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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Vocal Folds Clear all
Withdrawn Not applicable Interventional

The Effects of Adding Expiratory Muscle Strength Training in Voice Therapy

NCT03692494
View directory record Official record
Conditions
Dysphonia, Unilateral Vocal Cord Paralysis
Interventions
Standard of care voice therapy, Expiratory muscle strength training (EMST)
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Feb 6, 2025 · Synced Sep 24, 2026, 8:26 AM EDT
Completed Not applicable Interventional

The Efficacy of Vocal Function Exercises for Laryngeal Cancers

NCT02156518
View directory record Official record
Conditions
Vocal Folds
Interventions
Vocal Function Exercises, Vocal Hygiene
Procedure
Lead sponsor
Vrushali Angadi
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
2
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated May 7, 2018 · Synced Sep 24, 2026, 8:26 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

APrevent-VOIS-Implant-002 - a Two-Part, Open-Label, Non-Randomized Multicenter Study

NCT05119842
View directory record Official record
Conditions
Paralysis, Unilateral, Vocal Cord
Interventions
APrevent® VOIS-Implant
Device
Lead sponsor
APrevent Biotech GmbH
Industry
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
4
States / cities
Phoenix, Arizona • Baltimore, Maryland • Cleveland, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2025 · Synced Sep 24, 2026, 8:26 AM EDT
Withdrawn Not applicable Interventional

Dynamic Laryngotracheal Separation for Aspiration

NCT00580346
View directory record Official record
Conditions
Aspiration Pneumonia
Interventions
Placement of laryngeal implant
Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 20, 2022 · Synced Sep 24, 2026, 8:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Technology-assisted Vocal Exercise for Older Adults

NCT03015870
View directory record Official record
Conditions
Aging
Interventions
Vocal exercise with real-time feedback, Vocal exercise with recording
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
65 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Champaign, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 9, 2017 · Synced Sep 24, 2026, 8:26 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Patient Augmented Reality and Vibratory Array Otorhinolaryngology Procedures

NCT06227039
View directory record Official record
Conditions
Pain, Acute, Vocal Fold Polyp, Vocal Cord Paralysis, Laryngeal Neoplasms
Interventions
Vibroacoustic stimulation on, Augmented Reality on, Vibroacoustic stimulation off, Augmented reality off
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 25, 2024 · Synced Sep 24, 2026, 8:26 AM EDT
Active, not recruiting Not applicable Interventional

Functional Electrical Stimulation of the Bilaterally Paralyzed Human Larynx

NCT04028674
View directory record Official record
Conditions
Bilateral Vocal Fold Paralysis (BVFP)
Interventions
Laryngeal Pacing Device
Device
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
22 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Sep 24, 2026, 8:26 AM EDT
Active, not recruiting No phase listed Observational

Vitamin A Status in Patients With Vocal Fold Leukoplakia

NCT05323292
View directory record Official record
Conditions
Vitamin A, Vitamin A Deficiency, Leukoplakia, Vocal Cord Neoplasm
Interventions
Not listed
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 24, 2026, 8:26 AM EDT
Recruiting Not applicable Interventional

Deconstructing Voice Therapy: Towards Enhanced Communication Outcomes

NCT07176988
View directory record Official record
Conditions
Dysphonia, Primary Muscle Tension Dysphonia (MTD)
Interventions
Hierarchical method, Non Hierarchical method
Other
Lead sponsor
Emory University
Other
Eligibility
16 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 19, 2025 · Synced Sep 24, 2026, 8:26 AM EDT
Not yet recruiting Not applicable Interventional

PhoRTE® Therapy Efficacy: In-Person Versus Telehealth

NCT06934265
View directory record Official record
Conditions
Atrophy of Vocal Cord, Presbyphonia, Dysphonia, Glottic Insufficiency, Voice Change, Voice Disorder, Adults, Aging, Speech Therapy, Voice Alteration
Interventions
exuberant voice therapy
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
54 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
4
States / cities
Arcadia, California • Beverly Hills, California • Glendale, California + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Sep 24, 2026, 8:26 AM EDT
Enrolling by invitation No phase listed Observational

Outcomes Tracking in Unilateral Vocal Fold Paralysis (UVFP) and Atrophy After Medialization Laryngeal Surgery

NCT07579364
View directory record Official record
Conditions
Unilateral Vocal Cord Paralysis, Vocal Cord Atrophy
Interventions
Laryngeal Framework Surgery
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
10
States / cities
La Jolla, California • Los Angeles, California • San Francisco, California + 7 more
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Sep 24, 2026, 8:26 AM EDT
Completed Not applicable Interventional

A Multidisciplinary Approach to Vocal Cord Dysfunction: A Novel Pilot Study

NCT01916616
View directory record Official record
Conditions
Vocal Cord Dysfunction
Interventions
Four therapy sessions with a psychologist utilizing cognitive-behavioral therapy techniques, Cognitive Behavioral Therapy (CBT)
Behavioral
Lead sponsor
CAMC Health System
Other
Eligibility
13 Years to 18 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Charleston, West Virginia
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 24, 2026, 8:26 AM EDT
Completed Phase 2 Interventional Results available

Controlled Study to Evaluate the Safety and Efficacy of Azficel-T for Vocal Fold Scarring and Age-Related Dysphonia

