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Showing 1–24 of 32 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Volume Loss Clear all
Completed Phase 2 Interventional Results available

A Dose-ranging Safety and Efficacy Study of Ecallantide to Reduce Surgical Blood Loss Volume

NCT00816023
View directory record Official record
Conditions
Bloodloss, Surgical Procedures, Operative
Interventions
ecallantide, placebo
Drug
Lead sponsor
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Industry
Eligibility
18 Years to 85 Years
Enrollment
276 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
21
States / cities
Birmingham, Alabama • Montgomery, Alabama • Aurora, Colorado + 14 more
Source: ClinicalTrials.gov public record
Updated Aug 10, 2015 · Synced Jul 22, 2026, 10:21 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Hyaluronic Acid Filler for Dorsal Finger Volume Loss

NCT02793739
View directory record Official record
Conditions
Personal Satisfaction
Interventions
Hyaluronic acid filler injection
Procedure
Lead sponsor
Marmur Medical
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 4, 2021 · Synced Jul 22, 2026, 10:21 PM EDT
Completed Phase 2 Interventional Results available

Outcomes and Safety Trial Investigating Ecallantide's Effect on Reducing Surgical Blood Loss Volume in Subjects at High Risk of Bleeding Exposed to Cardio-pulmonary Bypass During Cardiac Surgery

NCT00888940
View directory record Official record
Conditions
Bloodloss, Surgical Procedures, Operative
Interventions
Ecallantide, Cyklokapron(R)
Drug
Lead sponsor
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Industry
Eligibility
18 Years to 85 Years
Enrollment
243 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 9, 2015 · Synced Jul 22, 2026, 10:21 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Radiesse® Safety Study For the Treatment of Hands

NCT02904096
View directory record Official record
Conditions
Volume Loss in the Dorsum of the Hand
Interventions
Radiesse injectable implant and 2% lidocaine HCL
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
22 Years and older
Enrollment
256 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
9
States / cities
Sacramento, California • San Diego, California • Vista, California + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 12, 2020 · Synced Jul 22, 2026, 10:21 PM EDT
Active, not recruiting Phase 4 Interventional

A Study to Evaluate the Safety and Effectiveness of JUVÉDERM Products in Adult Participants for the Change of Their Overall Facial Appearance

NCT07186595
View directory record Official record
Conditions
Mid Face Volume Deficit
Interventions
JUVÉDERM VOLUX XC, JUVÉDERM VOLUMA XC, JUVÉDERM VOLBELLA XC, JUVÉDERM VOLLURE XC, SKINVIVE by JUVÉDERM, JUVÉDERM ULTRA XC, JUVÉDERM ULTRA PLUS XC
Device
Lead sponsor
AbbVie
Industry
Eligibility
22 Years to 65 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
10
States / cities
Los Angeles, California • San Diego, California • Vista, California + 7 more
Source: ClinicalTrials.gov public record
Updated Feb 22, 2026 · Synced Jul 22, 2026, 10:21 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Apple Hearing Study

NCT04172766
View directory record Official record
Conditions
Hearing Loss, Noise-Induced, Hearing Loss, Tinnitus
Interventions
Not listed
Lead sponsor
Apple Inc.
Industry
Eligibility
18 Years and older
Enrollment
300,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2029
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Jul 22, 2026, 10:21 PM EDT
Withdrawn Not applicable Interventional

Evaluation of Leak-Free Bronchoscope Adapter to Limit Ventilated Air Volume Loss During Bronchoscopy

NCT06310577
View directory record Official record
Conditions
Pulmonary Disease
Interventions
Leak-free bronchoscope adapter
Device
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 29, 2025 · Synced Jul 22, 2026, 10:21 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Single-Center Investigator-Initiated Evaluator-Bilateral-Comparison Pilot Study of Injectable Calcium Hydroxylapatite With and Without Triamcinolone Acetate for the Treatment of Volume Loss to Dorsum Areas of the Hands

NCT02454088
View directory record Official record
Conditions
Volume Loss to Dorsum of Hands
Interventions
Calcium Hydroxylapatite and Triamcinolone acetate, Calcium Hydroxylapatite and Placebo
Other · Device
Lead sponsor
Goldman, Butterwick, Fitzpatrick and Groff
Other
Eligibility
22 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 28, 2017 · Synced Jul 22, 2026, 10:21 PM EDT
Completed Phase 1 Interventional

Endoscopic Gastric Reduction for Weight Management

NCT01682733
View directory record Official record
Conditions
Obesity
Interventions
Botulinum toxin, Overstitch Endoscopic Suturing System
Drug · Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 50 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 6, 2015 · Synced Jul 22, 2026, 10:21 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Laser Fluorescent Imaging of Nipple and Areola During Breast Lift

NCT02201979
View directory record Official record
Conditions
Breast Sagging, Ptosis, Loss of Breast Volume
Interventions
Vertical breast lift with implants
Procedure
Lead sponsor
Swanson Center
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Leawood, Kansas
Source: ClinicalTrials.gov public record
Updated Nov 19, 2014 · Synced Jul 22, 2026, 10:21 PM EDT
Recruiting Phase 1Phase 2 Interventional

Autologous Adipose Cells Therapy

NCT06869252
View directory record Official record
Conditions
Hair Loss/Baldness, Wrinkle Appearance, Volume, Fine Lines, Skin Elasticity, Hair Thinning, Skin Pigmentation, Skin Texture
Interventions
Autologous Adipose Cells Therapy
Biological
Lead sponsor
CERM INC.
Industry
Eligibility
21 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Lewes, Delaware • Newark, Delaware
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Jul 22, 2026, 10:21 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Noninvasive Monitor of Vascular Volume Fluid Shifts

