker
Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 21, 2022 · Synced Jul 22, 2026, 4:38 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Study to Evaluate the Efficacy of Optical Imaging to Evaluate the Anatomy of the Developing Pediatric Vocal Fold

NCT01810107
View directory record Official record
Conditions
Vocal Fold Development
Interventions
Children Examined with the OCT Probe
Procedure
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
1 Month to 99 Years
Enrollment
557 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 26, 2020 · Synced Jul 22, 2026, 4:38 AM EDT
Terminated Phase 3 Interventional

Surgery for Vocal Cord Paralysis

NCT00064571
View directory record Official record
Conditions
Unilateral Vocal Cord Paralysis
Interventions
vocal fold medialization, vocal fold reinnervation
Procedure
Lead sponsor
National Institute on Deafness and Other Communication Disorders (NIDCD)
NIH
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
12
States / cities
Birmingham, Alabama • Irvine, California • Washington D.C., District of Columbia + 9 more
Source: ClinicalTrials.gov public record
Updated Apr 23, 2006 · Synced Jul 22, 2026, 4:38 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Usefulness and Feasibility of Ultrasound in Office Laryngology Procedures

NCT06579989
View directory record Official record
Conditions
Cough, Vocal Cord Atrophy, Vocal Cord Paresis, Vocal Cord Paralysis, Dysphagia, Dysphonia
Interventions
Ultrasound for cough, Ultrasound for vocal fold atrophy or vocal fold paresis/paralysis, Ultrasound for dysphagia, Ultrasound for dysphonia
Diagnostic Test
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 99 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2030
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Jul 22, 2026, 4:38 AM EDT
Recruiting Early Phase 1 Interventional

Project 4: Ambulatory Biofeedback and Voice Therapy for Patients With Vocal Hyperfunction

NCT05970562
View directory record Official record
Conditions
Voice Disorders, Vocal Fold Polyp, Vocal Nodules in Adults, Muscle Tension Dysphonia
Interventions
Ambulatory Voice Monitoring with Biofeedback (AVM-B), Conversation Training Therapy
Device · Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Jul 22, 2026, 4:38 AM EDT
Completed Not applicable Interventional

Serial Platelet-Rich Plasma Injections for Vocal Fold Atrophy, Scar, and/or Sulcus Vocalis

NCT03749863
View directory record Official record
Conditions
Presbylarynx, Atrophy; Larynx, Dysphonia, Vocal Cord Atrophy, Presbylarynges, Vocal Fold Scar, Sulcus Vocalis of Vocal Cord
Interventions
Serial PRP injections
Procedure
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 9, 2023 · Synced Jul 22, 2026, 4:38 AM EDT
Withdrawn Phase 2 Interventional

Efficacy Study of Botulinum Toxin (BOTOX) Injections to Treat Vocal Fold Granulomas

NCT01678053
View directory record Official record
Conditions
Contact Ulcer of Vocal Folds, Granuloma of Vocal Cords, Granuloma, Laryngeal, Granuloma
Interventions
onabotulinumtoxinA, omeprazole (proton pump inhibitor)
Drug
Lead sponsor
Phillip Song, MD
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 27, 2017 · Synced Jul 22, 2026, 4:38 AM EDT
Withdrawn Not applicable Interventional

The Effects of Adding Expiratory Muscle Strength Training in Voice Therapy

NCT03692494
View directory record Official record
Conditions
Dysphonia, Unilateral Vocal Cord Paralysis
Interventions
Standard of care voice therapy, Expiratory muscle strength training (EMST)
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Feb 6, 2025 · Synced Jul 22, 2026, 4:38 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Respiratory and Real-time Dynamics in Exercise-Induced Paradoxical Vocal Fold Motion

NCT07420530
View directory record Official record
Conditions
Exercise-Induced Vocal Cord Dysfunction, Paradoxical Vocal Fold Motion, Vocal Cord Dysfunction
Interventions
Carbon Dioxide, Breathing treatment
Drug · Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 26 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2032
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 1, 2026 · Synced Jul 22, 2026, 4:38 AM EDT
Completed Not applicable Interventional Results available

Preliminary Study 1 to Test the Effects of Ambulatory Voice Biofeedback

NCT03416829
View directory record Official record
Conditions
Vocal Fold Nodules
Interventions
Ambulatory voice biofeedback
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 13, 2022 · Synced Jul 22, 2026, 4:38 AM EDT
Withdrawn Not applicable Interventional

Dynamic Laryngotracheal Separation for Aspiration

NCT00580346
View directory record Official record
Conditions
Aspiration Pneumonia
Interventions
Placement of laryngeal implant
Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 20, 2022 · Synced Jul 22, 2026, 4:38 AM EDT
Completed Phase 3 Interventional

Radiation Therapy in Treating Patients With Stage II Cancer of the Vocal Cord

NCT00002727
View directory record Official record
Conditions
Head and Neck Cancer
Interventions
radiation therapy
Radiation
Lead sponsor
Radiation Therapy Oncology Group
Network
Eligibility
18 Years to 120 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 2016
U.S. locations
218
States / cities
Birmingham, Alabama • Huntsville, Alabama • Mobile, Alabama + 166 more
Source: ClinicalTrials.gov public record
Updated Jan 3, 2017 · Synced Jul 22, 2026, 4:38 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Detection of Vocal Fold Motion Impairment on Noninvasive Positive Pressure