NCT02120781
View directory record Official record
Conditions
Dysphonia Resulting From Vocal Fold Scarring, Age-related Dysphonia
Interventions
Azficel-T (autologous fibroblasts), Placebo
Biological · Drug
Lead sponsor
Castle Creek Biosciences, LLC.
Industry
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
3
States / cities
Los Angeles, California • Stanford, California • New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 2, 2021 · Synced Sep 24, 2026, 8:26 AM EDT
Completed Not applicable Interventional

Serial Platelet-Rich Plasma Injections for Vocal Fold Atrophy, Scar, and/or Sulcus Vocalis

NCT03749863
View directory record Official record
Conditions
Presbylarynx, Atrophy; Larynx, Dysphonia, Vocal Cord Atrophy, Presbylarynges, Vocal Fold Scar, Sulcus Vocalis of Vocal Cord
Interventions
Serial PRP injections
Procedure
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 9, 2023 · Synced Sep 24, 2026, 8:26 AM EDT
Completed Not applicable Interventional

Exercise-induced Paradoxical Vocal Fold Motion Disorder: Clinical Features and Potential Mechanisms

NCT02947009
View directory record Official record
Conditions
Disorder of Vocal Cord
Interventions
Diagnostic Study
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years to 18 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 13, 2017 · Synced Sep 24, 2026, 8:26 AM EDT
Completed Not applicable Interventional Results available

Efficacy of a Semi-occluded Mask in the Treatment of Patients With Voice Disorders

NCT03410797
View directory record Official record
Conditions
Voice and Resonance Disorders, Vocal Fold Polyp, Vocal Cord Cyst, Vocal Cord Polyp, Atrophy of Vocal Cord
Interventions
Inclusion of semi-occluded mask in voice therapy
Device
Lead sponsor
Jacqueline Gartner-Schmidt
Other
Eligibility
18 Years to 60 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 4, 2021 · Synced Sep 24, 2026, 8:26 AM EDT
Terminated Phase 3 Interventional

Surgery for Vocal Cord Paralysis

NCT00064571
View directory record Official record
Conditions
Unilateral Vocal Cord Paralysis
Interventions
vocal fold medialization, vocal fold reinnervation
Procedure
Lead sponsor
National Institute on Deafness and Other Communication Disorders (NIDCD)
NIH
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
12
States / cities
Birmingham, Alabama • Irvine, California • Washington D.C., District of Columbia + 9 more
Source: ClinicalTrials.gov public record
Updated Apr 23, 2006 · Synced Sep 24, 2026, 8:26 AM EDT
Active, not recruiting No phase listed Observational

Clinical Markers of Dysphagia in Cardiac Surgical Patients

NCT05304416
View directory record Official record
Conditions
Cardiovascular Diseases, Dysphagia
Interventions
Fiberoptic Endoscopic Evaluation of Swallowing, Simultaneous FEES and Videofluoroscopy instrumental swallowing exam, Videofluoroscopy instrumental swallowing exam (VFSS), Voluntary Cough Peak Expiratory Flow (PEF) Testing, Reflex Cough Screen, Lingual Pressure Testing, Speech Testing
Diagnostic Test · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 90 Years
Enrollment
347 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
2
States / cities
Gainesville, Florida • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 24, 2026, 8:26 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Straw Phonation Exercise Program for Pitch Extension

NCT05357222
View directory record Official record
Conditions
Voice Fatigue, Voice Disorders, Voice Hoarseness
Interventions
Straw phontion
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Sep 24, 2026, 8:26 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Study to Evaluate the Efficacy of Optical Imaging to Evaluate the Anatomy of the Developing Pediatric Vocal Fold

NCT01810107
View directory record Official record
Conditions
Vocal Fold Development
Interventions
Children Examined with the OCT Probe
Procedure
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
1 Month to 99 Years
Enrollment
557 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 26, 2020 · Synced Sep 24, 2026, 8:26 AM EDT
Completed Phase 1 Interventional Results available

Bevacizumab for Treatment of Recurrent Respiratory Papillomatosis (RRP)

NCT01020747
View directory record Official record
Conditions
Recurrent Respiratory Papillomatosis
Interventions
Avastin® (bevacizumab), Saline
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 19, 2012 · Synced Sep 24, 2026, 8:26 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Modeling the Effects of Vocal Cord Atrophy on Airflow and Voice Quality in Elderly Individuals

NCT03458104
View directory record Official record
Conditions
Vocal Cord Atrophy
Interventions
Cone Beam Computed Tomography, Acoustic/Auerodynamic testing, Laryngovideostroboscopy
Other · Diagnostic Test
Lead sponsor
Duke University
Other
Eligibility
65 Years to 80 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 6, 2020 · Synced Sep 24, 2026, 8:26 AM EDT
Terminated Phase 1 Interventional

Evaluating Autologous Stromal Vascular Fraction in Subjects with Vocal Fold Scar

NCT05354544
View directory record Official record
Conditions
Vocal Fold Scars
Interventions
Autologous adipose derived SVF
Biological
Lead sponsor
Shane A. Shapiro
Other
Eligibility
18 Years to 80 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 18, 2024 · Synced Sep 24, 2026, 8:26 AM EDT
Completed Not applicable Interventional

Comparison of Office-based KTP and CO2 Laser Outcomes in Patients With Vocal Cord Lesions.

NCT04575142
View directory record Official record
Conditions
Laryngeal Diseases
Interventions
CO2 laser
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 88 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 23, 2024 · Synced Sep 24, 2026, 8:26 AM EDT