NCT05080881
View directory record Official record
Conditions
Blood Loss
Interventions
phonocardiographic measurement: InnoVital Systems, phonocardiographic measurement: ThinkLabs StethOne, physiological measurements: BIOPAC, physiological measurements: Masimo Radical-7, physiological measurements: CoVa Monitoring System 2, Thoracic impedance
Diagnostic Test
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 49 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Apr 24, 2023 · Synced Jul 22, 2026, 10:21 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Injectable Poly-L-Lactic Acid for Volumization and Adipogenesis of the Hip Dell

NCT05269654
View directory record Official record
Conditions
Skin Laxity
Interventions
injectable poly-L-lactic acid, Normal Saline
Device · Other
Lead sponsor
Goldman, Butterwick, Fitzpatrick and Groff
Other
Eligibility
30 Years to 60 Years · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 7, 2022 · Synced Jul 22, 2026, 10:21 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Radiological Evaluation of Radiesse Implantation in the Hands

NCT02949921
View directory record Official record
Conditions
Volume Loss in the Dorsum of the Hand
Interventions
Radiesse injectable implant and 2% lidocaine HCL
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
22 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Vista, California
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Jul 22, 2026, 10:21 PM EDT
Completed Not applicable Interventional Results available

Assessment of Gastric Volume Reduction in Surgical Weight Loss Candidates

NCT00721227
View directory record Official record
Conditions
Obesity
Interventions
Reduction Gastroplasty
Procedure
Lead sponsor
Ethicon Endo-Surgery
Industry
Eligibility
21 Years to 60 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 7, 2010 · Synced Jul 22, 2026, 10:21 PM EDT
Withdrawn Not applicable Interventional

Transoral Gastric Volume Reduction as an Intervention for Weight Management

NCT02578836
View directory record Official record
Conditions
Obesity, Overweight, Weight Loss
Interventions
Fogel Gastroplasty
Procedure
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 30, 2017 · Synced Jul 22, 2026, 10:21 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Facial Asymmetrical Clinical Evaluation Study

NCT03347747
View directory record Official record
Conditions
Loss of Facial Adipose Tissue
Interventions
Study Photography + Personal & Medical History Collection
Other
Lead sponsor
McDaniel Institute of Anti-Aging Research
Industry
Eligibility
45 Years to 80 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Virginia Beach, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 19, 2017 · Synced Jul 22, 2026, 10:21 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Clinical Evaluation of the Zynex Blood Volume Monitor (CM-1500) in Healthy Male Adult Subjects During a Blood Draw

NCT01646060
View directory record Official record
Conditions
Blood Loss, Healthy
Interventions
CM-1500
Device
Lead sponsor
Zynex Monitoring Solutions
Industry
Eligibility
18 Years to 65 Years · Male only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 19, 2012 · Synced Jul 22, 2026, 10:21 PM EDT
Not yet recruiting Phase 4 Interventional Accepts healthy volunteers

Assess Injectable Hyaluronic Acid Gel for the Treatment of Volume Loss, Skin Laxity and Fine Lines

NCT07421544
View directory record Official record
Conditions
Fine Lines, Wrinkle, Facial Laxity, Volume Loss
Interventions
Obagi® Saypha® MagIQ™ Injectable Hyaluronic Acid
Other
Lead sponsor
Goldman, Butterwick, Fitzpatrick and Groff
Other
Eligibility
30 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Jul 22, 2026, 10:21 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of the Zynex Blood Volume Monitor in Healthy Adult Patients During a Blood Draw

NCT01846195
View directory record Official record
Conditions
Blood Loss
Interventions
CM 1500
Device
Lead sponsor
Zynex Monitoring Solutions
Industry
Eligibility
18 Years to 35 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 8, 2022 · Synced Jul 22, 2026, 10:21 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Effectiveness and Safety of Belotero Balance® (+) Lidocaine for Volume Augmentation of the Infraorbital Hollow

NCT04594239
View directory record Official record
Conditions
Volume Loss in the Infraorbital Hollow Area
Interventions
Belotero Balance (+) Lidocaine, needle, Belotero Balance (+) Lidocaine, cannula, Untreated-control / delayed-treatment, needle, Untreated-control / delayed-treatment, cannulas
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
22 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
8
States / cities
Solana Beach, California • Vista, California • Atlanta, Georgia + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 29, 2024 · Synced Jul 22, 2026, 10:21 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of the Effects of a Biostimulator and Dermal Fillers for Cheek Augmentation and Contour Deficiencies

NCT06351358
View directory record Official record
Conditions
Photoaging, Weight Loss, Skin Laxity, Photodamaged Skin, Volume Deficiency of the Midface
Interventions
Sculptra treatment, Restylane Treatment
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years to 65 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Washington D.C., District of Columbia • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Jul 22, 2026, 10:21 PM EDT
Completed Not applicable Interventional Results available

Auto Control of Volume Management for Limb Loss

NCT03550118
View directory record Official record
Conditions
Lower Limb Amputation Below Knee (Injury)
Interventions
Adjustable socket
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 2, 2023 · Synced Jul 22, 2026, 10:21 PM EDT
Completed Phase 1 Interventional

Transoral Gastric Volume Reduction as an Intervention for Weight Management

NCT00679848
View directory record Official record
Conditions
Obesity
Interventions
RS2 (RESTORe Suturing System)
Device
Lead sponsor
C. R. Bard
Industry
Eligibility
18 Years to 60 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
2
States / cities
Boston, Massachusetts • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Jul 22, 2026, 10:21 PM EDT