NCT06406725
View directory record Official record
Conditions
Vocal Cord Dysfunction, Vocal Cord Paralysis, Vocal Cord Paresis, Recurrent Laryngeal Nerve Palsy, Recurrent Laryngeal Nerve Injuries
Interventions
Point-of-Care Ultrasound of the Airway
Diagnostic Test
Lead sponsor
Nemours Children's Clinic
Other
Eligibility
1 Day to 18 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Queens, New York
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jul 22, 2026, 4:38 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Characteristics of Idiopathic Familial Voice Disorders

NCT00001552
View directory record Official record
Conditions
Laryngeal Disease, Spastic Dysphonia, Voice Disorder
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
270 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 1996
U.S. locations
2
States / cities
Iowa City, Iowa • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jul 22, 2026, 4:38 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Intraoperative Laryngeal Electromyography (LEMG) in Children With Vocal Fold Immobility: a Longitudinal Study

NCT00771186
View directory record Official record
Conditions
Vocal Fold Immobility
Interventions
Not listed
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
Up to 18 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 21, 2010 · Synced Jul 22, 2026, 4:38 AM EDT
Not yet recruiting Not applicable Interventional

PhoRTE® Therapy Efficacy: In-Person Versus Telehealth

NCT06934265
View directory record Official record
Conditions
Atrophy of Vocal Cord, Presbyphonia, Dysphonia, Glottic Insufficiency, Voice Change, Voice Disorder, Adults, Aging, Speech Therapy, Voice Alteration
Interventions
exuberant voice therapy
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
54 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
4
States / cities
Arcadia, California • Beverly Hills, California • Glendale, California + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Jul 22, 2026, 4:38 AM EDT
Completed Not applicable Interventional Results available

Efficacy of a Semi-occluded Mask in the Treatment of Patients With Voice Disorders

NCT03410797
View directory record Official record
Conditions
Voice and Resonance Disorders, Vocal Fold Polyp, Vocal Cord Cyst, Vocal Cord Polyp, Atrophy of Vocal Cord
Interventions
Inclusion of semi-occluded mask in voice therapy
Device
Lead sponsor
Jacqueline Gartner-Schmidt
Other
Eligibility
18 Years to 60 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 4, 2021 · Synced Jul 22, 2026, 4:38 AM EDT
Completed Not applicable Interventional Results available

Preliminary Study 2 to Test the Effects of Ambulatory Voice Biofeedback

NCT03416868
View directory record Official record
Conditions
Vocal Fold Nodules, Muscle Tension Dysphonia
Interventions
Ambulatory voice biofeedback
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 16, 2024 · Synced Jul 22, 2026, 4:38 AM EDT
Completed Not applicable Interventional

Silk Protein Microparticle-based Filler for Injection Augmentation

NCT03790956
View directory record Official record
Conditions
Vocal Cord Paralysis Unilateral, Dysphonia, Dysphagia, Oropharyngeal
Interventions
Silk Microparticle Filler Injection
Procedure
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 9, 2023 · Synced Jul 22, 2026, 4:38 AM EDT
Completed No phase listed Observational

Dysphagia and VFMI in Cardiac Patients

NCT03768739
View directory record Official record
Conditions
Cardiac Disease
Interventions
Fiberoptic Endoscopic Evaluation of Swallowing
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 90 Years
Enrollment
207 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
3
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 3, 2020 · Synced Jul 22, 2026, 4:38 AM EDT
Completed Not applicable Interventional

A Multidisciplinary Approach to Vocal Cord Dysfunction: A Novel Pilot Study

NCT01916616
View directory record Official record
Conditions
Vocal Cord Dysfunction
Interventions
Four therapy sessions with a psychologist utilizing cognitive-behavioral therapy techniques
Behavioral
Lead sponsor
CAMC Health System
Other
Eligibility
13 Years to 18 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Charleston, West Virginia
Source: ClinicalTrials.gov public record
Updated Mar 3, 2020 · Synced Jul 22, 2026, 4:38 AM EDT
Completed Not applicable Interventional

Prospective Study of Voice Therapy in Children: A Pilot Study

NCT02217111
View directory record Official record
Conditions
Vocal Fold Nodules
Interventions
Adventures in Voice: Pediatric Voice Therapy
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
4 Years to 11 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 24, 2016 · Synced Jul 22, 2026, 4:38 AM EDT
Active, not recruiting Not applicable Interventional

Functional Electrical Stimulation of the Bilaterally Paralyzed Human Larynx

NCT04028674
View directory record Official record
Conditions
Bilateral Vocal Fold Paralysis (BVFP)
Interventions
Laryngeal Pacing Device
Device
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
22 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 11, 2026 · Synced Jul 22, 2026, 4:38 AM EDT
Terminated Phase 1 Interventional

The Effect of Inhaled Corticosteroids on Vocal Fold Nodules in Children

NCT03040596
View directory record Official record
Conditions
Vocal Fold Nodules
Interventions
Fluticasone propionate, Standard voice therapy
Drug · Behavioral
Lead sponsor
Joseph Dohar, MD
Other
Eligibility
4 Years to 11 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 5, 2025 · Synced Jul 22, 2026, 4:38 AM EDT